Concise Guide to Hematology

429 Pages·2011·19.28 MB·English

Concise
Guide to
Hematology
Dr. Schmaier dedicates this book to his life partner Linda and to Alec and
Lauren who are contributing to the next generation of physicians.
Dr. Lazarus dedicates this book to his loving wife Joan and sons Jeffrey and
Adam and spouses Jana and Sarah for their unwavering support.
Concise
Guide to
Hematology
EDITED BY
Alvin H. Schmaier
MD
Robert W. Kellermeyer Professor of Hematology/Oncology
Case Western Reserve University
University Hospitals Case Medical Center
Cleveland, OH, USA
Hillard M. Lazarus
MD, FACP
Professor of Medicine
Case Western Reserve University
University Hospitals Case Medical Center
Cleveland, OH, USA
A John Wiley & Sons, Ltd., Publication
This edition fi rst published 2012 © 2012 by Blackwell Publishing Ltd.
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Library of Congress Cataloging-in-Publication Data
Concise guide to hematology / edited by Alvin H. Schmaier, Hillard M. Lazarus.
p. ; cm.
Includes bibliographical references and index.
ISBN-13: 978-1-4051-9666-6 (hardcover : alk. paper)
ISBN-10: 1-4051-9666-1 (hardcover : alk. paper) 1. Blood–Diseases.
2. Hematology. I. Schmaier, Alvin H. II. Lazarus, Hillard M.
[DNLM: 1. Hematologic Diseases. 2. Hematopoiesis. 3. Neoplasms, Plasma
Cell. WS 39]
RC633.C66 2011
616.1′5–dc23
2011015323
A catalogue record for this book is available from the British Library.
This book is published in the following electronic formats: ePDF 9781444345223;
Wiley Online Library 9781444345254; ePub 9781444345230; Mobi 9781444345247
Set in 9.5/12 pt Palatino by Toppan Best-set Premedia Limited
1 2012
Contents
List of Contributors, ix
Preface, xii
1 Introduction to Hematology, 1
Alvin H. Schmaier
2 Hematopoiesis, 6
Yuan Lin and Stanton L. Gerson
3 Red Blood Cell Biochemistry and Physiology, 16
Kevin T. McDonagh
4 Anemia: Clinical Approach, 24
Peter W. Marks
5 Iron Defi ciency, 35
Alice Ma
6 Vitamin-B (Cobalamin) and Folate Defi ciency, 44
12
As´ok C. Antony
7 Congenital Hemolytic Anemias, 62
Archana M. Agarwal and Josef T. Prchal
8 Acquired Hemolytic Anemias, 75
Scott D. Gitlin
9 Overview of Hemostasis, 91
Alvin H. Schmaier
10 Approach to the Bleeding Patient, 103
Alvin H. Schmaier
v
vi Contents
11 Congenital Bleeding Disorders, 112
Anjali A. Sharathkumar and Steven W. Pipe
12 Acquired Bleeding Disorders, 131
Howard A. Liebman
13 Platelet Function in Hemostasis and Inherited Disorders of Platelet
Number and Function, 140
A. Koneti Rao and David W. Essex
14 Acquired Thrombocytopenia, 154
Theodore E. Warkentin and Andrew E. Warkentin
15 Thrombosis and Anticoagulation, 174
Alvin H. Schmaier
16 Myeloid Cell Physiology and Disorders, 184
Alvin H. Schmaier, Lilli M. Petruzzelli, Niels Borregaard and
Laurence A. Boxer
17 Bone Marrow Structure and Diagnostic Testing, 197
Howard J. Meyerson and Hillard M. Lazarus
18 Myeloproliferative Neoplasms and Myelodysplastic Syndromes, 220
Gabriela Motyckova and Richard M. Stone
19 Acute Leukemia, 235
Tsila Zuckerman and Jacob M. Rowe
20 Classifi cation of Lymphoma, 251
Yi-Hua Chen and Amy Chadburn
21 Clinical Evaluation and Management of Lymphoma, 268
Makiko Ban-Hoefen, Jonathan W. Friedberg and Richard I. Fisher
22 Plasma Cell Disorders, 287
Sumit Madan and Philip R. Greipp
23 Pediatric Hematology, 307
Sanjay P. Ahuja
24 Blood Banking, 319
Lawrence Tim Goodnough
25 Transfusion Therapy, 332
Beth H. Shaz and Christopher D. Hillyer
Contents vii
26 Hematopoietic Cell Transplantation, 344
Hillard M. Lazarus
27 Atlas of Hematology Slides, 363
Alvin H. Schmaier
Index, 389
Contributors
Archana M. Agarwal MD Amy Chadburn MD
Assistant Professor, Pathology Professor of Pathology
University of Utah and ARUP Laboratories Division of Hematopathology
Salt Lake City, UT, USA Department of Pathology
Northwestern University, Feinberg School of
Medicine
Sanjay P. Ahuja MD, MS
Chicago, IL, USA
Assistant Professor, Pediatric Hematology/
Oncology
Director, Hemostasis and Thrombosis Center Yi- Hua Chen MD
Rainbow Babies and Children ’ s Hospital Assistant Professor of Pathology
Case Western Reserve University Division of Hematopathology
Cleveland, OH, USA Department of Pathology
Northwestern University, Feinberg School of
Medicine
A s´ ok C. Antony MD, FACP
Chicago, IL, USA
Professor of Medicine
Indiana University School of Medicine
Indianapolis, IN, USA David W. Essex MD
Associate Professor of Medicine
Sol Sherry Thrombosis Research Center and
Makiko Ban- Hoefen MD
Division of Hematology
Hematology/Oncology Fellow Temple University School of Medicine
James P. Wilmot Cancer Center Philadelphia, PA, USA
University of Rochester Medical Center
Rochester, NY, USA
Richard I. Fisher MD
Director, James P. Wilmot Cancer Center
Niels Borregaard MD, PhD
Samuel E. Durand Chair in Medicine
Professor of Hematology and Internal Medicine Professor of Medicine
University of Copenhagen; University of Rochester Medical Center
Department of Hematology Rochester, NY, USA
Rigshospitalet
Copenhagen, Denmark
Jonathan W. Friedberg MD, MMSc
Professor of Medicine and Oncology
Laurence A. Boxer MD
Chief, Hematology Oncology Division
Henry and Mala Dorfman Family Professor of James P. Wilmot Cancer Center
Pediatric Hematology/Oncology University of Rochester Medical Center
Department of Pediatrics and Communicable Rochester, NY, USA
Diseases
University of Michigan
Ann Arbor, MI, USA
ix
x Contributors
Stanton L. Gerson MD Yuan Lin PhD
Director, Case Comprehensive Cancer Center Division of Hematology and Oncology
Director, Seidman Cancer Center Case Western Reserve University
Asa and Patricia Shiverik Professor of University Hospitals Case Medical Center
Hematology and Oncology Seidman Cancer Center
Case Western Reserve University Cleveland, OH, USA
University Hospitals Case Medical Center
Cleveland, OH, USA
Alice Ma MD
Associate Professor of Medicine
Scott D. Gitlin MD, FACP Department of Medicine
Associate Professor of Internal Medicine Division of Hematology/Oncology
Division of Hematology/Oncology University of North Carolina
University of Michigan Chapel Hill, NC, USA
Ann Arbor VA Health System
Ann Arbor, MI, USA
Sumit Madan MD
Research Fellow
Lawrence Tim Goodnough MD Division of Hematology
Professor of Pathology and Medicine Mayo Clinic
Director of Transfusion Service Rochester, MN, USA
Department of Pathology
Stanford University Medical Center
Peter W. Marks MD, PhD
Stanford, CA, USA
Associate Professor of Medicine
Department of Internal Medicine/Hematology
Philip R. Greipp MD Yale University School of Medicine
Professor of Medicine New Haven, CT, USA
Division of Hematology
Mayo Clinic
Kevin T. McDonagh MD
Rochester, MN, USA
Markey Foundation Chair
Chief, Division of Hematology, Oncology and
Christopher D. Hillyer MD Blood and Marrow Transplantation
President and Chief Executive Offi cer University of Kentucky College of Medicine
New York Blood Center Lexington, KY, USA
Professor of Medicine
Department of Medicine
Howard J. Meyerson MD
Weill Cornell Medical College
New York, NY, USA Director of Hematopathology and Flow
Cytometry
University Hospitals Case Medical Center;
Hillard M. Lazarus MD, FACP Associate Professor of Pathology
Professor of Medicine Case Western Reserve University
Case Western Reserve University Cleveland, OH, USA
University Hospitals Case Medical Center
Cleveland, OH, USA
Gabriela Motyckova MD, PhD
Hematology/Oncology Fellow
Howard A. Liebman MD Dana - Farber Cancer Institute
Professor of Medicine and Pathology Boston, MA, USA
Jane Anne Nohl Division of Hematology
Department of Medicine
Lilli M. Petruzzelli
University of Southern California - Keck School of
Medicine Sr. Medical Director, Oncology Translational
Los Angeles, CA, USA Medicine
Novartis Institutes for BioMedical Research, Inc.
Cambridge, MA, USA
Contributors xi
Steven W. Pipe MD Beth H. Shaz MD
Associate Professor of Pediatrics and Pathology Chief Medical Offi cer
Laurence A. Boxer Research Professor of New York Blood Center
Pediatrics and Communicable Diseases New York, NY, USA;
Director, Division of Pediatric Hematology and Clinical Associate Professor
Oncology Department of Pathology and Laboratory
Pediatric Medical Director, Hemophilia and Medicine
Coagulation Disorders Program Emory University School of Medicine
Director, Special Coagulation Laboratory Atlanta, GA, USA
C.S. Mott Children ’ s Hospital
University of Michigan
Richard M. Stone MD
Ann Arbor, MI, USA
Professor of Medicine
Dana - Farber Cancer Institute
Josef T. Prchal MD Boston, MA, USA
Professor of Medicine, Genetics and Pathology
University of Utah and ARUP Laboratories;
Andrew E. Warkentin BHSc(Hon)
Huntsmar Cancer Hospital
George E. Waheln VA Medical Center Medical Student
Salt Lake City, UT, USA Faculty of Medicine
University of Toronto
Toronto, ON, Canada
A. Koneti Rao MBBS, FACP
Sol Sherry Professor of Medicine
Theodore E. Warkentin MD,
Chief, Hematology Section
Co - Director, Sol Sherry Thrombosis Research BSc(Med), FRCP(C), FACP
Center Professor, Department of Pathology and
Temple University School of Medicine Molecular Medicine, and Department of
Philadelphia, PA, USA Medicine
Michael G. DeGroote School of Medicine
McMaster University
Jacob M. Rowe MD
Hamilton, ON, Canada
Professor of Hematology
Director, Department of Hematology and Bone
Marrow Transplantation Tsila Zuckerman MD
Rambam Medical Center and Director, Bone Marrow Transplantation Unit
Bruce Rappaport Faculty of Medicine Department of Hematology and Bone Marrow
Technion — Israel Institute of Technology Transplantation
Haifa, Israel Rambam Medical Center and
Bruce Rappaport Faculty of Medicine
Technion – Israel Institute of Technology
Alvin H. Schmaier MD
Haifa, Israel
Robert W. Kellermeyer Professor of Hematology/
Oncology
Case Western Reserve University
University Hospitals Case Medical Center
Cleveland, OH, USA
Anjali A. Sharathkumar MD, MS
Medical Director of Hemophilia and
Thrombophilia Program
Assistant Professor of Pediatrics
Children ’ s Memorial Hospital
Northwestern University, Feinberg School of
Medicine
Chicago, IL, USA