Cerebral Vasospasm: Neurovascular Events After Subarachnoid Hemorrhage

325 Pages·2013·7.7 MB·English

by  John M. Tew Jr. M.D. (auth.)

Acta Neurochirurgica
Supplements
Editor: H.-J. Steiger

Cerebral Vasospasm: Neurovascular Events After Subarachnoid Hemorrhage
Edited by
M. Zuccarello, J.F. Clark, G. Pyne-Geithman, N. Andaluz,
J.A. Hartings, and O.M. Adeoye
Acta Neurochirurgica
Supplement 115
Prof. Mario Zuccarello
Department of Neurosurgery, University of Cincinnati
Stetson Suite 2200 260, Cincinnati 45267-0515 OH, USA
Dr. Joseph F. Clark
College of Medicine, Department of Neurology, University of Cincinnati
Albert Sabin Way 231MSB, Cincinnati 46267-0536 OH, USA
Dr. Gail Pyne-Geithman
College of Medicine, Department of Neurosurgery, University of Cincinnati
Albert Sabin Way 231ML0517, Cincinnati 45267-0517 OH, USA
Dr. Norberto Andaluz
College of Medicine, Department of Neurosurgery, University of Cincinnati
Stetson St. Suite 260ML0515, Cincinnati 45219 OH, USA
Dr. Jed A. Hartings
College of Medicine, Department of Neurosurgery, University of Cincinnati
Stetson Suite 2200 260, Cincinnati 45219 OH, USA
Dr. Opeolu M. Adeoye
Department of Emergency Medicine, University of Cincinnati
Albert Sabin Way 231ML0769, Cincinnati 45267-0769 OH, USA
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With 77 (partly coloured) Figures
ISSN 0065-1419
ISBN 978-3-7091-1191-8 ISBN 978-3-7091-1192-5 (eBook)
DOI 10.1007/978-3-7091-1192-5
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Preface

This book contains the proceedings of the 11th International Conference on Cerebral
Vasospasm: Neurovascular Events after Subarachnoid Hemorrhage . The conference was held
in Cincinnati, Ohio, USA, from July 21–23, 2011, with the recurrent goal to share the latest
knowledge on the pathophysiologic phenomena that take place after aneurysmal subarachnoid
hemorrhage. This collection of papers represents a cross section of the enormous progress that
has been made toward a thorough understanding and effective treatment of neurovascular
events following aneurysmal subarachnoid hemorrhage, including cerebral vasospasm. The
editors would like to extend their gratitude to the many participants of this most recent confer-
ence and thank previous participants for setting the stage for continued progress in this fi eld.
We also want to acknowledge the authors of the chapters of this book. We are indebted to these
contributors for providing such excellent material. Finally, we would like to express our deep-
est gratitude to all those who made a fl awless meeting possible: our sponsors, the scienti fi c
committee, and the members of the organizing committee, especially Ms. Christa McAlpin
and Ms. Joanie Pope. This book will be of interest to basic scientists wishing to expand their
understanding of cerebrovascular and neural pathophysiology related to subarachnoid hemor-
rhage and to clinicians who wish to apply state-of-the-art knowledge to their management of
this devastating condition.
Cincinnati, USA Mario Zuccarello
Joseph F. Clark
v

Acknowledgment
This volume has been made possible thanks to a generous educational grant from the May fi eld
Education and Research Foundation.
vii

Contents
Frank H. Mayfield, MD, FACS, FAANS (1909–1991):
75th Anniversary Tribute . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1
John M. Tew Jr.
Clinical Trials and Dilemmas
Methodology
History and Definition of Delayed Cerebral Ischemia . . . . . . . . . . . . . . . . . . . . . . . . 3
R. Loch Macdonald
Clinical, Transcranial Doppler Ultrasound, Radiological Features
and, Prognostic Significance of Delayed Cerebral Ischemia . . . . . . . . . . . . . . . . . . . 9
George Kwok Chu Wong and Wai Sang Poon
Identifying Patient Report Outcomes Relevant to
Aneurysmal Subarachnoid Hemorrhage Follow-Up . . . . . . . . . . . . . . . . . . . . . . . . . 13
Stuart Ross, Deepti Bhargava, Yahia Al-Tamimi, Tony Goddard,
Alan Tennant, and Audrey Quinn
Global Cerebral Atrophy After Subarachnoid Hemorrhage:
A Possible Marker of Acute Brain Injury and
Assessment of Its Impact on Outcome. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 17
Alan K.H. Tam, Don Ilodigwe, Zeyu Li, Tom A. Schweizer,
and R. Loch Macdonald
Protein Biomarkers in Patients with Subarachnoid Hemorrhage,
Vasospasm, and Delayed Ischemic Neurological Deficits. . . . . . . . . . . . . . . . . . . . . . 23
Paul A. Nyquist, Honghui Wang, and Anthony F. Suffredini
Approaches
Randomised Trial of Clazosentan, an Endothelin Receptor
Antagonist, in Patients with Aneurysmal Subarachnoid
Hemorrhage Undergoing Surgical Clipping (CONSCIOUS-2). . . . . . . . . . . . . . . . . 27
R. Loch Macdonald, Randall T. Higashida, Emanuela Keller,
Stephan A. Mayer, Andy Molyneux, Andreas Raabe, Peter Vajkoczy,
Isabel Wanke, Doris Bach, Aline Frey, Angelina Marr,
Sébastien Roux, and Neal Kassell
Angiographic Vasospasm Versus Cerebral Infarction as
Outcome Measures After Aneurysmal Subarachnoid Hemorrhage. . . . . . . . . . . . . 33
Nima Etminan, Mervyn D.I. Vergouwen, and R. Loch Macdonald
Development of Nicardipine Prolonged-Release Implants
After Clipping for Preventing Cerebral Vasospasm:
From Laboratory to Clinical Trial. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 41
Hidetoshi Kasuya
ix