Chicken antimicrobial peptides

188 Pages·2007·3.23 MB·English

Chicken antimicrobial peptides:
biological functions and possible applications
Albert van Dijk

Chicken antimicrobial peptides:
biological functions and possible applications
Antimicrobiële peptiden van de kip:
biologische functies en mogelijke toepassingen
(met een samenvatting in het Nederlands)
Proefschrift
ter verkrijging van de graad van doctor aan de Universiteit Utrecht
op gezag van de rector magnificus, prof. dr. J.C. Stoof,
ingevolge het besluit van het college voor promoties
in het openbaar te verdedigen op
donderdag 15 november 2007
des middags te 4.15 uur
door
Albert van Dijk
geboren op 23 maart 1965 te Heerjansdam
Promotor: Prof. dr. H. P. Haagsman
Co-promotor: Dr. E. J. A. Veldhuizen
The work in this thesis was supported by a research grant (Adaptation and Resistance
Program) from the Animal Science Group (Wageningen University and Research
Center) and the Faculty of Veterinary Medicine (Utrecht University), The Netherlands.
Chicken antimicrobial peptides: biological functions and possible applications /Albert
van Dijk
Department of Infectious Diseases and Immunology
Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands
ISBN: 978-90-393-4667-9
Cover design: Albert van Dijk & Marije Brouwer
Lay-out: Harry Otter
Printing: Gildeprint Drukkerijen Enschede

Contents
Chapter 1 Introduction 1
Chapter 2 The role of antimicrobial peptides in birds 9
Chapter 3 The β-defensin gallinacin-6 is expressed in the chicken
digestive tract and has antimicrobial activity against
food-borne pathogens 65
Chapter 4 CMAP27, a novel chicken cathelicidin-like antimicrobial
Peptide 93
Chapter 5 Localization and function of the chicken cathelicidin
CMAP27 in peripheral blood cells and digestive tract tissues 105
Chapter 6 CMAP27 in chicken uropygial gland secretion and
skin injury – Putative role in growth inhibition of
feather-degrading microorganisms and wound-repair 129
Chapter 7 General discussion 155
List of publications 171
Samenvatting 173
Dankwoord 177
Curriculum vitae 180

Chapter 1
Introduction
Chapter 1
2