Disseminated Intravascular Coagulation (DIC) Clinical Manifestations, Diagnosis and Treatment Options

202 Pages·2013·4.217 MB·English

by  Balwinder Singh

RECENT ADVANCES IN HEMATOLOGY RESEARCH

D I
ISSEMINATED NTRAVASCULAR
C (DIC)
OAGULATION

C M ,
LINICAL ANIFESTATIONS
D
IAGNOSIS AND
T O
REATMENT PTIONS

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R A
ECENT DVANCES
H R
IN EMATOLOGY ESEARCH

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RECENT ADVANCES IN HEMATOLOGY RESEARCH

D I
ISSEMINATED NTRAVASCULAR
C (DIC)
OAGULATION

C M ,
LINICAL ANIFESTATIONS
D
IAGNOSIS AND
T O
REATMENT PTIONS

BALWINDER SINGH, M.D.
EDITOR

New York
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ISBN: (cid:28)(cid:26)(cid:27)(cid:16)(cid:20)(cid:16)(cid:25)(cid:21)(cid:28)(cid:23)(cid:27)(cid:16)(cid:22)(cid:21)(cid:26)(cid:16)(cid:25) (eBook)

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Published by Nova Science Publishers, Inc. † New York
Contents

Preface vii
Chapter I Disseminated Intravascular Coagulation:
Clinical Manifestations 1
Akhilesh Kumar Tiwari, MD, Michell Gulabani, MD,
Prashant Dass, MD and Rishi Raj Sanjay, MD
Chapter II Risk Factors for Disseminated Intravascular
Coagulation 15
Akhilesh Kumar Tiwari, MD, Rajiv Ratan Singh, MD,
Rishi Raj Sanjay, MD, Naveen Ganjoo, MD
and Balwinder Singh, MD
Chapter III Thrombomodulin and Disseminated
Intravascular Coagulation 41
Shu-Min Lin MD and Han-Pin Kuo MD, PhD
Chapter IV Diagnostic Scoring System for Disseminated
Intravascular Coagulation 57
R. K. Singh, MD
Chapter V Outcome of Critically Ill Patients with Disseminated
Intravascular Coagulation in a Tertiary Care Center 77
Balwinder Singh MD, Rabe’ Elias Alhurani MBBS
and Pablo Moreno Franco MD
Chapter VI Sepsis and Disseminated Intravascular Coagulation 93
Luis Aurelio Diaz Caballero, MD
vi Contents
Chapter VII Coagulopathy of Liver Disease versus Disseminated
Intravascular Coagulation: Who is Who? 119
Pablo Moreno Franco MD, Jose Yataco MD
Balwinder Singh MD and Juan Canabal MD
Chapter VIII Disseminated Intravascular Coagulation in
Urological Malignancy 143
Aydin Pooli MD and Dharam Kaushik MD
Chapter IX Chronic Disseminated Intravascular Coagulation
(DIC) in Solid Tumors: When, Whom and
How to Treat? 155
Felice Vito Vitale, MD, Giovanna Antonelli, MD,
Rosalba Rossello, MD and Francesco Ferraù, MD
Chapter X Treatment Options for Disseminated
Intravascular Coagulation 167
Vaibhav Wadhwa MD and Kriti Kalra MD
Index 181
Preface

Disseminated Intravascular Coagulation is a devastating syndrome
characterized by the systemic activation of widespread activation of the
coagulation cascade and thrombosis, which may result in severe bleeding and
may lead to organ failure. Recent studies have shown that the incidence of
DIC is decreasing, especially in men. Despite the improvements in health care
delivery, the morbidity and mortality due to DIC remains very high. Early
diagnosis and accurate prognosis are important in improving the outcomes of
patients with DIC.
However, there is a lack of a gold standard diagnostic test to diagnose DIC
and there is a scarcity of treatment or management strategies. Therefore, an
understanding of the pathophysiology, ability to diagnose the DIC syndrome
and to treat early, is the key. This book provides an important timely update on
the clinical manifestations, important risk factors, and treatment strategies for
DIC, and provides in-depth information on pathophysiological aspects and
various diagnostic scores used to diagnose DIC. Furthermore, we focused on
certain important factors related to DIC such as Sepsis, chronic DIC in cancer
patients, coagulopathy of liver disorders vs DIC, and DIC in urological
malignancies.
In addition, this book provides evidence from an important study
determining the predictors influencing the hospital mortality rates of the
critically ill patients with DIC. This book offers a wide scope of information
for physicians in all fields, whether they are intensivists, primary care
physicians or oncologists, this will be an important source for identifying the
DIC syndrome early, and the appropriate steps to improve patient outcomes
will be taken sooner.
viii Balwinder Singh
I would like to thank all the contributing authors from different fields,
who have made a sincere effort to provide in-depth knowledge of DIC in
various different settings. I hope that this book would be able to impart
important knowledge and understanding on this serious syndrome and help the
physicians to diagnose and manage DIC appropriately.