Chronic Rhinosinusitis: Pathogenesis and Medical Management (Clinical Allergy and Immunology)

376 Pages·2007·11.12 MB·English

by  Daniel Hamilos

Chronic Rhinosinusitis
CLINICAL ALLERGYAND IMMUNOLOGY
SeriesEditors
MICHAELA. KALINER,M.D.
MedicalDirector
InstituteforAsthmaandAllergy
Washington,D.C.
RICHARD F. LOCKEY,M.D.
ProfessorofMedicine,Pediatrics,andPublicHealth
JoyMcCannCulverhouseProfessorofAllergyandImmunology
Director,DivisionofAllergyandImmunology
UniversityofSouthFloridaCollegeofMedicine
andJamesA.HaleyVeteransHospital
Tampa,Florida
1. Sinusitis:PathophysiologyandTreatment,editedbyHowardM.Druce
2. EosinophilsinAllergyandInflammation,editedbyGeraldJ.Gleich
andA.BarryKay
3. MolecularandCellularBiologyoftheAllergicResponse,editedby
ArnoldI.LevinsonandYvonnePaterson
4. NeuropeptidesinRespiratoryMedicine,editedbyMichaelA.Kaliner,
PeterJ.Barnes,GertH.H.Kunkel,andJamesN.Baraniuk
5. ProvocationTestinginClinicalPractice,editedbySheldonL.Spector
6. MastCellProteasesinImmunologyandBiology,editedbyGeorgeH.Caughey
7. HistamineandH -ReceptorAntagonistsinAllergicDisease,editedby
1
F.EstelleR.Simons
8. ImmunopharmacologyofAllergicDiseases,editedbyRobertG.Townley
andDevendraK.Agrawal
9. IndoorAirPollutionandHealth,editedbyEmilJ.Bardana,Jr.andAnthonyMontanaro
10. GeneticsofAllergyandAsthma:MethodsforInvestigativeStudies,
editedbyMalcolmN.BlumenthalandBengtBjörkstén
11. AllergicandRespiratoryDiseaseinSportsMedicine,editedbyJohnM.Weiler
12. AllergensandAllergenImmunotherapy:SecondEdition,Revisedand
Expanded,editedbyRichardF.LockeyandSamuelC.Bukantz
13. EmergencyAsthma,editedbyBarryE.Brenner
14. FoodHypersensitivityandAdverseReactions,editedbyMarianneFrieri
andBrettKettelhut
15. DiagnosticTestingofAllergicDisease,editedbyStephenF.Kempand
RichardF.Lockey
16. InflammatoryMechanismsinAllergicDiseases,editedbyBurtonZweiman
andLawrenceB.Schwartz
17. HistamineandH1-AntihistaminesinAllergicDisease,SecondEdition,
editedbyF.EstelleR.Simons
18. AllergensandAllergenImmunotherapy,ThirdEdition,editedbyRichard
Lockey,SamuelBukantz,andJeanBousquet
19. NonallergicRhinitis,editedbyJamesN.BaraniukandDennisShusterman
20. ChronicRhinosinusitis:PathogenesisandMedicalManagement,
editedbyDanielL.HamilosandFuadM.Baroody

Chronic Rhinosinusitis
Pathogenesis and Medical Management
Edited by
Daniel L. Hamilos
Massachusetts General Hospital
Harvard Medical School
Boston, Massachusetts, USA
Fuad M. Baroody
University of Chicago
Chicago, Illinois, USA
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Chronicrhinosinusitis:pathogenesisandmedicalmanagement/editedby
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1. Sinusitis. I.Hamilos,DanielL.II.Baroody,M.FuadIII.Series.
[DNLM:1. Rhinitis.2. ChronicDisease.3. Sinusitis. W1CL652v.202007/WV
335C5572007]
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Introduction
Itwasnottoolongagowhenthetreatmentparadigmforchronicrhinosinusitiswas
a failure to respond to several courses of antibiotics, followed by surgery, which
usuallyconsistedofnasal-antralwindowsand/oraCaldwell-Luckprocedure.Both
procedures were developed many years ago and have been almost uniformly
abandonedwithinthelast10to15years.Ifphysicianstodayarefrustratedwiththe
difficulty in managing chronic rhinosinusitis, they need only remember that the
standardsdescribedabove,althoughtheyseemtobeancientrelativetoouroptions
today,werefolloweduntilveryrecently.
Yet even today the symptoms of chronic rhinosinusitis are not always well
defined, it is still difficult to properly examine and assess the sinus cavities, and
the treatments employed are often less than spectacular. Thus, it takes a specialist
physician to diagnose and treat this chronic disorder. Rhinosinusitis is an excep-
tionally prevalent disease, and its frequency appears to be increasing. Not only is
the disease disabling in its own right, it often complicates the ability to smell,
taste, and hear, causes chronic cough and headache, and is a co-morbid condition
for asthma. New understanding of rhinosinusitis has improved our knowledge
of its pathophysiology, classification, symptoms, and signs, and has led to more
effectivemedicalandsurgicaltreatments.
For these reasons, it is indeed a pleasure to welcome Chronic Rhinosinusitis
as the 20th volume in the Clinical Allergy and Immunology Series. This work
represents the combined talents of two outstanding leaders—one in the field of
allergy/immunology and one in the field of otolaryngology—and their guidance
has led to a wonderfully readable and important book. Thanks to Drs. Daniel
HamilosandFuadBaroodyfortheircreativityandhardworkinbringingthisfine
book to publication. The authors are a “Who’s Who” of leaders in this field, and
the chapters included allow the reader to better understand the pathogenesis,
diagnosis,andnewandnoveltreatmentsforchronicrhinosinusitis.
The series of books that this volume joins is designed to translate basic
science into clinical medicine. Chronic Rhinosinusitis continues this tradition. It
should be of interest to both scientists and clinicians, and should be required
reading for all physicians interested in rhinosinusitis, including those in family
medicine, internal medicine, pediatrics, allergy, and otolaryngology. Each of the
editorsispleasedtowelcomethisnewandworthwhilebook.
MichaelA.Kaliner,MD
RichardF.Lockey,MD
v