Cellular and Molecular Biology of Myelination

557 Pages·1990·15.995 MB·English

by  Monique Dubois-Dalcq, Regina Armstrong, Bryn Watkins, Randall McKinnon (auth.), Gunnar Jeserich, Hans H. Althaus, Thomas V. Waehneldt (eds.)

NATO ASI Series
Advanced Science Institutes Series
A series presenting the results of activities sponsored by the NATO Science
Committee, which aims at the dissemination of advanced scientific and
technological knowledge, with a view to strengthening links between scientific
communities.
The Series is published by an international board of publishers in conjunction with
the NATO Scientific Affairs Division
A Life Sciences Plenum Publishing Corporation
B Physics London and New York
C Mathematical and Kluwer Academic Publishers
Physical Sciences Dordrecht, Boston and London
o
Behavioural and
Social Sciences
E Applied Sciences
F Computer and Springer-Verlag
Systems Sciences Berlin Heidelberg New York
G Ecological Sciences London Paris Tokyo Hong Kong
H Cell Biology
Series H: Cell Biology Vol. 43
The ASI Series Books Published as a Result of
Activities of the Special Programme on
CELL TO CELL SIGNALS IN PLANTS AND ANIMALS
This book contains the proceedings of a NATO Advanched Research Workshop held within the
activities of the NATO Special Programme on Cell to Cell Signals in Plants and Animals, running
from 1984 to 1989 under the auspices of the NATO Science Committee.
The books published as a result of the activities of the Special Programme are:
Vol. 1: Biology and Molecular Biology of Plant-Pathogen Interactions. Edited by JA Bailey. 1986.
Vol. 2: Glial-Neuronal Communication in Development and Regeneration.
Edited by H.H. Althaus and W Seifert. 1987.
Vol. 3: Nicotinic Acetylcholine Receptor: Structure and Function. Edited by A. Maelicke. 1986.
Vol. 4: Recognition in Microbe-Plant Symbiotic and Pathogenic Interactions.
Edited by B. Lugtenberg. 1986.
Vol. 5: Mesenchymal-Epithelial Interactions in Neural Development.
Edited by J.R. Wolff, J. Sievers, and M. Berry. 1987.
Vol. 6: Molecular Mechanisms of Desensitization to Signal Molecules.
Edited byTM. Konjin, P.J.M. Van Haastert, H. Van der Starre, H. Van derWel,
and M.D. Houslay. 1987.
Vol. 7: Gangliosides and Modulation of Neuronal Functions. Edited by H. Rahmann. 1987.
Vol. 9: Modification of Cell to Cell Signals During Normal and Pathological Aging.
Edited By S. Govoni and F. Battaini. 1987.
Vol. 10 Plant Hormone Receptors. Edited by D. KIEimbt. 1987.
Vol. 11: Host-Parasite Cellular and Molecular Interactions in Protozoal Infections.
Edited by K.-P. Chang and D. Snary. 1987.
Vol.12 The Cell Surface in Signal Transduction. Edited by E. Wagner, H. Greppin, and B. Millet. 1987.
Vol. 19: Modulation of Synaptic Transmission and Plasticity in Nervous Systems.
Edited byG. Hertting and H.-C. Spatz. 1988.
Vol. 20: AminoAcid Availability and Brain Function in Health and Disease. Edited by G. Huether. 1988.
Vol. 21: Cellular and Molecular Basis of Synaptic Transmission. Edited by H. Zimmermann. 1988.
Vol. 23: The Semiotics of Cellular Communication in the Immune System.
Edited by E.E. Sercarz, F. Celada, NA Mitchison, and 1. Tada. 1988.
Vol. 24 Bacteria, Complement and the Phagocytic Cell. Edited by F. C. Cabello and C. Pruzzo. 1988.
Vol. 25: Nicotinic Acetylcholine Receptors in the Nervous System.
Edited by F. Celementi, C. Gotti, and E. Sher. 1988.
Vol. 26: Cell to Cell Signals in Mammalian Development.
Edited by SW. de Laat, J.G. Bluemink, and C.L. Mummery. 1989.
Vol. 27: Phytotoxins and Plant Pathogenesis. Edited by A. Graniti, R.D. Durbin, and A. Ballio. 1989.
Vol. 31: Neurobiology of the Inner Retina. Edited by R. Weiler and N.N. Osborne. 1989.
Vol. 32: Molecular Biology of Neuroreceptors and Ion Channels. Edited by A. Maelicke. 1989.
Vol. 33: Regulatory Mechanisms of Neuron to Vessel Communication in the Brain.
Edited by F. Battaini, S. Govoni, M.S. Magnoni, and M. Trabucchi. 1989.
Vol. 35: Cell Separation in Plants: Physiology, Biochemistry and Molecular Biology.
Edited by D.J. Osborne and M.B. Jackson. 1989.
Vol. 36: Signal Molecules in Plants and Plant-Microbe Interactions. Edited by B.J.J. Lugtenberg. 1989.
Vol. 39: Chemosensory Information Processing. Edited by D. Schild. 1990.
Vol. 41: Recognition and Response in Plant-Virus Interactions. Edited by R.S.S. Fraser. 1990.
Vol. 43: Cellular and Molecular Biology of Myelination.
Edited by G. Jeserich, H. H. Althaus, and 1. V. Waehneldt. 1990.
Cellular and Molecular Biology
of Myelination
Edited by
G. Jeserich
Universitat OsnabrOck, FB Biologie/Chemie
BarbarastraBe 11 , 4500 OsnabrOck, FRG
H. H. Althaus
T.V. Waehneldt
Max-Planck-Institut fOr Experimentelle Medizin
Hermann-Rein-StraBe 3, 3400 Gottingen, FRG
Springer-Verlag Berlin Heidelberg New York
London Paris Tokyo Hong Kong
Published in cooperation with NATO Scientific Affairs Division
Proceedings of the NATO Advanced Research Workshop on Cellular and
Molecular Biology of Myelination, held at Monastery Ohrbeck near Osnabruck,
FRG, August 28-September 2,1989
ISBN-13: 978-3-642-83970-2 e-ISBN-13: 978-3-642-83968-9
001: 10.1007/978-3-642-83968-9
Library of Congress Cataloging-in-Publication Data. Cellular and molecular biology of myelination/edited by
G. Jeserich, H. H. Althaus, TV Waehneldt p. cm.-(NATO ASI series. Series H, Cell biology; vol. 43) "Proceed
ings of the NATO Advanced Research Workshop on Cellular and Molecular Biology of Myelination held at
Monastery Ohrbeck near OsnabrOck, FRG, August 28-September 2, 1989"-Tp. verso.
ISBN-13 978-3-642-83970-2 (U.S.)
1. Neuroglia-Growth-Molecular aspects-Congresses. 2. Myelination-Congresses. I. Jeserich, G.
(Gunnar),1950- . II. Althaus, Hans H. III. Waehneldt, TV (Thomas V), 1932- . IV NATO Advanced
Research Workshop on Cellular and Molecular Biology of Myelination (1989: OsnabrOck, Germany) V Series.
OP363.2C45 1989 599'.0188-dc20 90-9587
This work is subject to copyright All rights are reserved, whether the whole or part of the material is concerned,
specifically the rights of translation, reprinting, re-use of illustrations, recitation, broadcasting, reproduction on
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permitted under the provisions ofthe German Copyright Law of September 9,1965, in its current verSion, and a
cOPYright fee must always be paid. Violations fall under the prosecution act of the German Copyright Law.
© Springer-Verlag Berlin Heidelberg 1990
Softeover reprint of the hardcover 1st edition 1990
2131/3140-543210-Printed on acid-free-paper
PREFACE
The process of myelination is one of the key events during nervous system
development and represent the ultimate step of cellular differentiation by which
proper neuronal function is attained. Knowledge of the biochemistry and cell
biology of the myelin-forming glia has advanced rapidly in recent years. This
progress was to a large extent conveyed by the concerted application of new
experimental tools, including improved cell culture systems, availability of
specific immunological probes and the powerful development of recombinant
DNA technology and cell transfection.
The multidisciplinary aspects of glial cell biology and myelination were com
prehensively dicussed by leading neuroscientist from Europe, Israel, USA and
Canada at a NATO Advanced Research Workshop held at Monastery Ohrbeck,
near Osnabruck, August 28 -September 2,1989.
The meeting concentrated on the following major topics:
A detailed characterization of the different steps of oligodendroglial
differentiation ranging from a bipotential precurser to the actively myelinating
oligodendrocyte was given. Subsequently the regenerative potential of mature
oligodendrocytes after experimental lesioning was discussed and most recent
progress made in the field of glial cell transplantation was reported.
Furthermore the role of specific growth factors and their receptors for glial cell
proliferation and differentiation were evaluated in detail. Special emphasis was
given to the involvement of proteinkinases A and C in the underlying
transmembrane signalling events. New avenues of glial cell biology were pursued
by means of genetically manipulated cells. In a subsequent session recent
developments in the field of myelin membrane biochemistry were discussed.
Another topic of major interest was related to the molecular structure and
regulation of genes coding for myelin proteins. Detailed information was given as
regards the structure of myelin basic protein and proteolipid protein genes as well
as the chain of events underlying myelin gene expression in the peripheral
nervous system.
VI
The rather remote location of the meeting place and its intimate setting
provided an appropriate frame for fruitful discussions and a stimulating exchange
of ideas in a friendly and harmonious atmosphere. We hope that these positive
experiences are reflected in the contents of this book.
The papers presented at the conference are combined m the present volume.
The editors are very grateful to the participants for their cooperative efforts.
We are particularly grateful to the NATO Scientific Affairs Division who
provided the major fmanciaI support of this conference. In addition the meeting
was sponsored by the following companies: Becton-Dickinson (Heidelberg),
Boehringer (Mannheim), Millipore (Eschborn), Sartorius (Gottingen), Schleicher
& Schuell (Dassel).
Finally we would like to thank the administration and staff of Monastery
Ohrbeck for their kind hospitality as well as our coworkers who contributed to
the success of the meeting.
Gunnar Je serich Hans H. Althaus Thomas v. Waehne1dt
VII
1 J.N. Larocca, 2 A. Stratmann, 3 D. Michaelis, 4 W.T. Norton, 5 J. Malotka, 6 M.G. Rumsby,
7 JA. Black, 8 P. Morell, 9 DA. Kirschner, 10 M. Dubois-Dalcq, 11 G. Almazan, 12 J.F. Poduslo,
13 M. Tosic, 14 P.E. Braun, 15 M. Gumpel, 16 S.E. Pfeiffer, 17 P. Honegger, 18 F. Kirchhoff,
19 J.-P. Zanetta, 20 S.K. Ludwin, 21 M. Schuch, 22 U. Walter, 23 G. Lemke, 24 B.D. Trapp,
25 H. Marahrens, 26 W.D. Richardson, 27 FA. McMorris, 28 B. Zalc, 29 A. Roach, 30 A. Espinosa
de los Monteros, 31 G. Jeserich, 32 C. Linington, 33 S. Szuchet, 34 H. Beriet, 35 W.F. Blakemore,
36 S.U. Kim, 37 F.x. Omlin, 38 D.R. Colman, 39 T.V. Waehneldt, 40 T. Rauen, 41 R.K. Yu,
42 M.V. Gardinier, 43 H.H. Althaus.
CELLULAR AND MOLECULAR BIOLOGY
OF MYELINATION
August, 28 - September 2, 1989
Monastery Ohrbeck, FRG
Almazan, Guillermina Braun, Peter E.
Department of Pharmacology Department of Biochemistry
& Therapeutics McGill University
McGill University 3655 Drummond Street
3655 Drummond Street McIntyre Medical Science Building
Montreal, PQ H3G 1Y6 Montreal, PO H3G 1Y 6
Canada Canada
Althaus, Hans H. Colman, David R.
Max-Planck-Institut Department of Anatomy
f. Experimentelle Medizin Columbia University
Hermann-Reinstr.3 630 W 168th Street
3400 Gottingen New York, NY 10032
FRG USA
Black, Joel A. Dubois-Dalcq, Monique
Department of Neurology Laboratory of Molecular Genetics
Yale University of Medicine National Institute of Neurology
333 Cedar Street and Communicative Disorders and
New Haven, Connecticut 06510 Stroke
USA National Institutes of Health
Bethesda, MD 20892
Blakemore, William F. USA
Department of Clinical
Veterinary Medicine Espinosa de los Monteros, Aracelie
University of Cambridge Neuropsychiatric Institute
Madingleyroad University of California
Cambridge CB3 OES Rm68-225
England 760 Westwood Plaza
Los Angeles, CA 90024-1759
USA
IX
Gardinier, Minnetta V. Kirschner, Daniel A.
Laboratoire de Neurochimie Neurology Research
Service de P6diatrie Children's Hospital
Centre Hospitalier Department of Neurology
U niversitaire Vaudois Harvard Medical School
CH-1011 Lausanne 300 Longwood Avenue
Switzerland Boston, MA 02115
USA
Gumpel, Madelaine
Laboratoire de Neurochimie Kuo, J.F.
I.N.S.E.R.M. U.134 Department of Pharmacology
Hopital de la Salpetriere Amory University
47, Boulevard de l'Hopital Atlanta, Georgia 30322
F-75651 Paris Cedex 13 USA
France
Larocca, Jorge N.
Honegger, Paul Albert Einstein College
Institut de Physiologie Yeshiva University
Universite Lausanne Department of Neurology
Faculte de Medicine 1300 Morris Park Avenue
7, Rue du Bugnon Bronx, NY 10461
CH-1011 Lausanne USA
Switzerland
Lemke, Greg
Jeserich, Gunnar Molecular Neurobiol. Laboratory
Universitat Osnabriick Salk Institute
FE Biologie/Chemie 10010 Torrey Pines Rd
Abt. Zoophysiologie La Jolla, CA 92037
Barbarastr.11 USA
4500 Osnabriick
FRG Linington, Christopher
University of Wales
Kim, Seung U. Department of Medicine
Department of Medicine Heath Park
Division of Neurology Cardiff, CF4 4XN
University of British Columbia England
Vancouver
Canada
x
Ludwin, Samuel K. Pfeiffer, Steven E.
Department of Pathology Department of Microbiology
Queen's University University of Connecticut
Kingston, Ontario K7L 3N6 Health Center
Canada Farmington, cr 06032
USA
McMorris, F. Arthur
The Wistar Institute and Poduslo, Joseph F.
Children's Hospital of Membrane Biochemistry Laboratory
Philadelphia Departments of Neurology and
36th Street at Spruce Biochemistry
Philadelphia, P A 19104 Mayo Medical School and
USA Mayo Clinic
Rochester, MN 55905
Morell, Pierre USA
Biological Sciences Research
Center Richardson, William D.
Building 220H Department of Zoology
University of North Carolina University College London
School of Medicine Gower Street
Chapel Hill, NC 27514 London WC1E 6BT
USA England
Norton, William T. Roach, Arthur
Department of Neurology Mount Sinai Hospital
Albert Einstein College Research Institute
of Medicine 600 University Avenue
1300 Morris Park Ave Toronto, Ontario M5G 1X5
Building F Rml40 Canada
Bronx, NY 10461
USA Rumsby, Martin G.
Department of Biology
Omlin, Francois X. University of York
Institut d'Histologie et York, Y01 5DD
d'Embryologie England
Universite de Lausanne
Rue du Bugnon 9
CH-1011 Lausanne
Switzerland