Table Of ContentBreCaasntca enIrdo dine
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Acknowledgements:
Myw ifeP amty,s omualt ieis,ne vesreyno sfte h weo rtdh e
reafosrot nhb ioso k.
Twoo thhearvbsee einm porstoaunntbd oiantrgotd hse
develoopftm hceeon tn cepts;
MarjMocrKiien annoFdnr anSktiaep les.
Kudfoorsa lylo uerf forts.
Authnoort'es
Thiboso ikas t heordeitsiccuaaslns hdia oasnl ,bs oen ep roductoe d
priodvien foramnaddti isocnu osdfsi iffoenirsde eanabtso a uptp roatcoh es
brecaasntcS eorme.ex amopafl neesc droetshauallv tes dbiesecnub suste d
arneo mte atnoit m ptlhyta htre e swuelrtmeso rteh an Tthhtahte.o ries
e,
pufto rwhaerardret e e stiatnbh tleie m e-homnaonunorepfer rod p setru dies
witahd eqnuuamtbeoe fpr eso tpoml aek tehs et atsiisgtniificcsa nt.
Wek notwh aatls li gnifiicdaenoatras p nperwo atcodh iffiecsu lt
problheamvste os tasrotm ewwhieotrhnep e a tiTehnmitas.b y e p lanned
ora cceindtFarolmt. heprehera past enttahteimovarebyy e f ormeadn d
thceo ncepto nar neo-ttphraeitreiO dev nettri. am newd i atk hn owloefd ge
thleo ngearn-etcedrmro etsauwllec t asgn,e a tf efeoltrh v ea liodfni etwy
ideas. PGracetnietraailroi entn e hbrees ps ots imteidoinct aoel xlaym ine
three soufla tltslr eatBmyet nhnteas t.ou ftr hee rierl attoti hopena tient
thceaywn a tncohot n tlhyee ff eoctft ht er eatbmuaetln astloo,l ft hoet her
factwohrimsca hiy n flutehnoecu et come.
Nootn iltsyh bioso ikn combpulsteo tmaees, p eocftt htseh eoarriee s
steivloll ovnit nhbgea soiffs u rtehxepre rAites nomcpeeo .id nutr ai ng
proceosfis n vesthiogwaetovineoher;na t,sos it adnosdwa nsy o mheitng
abowuhte wreae r Iedt.o e'smtne atnh waeth avteha en swbeurttsh t,ah ti s
iwsh aitts h ouagtthh pti osi Tnhtbi.os o ikts h erreefaotlrhpleeroy l otgou e
al aregdeirtT iiomhneab. se net hmea ifna cptroerv emnefrt oimmn agk ing
thbioso aksc ompalneddte et aaisIlw eodul lidTk hepe.u rpoosfiei t ts o
stuipdr i scuostfsh dieiffio cnu alnctd o mpplroebxlo ebfmr ecaasntac nedr
canicnge re neral.
Becatuhseieras ed istinocfct o mlparcekht ehnesoairbvioeetu sht e
mechanoicfsa mnscn eorr, ee afflo rt hmaasdi etnb h eiesnt cobo omopka re
competthienogIr nif easci.tnm , o sitn staonfdc iessc ubsyws oirolnd
authorciotmipeasro,ift s hoeno hraibsee nsed iscoubreacgaeoudfs e
cancceorm'psl meuxlittiyop,fcl aiucsiaetynvs da, r iyao bfci lliinatincda l
microsocuotpciocm es.
Id on ofte el we dsihsocuolufrdrao gmtb eriedyn Tgh.e oarriweeh sa t
allsocwi enttoei xsptlnsoa rtewu irtee hy easnbd ra itnhsaa trm eo re
focuEsvseeifnd t a.h eiossrh yo twobn e warnosdnt gi mutlhaotuteghshe t ,
nerwe searccahln ev taioadgm oorrc eo rrectC otmhpeetothrieyno.gr ies
malyae dt moo rraep iadda vncemorfe enstce hpa rrogratmosw atrhrede al
goaolfc onqucearnicTnehgr.u t shi,en formparteiosneh netrieeisdinn n o
waiyn teansads eudb stfioptrru otmpeee irdc aadlv efri ocmt hree aders
physiIctfih baionsos. ke rtvsoe tsi mduilsactueis wtsi ihloalnvs ,eev reidt s
purpaoths ies time.
Tabolfce o ntents
II.n trod.u.c.t.i.o.n. ..........I. ..............................................
2I.o d.i.n.e. ...............5. ......................................................
3T.h yrGoliadan ndtd h yrhooirdm. o.n.e. ...3.5. ...............
4.C anc..e.r. ...............5.5. ..................................................
5.B reCaasnt.c .e.r. ............8.1. ..........................................
Introduction
Thibso oiksa botuhtce a use, parntedrv eeanottfmbi eronenta st
cancOevret.rhl ea csetn teunroyud gahat naod b servhaatvieo ns
becoamvea itloaa blllteoh wce o lleocftt himioasnt eirniata ol
coheurnednetr,s taantnded satbtalhbeeol sfhei o sbw r ecaasntc er
staarnhtdos iw pt r ogrTehsmisosen so.gt rhaeprhie dsfoe rveot toe d
theex ploorfaan teiowou nt ltooowkab rrdecsaa sntwc ieptrah s sing
mentoirfoe nl caatnecaden drdis s eWahseednsi .s cucsasnwicene gr
are taabloakus iytns gtp ermoicwceh siascl,hl tohwdese velopment
ofap rediscetqauboelfbne ic oel ocghiacnlagelea sdt iocn agn cer.
Thpirse seinnsto matet aitnobotnee xhauansdIt h iovpteceo,o mplete
·mao rceo mprethreenasotitfmvh eetin hstei stnih fuset uPreu.r posely,
Ih aavded rtehsbisoseot dwko o mweinbt rhe caasntSc ienrrc.ee a ding
somoeft hset oorfpi eerss onal exbpreecraaisnetIcn a ecmre,s with
fuolafld mirfoartt hkieno onw laeneddng teh uwsiiwtahhsi tmch he y
purtshudieis s aenads ert ehseec aorncnhew cititethd.
Paorftt hper espeanrtt icbiywp oamteiinsro enl attote hde
actiwvhiiasccmhc omptahAneIi DdeSid s oeuatsbeF roetrahfi ker. s t
tiwmoem seantw l tmhtte oyho aa dp laictneh d ee cisioann dm aking
begtaionn flureenscefuean rdcithno gw aprrdosjt ehicentyss t inctively
knenwe eedxepdl Tohriiiassnd gm.i rable, breecsaeuasrec ha cademic
cananlowtsa eyoesb vihooulisetn sh r ee sefiaerlacdnhstd ,h meayy
nobtea bolrei nterienfis ltlieintdn h go hsoelI eitshs .a rtdog et
awafryo mb recaasntc er staasut,ni cshtaminocgrset,rda a lstiuetcsyh
sintchreee cowredrksee ipntth 1e9 2A0lss.o disacrtoehu er aging,
2 • BreaasnItdo dCiannec er
newdleys idgenteedac ntsdic orne emneitnhwgoh dissc,eh et mofa il
icnh andgiisneogau stceo Imitees vs ed.ni sapptohioanltfatd si hnigo n
seelxfa minaaptpienoaotnrtho s e wlipst uhr vTihveadslie.s couraging
resaunlsdtt sa tmiasyotn ilbcyest hree soufall ta ocfkac oherent
understtahnedooafrtb yhcl eae u osfbe r ecaasntsc oet rha ac tl ean
newa ppro.taotc hhde i secaasne s btea rStleodwd.li yf ferent
exploraaptporroyta ocb hreesca asntca ererem ergfrionmtg h e
peripohfte hprery e seesntta bclainsuchneedrde rstbaunntod nien g,
yesth oawc leoapre ntiocn rga tchkme y stoeftr hydi iss eIaitss e .
hoptehdta hti sp rleistetwnlitegla iltfov ioeofod nr t houagnmhdat y be
letaosd o mfuer tahdevra nces.
Thmeo nogriadspi hv iidnefotduo r p arts:
1.Iodainnidete sv olutriooilnnte h acene dl l
2.Iodainntdeh yrhooirdma onnidetr se lattoti hopena st ient's
constitution
3.Canciengr e nearsapa rlo cess.
4.Brecaasntfic berro cdyissteiiatcpss re e,v eanntadir orne st.
Thfier psatir istn formoanti ioodanin nidetr se latttoi hboeon d y
antdh yrgoliaIdno dd.ai pnpeet abore ts hl ee uansdte rstood important
elemmeanktiu nptg h beo dfyl uaindcdse lolfhs u maInosd.hi anse
beenne gleachst uegadem, o uonrfte ss efuanrdhcsah vn eou tn covered
anoyt her offiu ondctithnitaeohn nia mtta kes htohrymraoonnided
iste ravsae nse xcealnlteinste ptwiehc a,vk enw ohwfoinrcm ho re
thaahn u ndyreeadIr nss p.i otfae lt lhr ee sewaerd conh o ktn ow
whabti ochepmrioccaeiplsta s retsi iconir wp haatpteai srpt tl aiyns
thoev erall omfteh tbeao bdooytl htiehsriam tnr s oi ltneh foer mation
oft hyrhooirdm one.
Ip ropporsiem atrhialty i isto hdteir niegm geecrh afonri sm
apopt(otsnhiaest udreaaoltf ch e lalnstd)h mea isnu rveillance
mechafonria sbmn ocrmealillnt s hb eo dIyo.d tirnieg tghdeeer ast h
ofc elwlhsia craheb noorrwm hailhc ahvn eo rpmralo grammed death
asp aorftt h eliicrfey cTlheii.pss a orfat getnheertsahilias ot d ine
antdh yrhooirdma ocnatesa t eatmpo rovaci odnes stuarnvte illance
agaianbsnto rcmedalellv elocphmeemnittch,aaa rltces a rcinogenic
antdh sep reofac da ncceelrwl ist thhibeno .dI yodaipnpee taor s
havsee vemroarrelo lietnsh b eo dIyo.d pirnoet aegcatiasnb snto rmal
growotfbh a ctientr hiseat om(ahcehl icpoyblaoicrsttih me eor s t
clinsiicganlilyfiI coadcniatncn)eo . ia ntc omailnlgep rrgoittceo i ns
make ntohne-ma lwlheirlcgihik cae,lls ayop pltiote hisen ternal
equeinvctaa llaluetdo imdmiusneIeao sdebi.in nesd osft tloty h e
douabnltder ibpolnoedfl iptiopdr so ttheecst e botnhdaesry e w hile
beitnrga nspsoyrntaespdit tiitentcos h b er aainbndl ood ovfe ssels
thbeod yA.sw eilold iitnnh ese t omdaecahc tailbvlia otleosag nidc al
moscth empiociaslAo lonlfts h.e nseepw r optoessetdfa ubnlcet ions
ofi odairndeei scuTshseierasded . i scuosfts hpieoo sns riobollfee
iodiinen veo luitnri eolnat todi eovne loopfmm uelntti -cellularity
anmda turoafvt eirotne Tbhrgeae tneetsrh aeolsft i hsbi osoi kts h at
theiarss e p ecdiofioscefi o diinntea kew haiibcptohr v eevs eenvtesr al
disease ipnrcolcutedhsiorsnseegels ta tofie bdr ocdyissteiacs e and
brecaasntc er
Thsee cpoanirdrst e ltatoth etedh yrhooirdm oanntedhs te h yroid
glaInnbd o.to hft hefisrets wtso e ctsioomsneus g geasstt ioto hnes
evolutioonfia ordyai nsntdoeh u yrrcoei da rhoeou rtmlFoirnnoeem d .
hewreec aunn dertshttaaitns ldse uveoe ftl hsy rhooirdma ornjeeu st
asi mporintfoa mtno tri em portthacanintr cubllaoltoeidvn Iegitl s s .
proptohstaehtdy rhooirdmh oancseo ntrtohgleel neod(m Neu clear
DNAs equeentsccie)ns tc hbeee ginBneicnagouf.ts heci osn,t orfo l
intracleollwel vuoelftla hsry rhooirdmw oonuetl edtn odl e gte nes,
whiccahcn a udsies etaeoss ec,aa npedex press tThheemrseefolrvee s.
thyroid mhaoirpnmu ornpaeos'sisefrd ,oe mk eeptihngege nome
staibtslor e u,en a cohft hcee lilnrs e lattoei aoconht haenardl tsoo
permissailvloeotlwhyh e orrm onteoas c t.
Thyrhooirdm coanmewe e lble foarneoy ft hoet hheorr mones
anhda tsa kueptn h peo siotfti homeno sitm porhtoarnmtoS nien.c e
iodcianmebe e fo'rteh yhroorimdot nheie,on d iimsno er iem portant
thatnhh eo rmoSnoemo.eft hcel inaiscpaeolcft t hsy rhooirdm one
treatamrdeein st'c uisnrs eeldat todi iosnt ur"bitanhnr ece ecse ptor
mechanainisdtmr sse lattihoynrh ootirodm r oensei stance.
Thteh ipraddr eta llasr gweilttyhhfi en dionftg hsie n tensive
canicnevre stoiftg haleta 6is0oyt ne sao rrms o rTeh.le a DtreD. a vid
ClaJrrk.e wrdoettea tishlooemuodegn t h htbesi olodgeivceallo pment
4 B•r eCaasntca enIrdo dine
oft hcea npcreorc Neos,was l.o wnigtf hi ndbiyDn rgS.sa mposfo n
thMea ycol iinnti hce 1i9bt7e 0cso,m est hepavetir dhceaanpntsc er
iasb iphparsoic(cet swpsoh asMeosr)ce.l easrtlacyta endhc,ae sr
twpoh asesfi.r isscTt oh net rboyil oldeuidpnt eot hpeh enomena
cal"lceadr ciinns oimtoaur" " o cccualntca enrtd"h yrhooirdm one
seetmcoso ntrsoelc-pothnhadens aem,et lhsyep reoacfd a nwcietrh in
connetcitsisvuee s.
Thfeo ratnlhda psatcr otn ctehraenp sp liocfta htfieir otsnht r ee
parttobs r ecaasntcM eurco.hft hmea teirnti hapilas or ftt h beo ok
seetmofas l iln ptloa ictfeh p eo stuplufoatrt weasar rldee gitimately
represwehnaitthsi a npgp einnti hndigis s eWaisttehh. ec soen cepts
wec arne ltahtreei f sakc atnoedrp si demisotluodoginibe crsae la st
cantcope rre veannttdir oena tment.
Ona pernsooItwn eaa ntlteo x plbariimney flr yo utttoeh b ioso k.
Havibnegc ohmieg thrlayi annqedud a ltiofid eobd a sriecs earch,
domesrtei-ca rramnagdepemu ernsotuftsi h tci asr aefi enra ncial
impostsyHi.eb niIclh eia adc ompclaertceehe arni gn1e 9 7fr2o,m
acadehmailtclot s hfr eo nlti noefgs e neprraalcI twtia cmsey o. v er
ridpihnigl owshoepIenh n yt egreendep rraalct thiIawc toe u lleda rn
anpdr acttoli icstetot e hpnea tiSeiWnrit l.l Oisalsmea rii ctdl early
buSty ndesnahiiafitdmr stthi,ayf to lui sttote hpnea tiewnitl lt hey
teyloltu h dei agnaonisdyfi o slu i setveemnno rcel ostehlewyyi ll
·teyloltu h ceo rrterceta tIhm aevntetr .it eohd o nmeys kiilntl hsi s
onaer oefam edicainfondue n idtt o b eag olmdi noefi nteresting
necwo ncepts.
