Childhood Onset of ''Adult'' Psychopathology: Clinical and Research Advances

438 Pages·2000·4.17 MB·English

by  Judith L. Rapoport

Childhood Onset
of “Adult”
Psychopathology
Clinical and
Research Advances
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Childhood Onset
of “Adult”
Psychopathology
Clinical and
Research Advances
EDITED BY
Judith L. Rapoport, M.D.
Washington, DC
London, England
Note: The authors have worked to ensure that all information in this book
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Books published by the American Psychiatric Press, Inc., represent the views
and opinions of the individual authors and do not necessarily represent the
policies and opinions of the Press or the American Psychiatric Association.
Copyright © 2000 American Psychiatric Press, Inc.
ALL RIGHTS RESERVED
Manufactured in the United States of America on acid-free paper
03 02 01 00 4 3 2 1
First Edition
American Psychiatric Press, Inc.
1400 K Street, N.W., Washington, DC20005
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Library of Congress Cataloging-in-Publication Data
Childhood onset of “adult” psychopathology: clinical and research advances/
edited by Judith L. Rapoport. — 1st ed.
p. cm. —(American Psychopathological Association series)
Includes bibliographical references and index.
ISBN 0-88048-821-2
1. Child psychopathology Congresses. 2. Mental illness
Longitudinal studies Congresses. 3. Psychology, Pathological Congresses.
I. Series.
[DNLM: 1. Psychopathology—Child Congresses.
2. Psychopathology—Infant Congresses. 3. Developmental
Disabilities—prevention and control—Child Congresses.
4. Developmental Disabilities—prevention and control—Infant
Congresses. 5. Mental Disorders—Child Congresses. 6. Mental
Disorders—Infant Congresses. WS 350 C5362 1999]
RJ499.C4878 1999
618.92′ 89—dc21
DNLM/DLC
for Library of Congress 99-26039
CIP
British Library Cataloguing in Publication Data
A CIP record is available from the British Library.
Contents
Contributors ix
Introduction xiii
I Age at Onset: Mechanisms and Methods
1 Genetics of Early-Onset Manic-Depressive Illness and
Schizophrenia 3
Judith A. Badner, M.D., Ph.D.,
Sevilla D. Detera-Wadleigh, Ph.D.,
Elliot S. Gershon, M.D.
2 Genetics, Evolution, and Age at Onset of Disease 27
Barton Childs, M.D.
3 Trinucleotide Expansion in the FMR1 Gene and
Fragile X Syndrome 41
Stephanie Ceman, Ph.D., Stephen T. Warren, Ph.D.
II Neurodevelopmental Pathways to “Adult”
Psychiatric Disorders: Triggers of Disease Onset
4 Biological Markers as Precursors to Schizophrenia:
Specificity, Predictive Ability, and
Etiological Significance 65
C. Jane Tarrant, B.Med.Sci., B.M., B.S., M.R.C.Psych.,
Peter B. Jones, M.B., M.Sc., Ph.D., M.R.C.P., M.R.C.Psych.
5 PANDAS: A New “Species” of Childhood-Onset
Obsessive-Compulsive Disorder? 103
Susan E. Swedo, M.D., Margaret Pekar, M.A.
6 Prenatal Antecedents of Neuropsychiatric Disorder
Over the Life Course: Collaborative Studies of
United States Birth Cohorts 121
Ezra Susser, M.D., Dr.P.H., Alan Brown, M.D.,
Tom Matte, M.D., M.P.H.
III Schizophrenia: Specific Disorders
7 Late-Onset Schizophrenia: New Insights Into
Disease Etiology 149
Lisa T. Eyler Zorrilla, Ph.D., Dilip V. Jeste, M.D.
8 Childhood-Onset Schizophrenia:
What Can It Teach Us? 167
Rob Nicolson, M.D., Judith L. Rapoport, M.D.
9 Neurodevelopmental Hypothesis of
Schizophrenia 12 Years On: Data and Doubts 193
Colm McDonald, M.B., M.R.C.Psych.,
Paul Fearon, M.B., M.R.C.Psych.,
Robin Murray, D.Sc., F.R.C.Psych.
IV Depression and Anxiety
10 Childhood Depression: Is It the Same Disorder? 223
Richard Harrington, F.R.C.Psych.
11 Offspring at Risk: Early-Onset Major Depression and
Anxiety Disorders Over a Decade 245
Myrna M. Weissman, Ph.D., Virginia Warner, M.P.H.,
Priya Wickramaratne, Ph.D., Donna Moreau, M.D.,
Mark Olfson, M.D.
12 When Is Onset? Investigations Into Early
Developmental Stages of Anxiety and
Depressive Disorders 259
Hans-Ulrich Wittchen, Ph.D., Dipl.Psych.,
Roselind Lieb, Ph.D., Dipl.Psych.,
Peter Schuster, Dipl.Psych., Albertine J. Oldehinkel, Ph.D.
13 Very-Early-Onset Bipolar Disorder: Does It Exist? 303
Gabrielle A. Carlson, M.D.
V Early Prevention of Adult Psychiatric Disorders
14 Prevention of Mental Disorders and the Study of
Developmental Psychopathology: A Natural Alliance 333
William R. Beardslee, M.D.
15 Prevention of Alcoholism: Reflections of a Naturalist 357
George E. Vaillant, M.D.
16 Prevention of Antisocial Personality Disorder 379
David R. Offord, M.D.
Index 399
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Contributors
Judith A. Badner, M.D., Ph.D.
Assistant Professor, Department of Psychiatry, University of Chicago,
Chicago, Illinois
William R. Beardslee, M.D.
Department of Psychiatry, Children’s Hospital, Harvard Medical School,
Boston, Massachusetts
Alan Brown, M.D.
Department of Epidemiology of Brain Disorders, New York State Psychiatric
Institute, New York, New York
Gabrielle A. Carlson, M.D.
Professor of Psychiatry and Pediatics and Director, Child and Adolescent
Psychiatry, State University of New York at Stony Brook, Stony Brook, New
York
Stephanie Ceman, Ph.D.
Research Associate, Howard Hughes Medical Institute and Departments of
Biochemistry, Pediatrics and Genetics, Emory University School of
Medicine, Atlanta, Georgia
Barton Childs, M.D.
Professor Emeritus, Department of Pediatrics, Johns Hopkins University
School of Medicine, Baltimore, Maryland
Sevilla D. Detera-Wadleigh, Ph.D.
Clinical Neurogenetics Branch, National Institute of Mental Health,
Bethesda, Maryland
ix