Table Of ContentUNIPA Springer Series
Tommaso Angelone
Maria Carmela Cerra
Bruno Tota Editors
Chromogranins:
from Cell Biology
to Physiology
and Biomedicine
UNIPA Springer Series
Editors-in-chief
Carlo Amenta, Dept. of Economics, Management and Statistics Sciences,
University of Palermo, Italy
Series editors
Sebastiano Bavetta, Dept. of Economics, University of Palermo, Italy
Calogero Caruso, Dept. of Pathobiology, University of Palermo, Italy
Gioacchino Lavanco, Dept. of Psychology, University of Palermo, Italy
Bruno Maresca, Dept. of Pharmaceutical Sciences, University of Salerno, Italy
Andreas Öchsner, Dept. of Engineering and Information Technology,
Griffith University, Australia
Mariacristina Piva, Dept. of Economic and Social Sciences,
Catholic University of the Sacred Heart, Italy
Roberto Pozzi Mucelli, Dept. of Diagnostics and Public Health,
University of Verona, Italy
Antonio Restivo, Dept. of Mathematics and Computer Science,
University of Palermo, Italy
Norbert M. Seel, Dept. of Education, University of Freiburg, Germany
Gaspare Viviani, Dept. of Engineering, University of Palermo, Italy
More information about this series at http://www.springer.com/series/13175
Tommaso Angelone • Maria Carmela Cerra
Bruno Tota
Editors
Chromogranins: from Cell
Biology to Physiology
and Biomedicine
Editors
Tommaso Angelone Maria Carmela Cerra
Department of Biology, Ecology Department of Biology, Ecology
and Earth Sciences and Earth Sciences
University of Calabria University of Calabria
Arcavacata di Rende, Cosenza, Italy Arcavacata di Rende, Cosenza, Italy
Bruno Tota
Department of Biology, Ecology
and Earth Science
University of Calabria
Arcavacata di Rende, Cosenza, Italy
ISSN 2366-7516 ISSN 2366-7524 (electronic)
UNIPA Springer Series
ISBN 978-3-319-58337-2 ISBN 978-3-319-58338-9 (eBook)
DOI 10.1007/978-3-319-58338-9
Library of Congress Control Number: 2017956128
© Springer International Publishing AG 2017
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Contents
History and Perspectives . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1
Karen B. Helle
Secretogranin II: Novel Insights into Expression and Function
of the Precursor of the Neuropeptide Secretoneurin . . . . . . . . . . . . . . . . . . 21
Reiner Fischer-Colbrie, Markus Theurl, and Rudolf Kirchmair
Chromogranins as Molecular Coordinators at the Crossroads
between Hormone Aggregation and Secretory Granule Biogenesis . . . . . . 39
O. Carmon, F. Laguerre, L. Jeandel, Y. Anouar, and M. Montero-Hadjadje
Involvement of Chromogranin A and Its Derived Peptides
to Fight Infections . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 49
Marie-Hélène Metz-Boutigue and Francis Schneider
Conserved Nature of the Inositol 1,4,5-Trisphosphate Receptor
and Chromogranin Coupling and Its Universal Importance
in Ca2+ Signaling of Secretory Cells . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 69
Seung Hyun Yoo
Chromogranin A in Endothelial Homeostasis and Angiogenesis . . . . . . . . 83
Flavio Curnis, Fabrizio Marcucci, Elisabetta Ferrero, and Angelo Corti
Full Lenght CgA: A Multifaceted Protein in Cardiovascular
Health and Disease . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 99
Bruno Tota and Maria Carmela Cerra
Cardiac Physio-Pharmacological Aspects of Three Chromogranin
A-Derived Peptides: Vasostatin, Catestatin, and Serpinin . . . . . . . . . . . . . 113
Tommaso Angelone, Bruno Tota, and Maria Carmela Cerra
Comparative Aspects of CgA-Derived Peptides in Cardiac
Homeostasis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 133
Alfonsina Gattuso, Sandra Imbrogno, and Rosa Mazza
v
vi Contents
Molecular and Cellular Mechanisms of Action of CgA-Derived
Peptides in Cardiomyocytes and Endothelial Cells . . . . . . . . . . . . . . . . . . . 149
Giuseppe Alloatti and Maria Pia Gallo
Chromogranin A-Derived Peptides in Cardiac Pre- and
Post-conditioning . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 169
Claudia Penna and Pasquale Pagliaro
Naturally Occurring Single Nucleotide Polymorphisms in Human
Chromogranin A (CHGA) Gene: Association with Hypertension
and Associated Diseases . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 195
Nitish R. Mahapatra, Sajalendu Ghosh, Manjula Mahata,
Gautam K. Bandyopadhyay, and Sushil K. Mahata
Serpinin Peptides: Tissue Distribution and Functions . . . . . . . . . . . . . . . . 213
Y. Peng Loh, Niamh Cawley, Alicja Woronowicz, and Josef Troger
Action and Mechanisms of Action of the Chromogranin A
Derived Peptide Pancreastatin . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 229
N. E. Evtikhova, A. Pérez-Pérez, C. Jiménez-Cortegana,
A. Carmona- Fernández, T. Vilariño-García, and V. Sánchez-Margalet
Chromogranins and the Quantum Release of Catecholamines . . . . . . . . . 249
Leandro Castañeyra, Michelle Juan-Bandini, Natalia Domínguez,
José David Machado, and Ricardo Borges
Index . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 261
Contributors
Giuseppe Alloatti Department of Life Sciences and Systems Biology, University
of Turin, Turin, Italy
National Institute for Cardiovascular Research (INRC), Bologna, Italy
Tommaso Angelone Department of Biology, Ecology and Earth Sciences,
University of Calabria, Arcavacata di Rende (CS), Italy
Y. Anouar Inserm U1239, University of Rouen-Normandy, UNIROUEN, Institute
for Research and Innovation in Biomedicine, Mont-Saint-Aignan, France
Gautam K. Bandyopadhyay Department of Medicine, University of California,
San Diego, CA, USA
Ricardo Borges Unidad de Farmacología, Facultad de Medicina, Universidad de
La Laguna, Tenerife, Spain
O. Carmon Inserm U1239, University of Rouen-Normandy, UNIROUEN,
Institute for Research and Innovation in Biomedicine, Mont-Saint-Aignan, France
A. Carmona-Fernández Department of Clinical Biochemistry, Virgen Macarena
University Hospital, School of Medicine, University of Seville, Seville, Spain
Leandro Castañeyra Unidad de Farmacología, Facultad de Medicina, Universidad
de La Laguna, Tenerife, Spain
Niamh Cawley Section on Cellular Neurobiology, Eunice Kennedy Shriver
National Institute of Child Health and Human Development, National Institutes of
Health, Bethesda, MD, USA
Maria Carmela Cerra Department of Biology, Ecology and Earth Sciences,
University of Calabria, Arcavacata di Rende (CS), Italy
Angelo Corti Division of Experimental Oncology, San Raffaele Scientific Institute,
via Olgettina, Milan, Italy
vii
viii Contributors
Flavio Curnis Division of Experimental Oncology, San Raffaele Scientific
Institute, via Olgettina, Milan, Italy
Natalia Domínguez Unidad de Farmacología, Facultad de Medicina, Universidad
de La Laguna, Tenerife, Spain
VU Medical Center, Clinical Genetics, HV Amsterdam, Netherlands
N.E. Evtikhova Department of Clinical Biochemistry, Virgen Macarena University
Hospital, School of Medicine, University of Seville, Seville, Spain
Elisabetta Ferrero Division of Experimental Oncology, San Raffaele Scientific
Institute, via Olgettina, Milan, Italy
Reiner Fischer-Colbrie Department of Pharmacology, Medical University
Innsbruck, Innsbruck, Austria
Maria Pia Gallo Department of Life Sciences and Systems Biology, University of
Turin, Turin, Italy
Alfonsina Gattuso Department of Biology, Ecology, and Earth Science, University
of Calabria, Arcavacata di Rende, Italy
Sajalendu Ghosh Postgraduate Department of Zoology, Ranchi College, Ranchi,
India
Karen B. Helle Department of Biomedicine, University of Bergen, Bergen,
Norway
Sandra Imbrogno Department of Biology, Ecology, and Earth Science, University
of Calabria, Arcavacata di Rende, Italy
L. Jeandel Inserm U1239, University of Rouen-Normandy, UNIROUEN, Institute
for Research and Innovation in Biomedicine, Mont-Saint-Aignan, France
C. Jiménez-Cortegana Department of Clinical Biochemistry, Virgen Macarena
University Hospital, School of Medicine, University of Seville, Seville, Spain
Michelle Juan-Bandini Unidad de Farmacología, Facultad de Medicina,
Universidad de La Laguna, Tenerife, Spain
Rudolf Kirchmair Cardiology & Angiology, Internal Medicine III, Medical
University Innsbruck, Innsbruck, Austria
F. Laguerre Inserm U1239, University of Rouen-Normandy, UNIROUEN,
Institute for Research and Innovation in Biomedicine, Mont-Saint-Aignan, France
José David Machado Unidad de Farmacología, Facultad de Medicina, Universidad
de La Laguna, Tenerife, Spain
Nitish R. Mahapatra Department of Biotechnology, Bhupat and Jyoti Mehta
School of Biosciences, Indian Institute of Technology Madras, Chennai, India
Manjula Mahata Department of Medicine, University of California, San Diego,
CA, USA
Contributors ix
Sushil K. Mahata VA San Diego Healthcare System, San Diego, CA, USA
Metabolic Physiology & Ultrastructural Biology Laboratory, Department of
Medicine, University of California, San Diego, CA, USA
Fabrizio Marcucci Department of Pharmacological and Biomolecular Sciences,
University of Milan, Milan, Italy
Rosa Mazza Department of Biology, Ecology, and Earth Science, University of
Calabria, Arcavacata di Rende, Italy
Marie-Hélène Metz-Boutigue Inserm U1121, Université de Strasbourg, FMTS,
Faculté de Chirurgie Dentaire Hôpital Civil, Porte de l’hôpital, Strasbourg, France
M. Montero-Hadjadje Inserm U1239, University of Rouen-Normandy,
UNIROUEN, Institute for Research and Innovation in Biomedicine, Mont-Saint-
Aignan, France
A. Pérez-Pérez Department of Clinical Biochemistry, Virgen Macarena University
Hospital, School of Medicine, University of Seville, Seville, Spain
Pasquale Pagliaro Department of Clinical and Biological Sciences, University of
Turin, Orbassano (TO), Italy
Y. Peng Loh Section on Cellular Neurobiology, Eunice Kennedy Shriver National
Institute of Child Health and Human Development, National Institutes of Health,
Bethesda, MD, USA
Claudia Penna Department of Clinical and Biological Sciences, University of
Turin, Orbassano (TO), Italy
V. Sánchez-Margalet Department of Clinical Biochemistry, Virgen Macarena
University Hospital, School of Medicine, University of Seville, Seville, Spain
Francis Schneider Inserm U1121, Université de Strasbourg, FMTS, Service de
Réanimation Médicale, Hôpital Hautepierre, Avenue Molière, Strasbourg, France
Markus Theurl Cardiology & Angiology, Internal Medicine III, Medical
University Innsbruck, Innsbruck, Austria
Bruno Tota Department of Biology, Ecology and Earth Sciences, University of
Calabria, Arcavacata di Rende (CS), Italy
Josef Troger Department of Ophthalmology, Medical University of Innsbruck,
Innsbruck, Austria
T. Vilariño-García Department of Clinical Biochemistry, Virgen Macarena
University Hospital, School of Medicine, University of Seville, Seville, Spain
Alicja Woronowicz Section on Cellular Neurobiology, Eunice Kennedy Shriver
National Institute of Child Health and Human Development, National Institutes of
Health, Bethesda, MD, USA
Seung Hyun Yoo Gran Med Inc., Incheon, South Korea
