Control of Innate and Adaptive Immune Responses During Infectious Diseases

189 Pages·2012·2.5 MB·English

by  Julio Aliberti (eds.)

Control of Innate and Adaptive Immune
Responses during Infectious Diseases

Julio Aliberti
Editor
Control of Innate and
Adaptive Immune Responses
during Infectious Diseases
Editor
Julio Aliberti
Associate Professor
Divisions of Molecular Immunology and Pulmonary Medicine
Cincinnati Children’s Hospital Medical Center and School of Medicine
University of Cincinnati
Cincinnati, OH, USA
[email protected]
ISBN 978-1-4614-0483-5 e-ISBN 978-1-4614-0484-2
DOI 10.1007/978-1-4614-0484-2
Springer New York Dordrecht Heidelberg London
Library of Congress Control Number: 2011936972
© Springer Science+Business Media, LLC 2012
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Preface
Upon infection, pathogen and host perform a complex interaction that ultimately
aims to achieve elimination of the invading microbe with the least amount of dam-
age to host tissues and organs. Interestingly, both sides of this equation co-evolved
several mechanisms that mediate pathogen recognition, initiation and expansion of
immune responses, neutralization of toxic elements and elimination of replicating
organisms and finally healing and remodeling of damaged tissues. On one side
pathogens evolved mechanisms to evade recognition and killing, while on the other
side, host express numerous (sometimes redundant) mechanisms of recognition and
elimination of the pathogen. Nonetheless, it is clear that an absolute successful
strategy on the pathogen side would be lethal to both host and pathogen. Therefore,
several evasion mechanisms are seen among several microbes. The most successful
ones are not necessarily the most abundantly found within the host, but those that
can achieve transmission. On the other hand, hosts need a robust and extended
immune response in order to expand memory cells. This critical balance is where
the co-evolution between host and pathogens lies. This book covers several aspects
of induction, control and evasion of host immune response during infectious dis-
eases. Multiple aspects are covered and each chapter focuses on one prominent
infectious agent.
Cincinnati, OH Julio Aliberti
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Contents
1 Resolution of Inflammation During Toxoplasma gondii Infection ........ 1
Julio Aliberti
2 Mechanisms of Host Protection and Pathogen
Evasion of Immune Response During Tuberculosis .............................. 23
Andre Bafica and Julio Aliberti
3 NKT Cell Activation During (Microbial) Infection ............................... 39
Jochen Mattner
4 Regulation of Innate Immunity
During Trypanosoma cruzi Infection ....................................................... 69
Fredy Roberto Salazar Gutierrez
5 B Cell-Mediated Regulation of Immunity
During Leishmania Infection ................................................................... 85
Katherine N. Gibson-Corley, Christine A. Petersen,
and Douglas E. Jones
6 Control of the Host Response to Histoplasma Capsulatum .................... 99
George S. Deepe, Jr.
7 Modulation of T-Cell Mediated Immunity by Cytomegalovirus .......... 121
Chris A. Benedict, Ramon Arens, Andrea Loewendorf,
and Edith M. Janssen
8 T Cell Responses During Human Immunodeficiency
Virus (HIV)-1 Infection ............................................................................ 141
Claire A. Chougnet and Barbara L. Shacklett
Index ................................................................................................................. 171
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Contributors
Julio Aliberti, Ph.D. Associate Professor, Divisions of Molecular Immunology

and Pulmonary Medicine, Cincinnati Children’s Hospital Medical Center
and School of Medicine, University of Cincinnati, Cincinnati, OH, USA
[email protected]
Ramon Arens Division of Developmental Immunology, La Jolla Institute

for Allergy and Immunology, La Jolla, CA, USA
Andre Bafica, M.D., Ph.D. Assistant Professor, Department of Microbiology,

Immunology and Parasitology, Federal University of Santa Catarina,
Florianopolis, SC, Brazil
andre.bafi[email protected]
Chris A. Benedict Division of Immune Regulation, La Jolla Institute

for Allergy and Immunology, La Jolla, CA, USA
[email protected]
Claire A. Chougnet Division of Molecular Immunology, Cincinnati Children’s

Hospital Research Foundation and Department of Pediatrics, University of
Cincinnati, Cincinnati, OH, USA
[email protected]
George S. Deepe. Jr, M.D. Professor, Veterans Affairs Hospital, Cincinnati, OH,

USA; Division of Infectious Diseases, University of Cincinnati College of Medicine,
Cincinnati, OH, USA
[email protected]
Katherine N. Gibson-Corley Department of Veterinary Pathology,

College of Veterinary Medicine, Iowa State University, Ames, IA, USA
Fredy Roberto Salazar Gutierrez, M.D., Ph.D. Assistant Professor,

School of Medicine, Antonio Nariño University, Bogotá, Colombia
[email protected]
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