Current Trends in Lithium and Rubidium Therapy: Proceedings of an International Symposium on Lithium and Rubidium Therapy held in Venice, 29 September–1st October 1983

329 Pages·1984·15.053 MB·English

by  M. Schou (auth.), Professor Giovanni Umberto Corsini (eds.)

Current Trends in
Lithium and
Rubidium Therapy
Current Trends in
Lithium and
Rubidium Therapy
EDITED BY
Professor Giovanni (lmberto Corsini
Department of Clinical Pharmacology
University of CagJiari
Italy
Proceedings of an International Symposium on Uthium and Rubidium Therapy held in Venice,
29 September-1st October 1983
~ M.TP PRESS LIM.ITED .-
~ a member of the KLUWER ACADEMIC PUBLISHERS GROUP
, LANCASTER / BOSTON / THE HAGUE / DORDRECHT
Published in the UK and Europe by
MTP Press Limited
Falcon House
Lancaster, England
British Ubrary Cataloguing in Publication Data
Current trends in lithIum and rubidium therapy.
1 . Lithium-Therapeutic use
2. Rubidium-Therapeutic use
I. Corsini, G. U.
616.89'18 RC483.5.L5
ISBN-13: 978-94-011-7320-9
Published in the USA by
MTP Press
A division of Kluwer Boston Inc
190 Old Derby Street
Hingham, MA 02043, USA
Library of Congress Cataloging in Publicatiqn Data
International Symposium on Lithium and Rubidium Therapy
(1983: Venice, Italy)
Current trends in lithium and rubidium therapy.
Includes bibliographical references.
1. Mental illness - Chemotherapy - Congresses.
2. Lithium - Therapeutic use - Congresses. 3. Rubidium
Therapeutic use - Congresses. I. Corsini, Giovanni
Umberto. II. Title. (DNLM: 1. Lithium-therapeutic use
congresses. 2. Mental Disorders - drug therapy - congresses.
3. Rubidium - therapeutic use - congresses.
Ovn.9 158c 1983)
RC483.5.L5158 1983 616.89'18 84-10042
ISBN-13: 978-94-011-7320-9 e-ISBN-13: 978-94-011-7318-6
001: 10.1007/978-94-011-7318-6
Copyright © 1984 MTP Press Limited
Softcover reprint of the hardcover 15t edition 1984
All rights reserved. No part of this publication
may be reproduced, stored in a retrieval
system, or transmitted in any form or by any
means, electronic, mechanical, photocopying
recording or otherwise, without prior permission
from the p~blishers.
Contents
Preface ix
List of Contributors xi
Acknowledgements xvii
PART I: INTRODUCTION AND HISTORICAL REVIEW
Recent developments in lithium treatment and research
M. Schou 3
2 Lithium treatment of mania and depression over one
hundred years
A. Amdisen 11
PART II: MECHANISM OF ACTION OF LITHIUM AND RUBIDIUM
3 Some recent and some not-so-recent findings on the
behavioural effects of lithium in animals
~ N.Johnson 29
4 Opposite effects of lithium and rubidium on neurohormone
stimulated cyclic AMP accumulation in rat brain
A. Geisler, R. Klysner and P. H. Andersen 37
v
vi CURRENT TRENDS IN LITHIUM AND RUBIDIUM THERAPY
5 The effect of rubidium and lithium on adenylate cyclase and
neurotransmitter receptors
R. H. Be/maker. R. Hamburger-Bar. M. Newman and
J. Bannet 59
6 Does lithium prevent the development of dopamine
receptor supersensitivity? Behavioural studies
H. M. Calil and F. C. Rodrigues 77
PART III: CLINICAL ASPECTS OF LONG-TERM LITHIUM TREATMENT
7 Critical issues in the evaluation of long-term lithium
treatment
C. L. Cazzullo and E. Sacchetti 95
8 A prospective study of long-term lithium treatment. An
interim report
L. Smigan and C. Perris 111
9 Lithium dosage and prophylaxis. A double-blind controlled
study
A. Coppen and K. Wood 125
10 Lithium discontinuation in bipolar illness: a double-blind
prospective controlled study
J. Mendlewicz 135
11 Lithium treatment in schizoaffective patients
M. Del Zompo. A. Bocchetta. C. Burrai. M. Melis.
and G. U. Corsini 143
12 Static and kinetic study of the RBC/plasma lithium ratio in
manic-depressive. schizoaffective and schizophrenic
patients in thymic remission: significance for diagnosis
and monitoring
P. Deniker. H. Loo. J. P. Olie. C. Gay. C. Benkelfat.
and P. Binet 151
13 Lithium prophylaxis in major affective disorders: on the
specificity and sensitivity of some "new" predictors of
treatment outcome
E. Sacchetti. A. Vita. G. Conte and A. Pennati 165
14 Practical value of biological and psychological indicators in
predicting response to lithium prophylaxis of manic
depressive psychosis
M. Maj. F. Arena. R. Pirozzi and D. Kemali 189
CURRENT TRENDS IN LITHIUM AND RUBIDIUM THERAPY vii
15 Outcome to treatment with lithium in affective patients and
family history
E. Smeraldi, F. Macciardi, M. Gasperini and L. Bellodi 201
16 Antidepressant-induced switch and outcome to lithium
prophylaxis in bipolar patients
G. Conte, A. Vita, A. Alciati, A. Pennati and E. Sacchetti 211
PART IV: CLINICAL ASPECTS OF LONG-TERM RUBIDIUM TREATMENT
17 Rubidium salts in depressed patients. An open pilot study
using standardized techniques
P. Sarteschi, G. F. Placidi, A. Lenzi, E. Rampello and G. B.
Cassano 225
18 Preliminary results with rubidium in depressed patients
G. U. Corsini, M. Reda, C. Burrai, A. Poddighe and N. Rudas 247
19 The use of rubidium chloride in depressive disorders:
clinical aspects
M. Casacchia, A. Rossi, V. Marola and G. Meco 255
PART V: NEW ASPECTS IN LITHIUM AND RUBIDIUM TREATMENT
20 The effect of lithium treatment in humans of
psychophysiological increases and decreases in heart rate
S. Chazan-Gologorsky, P. Golan, S. Kugelmass and
R. H. Belmaker 263
21 Left ventricular performance following lithium treatment
M. R. Pisano, R. Fonzo, M. Del Zompo, P. Bonomo,
G. U. Corsini and A. Cherchi 273
22 Lithium carbonate and granulocyte function during cancer
chemotherapy. Preliminary report
S. Milani, G. Mustacchi, F. De Lazzer, P. Sandri, S. De Luyk,
C. Piccinini, N. Ferrantelli, L. Linda and E. Rorai 281
23 Cancer chemotherapy induced neutropenia: effects of
lithium carbonate
E. T. Menichetti, R. R. Silva and R. Cellerino 287
viii CURRENT TRENDS IN LITHIUM AND RUBIDIUM THERAPY
24 Lithium and rubidium compounds in cluster headache:
overview and perspectives
F. Savoldi, G. Bono, G. C. Manzoni, G. Micieli,
M. Lanfranchi and G. Nappi 299
25 Lithium therapy in cluster headache. Effect on iris neuro
muscular junction
M. Fanciullacci, U. Pietrini, M. Boccuni and F. Sicuteri 311
26 Changes in tubular enzymes during acute lithium treatment
A. Lenzi, M. Tuoni, E. Rampello, R. Palla, P. Fornaro and
G. F. Placidi 317
27 Prophylactic efficacy of carbamazepine in lithium-resistant
affective disorders
M. Del Zompo, C. Burrai, M. P. Piccardi, A. Marelli and
G. U. Corsini 325
Preface
Lithium research and therapy needs to be continually re-evaluated on
the basis of modern methodological approaches in order to shed new
light on the mechanism of action and to improve therapeutic use.
This book. based on the proceedings of the "International Meeting on
Lithium and Rubidium Therapy" held in Venice from September 30th to
October 2nd 1983. is devoted to current trends in the pharmacology and
clinical aspects of lithium and of a newly born therapeutic cation.
rubidium.
The first part of this volume deals with modern trends in behavioural
and biochemical approaches to the mechanism of action of lithium. A
larger consideration is reserved for lithium therapy from a clinical point of
view and includes re-assessment of long-term treatment with regard to
serum levels. biological and psychological predictors. side-effects and
new therapeutic uses.
A smaller section is concerned with some recent clinical studies on
rubidium.
This volume should be an invaluable aid to all psychiatrists and those
who work in the field of research of these pharmacological active
metals.
G. U. Corsini
List of contributors
A. ALCIATI L. BELLODI
Institute of Clinical Psychiatry Institute of Clinical Psychiatry
University of Milan University of Milan
Milan Milan
Italy Italy
R. H. BELMAKER
A. AMDISEN
Jerusalem Mental Health Center
Psychopharmacology Research Unit
Ezrath Nashim
Aarhus University,
Jerusalem
Psychiatric Hospital.
Israel
Risskov, Denmark
C. BENKELFAT
P. H. ANDERSEN Mental Health Service
Department of Pharmacology Hospital S.te Anne
University of Copenhagen, Paris
Copenhagen, Denmark France
P. BINET
F. ARENA
Mental Health Service
Psychiatric Clinic
Hospital S.te Anne
University of Naples
Paris
Naples
France
Italy
A. BOCCHETTA
J. BANNET Clinical Pharmacology
Jerusalem Mental Health Center University of Cagliari
Jerusalem Cagliari
Israel Italy
xi
xii CURRENT TRENDS IN LITHIUM AND RUBIDIUM THERAPY
M. BOCCUNI S. CHAZAN·GOLOGORSKY
Institute of Internal Medicine Department of Psychology
and Clinical Pharmacology Hebrew University
University of Florence Jerusalem
Florence Israel
Italy
A. CHERCHI
G. BONO Department of Cardiology
Headache Centre University of Cagliari
University of Pavia Cagliari
Pavia Italy
Italy
G.CONTE
P. BONOMO Institute of Clinical Psychiatry
University of Milan
Department of Cardiology
University of Cagliari Milan
Cagliari Italy
Italy
A.COPPEN
C. BURRAI MRC Neuropsychiatry Research
Clinical Phamacology Laboratory
University of Cagliari West Park Hospital
Cagliari Epsom
Italy Surrey
England
H. M. CAUL
Department of Psychobiology G. U. CORSINI
School of Medicine Clinical Pharmacology
Sao Paolo University of Cagliari
Brazil Cagliari
Italy
M. CASACCHIA
Institute of Psychiatry F De LAZZER
University of L' Aquila Centre for the Diagnosis and
Aquila Treatment of Tumours
Italy Trieste
Italy
G.B.CASSANO
Institute of Clinical Psychiatry S. De LUYK
University of Pisa Scientific Institute Burlo Garofolo
Pisa Trieste
Italy Italy
C. L. CAZZULLO M. DeiZOMPO
Institute of Clinical Psychiatry Clinical Pharmacology
University of Milan University of Cagliari
Milan Cagliari
Italy Italy
R. CELLERINO P. DENIKER
Clinical Oncology Mental Health Service
University of Ancona Hospital S.te Anne
Ancona Paris
Italy France