(Digital Academic Repository) The influence of thyroid disorders on adverse pregnancy outcomes ...

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The influence of thyroid disorders on adverse pregnancy outcomes
Vissenberg, R.
Publication date
2016
Document Version
Final published version
Link to publication
Citation for published version (APA):
Vissenberg, R. (2016). The influence of thyroid disorders on adverse pregnancy outcomes.
[Thesis, fully internal, Universiteit van Amsterdam].
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Download date:13 Jan 2023
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13407_Vissenberg_OM.indd 1 10-02-16 13:17

THE INFLUENCE OF THYROID DISORDERS ON
ADVERSE PREGNANCY OUTCOMES
Rosa Vissenberg
Financial support for printing of this thesis was kindly provided by Stichting Gynaecologische Endocrinologie
en Kunstmatige Humane Voortplanting, Schildklier Organisatie Nederland, Stichting Fertiliteitsfonds
(www.fertiliteitsfonds.nl), Toshiba Medical Systems Nederland, Nutricia Early life Nutrition and by SBOH.
Met dank aan: Saskia’s huiskamerrestaurant
ISBN: 978-94-6299-306-8
Printed by: Ridderprint BV – www.ridderprint.nl
Layout: Ridderprint BV – www.ridderprint.nl
Cover design: Lyanne Tonk, www.persoonlijkproefschrift.nl
© All rights reserved. Save exceptions stated by the law, no part of this publication may be reproduced, stored in a
retrieval system of any nature, or transmitted in any form or by any means, electronic, mechanical, photocopying,
recording or otherwise, included a complete or partial transcription, without the prior written permission of the
publishers, application for which should be addressed to the author.
THE INFLUENCE OF THYROID DISORDERS ON ADVERSE
PREGNANCY OUTCOMES
ACADEMISCH PROEFSCHRIFT
ter verkrijging van de graad van doctor
aan de Universiteit van Amsterdam
op gezag van de Rector Magnificus
prof. dr. D.C. van den Boom
ten overstaan van een door het College voor Promoties ingestelde commissie,
in het openbaar te verdedigen in de Agnietenkapel
op vrijdag 29 april 2016, te 12.00 uur
door Rosa Vissenberg
geboren te Eindhoven
PROMOTIECOMMISSIE
Promotores: Prof. dr. J.A.M. van der Post Universiteit van Amsterdam
Prof. dr. E. Fliers Universiteit van Amsterdam
Co-promotores: Dr. M. Goddijn Universiteit van Amsterdam
Dr. P.H.L.T. Bisschop Universiteit van Amsterdam
Overige leden: Prof. dr. J.H. Kok Universiteit van Amsterdam
Prof. dr. F. van der Veen Universiteit van Amsterdam
Prof. dr. C.B. Lambalk Vrije Universiteit Amsterdam
Prof. dr. E.A.P. Steegers Erasmus Universiteit Rotterdam
Dr. R.P. Peeters Erasmus Universiteit Rotterdam
Dr. C. Ris-Stalpers Universiteit van Amsterdam
Faculteit der Geneeskunde
CONTENTS
Chapter 1 General introduction and outline of the thesis 7
Chapter 2 Significance of (sub)clinical thyroid dysfunction and thyroid autoimmunity 17
before conception and in early pregnancy: a systematic review
Human Reproduction Update 2011;17:605-19
Chapter 3 Increased Thyroid Stimulating Hormone in early pregnancy is associated with 49
breech presentation at term: a nested cohort study
Accepted in adapted form in European Journal of Obstetrics and Gynecology and
Reproductive Biology
Chapter 4 Is subclinical hypothyroidism associated with lower live birth rates in women 65
with unexplained recurrent miscarriage?
Submitted
Chapter 5 Pathophysiological aspects of thyroid hormone disorders/ thyroid peroxidase 79
autoantibodies and reproduction
Human Reproduction Update 2015;21:378-87
Chapter 6 Treatment of thyroid disorders before conception and in early pregnancy: 105
a systematic review
Human Reproduction Update 2012;18:360-73

Chapter 7 Live-birth rate in euthyroid women with recurrent miscarriage and thyroid 131
peroxidase antibodies
Gynecological Endocrinology 2015;2:1-4
Chapter 8 Effect of levothyroxine on live birth rate in euthyroid women with recurrent 141
miscarriage and TPO antibodies (T4-LIFE study)
Contemporary Clinical Trials 2015;44:134–138
Chapter 9 General discussion 159
Chapter 10 Summary 167
Nederlandse samenvatting 172
Addendum 177
List of co-authors and their contribution 178
List of publications 182
Portfolio 184
Dankwoord 186
Curriculum Vitae 188

1 |
General introduction and outline of the thesis