Table Of ContentCells and Biomaterials
in Regenerative Medicine
Edited by Daniel Eberli
Cells and Biomaterials in Regenerative Medicine
Edited by Daniel Eberli
D3pZ4i & bhgvld, Dennixxx & rosea (for softarchive)
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Published by AvE4EvA
Copyright © 2014
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Published: 26 November, 2014
ISBN-10 : 953-51-1731-9
ISBN-13 : 978-953-51-1731-5
C ontents
Preface
Chapter 1 Adipose-Derived Stem Cells — Are They the Optimal Cell
Source for Urinary Tract Regeneration?
by Hazem Orabi, Cassandra R. Goulet, Julie Fradette
and Stÿphane Bolduc
Chapter 2 Mechanisms of Cell Regeneration — From Differentiation
to Mainten ance of Cell Phenotype
by Arnaldo Rodrigues Santos Jr, Vitor Andrade Nascimento,
Selma Candelÿria Genari and Christiane Bertachini Lombello
Chapter 3 Regulatory Loops Consisting of Transcription Factors and
microRNA Species Determine the Mineralizing Characteristics
of Cell Phenotypes — Implications for Bone Engineering and
Prevention of Soft Tissue Mineralization
by Jan O. Gordeladze, ÿystein Stakkestad, Sigrid Haugen,
Janne E. Reseland, Unni Syversen, Gaute F. Johnsen,
Hÿvard J. Haugen, Stÿle P. Lyngstadaas, Mona Mÿller
and Mauro Valtieri
Chapter 4 Adult Mesenchymal Stem Cells in Current Tissue Engineering
Concepts
by Susanne Jung and Johannes Kleinheinz
Chapter 5 Mass Production of Mesenchymal Stem Cells — Impact of
Bioreactor Design and Flow Conditions on Proliferation
and Differentiation
by Valentin Jossen, Ralf Pÿrtner, Stephan C. Kaiser,
Matthias K raume, Dieter Eibl and Regine Eibl
Chapter 6 Non-Invasive Imagin g Modalities for Clinical Investigation
in Regenerative Medicine
by Deana G. Haralampieva, Simon M. Ametamey, Tullio Sulser
and Daniel Eberli
VI Contents
Chapter 7 Materials for Central Nervous System Tissue Engineering
by Manuel Pÿrez-Garnes, Juan A Barcia, Ulises Gÿmez-Pinedo,
Manuel M onleÿn Pradas and Ana Vallÿs-Lluch
Chapter 8 The Role of Acellular Fl owable Matrix in Tissue Regeneration
by Dragica Maja Smrke and Danijela Semenic
Chapter 9 An Organ Regeneration Platform for Industrial Production
of Hollow Neo-Organs
by Joydeep Basu
Chapter 10 Bioengineering of Vascular Conduits
by A. Pontini, M.M. Sfriso, M.I. Bompensiere, V. Vindigni
and F. Bassetto
Chapter 11 Production of Tissue-Engineered Human 3D Bronchi In Vitro
by Sara Bouhout, Jadson Moreira Pereira, Franck Simon,
Stÿphane Chabaud, Stÿphane Bolduc, Massimo Conti, Alex Therien,
Eric Rousseau, Vÿronique J. Moulin, Jean-Pierre Lavoie,
Michel Rouleau and Francine Goulet
Chapter 12 Experimental Design for the Innervation of Tooth Forming
from Implanted Cell Re-associations
by T. Kÿkten, H. Lesot and S. Kuchler-Bopp
Preface
This book serves as a good starting point for anyone interested
in the application of tissue engineering. It offers a colorful
mix of topics, which explain the obstacles and possible solutions
for TE applications.
The first part covers the use of adult stem cells and their
applications.
The following chapters offer an insight into the development of
a tailored biomaterial for organ replacement and highlight the
importance of cell-biomaterial interaction.
In summary, this book offers insights into a wide variety of
cells, biomaterials, interfaces and applications of the next
generation biotechnology, which is tissue engineering.
Chapter 1
Adipose-Derived Stem Cells — Are They the Optimal Cell
Source for Urinary Tract Regeneration?
Hazem Orabi, Cassandra R. Goulet,
Julie Fradette and Stéphane Bolduc
Additional information is available at the end of the chapter
http://dx.doi.org/10.5772/59223
1. Introduction
The urinary system consists of two kidneys, two ureters, urinary bladder and urethra. The
main function of the urinary system is to eliminate wastes and harmful materials from the
body. Additionally, it adjusts blood volume and pressure, regulates electrolytes and blood pH.
The urine passes from the kidneys via the muscular tubes of ureters to the urinary bladder
where it is stored until it is socially convenient to be expelled outside through the urethra by
the act of micturition.
The urinary tract (ureters, bladder and urethra) is composed of two main functional tissues:
epithelial coverage (urothelium) and muscular coat (smooth muscle). A highly impermeable
urothelial layer is necessary to prevent reabsorption of noxious materials present in urine
despite its large osmotic and chemical gradients. Muscular coat creates coordinated waves of
contractions necessary for urine transport and expulsion.
Since birth, the urinary system is subjected to a variety of diseases and pathologies including
congenital and acquired disorders that threaten the patient`s life. Current therapeutic options
to replace severely damaged urinary organs are associated with many complications and
hazards on patient survival and quality of life. Regenerative medicine has emerged as potential
replacement treatment. Although progenitor cells of the urinary tract have been used in
experimental studies and clinical trials, however, they are not amenable options in cases of
benign end-stage diseases and malignancy. Stem cells can be the source of cellular components
in regenerating urinary organs. Among those stem cell types, Adipose-derived Stem Cells
(ASCs) are the current most convenient source due to easiness of harvest in abundant quantity,
potential differentiation into many cell types and lack of ethical problems.
