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Diagnostic
Lymph Node Pathology
THIRD EDITION
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Diagnostic
Lymph Node Pathology
THIRD EDITION
Margaret Ashton-Key
Consultant Histopathologist
University Hospital Southampton NHS Foundation Trust
Honorary Senior Lecturer, University of Southampton, UK
Penny Wright
Consultant Histopathologist
Cambridge University Hospitals NHS Trust
Associate Lecturer, Cambridge University, UK
Dennis Wright
Emeritus Professor of Pathology
University of Southampton, UK
CRC Press
Taylor & Francis Group
6000 Broken Sound Parkway NW, Suite 300
Boca Raton, FL 33487-2742
© 2016 by Taylor & Francis Group, LLC
CRC Press is an imprint of Taylor & Francis Group, an Informa business
No claim to original U.S. Government works
Version Date: 20160317
International Standard Book Number-13: 978-1-4987-3270-3 (eBook - PDF)
This book contains information obtained from authentic and highly regarded sources. While all reasonable efforts have been made to publish reliable
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The publishers wish to make clear that any views or opinions expressed in this book by individual editors, authors or contributors are personal to them
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Contents
Preface to the third edition vii
Preface to the second edition ix
Preface to the first edition xi
Acknowledgements xiii
Authors xv
Abbreviations xvii
1 Handling of lymph node biopsies, diagnostic procedures and recognition of lymph node patterns 1
2 Normal/reactive lymph nodes: Structure and cells 13
3 Reactive and infective lymphadenopathy 19
4 Precursor B- and T-cell lymphomas 53
5 Mature B-cell lymphomas 59
6 T-cell lymphomas 101
7 Immunodeficiency-associated lymphoproliferative disorders 127
8 Hodgkin lymphoma 133
9 Histiocytic and dendritic cell neoplasms, mastocytosis and myeloid sarcoma 149
10 Non-haematolymphoid tumours of lymph nodes 163
11 Needle (trephine) core biopsies of lymph nodes 167
Appendix 1: Immunohistochemical markers used in diagnosis of lymphoproliferative conditions 187
Index 193
v
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Preface to the third edition
When our new publishers invited us to update Diagnostic readily available guide to the correct diagnosis and categori-
Lymph Node Pathology with a third edition we were happy sation of lymph node pathology.
to comply. This has enabled us to include a few new items, It is the custom in many administrations to refer biop-
to improve some of the illustrations and to introduce new sies diagnosed as malignant lymphoma to a panel of expert
ones. The text and references have been updated. We have haematopathologists for confirmation of the diagnosis.
retained the chapter on the handling of lymph node biop- Our hope is that this book will help general pathologists to
sies and revised the chapter on needle biopsies. The format identify cases in need of referral and to provide a readily
of the book remains as before with the use of high-quality available source of information as a bench book for trainees,
illustrations and boxes to succinctly present the clinical, for general pathologists and also for haematopathologists.
morphological, immunohistochemical and genetic features This book was originally conceived by Professor Anthony
of each entity. The text is concise and is accompanied by Leong. Sadly, Professor Leong died at the time the second
relevant and up-to-date references. These features make edition of the book was published.
the book more than an atlas. Our aim has been to create a
vii
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