Congress Proceedings. Radiation Research: A Twentieth-Century Perspective

1044 Pages·1992·36.457 MB·English

by  William C. Dewey, Martha Edington and R. J. Michael Fry (Eds.)

Published by Academic Press for the Ninth International
Congress of Radiation Research.
RADIATION RESEARCH:
A Twentieth-Century Perspective
Volume II: Congress Proceedings
Edited By
William C. Dewey
Martha Edington
R. J. Michael Fry
EricJ. Hall
Gordon F. Whitmore
@
ACADEMIC PRESS, INC.
Horcourt Brace Jovanovich, Publishers
San Diego New York Boston
London Sydney Tokyo Toronto
Academic Press Rapid Manuscript Reproduction
This book is printed on acid-free paper. ©
Copyright © Ί992 by ACADEMIC PRESS, INC.
All Rights Reserved.
No part of this publication may be reproduced or transmitted in any form
or by any means, electronic or mechanical, including photocopy, recording,
or any information storage and retrieval system, without permission in
writing from the publisher.
Academic Press, Inc.
1250 Sixth Avenue, San Diego, California 92101
United Kingdom Edition published by
Academic Press Limited
24-28 Oval Road, London NW1 7DX
Library of Congress Cataloging-in-Publication Data
Radiation research.
Vol. Ί prepared for participants of the 9th
International Congress of Radiation Research.
Vol. 1 edited by William C. Dewey.
Includes index.
Contents: v. 1. Congress abstracts ~ v. 2.
Congress proceedings
ISBN 0-12-168561 -6 (v. 1)
ISBN 0-12-168562-4 (v. 2)
1. Radiation—Physiological effect—Congresses.
2. Radiobiology-Congresses. 3. Radiology—Congresses
I. Chapman, J. Donald. II. Dewey, William C.
III. Whitmore, Cordon F. IV. International Congress
of Radiation Research (9th : 1991 : Toronto, Ont.)
QP82.2.R3R265 1991 6Ί2\0Ί448—dc20 91-19578
CIP
PRINTED IN THE UNITED STATES OF AMERICA
92 93 94 95 96 97 HA 9 8 7 6 5 4 3 2 1
PREFACE
The Ninth International Congress of Radiation Research was held in
Toronto, Canada, in July 1991. Its success is evident from the number of
participants. There were over 1500 active participants including almost 300
students. In addition there were exhibitors, relatives and friends, making a
grand total of 1827 registered from 36 countries. The scientific success of the
Congress was ensured by over 2300 contributions ranging from lectures,
symposia talks, and workshop contributions, to poster presentations. The
excellence of the conference center, the fair city of Toronto itself, the trips and
social events all contributed to a memorable Congress.
This volume is a record of the lectures given by the recipients of the
International Association of Radiation Research Henry S. Kaplan Dis-
tinguished Science, Ontario Cancer Treatment and Research Foundation
Richards, and North American Hyperthermia Group J. Eugene Robinson
Awards, the Congress Lectures and the talks given in the 35 symposia.
Abstracts of the various talks and poster presentations appeared in Volume I
of the Proceedings, which has been distributed to the participants.
Unfortunately, the words of the speakers who made the workshops so
successful are not included, nor are the telling and entertaining remarks made
at the debate on the role of DNA double-strand breaks in radiation-induced cell
killing. The Radiation Research Society Failla Memorial Lecture, given by E.
J. Hall, will be published in Volume 129 of Radiation Research.
The scientific sessions were stimulating and their content was
broadened by speakers whose research is not in radiation but in fields with
interests in common. The tone was set during the Opening Ceremony by a
stimulating lecture on Creativity in Science delivered by Dr. David Perkins of
Harvard University.
Papers had to be restricted in length, which has tested the ingenuity of
the authors and, in particular, the editors in their attempt not to allow brevity
to impair clarity.
The Award Lectures introduce the volume, and the other papers are
grouped under ten headings, a scheme that does not do justice to the
individuality of some of the contributions.
XXI
EDITORS' ACKNOWLEDGMENTS
The Editors would like to recognize the help that they have had from
many people, especially all those who read the manuscripts submitted for this
volume during the Congress. We would like to thank Oddvar F. Nygaard for
his help.
It is with great gratitude that we acknowledge the secretarial help we
have had from Bernice Corn, Donna Langston, Nancy Ribble, Jennifer
Thompson, and Faye Young.
We are grateful to Prof. J. W. Osborne and Krista Voyce for the
photographs that appear on pages xxv, xxvi, xxviii, 32, 312, 406, 532, 722,
862, 880, 1039, and 1040.
XXll
ACKNOWLEDGMENTS
The Board of Directors of the 9th ICRR expresses its appreciation to the
people and organizations listed below for their generous financial support of
this Congress.
Radiation Research Society
North American Hyperthermia Group
International Association of Radiation Research
8th International Congress of Radiation Research
Atomic Energy of Canada
Atomic Energy Control Board (Canada)
Defense Nuclear Agency (USA)
Department of Energy (USA)
Health and Welfare Canada
Medical Research Council of Canada
National Aeronautics and Space Administration (USA)
National Institutes of Health (USA)
Ontario Hydro (Canada)*
Leslie Botnick, M. D.
Luther W. Brady, M. D. & Associates
JCRT Foundation—Harvard Medical School
Massachusetts General Hospital, Department of Radiation Oncology*
Michael Reese/University of Chicago, Center for Radiation Therapy
New England Medical Center Hospital
New York Medical College, Department of Radiation Medicine
Ontario Cancer Institute*
Ontario Cancer Treatment and Research Foundation*
University Hospitals of Cleveland
University of Alabama Health Services
University of Arizona, Department of Radiation Oncology
University of California, San Francisco, Department of Radiation Oncology*
University of Kansas, Department of Radiation Oncology
University of Texas Medical Branch at Galveston*
University of Wisconsin Medical School, Department of Human Oncology
Bristol-Myers Squibb
GAMMEX
Imagenetics*
Mandel Scientific
Philips Medical Systems North America*
Siemens Medical Systems*
Sterling Drug*
Varian Associates*
*As listed in the Program for the 9th ICRR, particular lectures and symposia were
sponsored by these organizations.
xxiii
The Ninth
International Congress of Radiation Research
Organized by the Radiation Research Society and the North American
Hyperthermia Group at the invitation of the International Association of
Radiation Research.
Congress Board of Directors
G. F. Whitmore (Canada)—President
J. F. Ward (USA)—Vice President
J. D. Chapman (USA)—Secretary General
E. R. Epp (USA)—Treasurer
W. C. Dewey (USA)—Program Chairman
A. M. Rauth (Canada)—Local Arrangements Chairman
Laura Fleming Jones (USA)—Administrative Director
Radiation Research Society
John D. Zimbrick (USA)—President
North America Hyperthermia Group
Frederic A. Gibbs Jr. (USA)—President
International Association of Radiation Research
Gerald E. Adams (UK)—President
XXIV
G. E. Adams, President
of the International
Association of
Radiation Research
G. F. Whitmore, President
of the 9th ICRR Board of
Directors and Vice President
of the International
Association of Radiation
Research
J. F. Ward, Vice
President of the 9th
ICRR Board of
Directors
XXV
J. D. Chapman,
Secretary General of
the 9th ICRR
E. R. Epp, Treasurer of
the 9th ICRR
J. J. Broerse,
Secretary-Treasurer of
the International
Association of
Radiation Research
xxvi
Program Committee
William C. Dewey (USA), Chairman
M. Abe (Japan) E. P. Malaise (France)
G. E. Adams (UK) W. H. McBride (USA)a
K. Ando (Japan) N. J. McNally (UK)C
S. B. Balmukhanov (USSR) J. B. Mitchell (USA)
E. A. Blakely (USA)a N. L. Oleinick (USA)
J. S. Bedford (USA) J. Oleson (USA)
D. Bootsma (The Netherlands) J. Overgaard (Denmark)
D. J. Brenner (USA)a R. B. Painter (USA)a
J. J. Broerse (The Netherlands) H. G. Paretzke (Germany)
J. M. Brown (USA)a L. J. Peters (USA)
T. Cetas (USA) T. L. Phillips (USA)a
D. J. Chaplin (UK) M. Quintiliani (Italy)
A. Chatterjee (USA)a M. R. Raju (USA)
C.-K. Chou (USA)a J. A. Raleigh (USA)
J. E. Cleaver (USA)a J. L. Redpath (USA)a
C. N. Coleman (USA) M. A. J. Rodgers (USA)a
D. F. Deen (USA)a R. B. Roemer (USA)
J. Denekamp (UK) D. Schulte-Frohlinde (Germany)
S. Dische (UK) B. B. Singh (India)
S. S. Donaldson (USA)a G. G. Steel (UK)
E. M. Fielden (UK) T. Straume (USA)a
J. Fowler (USA) C. Streffer (Germany)
K. Fu (USA)a H. D. Suit (USA)
E. W. Gerner (USA) R. M. Sutherland (USA)a
D.Goodhead(UK) H. Tanooka (Japan)
J. W. Gray (USA)a J. K. Thomas (USA)
G. M. Hahn (USA)a E. L. Travis (USA)
E. J. Hall (USA) R. C. Urtasun (Canada)
M. Henkelman (Canada) E. Van Der Schueren (Belgium)
C. K. Hill (USA)a P. W. Vaupel (Germany)
R. P. Hill (Canada)b C. Von Sonntag (Germany)
S. S. Wallace (USA)
A. M. Kellerer (Germany)
J. F. Ward (USA)a
D. J. Li (China)
C. C. Ling (USA) P. Wardman (UK)
J. B. Little (USA) H. R. Withers (Australia)
J. T. Lyman (USA)a S. P. Yarmonenko (USSR)
aMembers who attended 2-3 special Program Committee meetings in San Francisco
Responsible for poster layout
cDeceased
XXVlll