Diabetes Mellitus and Human Health Care: A Holistic Approach to Diagnosis and Treatment

506 Pages·2014·5.6 MB·English

by  Anne George

DIABETES MELLITUS AND
HUMAN HEALTH CARE
A Holistic Approach to Diagnosis
and Treatment
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DIABETES MELLITUS AND
HUMAN HEALTH CARE
A Holistic Approach to Diagnosis
and Treatment
Edited by
Anne George, Robin Augustine,
and Mathew Sebastian
Apple Academic Press
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ABOUT THE EDITORS
Anne George
Anne George, MD, is an Associate Professor at Government Medical College,
Kottayam, Kerala, India. She did her MBBS (Bachelor of Medicine, Bachelor
of Surgery) at Trivandrum Medical College, University of Kerala, India. She ac-
quired a DGO (Diploma in Obstetrics and Gynaecology) from the University of
Vienna, Austria; Diploma Acupuncture from the University of Vienna; and an
MD from Kottayam Medical College, Mahatma Gandhi University, Kerala, India.
She has organized several international conferences, is a fellow of the American
Medical Society, and is a member of many international organizations. She has
five publications to her name and has presented 25 papers.
Robin Augustine
Mr. Robin Augustine is a research fellow working at International and Interuniver-
sity Centre for Nanoscience and Nanotechnology, Mahatma Gandhi University,
Kottayam, Kerala, India. He received a bachelor’s degree in botany from the Uni-
versity of Calicut, Kerala, India, and a master’s degree in bioengineering from
Madurai Kamaraj University, Tamil Nadu, India. He is experienced in develop-
ing smart biomaterials such as wound dressings, tissue engineering scaffolds, and
suture matrials. Presently he is engaged in the design and development of nano-
technology-based smart wound dressing materials for chronic diabetic wounds.
He has publications in international journals and conference proceedings in his
credit.
Mathew Sebastian
Mathew Sebastian, MD, has a degree in surgery (1976) with specialization in
Ayurveda. He holds several diplomas in acupuncture, neural therapy (pain
therapy), manual therapy, and vascular diseases. He was a missionary doctor in
Mugana Hospital, Bukoba in Tansania, Africa (1976–1978), and underwent surgi-
cal training in different hospitals in Austria, Germany, and India for more than
vi About the Editors
10 years. Since 2000 he is the doctor in charge of the Ayurveda and Vein
Clinic in Klagenfurt, Austria. At present he is a Consultant Surgeon at Privatclinic
Maria Hilf, Klagenfurt. He is a member of the scientific advisory committee of the
European Academy for Ayurveda, Birstein, Germany, and the TAM advisory com-
mittee (Traditional Asian Medicine, Sector Ayurveda) of the Austrian Ministry for
Health, Vienna. He conducted an International Ayurveda Congress in Klagenfurt,
Austria, in 2010. He has several publications to his name.
CONTENTS
List of Contributors ....................................................................................ix
List of Abbreviations ................................................................................xiii
Preface ...................................................................................................xxiii
1. Diabetes and Health Care: An Overview .................................................1
M. Abhilash and Robin Augustine
2. Withania coagulans Dunal: An Overview on Its Up to Date
Antidiabetic Investigations ....................................................................131
S. Hemalatha, Satyendra K. Prasad, Manish Kumar, and S. D. Dubey
3. Evaluation of Total Phenolics and Free Radical Quenching
Activity of Glycosmis pentaphylla (Retz.) A. DC. .................................169
Rahul Chandran and Thangaraj Parimelazhagan
4. Antioxidant, Antidiabetic, and Chemical Composition of Syzygium
aqueum Leaf Extracts .............................................................................187
Uma D. Palanisamy and Thamilvaani Manaharan
5. Review on Novel 2,4-Thiazolidinedione Derivatives as Potential
Therapeutic Agents for Type II Diabetes ..............................................229
Gangadhara Angajala and Radhakrishnan Subashini
6. Molecular Mechanism of S-Oxidation of Anti-Diabetic
Thiazolidinedione Class of Drugs: Computational Approaches
to Drug Metabolism ................................................................................247
Nikhil Taxak and P. V. Bharatam
7. Role of Wound Dressings in the Management of Chronic and
Acute Diabetic Wounds ..........................................................................273
Robin Augustine, Nandakumar Kalarikkal, and Sabu Thomas
8. Recent Advances in Diabetic Foot Care: The Role of Footwear
and Orthosis ............................................................................................315
G. Saraswathy, Gautham Gopalakrishna, B. N. Das, and Vijay Viswanathan
9. Temporal Effect of Repeated Stress on Type-2 Experimental
Diabetes ...................................................................................................357
Debapriya Garabadu and Sairam Krishnamurthy
viii Contents
10. Sugar Rich Diet Induced Insulin Resistance and Alteration in Gut
Microflora ................................................................................................393
Prasant Kumar Jena, Shilpa Singh, and Sriram Seshadri
11. Prevalence of Diabetes Mellitus in Patients Presenting With
Acute Myocardial Infarction .................................................................431
Meeakshi Narkhede, Satyanarayan Durgam, Harshal Bhitkar, Swapnil Yadav,
and Dilip Mhaisekar
12. Development of Therapeutic Strategy to Restore Coronary
Microcirculation and VEGF Signaling Cascade in Diabetes: A
Novel Approach to Prevent Cardiac Complication in Diabetes .........447
Subrina Jesmin, Arifur Rahman, Abdullah Al Mamun, Farzana Sohael,
Shamima Akter, Yoshio Iwashima, Nobutake Shimojo, Naoto Yamaguchi,
Michiaki Hiroe, Taro Mizutani, and Masao Moroi
Index ........................................................................................................479
LIST OF CONTRIBUTORS
M. Abhilash
School of Biosciences, Mahatma Gandhi University, Priyadarshini Hills, Kottayam–686560, Kerala,
India.
Shamima Akter
Health and Disease Research Center for Rural Peoples (HDRCRP), Dhaka–1207, Bangladesh.
Gangadhara Angajala
Chemistry Research Laboratory, School of Advanced Sciences, VIT University, Vellore–632014,
Tamil Nadu, India.
Robin Augustine
International and Interuniversity Centre for Nanoscience and Nanotechnology, Mahatma Gandhi
University, Priyadarshini Hills, Kottayam–686560, Kerala, India.
P. V. Bharatam
Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research
(NIPER), Sector-67, S. A. S. Nagar, Mohali–160062, Punjab, India.
Harshal Bhitkar
Department of Medicine, Dr. S. C. Government Medical College, Nanded–431601, Maharashtra,
India.
Rahul Chandran
Bioprospecting Laboratory, Department of Botany, Bharathiar University, Coimbatore–641046,
Tamil Nadu, India.
B. N. Das
Shoe Design and Development Centre, Council of Scientific and Industrial Research–Central Leather
Research Institute, Adyar, Chennai–600020, Tamil Nadu, India.
S. D. Dubey
Department of Dravaguna, Institute of Medical Sciences, Banaras Hindu University, Varanasi–221005,
India.
Satyanarayan Durgam
Department of Medicine, Dr. S. C. Government Medical College, Nanded–431601, Maharashtra,
India.
Debapriya Garabadu
Neurotherapeutics Lab, Department of Pharmaceutics, Indian Institute of Technology, Banaras Hindu
University, Varanasi–221005, India.
Gautham Gopalakrishna
Shoe Design and Development Centre, Council of Scientific and Industrial Research–Central Leather
Research Institute, Adyar, Chennai–600020, Tamil Nadu, India.