Table Of ContentCIBA FOUNDATION COLLOQUIA
ON ENDOCRINOLOGY
Vol. 11 Hormones in Blood
A leapet giving details of available earlier volumes in this serie8,
and also the Ciba Foundation General Symposia and Colloquia
on Ageing, is available from the Publishem.
CIBA FOUNDATION COLLOQUIA
ON ENDOCRINOLOGY
VOLUME 11
Hormones in Blood
Editors for the Ciba Foundation
G. E. W. WOLSTENHOLME,
O.B.E., M.A.,M.B., B.CL
and
ELAINE C. P. MILLAR,
AH.-W.C., A.R.I.C.
With 74 Illustrations
LITTLE, BROWN AND COMPANY
BOSTON
THE CIBA FOUNDATION
for the Promotion of International Co-operatwni n Medical and Chemical Research
41 PORTLAND PLACE, LONDONw, .1.
Trustees :
THER IGHTH ON.L ORDA DRIAN,O .M., F.R.S.
THE RIGHT HON.L ORDB EVERIDGKE.,C .B., F.B.A.
SIR RUSSELBLR AIN, BT.
THE HON. SIR GEORQEL LOYD-JACOB
SIR RAYMONNDE EDHAMQ, .C.
Director, and Secretary to the Executive Council:
DR. G. E. W. WOLSTENHOLMOE.,B .E.
Assistant to the Director:
DR. H. N. H. GENESE
Assistant Secretary:
MISSN . BLAND
Librahn:
MISS JOAENT HERINGTON
Editorial Assistants:
MISS CECILIA M. O'CONNOR,B .Sc.
MISS MAEVE O'CONNOR,B .A.
ALL RIGHTSR ESERVED
This book may not be reproduced by any means, in whole
or in part, without the permission of the Publishers
Library of Congress Catalog Number A58-7465
Published in London by
J. & A. Churchill Ltd.
10.1 Gloucester Place, W.l
First Published 1957
Printed in Great Britain
PREFACE
UNDERi ts eminent Trustees, the Ciba Foundation is
engaged in a number of activities with the purpose of improv-
ing co-operation in medical and chemical research between
workers in different countries and different disciplines. At
its house in London the Foundation provides accommodation
for scientists, organizes conferences, conducts a medical
postgraduate exchange scheme between Great Britain and
France, arranges a variety of short informal discussions,
awards two annual lectureships, is building up a library service
in special fields, and assists international congresses and
scientific institutions and societies.
This volume contains the proceedings of the forty-third
small international conference, each of which has lasted two to
four days, held at the Foundation since 1950. It was the
seventeenth conference on an endocrinological subject, pro-
posed in this instance by Professor F. G. Young. Its organiza-
tion was mainly in the hands, for the first time, of Dr. Genese,
who received much helpful advice from Professor Young,
Dr. A. S. Parkes, and Dr. J. A. Loraine.
Dr. Parkes very kindly acted as its Chairman, a r81e he had
filled with distinction several times before at the Foundation,
but never more effectively and delightfully than on this
occasion.
The Group was, as usual at the Ciba Foundation, much
restricted in size, partly because accommodation is limited,
but chiefly because it is found that useful exchanges and
arguments can best be obtained when the members can easily
and quickly come to know each other well.
The senior Editor wishes to place on record here the debt
of the Foundation and its guests to Miss Elaine Millar, who
now leaves to take up work in the United States. This volume
is the seventh she has edited for the Foundation in the past
V
vi PREFACE
two and a half years. Both Editors hope it will prove accept-
able and informative to the original participants in the
colloquium and to many readers throughout the world who
could not be present in person.
CONTENTS
PAGE
Chairman’s opening remarks
.
by A. S. PARKUS 1
The state and concentration of the neurohypophysial
hormones in the blood
.
by H. HELLER 3
Discussion: ASTWOODH, ARRISH, ELLER,I NGBARLO, RAINE,
.
PARKESQ, UERIDOS,A MUELSSO, NENBERG 14
Some general principles in the bioassay of anterior pituit-
ary and placental hormones in blood with special reference
to clinical problems
.
by J. A. LORAINE 19
Discussion: BORTH,B USH, FARRELL,H ELLER, LO.R AINE,
PARKEPSR, UNTYR, ANDLER, OBERTSS,T ACK-DUNNE 33
Inhibition of thyrotrophic activity with acetylated
thyrotrophic hormone preparations
. .
by M. SONENBERaGnd W. I,. MONEY 38
Discussion: ASTWOODB, OTTARIB, USH, INGBARM, ORRIS,
.
PARKESP, ITT-RIVERSQ, UERIDOS,O NENBERG 49
The concentration of thyrotrophic hormone in the blood of
the rabbit under different .e xperimental conditions
by P. M. BOTTARI 52
Discusszon: ASTWOOD,B OTTARI, DICZFALUSYF, OGLIA,
HARRISH, ELLERIN, GBAR, LORAINEM,O RREALED E ESCOBAR,
PARKES, PITT-RIVERS,Q UERIDO,R OBERTS,S AMUELS,
.
SONENBERG 69
General Discussion :A STWOOBDO, ITARI,D ICZFALUSHYE, LLER,
INGBAR,L ORAINE,M ORRIS, PEARLMANP, ITT-RIVERS,
QUERIDOR, ANDLER, OBERTSS,A VARDS,O NENBERSGZ, EGO 73
Thyroid hormones in the blood
by ROSALINPDII T-RIVERS 82
Discussion : ASTWOODB, USH, HELLER, INGBARM, IGEON,
MORRIS,P ITT-RIVERSP, RUNTY,S AMUELSS,O NENBERG 90
vii
viii CONTENTS
PAGE
Iodine in blood
by E. B. ASTWOODC., E. CASSIDY, M. S. RABENa nd
.
SARAM . ASTWOOD 95
Discussion: ASTWOODB, USH, GRAY, HELLER, INUBAR,
LORAINEM,O RREALE DE ESCOBAMRO, RR.I S, PARKESP, ~r.r -
RIVERSP, RUNTQYU, ERIDOSA, MUELS 110
Insulin in Blood .
.
by P. J. RANDLE 115
Discussion: ASTWOODD, ICZFA.L USFYO, GLIAG, RAY,P ARKE. S,
RANDLEV,A LLANCE-OWEN 132
Factors influencing the level of ACTH in the blood
. .
by G. SAYERS 138
Experiments on the level of blood corticotrophin with
particular reference to scurvy
by F. T. G. PRU.N TYB,A RBAREA. CLAYTONa nd JOYCE.E.
HAMMANT 150
Discussion: ASTWOODB, USH,F ARRELHLA, RRIS,P RUNTY,
. .
SAMG'ELSSA, VARDVO, GT 161
Corticosteroid-releasing activity in blood
.
by S. ROBERTS 167
Discussion :A STWOODF, ARRELHLE, L.L ERL, ORAINER,A NDL. E,
ROBERTSSA, MUELTSA, IT,V OGT 190
Morphological changes in the adrenal cortex in relation
to concentration of steroids in adrenal vein blood
. .
by MARTHEV OGT 193
Discussion : ASTWOODB, USH,D ICZFALUSMYIG, EON, MORRIS,
.
SAMUELSST, ACK-DUNNVAEL, LANCE-OWEN 199
General Discussion: ASTWOODB, USH,V ON EULERF, ARRELL,
HARRIS, PEARLMANP, ITT-RIVERS,R ANDLE, SHORT,
. .
STACK-DUNNE 205
Extra-adrenal factors affecting the levels of 17-hydroxy-
corticosteroids in plasma
by L. 1'. SAMUELHS., BROW. NK,. EIK-NESF, . H. TYLE.R
and 0. V. DOMINGUEZ 208
.
Disncssion: BUSH,H ELLERP, RUNTYSA, MUELSS,Z EGO 230
CONTENTS ix
PAGE
Circulating steroid hormone levels in relation to steroid
hormone production
. .
by W. H. PEARLMAN 233
.
Discussion: BUSH,D ICZFALUSMY,O RRIS,P EARLMASHNO,R T 248
Studies on the steroids of human peripheral blood
. .
by K. SAVARD 252
Discussion : BU. SH, KELLIE, MIGEON, MORRIS, SAMUEL. S,
SAVARD 258
The physicochemical state of cortisol in blood
. .
by I. E. BUSH 263
Discussion : BUSH, MIGEON, MORRIS, PRUNTY, SAMUELS,
. .
SONENBERTGA, ITS, . TAIT 282
Steroid interaction in the in vitro biosynthesis of steroid-
protein complexes
. .
by CLARAM . SZEGO 286
Discussion : ASTWOODB, USH, DICZFALUSYM,I GEON, PEARL-
. .
MAN, ROBERTSS,A MUELSS,Z EGO 306
The use of [16-8H] aldosterone in studies on human peri-
pheral blood
by P. J. AYRES,0 . GARRODS, YLVIAA . S. TAIT, J. F.
. .
TAIT,G . WALKERan d W. H. PEARLMAN 309
Discussion :B USH,D ICZFALUSYFA, RRELHLE,L LERL, ORAINE,
MIGEON,M ORRIS, PEARLMAPRNU, NTYQ, UERIDOS, AMUELS,
. .
SAVARDS,I NGERT, AIT 327
Short Communication:
The determination of plasma oestrogen levels in late
pregnancy
.
by E. H. AITKENa nd J. R. K. PREEDY. 331
General Discussion : BUSH., D ICZFALUSYFA, RRELLL, ORAIN.E ,
QUERIDOS,A MUELS 335
Metabolism and placental transmission of cortisol during
pregnancy, near term
by C. J. MIGEON, J. BERTRANDP,A TRICEIA. W ALL,R . S.
. .
STEMPFEaLn d H. PRYSTOWSKY 338
Discussion : BUSH, DICZ.F ALUSYG, RAY, HARRIS, MIGEON.,
SAMUELSSH, ORTT, AIT 356
X CONTENTS
PAGE
Progesterone and related steroids in the blood of domestic
animals
. .
by R. V. SHORT 862
Discussion :A STWOOBDO, RTHD, ICZFALUSLYO,R AINME,I GEON,
.
PARKESP,E ARLMASNA, MUELSSA, VARDS,H ORT 375
Catechol hormones in blood
. .
by U. S. VON EULER 379
Discussion : ASTWOODD,I .C ZFALUSVYO, N EULER,H ARR.IS ,
RANDLES,I NGERV, OGT 391
General Discussion :B USHD, ICZFALUSVYON, EULERF, ARRELL,
HARRIS,H ELLER,K ELLIE,L ORAINEM, ORRISP, ARKES,
PEARLMANP,I TT-RIVERSP, RUNTY,Q UERIDOR, ANDLE,
. .
SAMUELSSA, VARDS,O NENBERTGA, IT 394
