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Hadi Heidari and Sara Ghoreishizadeh (Editors) C Hadi Heidari and Sara Ghoreishizadeh (Editors)
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Circuits and Systems for Biomedical Applications-UKCAS IC
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2018 covers several advanced topics in the area of T
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Devices, Analog and Mixed-Signal Circuits and Systems for
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Biomedical Applications. The fundamental aspects of these S
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topics are discussed, and state-of-the-art developments are
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This book is based on the 1st United Kingdom Circuits and
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Systems (UKCAS 2018) Workshop. It addresses areas such as 1
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biosensing, memristors, next-generation medical diagnostics,
neural-inspired circuits, neural implants, neuro-prostheses,
prosthetic hand and neuro-rehabilitation. It presents these H
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technologies and the challenges these present for biomedical d
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scientists and engineers.
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River Publishers River Publishers
IEEE CIRCUITS AND SYSTEMS SOCIETY River IEEE CIRCUITS AND SYSTEMS SOCIETY
Circuits and Systems
for Biomedical
Applications
EDITORS
Dr Hadi Heidari
University of Glasgow, UK
Dr Sara Ghoreishizadeh
University College London, UK
Tutorials in Circuits and Systems
For a list of other books in this series, visit www.riverpublishers.com
Series Editors
Peter (Yong) Lian
President IEEE
Circuits and Systems Society
York University, Canada
Franco Maloberti
Past President IEEE
Circuits and Systems Society
University of Pavia, Italy
Published, sold and distributed by:
River Publishers
Niels Jernes Vej 10
9220 Aalborg Ø Denmark
River Publishers
Lange Geer 44
2611 PW Delft
The Netherlands
Tel.: +45369953197 www.riverpublishers.com
Availability: December 2018
ISBN: Print: 978-87-7022-053-8
E-book: 978-87-7022-052-1
Copyright © 2018 by The Institute of Electrical and Electronics Engineers -
Circuits and Systems Society (IEEE-CASS)
Published by River Publishers.
No part of this publication may be reproduced, stored in are trieval system, or
transmitted in any form or by any means, electronic, mechanical, photocopying,
recording, scanning, or otherwise, except as permitted under Section 107 or
108 of the 1976 United States Copyright Act, without either the prior written
permission of the IEEE-CASS. Requests to the IEEE-CASS for permission to reuse
content should be addressed to the IEEE-CASS Intellectual Property Rights Office
at [email protected]
Library of Congress Cataloging-in-Publication Data: November 2018
Editors: Hadi Heidari, University of Glasgow, UK
Sara Ghoreishizadeh, University College London, UK
Title: Circuits and Systems for Biomedical Applications
Sub-title: UKCAS 2018
Table of contents
Introduction 7
1. Integrated Circuits for Addressable Biosensing 9
By David Cumming
2. Construction of an Endoscopic Capsule for the Diagnostics of Dysmotilities
in the Gastro-intestinal Track 31
By Marc Desmulliez
3. Harnessing the Power of the Brain with Memory-resitors 49
By Themis Prodromakis
4. Analogue Building Blocks for Neural-inspired Circuits 71
By Steve Hall
5. Circuits for Bio-Potential Recording from the Brain 89
By Srinjoy Mitra
6. Advances in Scalable Implantable Stimulation Systems
for Neuro-prostheses using Networked ASICs 105
By Xiao Liu
7. CAS for Control of Prosthetic Hands 131
By Kia Nazarpour
8. Genetically Enhanced Brain-implants for Neuro-rehabilitation 149
By Patrick Degenaar 149
About the Editors 167
About the Authors 171
Introduction
Circuit and system techniques envisioned to build wearable and implantable technologies over
last several years. Large and ever-growing advances in developing and implementing such
technologies exhibited the potential utility of this unique platform as the future of biomedical
systems. Applications include lab-on-chip, lab-on-pill, Bio-inspired systems, bio-potential
recoding, implantable neural stimulation and neuro-rehabilitation. The book through various
chapters provides a deep insight into the technical problems that must be overcome to develop
such complex circuits and systems. The rationale for selecting these paradigms is provided by a
number of breakthroughs, which have been recently achieved in this field.
This book covers several advanced topics in the area of Wearable and ImplantableDevices,
Analogue and Mixed-signal Circuits and Systems for applications in biomedical diagnostics,
genomics, neural stimulation and rehabilitation. The fundamental aspects of these topics are
discussed, and state-of-the-art developments are presented.
The book proceeds the 1st United Kingdom Circuits and Systems (UKCAS) Workshop (www.
gla.uk/cas) and targets post-graduate students and young researchers as well as engineers
working in industry willing to understand and connect circuit and system design with state-of-
the-art and emerging medical applications. The field of biomedical electronics spanning from
device technology to prosthetics limb is covered with emphasis on circuits and systems. The
contents ensure a good balance between academia and industry, combined with a judicious
selection of distinguished world-leading UK-based authors.
In Chapter one we will see how CMOS sensor technology has been extended into biotechnology
and diagnostics such as for gene sequencing and biomarker detection on chip. We will introduce
the emerging applications of CMOS sensors in metabolomics research and lab-on-chip. This is
followed by a detailed description of a novel lab-on-a-pill endoscopic capsule in Chapter two.
We present various stages in the development of the technology demonstrating the capsule is
capable of capturing the contractile behavior of the Gastro-Intestinal. Chapter three introduces
a novel nano-electronic technology, known as memristor, and presents few examples on how
memristive technologies can be exploited in practical applications ranging from neuromorphic
systems to charge-based computing and even enabling bioelectronics medicines.
Chapter four introduces analogue building blocks for neural-inspired circuits. In particular, a
library of dynamically operating analogue functional blocks is described, based on principles, to
emulate synaptic behavior, spike-dependent plasticity, synaptic fan-in, axonal delay and spike
bursts. This is followed by introducing ideas for modelling of synaptic self-repair mediated by
so-called astrocytes. Chapter five focuses on state-of-the-art low-power CMOS electronics for
non-invasive and invasive bio-potential recoding (e.g. ambulatory EEG) from the central nervous
system and the CMOS design methodologies related to such devices. In chapter six covers recent
CIRCUITS AND SYSTEMS FOR BIOMEDICAL APPLICATIONS 8
advances in scalable implantable neural stimulation systems using networked Application Specific Integrated
Circuits (ASICs). Here we also discuss how such systems can meet the ever-growing demand for high-density
neural interfacing and long-term reliability. Chapter seven summarizes CAS-related developments in the area
of prosthetic limb and shows examples of success, in measurement of neuro-muscular activity, real-time
processing and sensory feedback. The last chapter presents emerging CAS-enabled technology of genetically-
enhanced brain implants for neuro-rehabilitation.
We hope that this book will serve as a useful resource to researchers and scientists in academia as well
as industry in their effort to turn the new paradigm of emerging wearable and implantable technology into
biomedical circuits and systems and to overcome bottlenecks in conventional silicon technology development.
We are grateful to all authors and speakers at the UKCAS workshop who have contributed their time and
energy to make this book a reality. In their name,we also thank those people within their organizations who
provided assistance to them. The compilation and editing of this book were, with great enthusiasm, supported
by IEEE Circuits and Systems Society (CASS) and River Publishers.
Sara GhoreiShizadeh
hadi heidari
November 2018
CHAPTER 01
Integrated Circuits
for
Addressable
Biosensing
David Cumming
University of Glasgow
