Table Of ContentChanging Syntheses in Development
The Twenty-Ninth Symposium
The Society for Developmental Biology
Albany, New York, June 17-19, 1970
EXECUTIVE COMMITTEE
1969-1970
MEREDITH N. RUNNER, University of Colorado, President
ANTON LANG, Michigan State University, Past-President
FOLKE SKOOG, University of Wisconsin, President-Designate
PAUL B. GREEN, University of Pennsylvania, Secretary
ELIZABETH D. HAY, Harvard Medical School, Treasurer
DONALD D. BROWN, Carnegie Institution of Washington
MAC V. EDDS, JR. Brown University, Editor-in-Chief
1970-1971
FOLKE SKOOG, University of Wisconsin, President
MEREDITH N. RUNNER, University of Colorado, Past-President
FRANK H. RUDDLE, Yale University, President-Designate
MALCOLM S. STEINBERG, Princeton University, Secretary
ELIZABETH D. HAY, Harvard University, Treasurer
PAUL B. GREEN, University of Pennsylvania
MAC V. EDDS, JR. Brown University, Editor-in-Chief
Business Manager
W. SUE BADMAN
P.O. Box 2782
Kalamazoo, Michigan 49003
616-345-7476
Changing Syntheses
in
Development
Edited by
Meredith N. Runner
Molecular, Cellular, and Developmental Biology
University of Colorado
Boulder, Colorado 80802
Developmental Biology, Supplement 4
Editor-in-Chief
Μ. V. EDDS, JR.
1970
ACADEMIC PRESS, Mew York and London
COPYRIGHT © 1971, BY ACADEMIC PRESS, INC.
ALL RIGHTS RESERVED.
NO PART OF THIS BOOK MAY BE REPRODUCED IN ANY FORM, BY PHOTOSTAT,
MICROFILM, BY RETRIEVAL SYSTEM, OR ANY OTHER MEANS, WITHOUT
WRITTEN PERMISSION FROM THE PUBLISHERS.
ACADEMIC PRESS, INC.
Ill Fifth Avenue, New York-, New York 10003
United Kingdom Edition published by
ACADEMIC PRESS, INC. (LONDON) LTD.
Berkeley Square House, London W.l
LIBRARY OF CONGRESS CATALOG CARD NUMBER: 55-10678
PRINTED IN THE UNITED STATES OF AMERICA
Changing Syntheses
in Development
The 29th Symposium was held at Albany, New York, June 17-19, 1970.
The Society gratefully acknowledges the efficiency of the host committee,
the hospitality of the State University of New York and the support from
the National Science Foundation.
Contributors and Presiding Chairmen
Numbers in parentheses indicate the pages on which the authors' contributions begin
I. Changing Syntheses
Chairmen. Philip Grant, Department of Biology, University of Oregon,
Eugene, Oregon 97403, and Melvin Spiegel, Department of Biology,
Dartmouth, Hanover, New Hampshire 03755.
RICHARD C. STARR, Department of Botany, Indiana University, Bloom-
ington, Indiana 47401 (59)
THOMAS H. SHEPARD AND TAKASHI TANIMURA, Department of Pediatrics,
AND MAURICE A. ROBKIN, Department of Nuclear Engineering,
University of Washington, Seattle, Washington 98105 (42)
R. A. FLICKINGER, Department of Biology, State University of New York,
Buffalo, New York 14214 (12)
Discussion. Localization of developmental information in the egg and
early embryo. Martin Nemer, Institute for Cancer Research, Phila
delphia, Pennsylvania 19111, Denis Smith, Biology Department,
Purdue University, Lafayette, Indiana 47907
Discussion. Synthesis of macromolecules during growth and differentia
tion. Tom Humphreys, Department of Biology, University of Cali
fornia, San Diego, California 92037, Joram Piatigorsky, National
Institute of Child Health and Human Development, National
Institutes of Health, Bethesda, Maryland 20014
II. Controls for Special Syntheses
Chairmen. John R. Coleman, Division of Biological and Medical Sciences,
Brown University, Providence, Rhode Island 02912 and Irwin
Königsberg, Department of Biology, University of Virginia, Char
lottesville, Virginia 29903
YALE J. TOPPER, S. H. FRIEDBERG, AND TAKAMI OKA, National Institute
of Arthritis and Metabolic Diseases, National Institutes of Health,
Bethesda, Maryland 20014 (101)
MARTIN POSNER, WILLIAM J. GARTLAND, JEFFREY L. CLARK, AND GORDON
SATO, Department of Biological Sciences, University of California,
San Diego, California 92037, AND CARL A. HIRSCH, Department of
Medicine, Beth Israel Hospital, Boston, Massachusetts 02215 (114)
ALBERT DORFMAN, Department of Pediatrics, University of Chicago,
Chicago, Illinois 60637
ν
vi CONTRIBUTORS
Discussion. Cell commitment and phenotypic expression. Stuart Haywood,
Department of Biological Sciences, University of Connecticut, Storrs,
Connecticut 06268. Jay Lash, Department of Anatomy, University
of Pennsylvania, Philadelphia, Pennsylvania 19104
Discussion. Regulation of synthesis in relation to the cell cycle. Robert R.
Klevecz, Division of Biology, City of Hope Medical Center, Duarte,
California 91010, David W. Martin, Department of Biochemistry,
University of California Medical Center, San Francisco, California
94122
III. The Role of Collagen
Chairmen. Elizabeth D. Hay, Department of Anatomy, Harvard Medical
School, Boston, Massachusetts 02115, and Edgar Zwilling, Depart
ment of Biology, Brandeis University, Waltham, Massachusetts 02154
ZACHARIAS DISCHE, Department of Ophthalmology, College of Physicians
and Surgeons, Columbia University, New York, New York 10032 (164)
MARSHALL R. URIST, Bone Research Laboratory, UCLA School of
Medicine, Los Angeles, California 90024 (125)
MERTON R. BERN FIELD, Department of Pediatrics, AND NORMAN K.
WESSELS, Department of Biological Sciences, Stanford University,
Stanford, California 94305 (195)
Discussion. Origin and morphogenetic functions of collagen. Alfred J.
Coulombre, National Eye Institute, National Institutes of Health
20014, Jerome Gross, Developmental Biological Laboratory, Mas
sachusetts General Hospital, Boston, Massachusetts 02114
Discussion. Significance of early appearance of differentiated products.
Howard Holtzer, Department of Anatomy, University of Pennsyl
vania, Philadelphia, Pennsylvania 19104
Chairman of Host Committee: Joseph Mascarenhas, Department of
Biological Sciences, State University of New York at Albany, Albany,
New York 12203
29th SYMPOSIUM, JUNE 17-19, 1970
STATE UNIVERSITY OF NEW YORK AT ALBANY
Opening remarks—Robert D. Allen
W. Sue Badman Elizabeth D. Hay Folke K. Skoog
Anton Lang Herbert Stern
Joseph Mascarenhas Donald L. Kimmel
Joan Abbott John R. Coleman
James Η. Gregg A. C. Clement Laurens N. Ruben
Melvin Spiegel Charles G. Melton Alex J. Haggis
Meredith Runner Eloise E. Clark Robert D. Allen
Erwin R. Königsberg Salome Gluecksohn-Waelsch
Alfred J. Coulombre
Intermission—Lecture Center
Quentin N. LaHam Jack Greenberg Reed Flickinger
Stuart Haywood Arnold I. Caplan
Richard Landesman
DEVELOPMENTAL BIOLOGY SUPPLEMENT 4, 1-11 (1970)
Changing Syntheses in Development1
MEREDITH N. RUNNER
Department of Molecular, Cellular, and Developmental Biology,
University of Colorado, Boulder, Colorado 80305
INTRODUCTION
"Every step of development is a physiological reaction, involving a
long and complex chain of cause and effect between the stimulus and the
response. The character of the response is determined not by the stimu
lus, but by the organization." [page 430] "It is the remarkable substance
nuclein*,—which is almost certainly identical with chromatin,—that
chiefly claims attention here on account of the physiological role of the
nucleus." [page 332] "If chromatin inheres the sum total of hereditary
forces, and if it be equally distributed at every cell division, how can its
mode of action vary in different cells to cause diversity of structure, e.g.
differentiation?" [page 413]
* Nuclein is degradable into protein, phosphoric acid, a carbohydrate
and nuclein bases such as adenine and guanosine. [page 336]
(Wilson, 1902).
This symposium of the Society for Developmental Biology, like
the twenty-eight symposia which went before it, attempts to serve
both a pedagogical and an investigational role. The published prod
uct of this symposium, a collection of reviews depicting changing
syntheses during several phases of cell and tissue interactions, should
be of interest to graduate students and teachers. The theme running
throughout the volume is emphasis upon changes which bridge the
gap between the biochemistry and the sculpturing of a new organ
ism. This assembly of reviews on changing syntheses during cell and
tissue interactions, perhaps a departure from the current trend to
ward molecular reductionalism, is intended to cover more than bio
chemical differentiation; perhaps it is an overambitious intention
that the collection of reports will relate cell and tissue interactions
to molecular biology, ultrastructure, and morphogenesis.
Irrespective of whether developmental biologists favor a concept
of environmental or extracellular evocators interacting with a system
1 The 29th Symposium was held at Albany, New York, June 17-19, 1970. The Society
gratefully acknowledges the efficiency of the host committee, the hospitality of the State
University of New York and the support from the National Science Foundation.
1
© 1971 by Academic Press, Inc.
