Development and Application of Novel Conformation-Specific Monoclonal Antibodies for

144 Pages·2016·10.7 MB·English

by  Nour Khaled Majbour

United Arab Emirates University
Scholarworks@UAEU
Accounting Dissertations Accounting
6-2014
Development and Application of Novel
Conformation-Specific Monoclonal Antibodies for
Parkinson’s Disease Pathology.
Nour Khaled Majbour
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Part of theMedical Pharmacology Commons
Recommended Citation
Majbour, Nour Khaled, "Development and Application of Novel Conformation-Specific Monoclonal Antibodies for Parkinson’s
Disease Pathology." (2014).Accounting Dissertations. 18.
https://scholarworks.uaeu.ac.ae/account_dissertations/18
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Acknowledgments
Iw oulldi kteoe xprmeyss sp ecaipaplr eciaantdti hoannt koms y s upervisor,
Preo forO maErI -Agfn.H aipsa ssihoiansm, b itainodhn ises n thustioawsamrh diss
worwk rea gra ti nspirfaotmrie o.Tn h eb esptr itzhea ltie o fffreemde w ast he
chantcoeb eh isst udaenndwt o rhka radtw orwko rtdho inHge.t augmhett oh ave
fiatihnm ye fla ndt oc onqumeyrf ae rsF.r ohmi mIl earnthta ntom attheorwm any
deefatIsm aye ncounitnme yrl ief,I m usnto bte d eefateIdh .a vbee eenx tremely
bleesdt oh ae au pervwihsooc ra rseodm ucahb omuytw orka,n dw hor esponded
tom yq uestanido qnu eri0ep sr omptly.
pecial ttomh yaf nmakisl fyor t heuinrc ondiltoivoaenn adsl u ppoWrotr.d s
cannovte erx prheo wg rautleI af nt1o m ym othaenrdm yf tahefro r all of their
sacreisaf nidp rayers.
Iw oulldi kteoe xtemnydt hantkoas l mly a cadeemdiucc ators, myes pecially
commitmteemeb erPsr eos forA bduA demP,r eosfsoArh madA l-Marzaonudq i
PreosfsSoeru ng-LJeaefeor t hepirri cealdevsitsch er ougmhyos uttu dy.
Specitahla ngkots o m yf irenidnst htee amN:is haVnati kaMtuhs taaA frdah,
ShiVjair gheSsalee,m Bae guma,n dS nidhMue nofno trh seu ppoarntdl ong-tern1
workirnagp ptohretsy h arweidtm he .Ir ealalpyp recoiuawrto er kitnegr amnsdt heir
heltph rougmhyow uotr akn dI 'ldi kteoe xtemnydg oowdi shfeostr h efiutru re.
Thank yocuo ldleeaarg ues.
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yearasn,di ncenmteet dos trtiovwea rmdygs o al.
Lastbluytn otl easIt'l,di kteot hantkh Ceo lleogfMe e dicainndeH ealth
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awayw eaa lotfh knowledge.
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Dedictaino
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Abstract
An abunndcaeo fg enetboiicch,ie cmaaln dh itsopathoelvodigeinccael
uggetshtatsth [ eon naitoonfa -synu(cal-espiyrnno )td eeipno issia tnis mp otrant,
andlk ielsye milsn,ta eipn dtehvee loopfms eenvtei rmpaolr tnaenoutdr egenerative
dsieasteh,e o -acldl seyunclneopiathiinecdsli,unP ga irskno'nsD iesas(eDP )
demn tiwaih t Lewyb odiaensdm uillpt-esystaetmr opDheys.p dietcea doefs
itnnesirveee a rcthod, a tteh,oe n layc cepdtigeando sfiorPs D i sb asoendc liicnal
critae-rSnic yaon.v ersforimos nol bulmeo nomienoro t ilgomoerfir bsrl irse presents
a rucitaelip n s ynluencioptiahse pathogehnoewseivse;re xatmchetec hanism
undr li gnt hel cuaerla lggreghaatnsio otn bfuelelenylc uiadteAd g.r oiwnbgo doyf
evidesnucgeet g st haat- snsy olubolileg oemrsr,a thtehram na tufrbierl isa,r teh e
neouotrxipc c ise.A lackb ioofrm kaefrrost heea rdlaiygo nsiosf PiDsa m ajor
obslteat cop orvigd eiranldyi esase-iymfiondtgh eraTpoiweasrt.dih sa imw,e
devoepleadn dt hogrholucyhr aactenroivzceeoldo n nfniaotn-csipfimeco nloocln a
anbtoiidset hastp ieccfiallyr ceoginzaes- ynp athoglyoI.mp ortaonutarln iytob,d si e
weraeb lteod etedfcieftr eansts beilmeosfa -ns ayggregraatnegsfio rnmgs olbule
oloimegrtso m atuirnoe l bulfiebr iClosn.ise dritnhgce r iatlpi acthiogcre olneo fa ­
sysno luabglegegr atesn ovoaeunlrt ibmoigdhipter so vipdoer tidamignanto satnidc
tehratpieocup porittsui.ne
Nextw,e d evoeplendwe immnuoassaqyunsat fitydo fie fresnptie sceo fa -syn
(ottaal- s.ya n-nso yloimegrasn pd- 1S92 -a-slvyeenli)sn recberioanslflp ui(dC S)F
form PpDa tsi eanantgde -mahtecahlectdoh noytl rCso.m ibngit nhmee asureomfe nts
dfiefreans-ty snp eciinCe SsF ,f ouwnead c laerd fiefrteinCaSlFp a ttbeernt wPeDen
viii
andc ontrOoulrrs e.ls tuvsla diattedh ues efulnoefcs osm ibnimnugl tiCpSlFe
biormkaeirnis m opvriPnDgd aignoasctciucra anpcdry o gnoesvtailcu ation.
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