Cystic Fibrosis Pulmonary Infections: Lessons from Around the World

336 Pages·1996·6.3 MB·English

by  Dr Barbara Przyklenk

Respiratory
Pharmacology and
Pharmacotherapy
Cystic Fibrosis Pulmonary
Infections: Lessons from
Around the World
Edited by
A. Bauernfeind
M. I. Marks
B. Strandvik
Birkhauser Verlag
Basel· Boston' Berlin
Editors:
Professor Dr. Adolf Bauernfeind Melvin I. Marks, MD
Max von Pettenkofer-Institut Professor and Vice C half of Pediatrics
Pettenkoferstrasse 9a University of California at Irvine
D-80336 Munich Medical Director/Administrator
Germany Memorial Miller Children's Hospital
Long Beach Memorial Medical Center
2801 Atlantic Avenue
Long Beach, California 90801
USA
Birgitta Strandvik, MD, PhD
Professor of Pediatrics
Department of Pediatrics
Faculty of Medicine
Gbteborg University
S-416 85 Gbteborg
Sweden
Library of Congress Cataloglng-in-Publlcatlon Data
Cystic fibrosis pulmonary Infections < lessons from around the world I
edited by A Bauernfeind, M I. Marks, B< Strandvik
(Respiratory pharmacology and pharmacotherapy)
Includes bibliographical references and Index
ISBN 978-3-0348-7361-1 ISBN 978-3-0348-7359-8 (eBook)
DOI 10.1007/978-3-0348-7359-8
1 <R espiratory organs -Infections -Treatment 2< Cystic fibrosis - Compllcations
Treatment I. Bauernfeind, A (Adolf) II. Marks,
Melvin I. III. Strandvik, B< (Birgitta) IV Series<
[DNLM: 1 <C ystic FibrOSIS - complications 2< Cystic Flbrosis
therapy< 3< Lung Diseases - complicatlons< 4< Lung Dlseases
therapy< WI 820 C9997 1996]
RC740< C96 1996
616<2' 4 - dc20
DNLM/DLC
for Library of Congress
Deutsche Blbliothek -Cataloging-in-Publishing Data
Cystic fibrosis pulmonary infections: lessons from around the
world I ed< by A Bauernfeind< << - Basel; Boston; Berlin:
Blrkhauser, 1996
(Respiratory pharmacology and pharmacotherapy)
ISBN 978-3-0348-7361-1
NE Bauernfeind, Adolf [Hrsg<]
The publisher and editors cannot assume any legal responsibility for information on drug dosage and
administration contained in this publication< The respective user must check ItS accuracy by consulting
other sources of reference in each individual case<
The use of registered names, trademarks, etc in this publication, even if not identified as such, does
not imply that they are exempt from the relevant protective laws and regulations or free for general use<
This work is subject to copyright All rights are reserved, whether the whole or part of the material is
concerned, specifically the rights of translation, reprinting, re-use of illustrations, recitation, broadcasting,
reproduction on microfilms or in other ways, and storage in data banks< For any kind of use the
permission of the copyright holder must be obtained<
© 1996 Birkhauser Verlag, PO Box 133, CHA01 0 Basel, Switzerland
Softcover reprint of the hardcover 1 5t edition 1996
Printed on acid-free paper produced from chlorine-free pulp< TCF =
ISBN 978-3-0348-7361-1
987654321
Contents
List of Contributors. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . IX
Introduction ............................................ " XV
Cystic Fibrosis Pulmonary Infections: General Aspects
1. Viral, Fungal and Atypical Bacterial Infections in Cystic
Fibrosis
B. Przyklenk and A. Bauernfeind ........................ .
2. Pharmacokinetics of Antibacterials in Cystic Fibrosis
F. Sorgel, M. Kinzig, C. Labisch, M. Hofmann and
U. Stephan .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 13
3. Antimicrobial Pharmacotoxicity
H. C. Farrar and G. L. Kearns. . . . . . . . . . . . . . . . . . . . . . . . . . 29
4. Microbial Resistance
L. Saiman and A. Prince .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 51
5. Microbial Virulence and Pathogenesis in Cystic Fibrosis
E. Mahenthiralingam and D. P. Speert. . . . . . . . . . . . . . . . . . . . 65
6. Lung Transplantation
B. P. Madden and M. E. Hodson. . . . . . . . . . . . . . . . . . . . . . . . 85
Cystic Fibrosis Pulmonary Infections: The International Perspective
7. The General Approach to Cystic Fibrosis-Related Pulmonary
Infection in the United States
H. R. Stutman . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 99
8. The General Approach to Cystic Fibrosis Pulmonary
Infection in Canada
N. MacDonald, M. Corey and R. Morrison. . . . . . . . . . . . . . .. 111
9. Cystic Fibrosis in Latin America
C. N. Macri, O. H. PiveUa, A. Gentile, E. G. Cafferata and
M. C. Luna........................................... 119
10. Pulmonary Infections in Venezuelan Patients with Cystic
Fibrosis
S. Alvarez de Garcia Tunon and H. Reyes. . . . . . . . . . . . . . . .. 139
11. Pulmonary Infection in Cystic Fibrosis: The Australian
Approach
P. D. Phelan. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. 149
VI Contents
12. Cystic Fibrosis in Japan
Y. Yamashiro, T. Shimizu, S. Oguchi, T. Shioya, S. Nagata
and Y. Ohtsuka ................................. -. . . . .. 161
13. The General Approach to Cystic Fibrosis Pulmonary
Infection in Russia
T. E. Guembitskaia, L. A. Vishnyakova, L. A. Zhelenina and
N. J. Kapranov. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. 167
14. Cystic Fibrosis in Israel: Clinical and Microbiological
Aspects
E. Kerem, J. Rivlin, Y. Yahav, A. Tal, A. Szeinberg and
I. Shalit. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. 175
15. The State of Cystic Fibrosis in Turkey
M. Demirkol, Z. Erturan, G. Huner, T. Baykal, G. Kurdoglu
and O. Ang. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. 189
16. The General Approach to Cystic Fibrosis Pulmonary
Infection in Greece
George S. Adam. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. 203
17. The General Approach to Cystic Fibrosis Pulmonary
Infection in Italy
R. Padoan, A. Pianaroli and A. Giunta . . . . . . . . . . . . . . . . . .. 209
18. The General Approach to Cystic Fibrosis Pulmonary
Infection in Spain
S. Carrasco and F. Baquero. . . . . . . . . . . . . . . . . . . . . . . . . . . .. 223
19. Cystic Fibrosis in the Western Part of Germany: A General
Review about Cystic Fibrosis Management
H.-G. Posselt . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. 229
20. The General Approach to Cystic Fibrosis Pulmonary
Infection in the Eastern Part of Germany: Patients' Register
and Clinical Research
P. Wunderlich, K.-D. Paul and B. Wiedemann............. 239
21. Pulmonary Infection and its Management in Cystic Fibrosis
Patients in the Czech Republic
V. Vavrova, Z. Jedlickova, O. Lochmann, D. Zemkova,
H. Krasnicanova, M. Macek, M. Macek Jr., A. Zapletal,
J. Biolek, A. HolCikova, H. Honomichlova, A. Kolek,
J. Musil, I. Sekyrova, M. Sulakova, L. Toukalkova and
H. Vanicek . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. 251
22. The General Approach to Cystic Fibrosis Pulmonary
Infection in Hungary
K. Gyurkovits . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. 259
23. The General Approach to Cystic Fibrosis Pulmonary
Infection in Denmark
S. S. Pedersen, N. HUiby and C. Koch. . . . . . . . . . . . . . . . . . .. 267
Contents VII
24. The General Approach to Cystic Fibrosis Pulmonary
Infection in The Netherlands
L. V. Moller, J. E. Dankert-Roelse, J. Margriet Coltee,
L. van Alphen and J. Dankert .......................... , 279
25. Cystic Fibrosis Pulmonary Infections: The Swedish
Experience
B. Strandvik, L. Hjelte and A.-S. Malmborg ............... 293
26. Cystic Fibrosis Pulmonary Infections: The UK Experience
S. Elhorn, J. Dodge and J. Littlewood ................... , 303
27. The General Approach to Cystic Fibrosis Pulmonary
Infection in Mexico
J. L. Lezana-Fernandez and D. Maza-Gonzales ........... , 315
28. The General Approach to Cystic Fibrosis Pulmonary
Infection in Uruguay
S. M. Caheza. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. 325
Subject index. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. 331
Contributors
G. S. Adam, Cystic Fibrosis Centre, "Aghia Sophia" Children's
Hospital, 11527 Athens, Greece
S. Alvarez de Garcia Tuiion, Department of Pediatrics, University
School of Medicine, Central University of Venezuela, Venezuela
O. Ang, Department of Microbiology, Istanbul Faculty of Medicine,
University of Istanbul, 34390 <";apa, Istanbul, Turkey
F. Baquero, Cystic Fibrosis Unit of the Ramon y Cajal Hospital,
28034 Madrid, Spain
A. Bauernfeind, Max von Pettenkofer-Institut, Ludwig-Maximilians
UniversiUi.t, Munchen, Germany
T. Baykal, Division of Nutrition and Metabolism, Department of
Pediatrics, Istanbul Faculty of Medicine, University of Istanbul,
34390 <";apa, Istanbul, Turkey
J. Biolek, Department of Pediatrics, Most Hospital, 434 64 Most,
Czech Republic
S. M. Cabeza, Scientific Medical Advisory Committee, Association of
Cystic Fibrosis in Uruguay, Costa Rica 2061, Montevideo,
Uruguay
E. G. Cafferata, Instituto Nacional de Genetica Medica, Las Heras
2670, 1425 Buenos Aires, Argentina
S. Carrasco, Cystic Fibrosis Unit, La Paz Children's Hospital, 28046
Madrid, Spain
J. M. CoHee, Department of Human Genetics, Free University, 1081
HV Amsterdam, The Netherlands
M. Corey, Canadian Cystic Fibrosis Foundation, Toronto, Ontario,
Canada M4S 2B4
J. Dankert, Department of Medical Microbiology, University of
Amsterdam, Academic Medical Centre, 1105 AZ Amsterdam, The
Netherlands
J. E. Dankert-Roelse, Department of Pediatrics and Pediatric
Pulmonology, Free University, 1081 HV Amsterdam, The
Netherlands
M. Demirkol, Division of Nutrition and Metabolism, Department of
Pediatrics, Istanbul Faculty of Medicine, University of Istanbul,
34390 <";apa, Istanbul, Turkey
J. Dodge, Department of Child Health, Royal Victoria Hospital,
Belfast, UK
x Contributors
S. Elborn, Adult Cystic Fibrosis Unit, Belfast City Hospital, Belfast
BT9 7AB, UK
Z. Erturan, Department of Microbiology, Istanbul Faculty of
Medicine, University of Istanbul, 34390 <;apa, Istanbul, Turkey
H. C. Farrar, Department of Pediatrics, University of Arkansas for
Medical Sciences, Little Rock, Arkansas, and Divisions of
Pediatrics, Clinical Pharmacology, and Emergency Medicine,
Arkansas Children's Hospital, Little Rock, Arkansas 72202, USA
A. Gentile, Hospital de Ninos "Ricardo Gutierrez", 1425 Buenos
Aires, Argentina
A. Giunta, Centre for the Diagnosis, Prevention and Therapy of
Cystic Fibrosis, "De Marchi" Pediatric Clinic, University of Milan,
20122 Milan, Italy
T. E. Guembitskaia, Cystic Fibrosis Centre, State Research Centre
for Pulmonology, St. Petersburg, Russia
K. Gyurkovits, Hospital for Chest Diseases, County Somogy, 7257
Mosd6s, Hungary
L. Hjelte, Department of Pediatrics, Karolinska Institutet, Huddinge
Hospital, S-14186 Stockholm, Sweden
M. E. Hodson, Department of Cystic Fibrosis, Royal Brompton
National Heart and Lung Hospital, London SW3 6NP, UK
M. Hofmann, IBMP - Institute for Biomedical and Pharmaceutical
Research, D-90562 Niirnberg-Heroldsberg, Germany
N. H0'iby, The Cystic Fibrosis Center, Rigshospitalet, DK-2100
Copenhagen, Denmark
A. Holcikova, University Children's Hospital, 662 63 Brno, Czech
Republic
H. Honomichlova, Department of Pediatrics, University Hospital
Plzen, 305 99 Plzen, Czech Republic
G. Hiiner, Division of Nutrition and Metabolism, Department of
Pediatrics, Istanbul Faculty of Medicine, University of Istanbul,
34390 <;apa, Istanbul, Turkey
N. J. Kapranov, Cystic Fibrosis Centre, State Research Centre for
Pulmonology, St. Petersburg Institute for Medical Genetics,
Moscow 197089, Russia
G. L. Kearns, Department of Pediatrics and Pharmaceutics,
University of Arkansas for Medical Sciences, Little Rock,
Arkansas, and Divisions of Pediatrics and Clinical Pharmacology,
Arkansas Children's Hospital, Little Rock, Arkansas 72202, USA
E. Kerem, Cystic Fibrosis Center, Shaare Zedek Medical Center,
Jerusalem 91031, Israel
M. Kinzig, IBMP - Institute for Biomedical and Pharamceutical
Research, D-90562 Niirnberg-Heroldsberg, Germany
Contributors XI
C. Koch, The Cystic Fibrosis Center, Rigshospitalet, DK-2100
Copenhagen, Denmark
A. Kolek, Department of Pediatrics, University Hospital Olomouc,
77520 Olomouc, Czech Republic
H. Krasnicanova, 2nd Medical Faculty, Charles University Prague,
University Hospital Prague-Motol, 15018 Prague, Czech Republic
G. Kurdoglu, Division of Nutrition and Metabolism, Department of
Pediatrics, Istanbul Faculty of Medicine, University of Istanbul,
34390 <;apa, Istanbul, Turkey
C. Labisch, Department of Radiology, University of Essen, D-45122
Essen, Germany
J. L. Lezana-Fernandez, Mexican Cystic Fibrosis Association,
Altavista 21, CP 01000, Mexico D.F.
J. Littlewood, Regional Cystic Fibrosis Unit, St. James' University
Hospital, Leeds LS9 7TF, UK
O. Lochmann, 2nd Medical Faculty, Charles University Prague,
University Hospital Prague-Motol, 150 18 Prague, Czech Republic
M. C. Luna, Instituto Nacional de Genetica Medica, Las Heras 2670,
1425 Buenos Aires, Argentina
N. MacDonald, Canadian Cystic Fibrosis Foundation, Toronto,
Ontario, Canada M4S 2B4
M. Macek, 2nd Medical Faculty, Charles University Prague,
University Hospital Prague-Motol, 15018 Prague, Czech Republic
M. Macek Jr., Johns Hopkins University, Baltimore, USA
C. N. Macri, Hospital de Ninos "Ricardo Gutierrez", 1425 Buenos
Aires, Argentina
B. P. Madden, Department of Cardiological Sciences, St. George's
Hospital, Tooting, London SW17 OQT, UK
E. Mahenthiralingam, Division of Infectious and Immunological
Diseases, Department of Paediatrics and the Canadian Disease
Network, University of British Columbia, Vancouver, Canada V5Z
4H4
A-S. Malmborg, Department of Clinical Microbiology, Karolinska
Institutet, Huddinge Hospital, S-14186 Stockholm, Sweden
D. Maza Gonzales, Mexican Cystic Fibrosis Association, Altavista
21, CP 01000, Mexico D.F.
L. V. Moller, Department of Medical Microbiology, University of
Amsterdam, Academic Medical Centre, 1105 AZ Amsterdam, The
Netherlands
R. Morrison, Policy Development and Medical/Scientific Program,
Canadian Cystic Fibrosis Foundation, Toronto, Ontario, Canada
M4S 2B4
J. Musil, 2nd Medical Faculty, Charles University Prague, University
Hospital Prague-Motol, 150 18 Prague, Czech Republic