Table Of ContentLecture Notes in Networks and Systems 374
Sotir S. Sotirov · Tania Pencheva ·
Janusz Kacprzyk ·
Krassimir T. Atanassov ·
Evdokia Sotirova ·
Galya Staneva Editors
Contemporary
Methods in
Bioinformatics and
Biomedicine and
Their Applications
Lecture Notes in Networks and Systems
Volume 374
Series Editor
Janusz Kacprzyk, Systems Research Institute, Polish Academy of Sciences,
Warsaw, Poland
Advisory Editors
Fernando Gomide, Department of Computer Engineering and Automation—DCA,
SchoolofElectricalandComputerEngineering—FEEC,UniversityofCampinas—
UNICAMP, São Paulo, Brazil
Okyay Kaynak, Department of Electrical and Electronic Engineering,
Bogazici University, Istanbul, Turkey
Derong Liu, Department of Electrical and Computer Engineering, University
of Illinois at Chicago, Chicago, USA
Institute of Automation, Chinese Academy of Sciences, Beijing, China
WitoldPedrycz,DepartmentofElectricalandComputerEngineering,Universityof
Alberta, Alberta, Canada
Systems Research Institute, Polish Academy of Sciences, Warsaw, Poland
Marios M. Polycarpou, Department of Electrical and Computer Engineering,
KIOSResearchCenterforIntelligentSystemsandNetworks,UniversityofCyprus,
Nicosia, Cyprus
Imre J. Rudas, Óbuda University, Budapest, Hungary
Jun Wang, Department of Computer Science, City University of Hong Kong,
Kowloon, Hong Kong
The series “Lecture Notes in Networks and Systems” publishes the latest
developmentsinNetworksandSystems—quickly,informallyandwithhighquality.
Originalresearchreportedin proceedings andpost-proceedings represents thecore
ofLNNS.
VolumespublishedinLNNSembraceallaspectsandsubfieldsof,aswellasnew
challenges in, Networks and Systems.
The series contains proceedings and edited volumes in systems and networks,
spanning the areas of Cyber-Physical Systems, Autonomous Systems, Sensor
Networks, Control Systems, Energy Systems, Automotive Systems, Biological
Systems, Vehicular Networking and Connected Vehicles, Aerospace Systems,
Automation, Manufacturing, Smart Grids, Nonlinear Systems, Power Systems,
Robotics,SocialSystems,EconomicSystemsandother.Ofparticularvaluetoboth
the contributors and the readership are the short publication timeframe and
the world-wide distribution and exposure which enable both a wide and rapid
dissemination of research output.
Theseriescoversthetheory,applications,andperspectivesonthestateoftheart
andfuturedevelopmentsrelevanttosystemsandnetworks,decisionmaking,control,
complex processes and related areas, as embedded in the fields of interdisciplinary
andappliedsciences,engineering,computerscience,physics,economics,social,and
lifesciences,aswellastheparadigmsandmethodologiesbehindthem.
Indexed by SCOPUS, INSPEC, WTI Frankfurt eG, zbMATH, SCImago.
AllbookspublishedintheseriesaresubmittedforconsiderationinWebofScience.
For proposals from Asia please contact Aninda Bose ([email protected]).
More information about this series at https://link.springer.com/bookseries/15179
Sotir S. Sotirov Tania Pencheva
(cid:129) (cid:129)
Janusz Kacprzyk Krassimir T. Atanassov
(cid:129) (cid:129)
Evdokia Sotirova Galya Staneva
(cid:129)
Editors
Contemporary Methods
in Bioinformatics
and Biomedicine and Their
Applications
123
Editors
Sotir S.Sotirov TaniaPencheva
Faculty of Technical Sciences Institute of Biophysics andBiomedical
University Prof. D-rAsen Zlatarov Engineering
Burgas, Bulgaria BulgarianAcademy of Sciences
Sofia,Bulgaria
JanuszKacprzyk
Systems Research Institute Krassimir T. Atanassov
Polish Academy ofSciences Institute of Biophysics andBiomedical
Warsaw,Poland Engineering
BulgarianAcademy of Sciences
Evdokia Sotirova Sofia,Bulgaria
Intelligent Systems Laboratory
University Prof. D-rAsen Zlatarov Galya Staneva
Burgas, Bulgaria Institute of Biophysics andBiomedical
Engineering
BulgarianAcademy of Sciences
Sofia,Bulgaria
ISSN 2367-3370 ISSN 2367-3389 (electronic)
Lecture Notesin Networks andSystems
ISBN978-3-030-96637-9 ISBN978-3-030-96638-6 (eBook)
https://doi.org/10.1007/978-3-030-96638-6
©TheEditor(s)(ifapplicable)andTheAuthor(s),underexclusivelicense
toSpringerNatureSwitzerlandAG2022
Thisworkissubjecttocopyright.AllrightsaresolelyandexclusivelylicensedbythePublisher,whether
thewholeorpartofthematerialisconcerned,specificallytherightsoftranslation,reprinting,reuseof
illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and
transmissionorinformationstorageandretrieval,electronicadaptation,computersoftware,orbysimilar
ordissimilarmethodologynowknownorhereafterdeveloped.
The use of general descriptive names, registered names, trademarks, service marks, etc. in this
publicationdoesnotimply,evenintheabsenceofaspecificstatement,thatsuchnamesareexemptfrom
therelevantprotectivelawsandregulationsandthereforefreeforgeneraluse.
The publisher, the authors and the editors are safe to assume that the advice and information in this
book are believed to be true and accurate at the date of publication. Neither the publisher nor the
authors or the editors give a warranty, expressed or implied, with respect to the material contained
hereinorforanyerrorsoromissionsthatmayhavebeenmade.Thepublisherremainsneutralwithregard
tojurisdictionalclaimsinpublishedmapsandinstitutionalaffiliations.
ThisSpringerimprintispublishedbytheregisteredcompanySpringerNatureSwitzerlandAG
Theregisteredcompanyaddressis:Gewerbestrasse11,6330Cham,Switzerland
Preface
The present book collects selected and peer-reviewed papers from the first
International Symposium on Bioinformatics and Biomedicine (BioInfoMed’2020)
held in Burgas, Bulgaria, on 8–10 October 2020. More than 100 abstracts were
submitted for the Symposium, yet only those which were topically relevant and
scientifically sound were considered and accepted.
Nine invited lecturers, highly reputed scientists from different countries around
the world—Australia, France, India, Mexico, Northern Macedonia, South Africa,
theUKandtheUSA—tookpartonline,whilemorethan50participants,including
a large number of young scientists, made 66 oral or poster presentations in pres-
ence. The undeniable success of BioInfoMed’2020 was mainly due to the
high-quality investigations in the fields of biomedicine, human medicine, health
care,bioinformatics,artificialintelligenceandmathematicalmodelling,whichwere
submitted for presentation by the Bulgarian and the international scientific
community.
Some of the presentations at the BioInfoMed’2020 Symposium have been
distinguished with diplomas, and the authors have been especially invited for
full-lengthpapersubmissions.Afteradouble-blindpeer-reviewprocess,thecurrent
book comprises 46 selected papers as the most representative of the topics and the
scientific level of the Symposium.
ThebookisorganizedinaccordancewiththetopicsoftheSymposium,namely
(cid:129) Decision Making in Bioinformatics, Biomedicine and Healthcare
(cid:129) Mathematical Modelling in Biomedicine and Healthcare
(cid:129) Artificial Intelligence in Biomedicine and Healthcare
(cid:129) Intuitionistic Fuzzy Sets with Applications in Bioinformatics and Biomedicine
(cid:129) Biomedical Approaches and Applications
(cid:129) Biomedical Imaging and Image Processing
(cid:129) Excitable Structures and Motor Activity
At the end of BioInfoMed’2020, all members of the programme and organizing
committees of the first International Symposium on Bioinformatics and
Biomedicine expressed a strong desire and determination to make the needed
v
vi Preface
efforts for this successful event to be the starting point of a biennial forum for
exchangingnovelknowledgeintheextremelyfastdevelopingtopicsinthefieldsof
bioinformatics and biomedicine.
The Editors
Sotir Sotirov
Tania Pencheva
Janusz Kacprzyk
Krassimir Atanassov
Evdokia Sotirova
Galya Staneva
Contents
Decision Making in Bioinformatics, Biomedicine and Healthcare
Comparative Analysis of Decision-Making Models in National
Healthcare Systems of EU Member-States:
Change-Drivers’ Identification . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3
Desisslava Atanasova and Nataliya Venelinova
A Comparative Machine Learning Modelling Approach
for Patients’ Mortality Prediction in Hospital Intensive Care Unit. . . . . 16
Mahmoud Aldraimli, Nodira Nazyrova, Abdumalik Djumanov,
Ikboljon Sobirov, and Thierry J. Chaussalet
Unified Approach for Designing a Database for the Needs
of the Anesthesiologists in Bulgaria . . . . . . . . . . . . . . . . . . . . . . . . . . . . 32
Rumen Rusev, Ivo Rusev, and Vladin Petrov
Computer-Based Rehabilitation of Cognitive Impairments in Patients
with Multiple Sclerosis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 39
Valentina Ignatova and Lyudmila Todorova
PointofCareLungDiagnosticinICU–OurExperiencewithBedside
Lung Ultrasound . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 50
Filip Naumovski and Biljana Kuzmanovska
Application of Digital Health and Telemedicine to Deal
with COVID-19 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 56
Vladimir Gonchev and Valentin Vasilev
Virtual Assisted Technologies as a Helping Tool for Therapists
in Assessment of Anxiety. Outcomes of a Pilot Trial
with Chatbot Assistance . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 60
Milen Todorov, Gergana Avramova-Todorova, Krasimira Dimitrova,
and Valentin Irmov
vii
viii Contents
InterCriteria Analysis Approach for Decision-Making in Virtual
Screening: Comparative Study of Various Scoring Functions . . . . . . . . 67
Dessislava Jereva, Maria Angelova, Ivanka Tsakovska, Petko Alov,
Ilza Pajeva, Maria Miteva, and Tania Pencheva
Bayesian Hierarchical Modelling for Antimicrobial Resistance . . . . . . . 79
MayaZhelyazkova,RoumyanaYordanova,IliyanMihaylov,StefanKirov,
Stefan Tsonev, David Danko, and Dimitar Vassilev
Mathematical Modelling in Biomedicine and Healthcare
Generalized Net Model of Telerehabilitation Program for Patients
with Socially Significant Diseases . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 91
Simeon Ribagin, Antoaneta Grozeva, and Gergana Popova
A Generalized Net Model with Intuitionistic Fuzzy Assessments
of the Process of Cardiopulmonary Resuscitation . . . . . . . . . . . . . . . . . 100
Hristo Bozov, Greta Bozova, Evdokia Sotirova, and Anthony Shannon
A Generalized Net Model of the Pattern of Behavior in Patients
with eGFR < 20 mL/min (CKD Stage IV-V) . . . . . . . . . . . . . . . . . . . . . 113
Martin Lubich, Anthony Shannon, Chavdar Slavov, Tania Pencheva,
Simeon Ribagin, and Krassimir Atanassov
Generalized Net Model of Biometric Authentication System Based
on Palm Geometry and Palm Vein Matching. . . . . . . . . . . . . . . . . . . . . 121
Zhelyana Ivanova and Veselina Bureva
A Generalized Net Model of the Process of Obtaining
and Diagnosing Convalescent Plasma from Patients with COVID-19. . . 131
Nikolay Andreev, Simeon Ribagin, and Krassimir Atanassov
Possible Application of Generalized Nets in Telemedicine Screening
of Corona Virus Disease 2019 (COVID-19) . . . . . . . . . . . . . . . . . . . . . . 139
Simeon Ribagin
Generalized Net Model of the Upper Limb Arterial Supply System. . . . 145
Valentin Vasilev, Krassimir Atanassov, and Evdokia Sotirova
Generalized Net Model of Ant Lion Optimizer. . . . . . . . . . . . . . . . . . . . 154
Elena Chorukova, Olympia Roeva, and Krassimir Atanassov
Implementation of Expanding Hierarchical Operators in GN IDE. . . . . 163
Dafina Zoteva
Artificial Intelligence in Biomedicine and Healthcare
Fuzzy U-Net Neural Network Design for Image Segmentation. . . . . . . . 177
Mark Kirichev, Todor Slavov, and Galina Momcheva
Contents ix
Effects of Variable Impulsive Perturbations on the Stability
of Fractional-Order Cohen–Grossberg Neural Networks
with Respect to Functions . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 185
Ivanka Stamova, Sotir Sotirov, Stanislav Simeonov, and Gani Stamov
Visualization on Stability of Impulsive Cohen-Grossberg Neural
Networks with Time-Varying Delays . . . . . . . . . . . . . . . . . . . . . . . . . . . 195
Gani Stamov, Stanislav Simeonov, and Ivan Torlakov
Performance Prediction of a Microbial Fuel Cell Based on Artificial
Neural Networks . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 202
Blagovesta Midyurova, Aleksandar Dimitrov, Sotir Sotirov,
and Todor Petkov
Functional Outcome Prediction of Operated Proximal Humerus
Fractures by Means of Artificial Neural Networks. . . . . . . . . . . . . . . . . 210
Stoyan Hristov, Asen Baltov, and Sotir Sotirov
Application of Virtual Reality as a Tool for Structural Analysis
of Molecules – Steroids, Pharmaceuticals and Pesticides . . . . . . . . . . . . 216
Todor Petkov, Stanislav Popov, Milen Todorov, Stanimir Surchev,
Guy De Tré, and Maciej Krawczak
In-silico Investigation of Human Visual System . . . . . . . . . . . . . . . . . . . 224
Petia Koprinkova-Hristova, Simona Nedelcheva, and Nadejda Bocheva
Sequence-Based Prediction of Food-Originated ACE Inhibitory
Peptides Using Deep Learning Algorithm. . . . . . . . . . . . . . . . . . . . . . . . 236
Margarita Terziyska, Ivelina Desseva, and Zhelyazko Terziyski
Cascading Approach for Automatic ICD-10 Codes Association
To Diseases in Bulgarian . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 247
BorisVelichkov,SimeonGerginov,PanayotPanayotov,SylviaVassileva,
Gerasim Velchev, Ivan Koychev, and Svetla Boytcheva
Intuitionistic Fuzzy Sets with Applications in Bioinformatics
and Biomedicine
Interval-Valued Intuitionistic Fuzzy Estimations of an Ultrasonic
Image for Recognition Purposes. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 263
Todor Kostadinov and Veselina Bureva
Intuitionistic Fuzzy Representation of Uncertainty in Biomedical
Operations . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 269
Stoyan Poryazov, Velin Andonov, and Emiliya Saranova
Intuitionistic Fuzzy Evaluations for Analysis of the Proximal
Humerus Fractures . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 279
Stoyan Hristov, Asen Baltov, Evdokia Sotirova, and Hristo Bozov
