Table Of ContentControversies in Assisted
Reproduction
To Dr. Ayten Murat, a very distinguished obstetrician and gynecologist,
for her incredible support during the production of this book
(BR)
I dedicate this to Professor Botros Rizk who transformed a friendly professional
conversation into this book, which does not aim to provide the ultimate answers
to all controversies in reproductive medicine but aims to encourage critical
thinking, open-mindedness, and acceptance that some clinical interventions we
practice now may or may not be corroborated by robust evidence in the future
(YK)
Controversies in Assisted
Reproduction
Edited by
Botros Rizk, MD, MA, FRCOG,
FRCS, HCLD, FACOG, FACS
Medical Director, California Elite Fertility
Pasadena, California, USA and Shanghai, China
President, Middle East Fertility Society
and formerly Professor and Head, Reproductive Endocrinology & Infertility
Department of Obstetrics & Gynecology
University of South Alabama
Mobile, Alabama, USA
Yakoub Khalaf, MB BCh, MSc, MD, FRCOG, MFFP
Professor of Reproductive Medicine and Surgery
Guy’s and St Thomas’ Hospital and King’s College London,
and Head, Fertility Service
Director, Assisted Conception Unit and Centre
for Pre-Implantation Genetic Diagnosis
Guy’s and St Thomas’ Hospital
London, UK
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Contents
Contributors .............................................................................................................................................vii
1. The Use of Ovarian Markers ..........................................................................................................1
Neena Malhotra and Siladitya Bhattacharya
2. Use of Molecular Markers of Endometrial Receptivity .............................................................12
Alejandro Rincón, David Bolumar, Diana Valbuena, and Carlos Simón
3. Use of GnRHa for Triggering Final Oocyte Maturation during Ovarian
Stimulation Cycles ..........................................................................................................................25
Dalia Khalife, Jad Farid Assaf, and Johnny Awwad
4. Use of Time-Lapse Embryo Imaging in Assisted Reproductive Technology Practice ............33
Fadi Choucair, Chantal Farra, and Johnny Awwad
5. Use of Cryopreservation for All Embryos ...................................................................................40
Samuel Santos-Ribeiro, Shari Mackens, Biljana Popovic-Todorovic, Annalisa Racca,
Christophe Blockeel, and Panagiotis Drakopoulos
6. Preimplantation Genetic Screening .............................................................................................56
M. Yusuf Beebeejaun and Sesh K. Sunkara
7. The Use of Single Embryo Transfer .............................................................................................63
Abha Maheshwari
8. Use of Luteal Phase Support .........................................................................................................71
Laura Melado, Barbara Lawrenz, and Human Fatemi
9. Measuring Safety and Efficiency in In Vitro Fertilization .........................................................86
Nicole C. Michel, Natalie Shammas, and Shima Elbakhit Albasha
10. To Flush Follicles during Egg Collection or Not .........................................................................98
Hans-Peter Steiner
11. Use of Blastocyst Culture ............................................................................................................107
Mohamed A. Aboulghar and Mona M. Aboulghar
12. Use of Mitochondrial Donation ....................................................................................................116
Andy Greenfield
13. Controversies in Recurrent Implantation Failure: From Theory to Practice .......................128
Efstratios Kolibianakis, Pavlidi Olga, and Christos A. Venetis
v
vi Contents
14. Fibroids: To Remove or Not ........................................................................................................138
Abdel-Maguid Ramzy
15. Limitations of Endometrioma Surgery in In Vitro Fertilization: Possibilities of
Early Disease Control ..................................................................................................................146
Vasilios Tanos and Elsie Sowah
Index .......................................................................................................................................................161
Contributors
Mohamed A. Aboulghar Christophe Blockeel
Department of Obstetrics and Gynecology Centre for Reproductive Medicine
Faculty of Medicine Universitair Ziekenhuis Brussel
Cairo University Brussels, Belgium
and
The Egyptian IVF Center, Maadi David Bolumar
Cairo, Egypt Igenomix Foundation
and
Mona M. Aboulghar Department of Obstetrics and Gynecology
Department of Obstetrics and Gynecology University of Valencia/INCLIVA
Faculty of Medicine Valencia, Spain
Cairo University
and Fadi Choucair
The Egyptian IVF Center, Maadi AUBMC Haifa Idriss Fertility Center
Cairo, Egypt and
Department of Obstetrics and Gynecology
Shima Elbakhit Albasha American University of Beirut Medical Center
Department of Obstetrics and Gynecology Beirut, Lebanon
Hamad Medical Corporation
Doha, Qatar Panagiotis Drakopoulos
Centre for Reproductive Medicine
Jad Farid Assaf Universitair Ziekenhuis Brussel
AUBMC Haifa Idriss Fertility Center Brussels, Belgium
and
Department of Obstetrics and Gynecology Chantal Farra
American University of Beirut Medical Center Department of Pathology and Laboratory
Beirut, Lebanon Medicine
American University of Beirut Medical Center
Johnny Awwad Beirut, Lebanon
AUBMC Haifa Idriss Fertility Center
and Human Fatemi
Department of Obstetrics and Gynecology Medical Department
American University of Beirut Medical Center IVI Middle East
Beirut, Lebanon Abu Dhabi and Dubai, United Arab Emirates
and
M. Yusuf Beebeejaun
King’s Fertility Medical Department
King’s College Hospital IVI Middle East
London, United Kindom Muscat, Oman
Siladitya Bhattacharya Andy Greenfield
School of Medicine Mammalian Genetics Unit
Cardiff University Medical Research Council Harwell Institute
Wales, United Kingdom Oxfordshire, United Kingdom
vii
viii Contributors
Dalia Khalife Biljana Popovic-Todorovic
Department of Obstetrics and Gynecology Centre for Reproductive Medicine
American University of Beirut Medical Center Universitair Ziekenhuis Brussel
Beirut, Lebanon Brussels, Belgium
Efstratios Kolibianakis Annalisa Racca
Unit for Human Reproduction Centre for Reproductive Medicine
First Department of Obstetrics and Gynaecology Universitair Ziekenhuis Brussel
Medical School Brussels, Belgium
Aristotle University of Thessaloniki
Thessaloniki, Greece Abdel-Maguid Ramzy
Department of Obstetrics and
Barbara Lawrenz Gynecology
Medical Department Cairo University
IVI Middle East and
Abu Dhabi, United Arab Emirates Kasr Al-Aini IVF Center
Cairo, Egypt
and
Obstetrical Department Samuel Santos-Ribeiro
Women’s University Hospital Tuebingen IVI-RMA Lisboa
Tuebingen, Germany Lisbon, Portugal
Shari Mackens
Alejandro Rincón
Centre for Reproductive Medicine
Igenomix SL
Universitair Ziekenhuis Brussel
Valencia, Spain
Brussels, Belgium
Natalie Shammas
Abha Maheshwari
Medical Student
Department of Aberdeen Fertility Centre
Georgetown University School of
NHS Grampian
Medicine
Aberdeen, United Kingdom
Washington, DC
Neena Malhotra
Carlos Simón
Department of Obstetrics and Gynecology
Igenomix SL
All India Institute of Medical Sciences
and
New Delhi, India
Igenomix Foundation
and
Laura Melado
Department of Obstetrics and
Medical Department
Gynecology
IVI Middle East
University of Valencia/INCLIVA
Abu Dhabi and Dubai, United Arab Emirates
Valencia, Spain
Nicole C. Michel and
Department of Reproductive Endocrinology
University of South Alabama Department of Obstetrics and
Mobile, Alabama Gynecology
Stanford University
Pavlidi Olga Stanford, California
Unit for Human Reproduction
and
First Department of Obstetrics and Gynecology
Medical School Department of Obstetrics and Gynecology
Aristotle University of Thessaloniki Baylor College of Medicine
Thessaloniki, Greece Houston, Texas
Contributors ix
Elsie Sowah Vasilios Tanos
St. George’s University of London University of Nicosia Medical School
MBBS Programme at University of Nicosia and
Medical School Aretaeio Hospital
Nicosia, Cyprus Nicosia, Cyprus
Hans-Peter Steiner Diana Valbuena
Inst. f. IVF Igenomix SL
IVF Future Valencia, Spain
IVFETFLEX.COM
Graz, Austria Christos A. Venetis
School of Women’s and Children’s Health
Sesh K. Sunkara and
Division of Women’s Health Centre for Big Data Research in Health
Faculty of Life Sciences and Medicine Faculty of Medicine
King’s College London University of New South Wales
London, United Kindom New South Wales, Australia
