Comparative Biology of Aging

397 Pages·2010·3.536 MB·English

by  Norman S. Wolf

The Comparative Biology of Aging
Norman S. Wolf
Editor
The Comparative Biology
of Aging
1 3
Editor
NormanS.Wolf
SeattleWA98195-7470
C-423HealthSciencesBldg.
USA
[email protected]
Coverphotocredits:
Human:45yearoldWerner’sSyndromepatient,InternationalRegistryofWernerSyndrome,
courtesy of Dru Leistritz.Rhesus monkey: 29 year old male (M. mulatta), NIA Study on
Primate Aging, courtesy of Dr. Julie Mattison, primate aging colony, NIA. Dog: “Tiger”,
13yearoldWestHighlandWhiteterrier,courtesyofDanandPatMcCutcheonandJeremy
andMicheleWolf.Mouse,BalbCstrain:CourtesyofDr.NormWolflaboratory,Department
of Pathology, University of Washington. Fruit fly (D. melanogaster): Courtesy of Dr. Rolf
Bodmer,DevelopmentandAging,BurnhamInstitute,LaJolla,Ca.Roundworm(C.elegans):
CourtesyofDrs.MattKaeberleinandBrianKennedy,DepartmentofPathology,University
ofWashington.
ISBN978-90-481-3464-9 e-ISBN978-90-481-3465-6
DOI10.1007/978-90-481-3465-6
SpringerDordrechtHeidelbergLondonNewYork
LibraryofCongressControlNumber:2009942696
©SpringerScience+BusinessMediaB.V.2010
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Contents
Introduction: Lifespans and Pathologies Present at Death
inLaboratoryAnimals . . . . . . . . . . . . . . . . . . . . . . . . . . . 1
NormanS.WolfandStevenAustad
AnimalSize,MetabolicRate,andSurvival,AmongandWithinSpecies 27
StevenN.Austad
HormonalInfluencesonAgingandLifespan . . . . . . . . . . . . . . . 43
AdamSpongandAndrzejBartke
Exploring Mechanisms of Aging Retardation by Caloric
Restriction:StudiesinModelOrganismsandMammals . . . . . . . . . 69
RozalynM.Anderson,RickiJ.Colman,andRichardWeindruch
CellReplicationRatesInVivoandInVitroandWoundHealing
asAffectedbyAnimalAge,Diet,andSpecies . . . . . . . . . . . . . . . 97
NormanS.Wolf
SirtuinFunctioninLongevity . . . . . . . . . . . . . . . . . . . . . . . . 123
DanielL.SmithJr.andJeffreyS.Smith
TheRoleofTORSignalinginAging . . . . . . . . . . . . . . . . . . . . 147
MattKaeberleinandLaraS.Shamieh
Mitochondria,OxidativeDamageandLongevity:WhatCan
ComparativeBiologyTeachUs? . . . . . . . . . . . . . . . . . . . . . . 163
YunShi,RochelleBuffenstein,andHollyVanRemmen
ComparativeGenomicsofAging . . . . . . . . . . . . . . . . . . . . . . 191
JanVijg,AnaMariaGarcia,BrentCalder,andMartijnDollé
Changes in Lysosomes and Their Autophagic Function in
Aging:TheComparativeBiologyofLysosomalFunction . . . . . . . . 201
SamanthaJ.OrensteinandAnaMariaCuervo
TelomeresandTelomerase . . . . . . . . . . . . . . . . . . . . . . . . . 227
N.M.V.Gomes,J.W.Shay,andW.E.Wright
v
vi Contents
CardiacAging . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 259
Dao-FuDai,RobertJ.Wessells,RolfBodmer,and
PeterS.Rabinovitch
ComparativeSkeletalMuscleAging . . . . . . . . . . . . . . . . . . . . 287
DavidJ.Marcinek,JonathanWanagat,andJasonJ.Villarin
AgingoftheNervousSystem . . . . . . . . . . . . . . . . . . . . . . . . 319
CatherineA.Wolkow,SigeZou,andMarkP.Mattson
AgingoftheImmuneSystemAcrossDifferentSpecies . . . . . . . . . . 353
JankoNikolich-ŽugichandLukaCˇicˇin-Šain
Index . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 377
Contributors
RozalynAnderson WisconsinNationalPrimateResearchCenter,Universityof
Wisconsin-Madison,Madison,WI,USA,[email protected]
StevenN.Austad DepartmentofCellular&StructuralBiology,BarshopInstitute
forLongevityandAgingResearch,UniversityofTexasHealthScienceCenterat
SanAntonio,SanAntonio,TX,USA,[email protected]
AndrzejBartke GeriatricResearch,DepartmentofInternalMedicine,Southern
IllinoisUniversitySchoolofMedicine,Springfield,IL62794,USA;Departmentof
Physiology,SouthernIllinoisUniversitySchoolofMedicine,Springfield,IL
62794,USA,[email protected]
RolfBodmer BurnhamInstitute,Developmentandagingprogram,LaJolla,
CA,USA
RochelleBuffenstein DepartmentofPhysiology,CellularandStructuralBiology,
BarshopInstituteforLongevityandAgingStudies,UniversityofTexasHealth
ScienceCenteratSanAntonio,SanAntonio,TX,USA
BrentCalder DepartmentofGenetics,AlbertEinsteinCollegeofMedicine,
Bronx,NY10461,USA
LukaCicin-Sain VaccineandGeneTherapyInstituteandtheOregonNational
PrimateResearchCenter,OregonHealthandScienceUniversity,Beaverton,OR
97006,USA
RickiColman WisconsinNationalPrimateResearchCenter,Universityof
Wisconsin-Madison,Madison,WI,USA;DepartmentofMedicine,Universityof
Wisconsin-Madison,Madison,WI,USA
AnaMariaCuervo DepartmentofDevelopmentalandMolecularBiology,
MarionBessinLiverResearchCenter,InstituteforAgingResearch,Albert
EinsteinCollegeofMedicine,Bronx,NY,USA,[email protected]
Dao-FuDai DepartmentofPathology,UniversityofWashington,Seattle,
WA,USA
vii
viii Contributors
MartijnDollé NationalInstituteofPublicHealthandtheEnvironment,Bilthoven,
TheNetherlands
AnaMariaGarcia UniversityofTexasatSanAntonio,SanAntonio,TX,USA
N.M.V.Gomes DepartmentofCellBiology,TheUniversityofTexas
SouthwesternMedicalCenteratDallas,Dallas,TX75390-9039,USA
YujiIkeno BarshopInstituteandUniversityofTexasScienceCenteratSan
Antonio,SanAntonio,TX,USA
MattKaeberlein DepartmentofPathology,UniversityofWashington,Seattle,
WA,USA,[email protected]
MarkP.Mattson LaboratoryofNeurosciences,NationalInstituteonAging
IntramuralResearchProgram,Baltimore,MD,USA,[email protected]
DavidJ.Marcinek DepartmentofRadiology,UniversityofWashington,Seattle,
WA98195,USA,[email protected]
JulieMattison LaboratoryofExperimentalGerontology,NIA,Baltimore,
MD,USA
JankoNikolich-Zugich DepartmentofImmunobiologyandtheArizonaCenter
onAging,UniversityofArizonaCollegeofMedicine,Tucson,AZ85718,USA;
VaccineandGeneTherapyInstituteandtheOregonNationalPrimateResearch
Center,OregonHealthandScienceUniversity,Beaverton,OR97006,USA,
[email protected]
SamanthaJ.Orenstein DepartmentofDevelopmentalandMolecularBiology,
MarionBessinLiverResearchCenter,InstituteforAgingResearch,Albert
EinsteinCollegeofMedicine,Bronx,NY,USA
BeverlyPaigen JAXLaboratories,BarHarbor,ME,USA
PeterS.Rabinovitch DepartmentofPathology,UniversityofWashington,
Seattle,WA,USA,[email protected]
LaraS.Shamieh DepartmentofPathology,UniversityofWashington,Seattle,
WA,USA
J.W.Shay DepartmentofCellBiology,TheUniversityofTexasSouthwestern
MedicalCenteratDallas,Dallas,TX75390-9039,USA
YunShi DepartmentofPhysiology,BarshopInstituteforLongevityandAging
Studies,UniversityofTexasHealthScienceCenteratSanAntonio,SanAntonio,
TX,USA
DanielL.Smith DepartmentofBiochemistryandMolecularGenetics,Schoolof
Medicine,UniversityofVirginiaHealthSystem,Charlottesville,VA22908,USA
Contributors ix
JeffreyS.Smith DepartmentofBiochemistryandMolecularGenetics,Schoolof
Medicine,UniversityofVirginiaHealthSystem,Charlottesville,VA22908,USA,
[email protected]
AdamSpong GeriatricResearch,DepartmentofInternalMedicine,Southern
IllinoisUniversitySchoolofMedicine,Springfield,IL62794,USA
HollyVanRemmen DepartmentofPhysiology,CellularandStructuralBiology,
BarshopInstituteforLongevityandAgingStudies,UniversityofTexasHealth
ScienceCenteratSanAntonio;AudieMurphyDivision,SouthTexasVeterans
HealthCareSystem,SanAntonio,TX,USA,[email protected]
JanVijg DepartmentofGenetics,AlbertEinsteinCollegeofMedicine,Bronx,
NY10461,USA,[email protected]
JasonJ.Villarin DepartmentofRadiology,UniversityofWashington,Seattle,
WA98195,USA
JonathanWanagat DivisionofGerontologyandGeriatricMedicine,University
ofWashington,Seattle,WA98195,USA
RichardWeindruch WisconsinNationalPrimateResearchCenter,Universityof
Wisconsin-Madison,Madison,WI,USA;DepartmentofMedicine,Universityof
Wisconsin-Madison,Madison,WI,USA;GRECCVAHospitalMadison,
UniversityofWisconsin-Madison,Madison,WI,USA
RobertJ.Wessells DepartmentofInternalMedicine,UniversityofMichigan,
AnnArbor,MI,USA
NormanS.Wolf DepartmentofPathology,UniversityofWashington,Seattle,
WA91895,USA,[email protected]
CatherineA.Wolkow LaboratoryofNeurosciences,NationalInstituteonAging
IntramuralResearchProgram,Baltimore,MD,USA,[email protected]
W.E.Wright DepartmentofCellBiology,TheUniversityofTexasSouthwestern
MedicalCenteratDallas,Dallas,TX75390-9039,USA,
[email protected]
RongYuan JAXLaboratories,BarHarbor,ME,USA
SigeZou LaboratoryofExperimentalGerontology,NationalInstituteonAging
IntramuralResearchProgram,Baltimore,MD,USA
Introduction: Lifespans and Pathologies Present
at Death in Laboratory Animals
NormanS.Wolf1andStevenAustad2
1DepartmentofPathology,UniversityofWashington,Seattle,WA
2BarshopInstituteandUniversityofTexasScienceCenteratSanAntonio,
SanAntonio,TX
Abstract This initial chapter introduces those that follow with a summary of the
lifespansandendoflifepathologiesoftheseveralspeciesthatareincludedinlater
chapters. It is not presented as a complete coverage, but rather as background for
what follows, as gathered from the literature and personal information. Included
here is that information on yeast as Saccharomyces cervisiae, round worms as
Caenorhabditis. elegans, the fruit fly, Drosophila melanogaster, mice, rats, dogs,
primates,andsomebatsandbirds.Thefollowingchapterswillcomparefindingsin
theirspecificareaofcoverageforthosespeciesforwhichsuchdataisavailable.
Thisbriefintroductionprovidesgenerallyacceptedspecieswildtypelifespansand
theendoflifepathologies,alongwithsomespecialattributesthatlendaspeciesto
acomparativebiologyapproach.
Keywords Aging·Lifespan·Endoflifeconditions·Humans·Dogs·Mice·Rates·
Fish·Amphibians·Causeofdeath
LaboratoryStrainsofYeast(Saccharomycescervisiae)
WildTypeOnly
ThelifespanofS.cervisiaevarieswithbothstrainandmediaused(especiallyglu-
cosecontent).Thelifespanofyeastmaybedeterminedbytwodifferentmeans:the
numberofdivisionsaccomplishedbythemothercell(replicativelifespan),orbythe
survival of individual cells in a non-dividing, quiescence-like state (chronological
lifespan).Replicativelifespanisdeterminedbyphysicalseparationofdaughtercells
from mother cells via micromanipulation, while tallying the number of daughter
cellsproducedbyeachmother[1].Chronologicallifespanistypicallydetermined
Data Contributors: Julie Mattison, Laboratory of Experimental Gerontology, NIA; Mathew
Kaeberlein,DepartmentofPathology,UniversityofWashington,Seattle,WA;BeverlyPaigenand
RongYuan,JAXLaboratories,BarHarbor,ME;YujiIkeno,BarshopInstituteandUniversityof
TexasScienceCenteratSanAntonio,TX;RochelleBuffenstein,DepartmentofPhysiologyand
BarshopInstitute,UniversityofTexasScienceCenteratSanAntonioTX
N.S.Wolf(ed.),TheComparativeBiologyofAging, 1
DOI10.1007/978-90-481-3465-6_1,(cid:2)C SpringerScience+BusinessMediaB.V.2010