Table Of ContentDiagnostic Gynecologic and Obstetric
Pathology
THIRD EDITION
Christopher P. Crum, MD
Professor
Department of Pathology
Harvard Medical School;
Vice Chair and Director of Women's and Perinatal Pathology
Department of Pathology
Brigham and Women's Hospital
Boston, Massachusetts
Marisa R. Nucci, MD
Professor of Pathology
Harvard Medical School;
Senior Pathologist
Department of Pathology
Brigham and Women's Hospital
Boston, Massachusetts
Brooke E. Howitt, MD
Assistant Professor
Department of Pathology
1
Harvard Medical School;
Associate Pathologist
Brigham and Women's Hospital
Boston, Massachusetts
Scott R. Granter, MD
Associate Professor of Pathology
Harvard Medical School;
Associate Pathologist
Department of Pathology
Brigham and Women's Hospital
Boston, Massachusetts
Mana M. Parast, MD, PhD
Associate Professor
Department of Pathology
University of California San Diego
La Jolla, California
Theonia K. Boyd, MD
Director, Anatomic Pathology
Department of Pathology
Boston Children's Hospital;
Staff Pathologist
Division of Women's and Perinatal Pathology
Department of Pathology
Brigham and Women's Hospital
Boston, Massachusetts
2
Associate Clinical Editors
Hope K. Haefner, MD
Professor
Department of Obstetrics and Gynecology
Michigan Medicine
Ann Arbor, Michigan
William A. Peters III, MD
Clinical Professor
Department of Obstetrics and Gynecology
University of Washington;
Division of Gynecologic Oncology
Swedish Cancer Institute
Seattle, Washington
3
Table of Contents
Instructions for online access
Cover image
Title Page
Copyright
Dedication
Contributors
Preface
Acknowledgments
Chapter 1 Female Genital Tract Development and Disorders of
Childhood
Abstract
Overview of Reproductive Tract Development
Common Disorders of Gonadal and Genital Tract Development
Key Points
References
Chapter 2 Noninfectious Inflammatory Disorders of the Vulva
Abstract
Introduction
Types of Disorders
Key Points
References
Chapter 3 Localized Vulvodynia
Abstract
4
Introduction
History of Vulvar Pain Terminology
Causative Theories of Vulvodynia
Histopathology
Treatment of Localized Vulvodynia
Key Points
References
Chapter 4 Infectious Disorders of the Lower Genital Tract
Abstract
Introduction
Common Infections
Common Infections Not Typically Linked to Sexually Transmitted
Diseases
Common Sexually Transmitted Infections
Uncommon Sexually Transmitted Diseases
Other Rare Infections
Common and Rare Vulvar Infections Associated With Immune
Suppression
Key Points
References
Chapter 5 Benign Cysts, Rests, and Adnexal Tumors of the Vulva
Abstract
Introduction
Benign Cysts
Benign Rests
Benign Adnexal Tumors
Key Points
References
Chapter 6 Squamous Neoplasia of the Vulva
Abstract
5
Introduction
Low-Grade Squamous Intraepithelial Lesions
Pediatric Complications of Human Papillomavirus Infection
High-Grade Squamous Intraepithelial Lesions
Diagnostic Terminology
Differentiated Exophytic Vulvar/Squamous Intraepithelial Lesions
Squamous Cell Carcinoma
HPV-Negative Squamous Cell Carcinomas
Proposed Report Wording With Diagnostic Terms
Outcome Variables in Vulvar Squamous Carcinoma
Extremely Well-Differentiated Verruco-Papillary Squamous Cell
Neoplasms
Basal Cell Carcinoma
Key Points
References
Chapter 7 Glandular and Other Malignancies of the Vulva
Abstract
Introduction
Adenosquamous Carcinoma
Adenocarcinoma
Carcinoma of Bartholin Gland
Merkel Cell Carcinoma
Cloacogenic Neoplasms
Other Rare Primary and Metastatic Tumors
Urethral Neoplasms
Key Points
References
Chapter 8 Melanocytic Lesions of the Vulva
Abstract
Introduction
6
Evaluation of Pigmentation
Genital Melanosis (Genital Melanotic Macule)
Genital-Type Nevus
Dysplastic Nevi
Melanoma
Key Points
References
Chapter 9 Soft Tissue Lesions of the Vulva and Vagina
Abstract
Introduction
Vulvovaginal Stromal Tumors and Tumor-Like Lesions
Fibrohistiocytic Tumors
Lipomatous Tumors
Smooth Muscle Tumors
Skeletal Muscle Tumors
Vascular Lesions
Neural Tumors
Miscellaneous Tumors
Key Points
References
Chapter 10 Diseases of the Anus
Abstract
Introduction
Non-Neoplastic Lesions
Neoplasms of the Anus
Key Points
References
Chapter 11 Benign Conditions of the Vagina
Abstract
7
Introduction
Benign Vaginal Epithelial Changes Occurring in Older Women
Benign Lesions Following Hysterectomy
Adenosis and Columnar Metaplasia
Cysts of the Vagina
Endometriosis
Fibroepithelial Polyps of the Lower Female Genital Tract
Traumatic Lesions
Infections of Systemic Importance
Rare Infections
Inflammatory and Ulcerative Lesions of Unknown Cause
Emphysematous Vaginitis
Key Points
References
Chapter 12 Epithelial and Mixed Epithelial-Stromal Neoplasms of the
Vagina
Abstract
Introduction
Vaginal Squamous Intraepithelial Lesions
Malignant Epithelial Neoplasms of the Vagina
Key Points
References
Chapter 13 Cervical Squamous Neoplasia
Abstract
Introduction
Cytology
Nondiagnostic Squamous Atypia (Atypical Squamous Cells of
Undetermined Significance)
Diagnosis and Management of Invasive Squamous Cell Carcinoma
Key Points
8
References
Chapter 14 Columnar Cell Neoplasia of the Cervix
Abstract
Overview
Principles of Cytology in the Diagnosis of Columnar Cell Neoplasia
Diagnosis and Management of Adenocarcinoma in Situ
Diagnosis and Management of Adenocarcinoma of the Cervix
Key Points
References
Chapter 15 Neuroendocrine Carcinoma, Mixed Epithelial/Mesenchymal
and Mesenchymal Tumors, and Miscellaneous Lesions of the Cervix
Abstract
Neuroendocrine Carcinoma
Undifferentiated Carcinoma
Mixed Epithelial/Mesenchymal Neoplasms
Adenomyoma and Polypoid Adenomyoma of the Endocervical Type
Cervical Adenofibroma
Cervical Adenosarcoma
Cervical Carcinosarcoma
Mesenchymal Neoplasms
Genital Rhabdomyoma
Glomus Tumor
Superficial Myofibroblastoma
Smooth Muscle Tumors
Alveolar Soft-Part Sarcoma
Peripheral Neuroectodermal Tumor/Ewing Sarcoma
Endometrial Stromal Sarcoma
Undifferentiated Endocervical Stromal Sarcoma
Melanocytic Lesions
Hematopoietic Lesions
9
