Clinical effectiveness, cost-effectiveness and acceptability of low-intensity interventions in the

165 Pages·2017·1.29 MB·English

This is a repository copy of Clinical effectiveness, cost-effectiveness and acceptability of
low-intensity interventions in the management of obsessive compulsive disorder : the
Obsessive Compulsive Treatment Efficacy randomised controlled Trial (OCTET).
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Article:
Lovell, Karina, Bower, Peter, Gellatly, Judith et al. (21 more authors) (2017) Clinical
effectiveness, cost-effectiveness and acceptability of low-intensity interventions in the
management of obsessive compulsive disorder : the Obsessive Compulsive Treatment
Efficacy randomised controlled Trial (OCTET). Health technology assessment. pp. 1-164.
ISSN 2046-4924
https://doi.org/10.3310/hta21370
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HEALTH TECHNOLOGY ASSESSMENT
VOLUME 21 ISSUE 37 JUNE 2017
ISSN 1366-5278
Clinical effectiveness, cost-effectiveness and
acceptability of low-intensity interventions in
the management of obsessive–compulsive disorder:
the Obsessive–Compulsive Treatment Efficacy
randomised controlled Trial (OCTET)
Karina Lovell, Peter Bower, Judith Gellatly, Sarah Byford, Penny Bee,
Dean McMillan, Catherine Arundel, Simon Gilbody, Lina Gega,
Gillian Hardy, Shirley Reynolds, Michael Barkham, Patricia Mottram,
Nicola Lidbetter, Rebecca Pedley, Jo Molle, Emily Peckham,
Jasmin Knopp-Hoffer, Owen Price, Janice Connell, Margaret Heslin,
Christopher Foley, Faye Plummer and Christopher Roberts
DOI 10.3310/hta21370

Clinical effectiveness, cost-effectiveness
and acceptability of low-intensity
interventions in the management of
–
obsessive compulsive disorder: the
–
Obsessive Compulsive Treatment Efficacy
randomised controlled Trial (OCTET)
Karina Lovell,1* Peter Bower,2 Judith Gellatly,1
Sarah Byford,3 Penny Bee,1 Dean McMillan,4
Catherine Arundel,5 Simon Gilbody,4 Lina Gega,6
Gillian Hardy,7 Shirley Reynolds,8 Michael Barkham,7
Patricia Mottram,9 Nicola Lidbetter,10
Rebecca Pedley,1 Jo Molle,11 Emily Peckham,5
Jasmin Knopp-Hoffer,2 Owen Price,1 Janice Connell,12
Margaret Heslin,3 Christopher Foley,13 Faye Plummer5
and Christopher Roberts13
1Division of Nursing, Midwifery and Social Work, University of Manchester,
Manchester, UK
2Centre for Primary Care, University of Manchester, Manchester, UK
3King’s Health Economics, Institute of Psychiatry, Psychology and Neuroscience,
King’s College London, London, UK
4Hull York Medical School and Department of Health Sciences, University of
York, York, UK
5Department of Health Sciences, University of York, York, UK
6Social Work and Communities, Northumbria University, Newcastle, UK
7Department of Psychology, University of Sheffield, Sheffield, UK
8School of Psychology, University of Reading, Reading, UK
9Cheshire & Wirral Partnership, NHS Foundation Trust, Wallasey, UK
10Anxiety UK, Manchester, UK
11Norwich Medical School, University of East Anglia, Norwich, UK
12School of Health and Related Research, University of Sheffield, Sheffield, UK
13Centre for Biostatistics in the Institute of Population Health, University of
Manchester, Manchester, UK
*Corresponding author

Declared competing interests of authors: Karina Lovell,Sarah Byford and Shirley Reynolds reportgrants
from theNational Institute for Health Researchduring the conductof thestudy. Michael Barkhamreports
that hewas the leadinvestigator in the development oftheClinical Outcomes in Routine Evaluation –
Outcome Measure, whichis used inthe trial. Simon Gilbody reportsprevious membership oftheHealth
Technology Assessment Clinical Trials Board.
Disclaimer: This report contains transcripts of interviews conducted in thecourse ofthe research and
contains language thatmay offend somereaders.
Published June 2017
DOI: 10.3310/hta21370
This reportshould be referenced as follows:
Lovell K,Bower P, Gellatly J,Byford S, Bee P, McMillan D, et al.Clinical effectiveness,
cost-effectiveness and acceptability of low-intensity interventions inthe management of
obsessive–compulsive disorder: the Obsessive–Compulsive Treatment Efficacy randomised
controlled Trial(OCTET). Health TechnolAssess 2017;21(37).
HealthTechnology Assessment isindexed and abstracted in IndexMedicus/MEDLINE, Excerpta
Medica/EMBASE, ScienceCitation Index Expanded (SciSearch®) andCurrent Contents®/
Clinical Medicine.

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DOI:10.3310/hta21370 HEALTHTECHNOLOGYASSESSMENT2017 VOL.21 NO.37
Abstract
Clinical effectiveness, cost-effectiveness and acceptability
of low-intensity interventions in the management of
– –
obsessive compulsive disorder: the Obsessive Compulsive
Treatment Efficacy randomised controlled Trial (OCTET)
Karina Lovell,1* Peter Bower,2 Judith Gellatly,1 Sarah Byford,3
Penny Bee,1 Dean McMillan,4 Catherine Arundel,5 Simon Gilbody,4
Lina Gega,6 Gillian Hardy,7 Shirley Reynolds,8 Michael Barkham,7
Patricia Mottram,9 Nicola Lidbetter,10 Rebecca Pedley,1 Jo Molle,11
Emily Peckham,5 Jasmin Knopp-Hoffer,2 Owen Price,1
Janice Connell,12 Margaret Heslin,3 Christopher Foley,13
Faye Plummer5 and Christopher Roberts13
1Division of Nursing,Midwifery andSocial Work, University of Manchester, Manchester, UK
2Centre forPrimary Care, University of Manchester, Manchester, UK
3King’s Health Economics, Institute ofPsychiatry, Psychology and Neuroscience, King’s College
London,London, UK
4Hull YorkMedical School and Department ofHealth Sciences, University ofYork, York, UK
5Department ofHealth Sciences, University ofYork, York, UK
6Social WorkandCommunities, Northumbria University, Newcastle, UK
7Department ofPsychology, University ofSheffield, Sheffield, UK
8School ofPsychology, University of Reading,Reading, UK
9Cheshire & Wirral Partnership, NHS FoundationTrust, Wallasey, UK
10Anxiety UK, Manchester, UK
11Norwich Medical School, University ofEast Anglia, Norwich, UK
12School ofHealth and Related Research, University of Sheffield, Sheffield, UK
13Centre forBiostatistics in theInstitute of Population Health,University ofManchester,
Manchester, UK
*Corresponding author [email protected]
Background: The Obsessive–Compulsive Treatment Efficacy randomised controlledTrial emergedfrom a
research recommendation inNational Institute for Health and Care Excellence obsessive–compulsive
disorder (OCD) guidelines, whichspecified the needtoevaluate cognitive–behavioural therapy (CBT)
treatment intensity formats.
Objectives: To determine theclinical effectiveness and cost-effectiveness of two low-intensity CBT
interventions [supported computerised cognitive–behavioural therapy (cCBT) and guidedself-help]:
(1) compared with waiting list for high-intensity CBTin adultswith OCD at3months; and (2) plus
high-intensity CBTcompared with waiting list plushigh-intensity CBTin adultswith OCD at 12months.
To determine patientand professional acceptability of low-intensity CBTinterventions.
Design: A three-arm, multicentre, randomised controlled trial.
©Queen’sPrinterandControllerofHMSO2017.ThisworkwasproducedbyLovelletal.underthetermsofacommissioningcontractissuedbytheSecretaryofStateforHealth.
Thisissuemaybefreelyreproducedforthepurposesofprivateresearchandstudyandextracts(orindeed,thefullreport)maybeincludedinprofessionaljournalsprovidedthat vii
suitableacknowledgementismadeandthereproductionisnotassociatedwithanyformofadvertising.Applicationsforcommercialreproductionshouldbeaddressedto:NIHR
JournalsLibrary,NationalInstituteforHealthResearch,Evaluation,TrialsandStudiesCoordinatingCentre,AlphaHouse,UniversityofSouthamptonSciencePark,Southampton
SO167NS,UK.