Table Of ContentCORNEA
Fourth Edition
cornea
Mark J. Mannis MD FACS
Natalie Fosse Endowed Chair in Vision Science Research
Professor and Chair
Department of Ophthalmology & Vision Science
University of California Davis Eye Center
Sacramento, CA, USA
Edward J. Holland MD
Director of Cornea
Cincinnati Eye Institute
Professor of Ophthalmology
University of Cincinnati
Cincinnati, OH, USA
Edinburgh London New York Oxford Philadelphia St Louis Sydney Toronto 2017
© 2017, Elsevier Inc. All rights reserved.
First edition 1997
Second edition 2005
Third edition 2011
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Michael E. Snyder retains copyright for his original figures and video clips in Chapter 145.
Notices
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Video Table of Contents
Clip Clip title Video contributor/s
50.1 The Application of Cryopreserved Amniotic Membrane in the Treatment Darren G. Gregory
of Acute Stevens–Johnson Syndrome: Part 1
50.2 The Application of Cryopreserved Amniotic Membrane in the Treatment Darren G. Gregory
of Acute Stevens–Johnson Syndrome: Part 2
50.3 The Application of Cryopreserved Amniotic Membrane in the Treatment Darren G. Gregory
of Acute Stevens–Johnson Syndrome: Part 3
110.1 Penetrating Keratoplasty Using the Barron Trephine and Interrupted Mauricio A. Perez, David S. Rootman
Sutures
110.2 Penetrating Keratoplasty Using the Hanna Trephine and Interrupted Mauricio A. Perez, David S. Rootman
Sutures
110.3 Penetrating Keratoplasty Using the Slipknot Technique for Suturing Clara C. Chan, Mauricio A. Perez
110.4 Penetrating Keratoplasty Using a Running Suture Mauricio A. Perez, Allan R. Slomovic
111.1 An Intraoperative Suprachoroidal Hemorrhage During Penetrating Michael C. Chen, Mark J. Mannis
Keratoplasty, which was Successfully Managed with the Assistance of a
Cobo Temporary Keratoprosthesis
112.1 Donor Preparation Marjan Farid, Roger F. Steinert, Sumit Garg,
Matthew Wade
112.2 Dissection and Suturing Marjan Farid, Roger F. Steinert, Sumit Garg,
Matthew Wade
112.3 Laser Incision Marjan Farid, Roger F. Steinert, Sumit Garg,
Matthew Wade
112.4 Femto DALK Marjan Farid, Roger F. Steinert, Sumit Garg,
Matthew Wade
117.1 Big Bubble DALK: A Video Presentation Mohammad Anwar
118.1 Techniques of Anterior Lamellar Keratoplasty: Stromal Delamination Luigi Fontana
118.2 Techniques of Anterior Lamellar Keratoplasty: ALTK 1 Luigi Fontana
118.3 Techniques of Anterior Lamellar Keratoplasty: ALTK 2 Luigi Fontana
118.4 Techniques of Anterior Lamellar Keratoplasty: Big Bubble Luigi Fontana
118.5 Techniques of Anterior Lamellar Keratoplasty: Big Bubble Using Luigi Fontana
a Cannula
118.6 Techniques of Anterior Lamellar Keratoplasty: Donor Preparation Luigi Fontana
119.1 Rupture of DM in a Keratoconus Patient Shigeto Shimmura
120.1 Cannula Big-Bubble Technique, Bubble Test, and the New Opening of Vincenzo Sarnicola, Enrica Sarnicola,
the Bubble Caterina Sarnicola
120.2 Air-Viscobubble Technique (AVB) Vincenzo Sarnicola, Enrica Sarnicola,
Caterina Sarnicola
120.3 Layer-by-Layer Manual Dissection Vincenzo Sarnicola, Enrica Sarnicola,
Caterina Sarnicola
120.4 dDALK Rupture Management Vincenzo Sarnicola, Enrica Sarnicola,
Caterina Sarnicola
120.5 Subtotal Full Thickness Circular Cut of the Recipient Bed Vincenzo Sarnicola, Enrica Sarnicola,
Caterina Sarnicola
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Video Table of Contents
Clip Clip title Video contributor/s
120.6 Total Full Thickness Circular Cut of the Recipient Bed Vincenzo Sarnicola, Enrica Sarnicola,
Caterina Sarnicola
120.7 Excessive Trephination and Perforation Vincenzo Sarnicola, Enrica Sarnicola,
Caterina Sarnicola
120.8 Traumatic Postoperative DM Disinsertion Vincenzo Sarnicola, Enrica Sarnicola,
Caterina Sarnicola
126.1 Eye Bank Preparation of DMEK Graft Tissue Using a Modified Mark A. Greiner, Gregory A. Schmidt,
SCUBA Technique Kenneth M. Goins
130.1 Ultrathin DSAEK Massimo Busin, Vincenzo Scorcia
131.1 DMEK Injectors Michael D. Straiko
131.2 Peripheral Iridotomy Kevin J. Shah, Michael D. Straiko,
Mark A. Greiner
132.1 Torn Donor Graft During DMEK Graft Preparation Using Dagny Zhu, Neda Shamie
SCUBA Technique
134.1 DSEK Under Top Hat PKP with Laplace Phenomenon Matthew T. Feng, Francis W. Price, Jr.,
Marianne O. Price
134.2 Suture Pull Through and Fixation Matthew T. Feng, Francis W. Price, Jr.,
Marianne O. Price
136.1 RHCIII Implantation Surgery May Griffith, Oleksiy Buznyk, Per Fagerholm
141.1 Primary Pterygium Excision and Conjunctival Autograft with Fibrin Glue Donald T.H. Tan, Elaine W. Chong
141.2 Recurrent Pterygium Excision and Extensive Tenon’s Excision with Donald T.H. Tan, Elaine W. Chong
Conjunctival Autograft Using Fibrin Glue
143.1 How to Know the Orientation of the Amniotic Membrane Jose L. Güell, Oscar Gris, Daniel Elies,
Felicidad Manero, Merce Morral
143.2 Surgical Videos of Several Cases where Amniotic Membrane Jose L. Güell, Oscar Gris, Daniel Elies,
Transplantation was Performed Felicidad Manero, Merce Morral
143.3 The Modified Gundersen Approach Consists of Four Main Steps Jose L. Güell, Oscar Gris, Daniel Elies,
Felicidad Manero, Merce Morral
143.4 Two-Step Approach to Treat Unilateral Total Limbal Stem Cell Jose L. Güell, Oscar Gris, Daniel Elies,
Deficiency Felicidad Manero, Merce Morral
145.1 Iris Oversew Michael E. Snyder, Jason H. Bell
145.2 Taco Down Fold of PCIOL for Insertion Behind 50-Series Iris Prostheses Michael E. Snyder, Jason H. Bell
145.3 CustomFlex Iris Device Injection and Capsular Bag Implantation Michael E. Snyder, Jason H. Bell
With Overfolding
151.1 KPro Assembly and Surgery Jose de la Cruz
155.1 Boston Keratoprosthesis Type 2 Surgical Techniques Duna Raoof, James Chodosh
156.1 Stage 1 OOKP Jean S.M. Chai, Donald T.H. Tan
156.2 Stage 2 OOKP Jean S.M. Chai, Donald T.H. Tan
158.1 LR-CLAU Edward J. Holland, Gary S. Schwartz,
Sheraz M. Daya, Ali R. Djalilian, Clara C. Chan
158.2 KLAL Edward J. Holland, Gary S. Schwartz,
Sheraz M. Daya, Ali R. Djalilian, Clara C. Chan
158.3 CLAU-KLAL Modified Cincinnati Procedure Edward J. Holland, Gary S. Schwartz,
Sheraz M. Daya, Ali R. Djalilian, Clara C. Chan
160.1 Combined LR-CLAL/KLAL (Cincinnati Procedure) Followed by Kevin J. Shah, Edward J. Holland,
Penetrating Keratoplasty Mark J. Mannis
165.1 LASEK Azar Flap Technique Dimitri T. Azar, Ramon C. Ghanem
166.1 Technique for Custom Femtosecond LASIK Louis E. Probst
167.1 Femtosecond LASIK Patricia B. Sierra, David R. Hardten
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Video Table of Contents
Clip Clip title Video contributor/s
169.1 Anterior Chamber Gas Bubbles Blocking the Tracking of the Pupil Louis E. Probst, Clara C. Chan,
Mario J. Saldanha
171.1 Small Incision Lenticule Extraction Jodhbir Mehta
172.1 Post LASIK Ectasia – Intrastromal CXL and Ring Adimara da Candelaria Renesto,
Mauro Campos
173.1 Femtosecond Laser Astigmatic Keratotomy Zaina Al-Mohtaseb, Leela V. Raju, Li Wang,
Mitchell P. Weikert, Douglas D. Koch
174.1 Implantation of an Artisan Lens Thomas Kohnen, Mehdi Shajari, Jose L. Güell,
Daniel Kook, Rudy M.M.A. Nuijts
174.2 Implantation of a Toric Artisan Lens Thomas Kohnen, Mehdi Shajari, Jose L. Güell,
Daniel Kook, Rudy M.M.A. Nuijts
174.3 Implantation of an Artiflex Lens Thomas Kohnen, Mehdi Shajari, Jose L. Güell,
Daniel Kook, Rudy M.M.A. Nuijts
174.4 Implantation of an ICL Thomas Kohnen, Mehdi Shajari, Jose L. Güell,
Daniel Kook, Rudy M.M.A. Nuijts
174.5 Performing LASIK in a Patient with an Iris-Fixated Lens Thomas Kohnen, Mehdi Shajari, Jose L. Güell,
Daniel Kook, Rudy M.M.A. Nuijts
175.1 Implanting the Kamra Small-Aperture Inlay Richard L. Lindstrom, Jay S. Pepose,
John A. Vukich
Total video running time: 2 hours 41 minutes
xiii
Preface
The subspecialty of cornea and external disease has under- new surgical videos in order to keep pace with the dramatic
gone significant transformation since the last edition of innovation in our field. The editors and authors have strived
Cornea. New diagnostic technology has vastly improved our to provide the most current material available for residents,
ability to detect disease. New medications and other thera- fellows, clinicians, and researchers to help in the manage-
peutic options have changed the treatment paradigm for ment of patients with cornea and external disease. We hope
many disorders. And new surgical techniques have had a this edition will benefit patients for years to come.
remarkable impact on surgical outcomes. Not only do these
new procedures provide better outcomes but, in addition, Mark J. Mannis
we can now offer surgical options earlier in the disease
process. Edward J. Holland
This edition of Cornea consists of numerous new chapters
and extensive revisions of existing chapters, as well as many
xiv
Acknowledgements
This fourth edition of Cornea is the result of an extraordinary, highest quality medical textbook possible both in print and
coordinated effort by many talented individuals. We cannot electronic format. Special thanks to Sharon Nash and Russell
thank our contributing authors and co-authors enough. We Gabbedy at Elsevier, who have motivated and guided us
appreciate their excellent contributions of the most current along this journey.
information on the diagnosis and management of cornea Finally, we would like to thank our families, who continue
and external disease. In addition, we thank these authors for to provide support and the considerable time needed to
adhering to the tight editorial requirements in order to keep produce what we hope is an outstanding textbook.
this textbook current and on time.
We have enjoyed our continued relationship with our
publisher, Elsevier, who shares our goal: to provide the
xv
We dedicate this book to patients suffering from corneal blindness that we cannot
help at this time but hope to be able to help in the future.
Mark J. Mannis
Edward J. Holland
