DNA Nanotechnology: From Structure to Function

360 Pages·2013·12.687 MB·English

by  Chunhai Fan, Di Li (auth.), Chunhai Fan (eds.)

Chunhai Fan Editor
DNA
Nanotechnology
From Structure to Function
DNA Nanotechnology

Chunhai Fan
Editor
DNA Nanotechnology
From Structure to Function
123
Editor
Prof.ChunhaiFan
ShanghaiInstituteofAppliedPhysics
ChineseAcademyofSciences
Shanghai
China
ISBN978-3-642-36076-3 ISBN978-3-642-36077-0(eBook)
DOI10.1007/978-3-642-36077-0
SpringerHeidelbergNewYorkDordrechtLondon
LibraryofCongressControlNumber:2013934031
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Preface
DNA is a fascinating biomoleculethat is well known for its genetic role in living
systems. The emergingarea ofDNA nanotechnologyprovidesan alternativeview
that exploits unparallel self-assembly ability of DNA molecules for material use
of DNA. Since the pioneering work by Professor Nadrian Seeman of New York
Universityinthe1980s,wehaveseenrapidgrowthofthisarea,whichhasintrigued
researchersfromvariousotherareas.Afternearlythreedecadesofresearchefforts,
themeaningofDNAnanotechnologyhasevolvedfromtoylikebeautifulnanoscale
structurestoreallyusefulbuildingblocksforavarietyofapplications.
ThisbookofDNANanotechnology:FromStructuretoFunctionaimstopresent
an overviewof manyfacets of DNA nanotechnology,with the particularattention
on their promising applications. We introduce recent advances in the area of
DNA nanotechnology to provide readers, including postgraduates, postdoctoral
researchers,andresearchscientists,animpressionofnewthingsthatarehappening.
In the spirit of this goal, we have invited active scientists in this area to describe,
mostlyinatutorialstyle,interestingthingsthatoccurredduringthepastdecadeand
topointout,intheirownview,promisingdirectionsinthefuture.
Thisbookiscomposedofthreeparts.InPartI,ElementsofDNANanotechnol-
ogy, we provide, extensively, basic knowledge of DNA nanotechnology. It starts
from a brief introduction to the history of DNA nanotechnology, followed by
introduction of key elements that are involved in DNA nanotechnologyincluding
functional nucleic acids, toolboxes for DNA manipulation, and new materials for
DNAassembly.InPartII,StaticandDynamicDNANanotechnology,wedescribe
the design and fabrication of static and dynamic DNA nanostructures. Recent
advancesofDNAorigami,DNAwalkers,andDNAnanodevicesarecoveredinthis
part. In Part III, Applications of DNA Nanotechnology,we introduce a variety of
applicationsofDNAnanotechnology,includingbiosensing,computation,anddrug
delivery. Together these provide a comprehensiveoverview of this emerging area
anditsbroadimpactonbiologicalandmedicalsciences.
v
vi Preface
I am very grateful to all contributing authors and my colleagues, who kindly
acceptedtoundertakesuchatime-consumingtaskofwritingachapter.Manythanks
to these contributors for their excellent work! Last but not least, the excellent
organizational support from Springer, and particularly warm editorial help from
Ms.JuneTang,isgreatlyacknowledged.
Shanghai,China ChunhaiFan
DiLi
Contents
PartI ElementsofDNANanotechnology
1 BriefHistoryofDNANanotechnology................................... 3
ChunhaiFanandDiLi
2 FunctionalNucleicAcidsforDNANanotechnology.................... 7
YishunHuang,ZhiZhu,andChaoyongYang
3 Selenium Atom-Specific Mutagenesis (SAM)
for Crystallography, DNA Nanostructure Design,
andOtherApplications.................................................... 29
SiboJiang,HuiyanSun,andZhenHuang
4 Liposomes for DNA Nanotechnology:Preparation,
Properties,andApplications .............................................. 57
NeeshmaDaveandJuewenLiu
5 ManipulationandIsolationofIndividualDNAMolecules
withAtomicForceMicroscope............................................ 77
YiZhangandJunHu
6 Single-MoleculeMechanicsofDNA...................................... 87
ShuxunCui
7 MicrofluidicToolsforDNAAnalysis..................................... 113
YiZhangandXingyuJiang
PartII StaticandDynamicDNANanotechnology
8 DNA-Directed Assembly of Nanophase Materials:
AnUpdatedReview ........................................................ 157
HuiqiaoWangandZhaoxiangDeng
vii
viii Contents
9 Self-AssembledDNA-InorganicNanoparticleStructures.............. 185
ZhongChen,XiangLan,andQiangbinWang
10 DNAOrigamiNanostructures ............................................ 207
HuajieLiuandChunhaiFan
11 Design,Fabrication,andApplicationsofDNANanomachines........ 225
ChenSong,Zhen-GangWang,andBaoquanDing
12 DNAWalkingDevices...................................................... 263
JieChaoandChunhaiFan
PartIII ApplicationsofDNANanotechnology
13 FunctionalDNA-IntegratedNanomaterialsforBiosensing............ 277
LeleLiandYiLu
14 NucleicAcidEnzyme-BasedDNANanomachineforBiosensing...... 307
DiLiandChunhaiFan
15 DNANanotechnologyandDrugDelivery................................ 321
WanqiuShen
16 DNA-Nanotube-EnabledNMRStructureDetermination
ofMembraneProteins ..................................................... 335
JohnMin,WilliamM.Shih,andGae¨tanBellot
17 Deoxyribozyme-BasedMolecularComputation ........................ 353
RenjunPei
Part I
Elements of DNA Nanotechnology