Disease Management

513 Pages·2009·6.266 MB·English

by  Randall, Michael D. Randall

Disease Management
Second edition

Disease Management
A guide to clinical pharmacology
Michael D Randall
MA, PhD
Associate Professor and Reader in Cardiovascular Pharmacology
University of Nottingham Medical School
Nottingham, UK
Karen E Neil
BPharm (Hons), PhD, MRPharmS
Pharmacist
Nottingham, UK
London •Chicago
Published by the Pharmaceutical Press
An imprint of RPS Publishing
1 Lambeth High Street, London SE1 7JN, UK
100 South Atkinson Road, Suite 200, Grayslake, IL 60030–7820, USA
© Michael D Randall and Karen E Neil 2009
is a trade mark of RPS Publishing
RPS Publishing is the publishing organisation of the
Royal Pharmaceutical Society of Great Britain
First edition published 2003
Second edition published 2009
Typeset by Type Study, Scarborough, North Yorkshire
Printed in Great Britain by Cambridge University Press, Cambridge
ISBN 978 0 85369 767 1
All rights reserved. No part of this publication may be reproduced,
stored in a retrieval system, or transmitted in any form or by any
means, without the prior written permission of the copyright holder.
The publisher makes no representation, express or implied, with
regard to the accuracy of the information contained in this book and
cannot accept any legal responsibility or liability for any errors or
omissions that may be made.
The right of Michael D Randall and Karen E Neil to be identified as
the authors of this work has been asserted by them in accordance
with the Copyright, Designs and Patents Act, 1988
A catalogue record for this book is available from the British Library
Cert no. SA-COC-1527
This book is dedicated to our other halves, Clare and Geoff,
and to Thomas and Tamsin Randall and Jenna Neil.

Contents
Preface xi
General reading xiii
Note to the reader xv
Acknowledgements xvi
About the authors xvii
Abbreviations xviii
Part A
The patient 1
1 Signs and symptoms 3
2 Clinical laboratory tests 15
3 Lifestyle 21
4 Herbal medicine and alternative remedies 37
Part B
Treatment 47
5 Adverse drug reactions and interactions 49
6 Clinical pharmacokinetics 73
Part C
Gastrointestinal diseases 83
7 Dyspepsia and peptic ulcer disease 85
8 Nausea and vomiting 97
viii Contents
9 Lower gastrointestinal problems 103
10 The liver patient 113
Part D
Cardiovascular diseases 117
11 Hypertension 119
12 Hyperlipidaemia 133
13 Obesity 147
14 Ischaemic heart disease 157
15 Heart failure 169
16 Thromboembolic prophylaxis 185
17 Anaemias 193
18 The renal patient 199
Part E
Respiratory diseases 207
19 Coughs and colds 209
20 Allergy 217
21 Respiratory diseases: asthma and chronic obstructive pulmonary disease 225
Part F
Central nervous system disorders 239
22 Migraine 241
23 Epilepsy 249
Contents ix
24 Affective disorders 259
25 Anxiety disorders 285
26 Insomnia 295
27 Schizophrenia 303
28 Parkinson’s disease 317
Part G
Pain and palliation 325
29 Pain management 327
30 Musculoskeletal pain 347
31 The cancer patient: cancer and palliative care 361
Part H
Infections 375
32 Bacterial infections 377
33 Non-bacterial infections 397
Part I
Dermatology 405
34 Dermatology 407
Part J
Endocrine disorders 425
35 Diabetes mellitus 427
36 Thyroid disorders 441