Cortical Development: Genes and Genetic Abnormalities

303 Pages·2008·7.48 MB·English

by  Novartis Foundation

Novartis Foundation Symposium 288
CORTICAL
DEVELOPMENT:
GENES AND GENETIC
ABNORMALITIES

CORTICAL DEVELOPMENT:
GENES AND GENETIC
ABNORMALITIES
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Novartis Foundation Symposium 288
CORTICAL
DEVELOPMENT:
GENES AND GENETIC
ABNORMALITIES
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Novartis Foundation Symposium 288
x + 282 pages, 45 fi gures, 3 tables
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Contents
Symposium on Cortical development: genes and genetic abnormalities, held at the Novartis
Foundation, London, 6–8 February 2007
Editors: Gregory Bock (Organizer) and Jamie Goode
This symposium is based on a proposal made by Zoltán Molnár
John G. Parnavelas Chair’s introduction 1
Bradley J. Molyneaux, Paola Arlotta and Jeffrey D. Macklis Molecular
development of corticospinal motor neuron circuitry 3
Discussion 15
Gordon Fishell Perspectives on the developmental origins of cortical
interneuron diversity 21
Discussion 35
Pasko Rakic, Kazue Hashimoto-Torii and Matthew R. Sarkisian Genetic
determinants of neuronal migration in the cerebral cortex 45
Discussion 53
Stephen C. Noctor, Veronica Martinez-Cerdeño and Arnold R. Kriegstein
Neural stem and progenitor cells in cortical development 59
Discussion 73
Teresa H. Chae and Christopher A. Walsh Genes that control the size of
the cerebral cortex 79
Discussion 91
General discussion I 96
Vicki Hammond, Joanne Britto, Eva So, Holly Cate and Seong-Seng Tan
Control of cortical neuron layering: lessons from mouse chimeras 99
Discussion 108
v
vi CONTENTS
Fujio Murakami, Daisuke Tanaka, Mitsutoshi Yanagida and
Emi Yamazaki Intracortical multidirectional migration of cortical
interneurons 116
Discussion 125
Libing Zhou, Fadel Tissir and André M. Goffi net The atypical cadherin
Celsr3 regulates the development of the axonal blueprint 130
Discussion 134
Dennis D. M. O’Leary , Shen-Ju Chou, Tadashi Hamasaki,
Setsuko Sahara, Akihide Takeuchi, Sandrine Thuret and
Axel Leingärtner Regulation of laminar and area patterning of mammalian
neocortex and behavioural implications 141
Discussion 159
Jeremy A. Cholfi n and John L. R. Rubenstein Genetic regulation of
prefrontal cortex development and function 165
Discussion 173
Henry Kennedy, Rodney Douglas, Kenneth Knoblauch and
Colette Dehay Self-organization and pattern formation in
primate cortical networks 178
Discussion 195
Nobuhiko Yamamoto, Takuro Maruyama, Naofumi Uesaka,
Yasufumi Hayano, Makoto Takemoto and Akito Yamada Molecular
mechanisms of thalamocortical axon targeting 199
Discussion 208
Zoltán Molnár, Anna Hoerder-Suabedissen, Wei Zhi Wang,
Jamin DeProto, Kay Davies, Sheena Lee, Erin C. Jacobs,
Anthony T. Campagnoni, Ole Paulsen, Maria Carmen Piñon and
Amanda F. P. Cheung Genes involved in the formation of
the earliest cortical circuits 212
Discussion 224
Michael Piper, Amber-Lee S. Dawson, Charlotta Lindwall, Guy Barry,
Céline Plachez and Linda J. Richards Emx and Nfi genes regulate cortical
development and axon guidance in the telencephalon 230
Discussion 242
CONTENTS vii
Paul J. Harrison Schizophrenia susceptibility genes and their
neurodevelopmental implications: focus on neuregulin 1 246
Discussion 255
Peter B. Crino Focal brain malformations: a spectrum of disorders along the
mTOR cascade 260
Discussion 272
Final discussion 276
Index of contributors 282
Subject index 284