Table Of ContentCORONARY ARTERY
DISEASE – NEW INSIGHTS
AND NOVEL APPROACHES
Edited by Angelo Squeri
Coronary Artery Disease – New Insights and Novel Approaches
Edited by Angelo Squeri
Published by InTech
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Copyright © 2012 InTech
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First published March, 2012
Printed in Croatia
A free online edition of this book is available at www.intechopen.com
Additional hard copies can be obtained from [email protected]
Coronary Artery Disease – New Insights and Novel Approaches, Edited by Angelo Squeri
p. cm.
ISBN 978-953-51-0344-8
Contents
Preface IX
Part 1 Pathogenesis 1
Chapter 1 Gene Polymorphism and Coronary Heart Disease 3
Nduna Dzimiri
Chapter 2 Lipoprotein(a) Oxidation,
Autoimmune and Atherosclerosis 49
Jun-Jun Wang
Chapter 3 ICAM-1: Contribution to Vascular
Inflammation and Early Atherosclerosis 65
Sabine I. Wolf and Charlotte Lawson
Chapter 4 Molecular and Cellular Aspects of Atherosclerosis:
Emerging Roles of TRPC Channels 91
Guillermo Vazquez, Kathryn Smedlund,
Jean-Yves K. Tano and Robert Lee
Chapter 5 Hypoxia-Regulated
Pro- and Anti-Angiogenesis in the Heart 103
Angela Messmer-Blust and Jian Li
Chapter 6 Paraoxonase 1 (PON1) Activity,
Polymorphisms and Coronary Artery Disease 115
Nidhi Gupta, Kiran Dip Gill and Surjit Singh
Part 2 Acute Coronary Syndrome 137
Chapter 7 Acute Coronary Syndrome:
Pathological Findings by Means of Electron
Microscopy, Advance Imaging in Cardiology 139
Mohaddeseh Behjati and Iman Moradi
VI Contents
Chapter 8 Shortened Activated Partial Thromboplastin Time (APTT):
A Simple but Important Marker of Hypercoagulable
State During Acute Coronary Event 157
Wan Zaidah Abdullah
Part 3 Cardiovascular Prevention 167
Chapter 9 Individualized Cardiovascular Risk Assessment 169
Eva Szabóová
Chapter 10 Metabolomics in Cardiovascular Disease:
Towards Clinical Application 207
Ignasi Barba and David Garcia-Dorado
Chapter 11 Novel Regulators of Low-Density Lipoprotein Receptor
and Circulating LDL-C for the Prevention and Treatment
of Coronary Artery Disease 225
Guoqing Cao, Robert J. Konrad, Mark C. Kowala and Jian Wang
Chapter 12 Serum Choline Plasmalogen
is a Reliable Biomarker for Atherogenic Status 243
Ryouta Maeba and Hiroshi Hara
Preface
Coronary Artery disease is one of the leading causes of death in industrialized
countries and is responsible for one out of every six deaths in the United States.
Remarkably, coronary artery disease is also largely preventable. The pathogenesis is
complex and involves many different pathways that are only partially understood.
Recently, the morbidity and mortality of ischaemic heart disease have substantially
improved because of progress in therapeutic strategies, represented by the dramatic
evolution of percutaneous coronary intervention. The biggest challenge in the next
years is, however, to reduce the incidence of coronary artery disease worldwide.
A complete knowledge of the mechanisms responsible for the development of
ischaemic heart disease is an essential prerequisite to a better management of this
pathology improving prevention and therapy.
This monograph deals with the pathophysiology of atherosclerosis with emphasis on
epigenetics, metabolomics, inflammation, molecular and cellular mechanisms
involved in cardiovascular disease development.
This book has been written with the intention of providing new concepts about
coronary artery disease pathogenesis that may link various aspects of the disease,
going beyond the traditional risk factors.
Angelo Squeri, MD
Maria Cecilia Hospital – GVM Care & Research
Italy
