Table Of ContentCell and Developmental Biology
of the Eye
Cell and Developmental Biology
of the Eye
Series Editors
Joel B. Sheffield and S. Robert Hilfer
Ocular Size and Shape: Regulation During Development
Cellular Communication During Ocular Development
Molecular and Cellular Basis of Visual Acuity
Heredity and Visual Development
Development and Order in the Visual System
The Microenvironment and Vision
Cell Interactions in Visual Development
The Proceedings of the Philadelphia Symposia on Ocular
and Visual Development
S. Robert Hilfer
Joel B. Sheffield
Editors
Cell Interactions in
Visual DevelopIllent
Springer-Verlag
New York Berlin Heidelberg
London Paris Tokyo
S. Robert Hilfer
Joel B. Sheffield
Department of Biology
Temple University
Philadelphia. Pennsylvania 19122. U.S.A.
Library of Congress Cataloging-in-Publication Data
Cell interactions in visual development.
(Cell and developmental biology of the eye)
Based on the 11th Symposium of Ocular and Visual
Development. held Oct. 1987 at Temple University.
Bibliography: p.
Includes index.
I. Eyes-Differentiation-Congresses. 2. Eyes
Growth-Congresses. 3. Eyes-Cytology-Congresses.
I. Hilfer, S. Robert. II. Sheffield. Joel B.
111. Symposium on Ocular and Visual Development
(11th: 1987 : Temple University) IV. Series.
[DNLM: I. Cell Communication--congresses. 2. Eye
cytology--congresses. 3. Eye-growth & development
congresses. 4. Vision-physiology--congresses.
WW 101 C3935 1987]
QP475.C47 1988 599'.01823 88-24757
ISBN-13 978-1-4612-8401-7 e-ISBN-13 978-1-4612-3920-8
DOL 10.\007/978-1-4612-3920-8
© 1988 by Springer-Verlag New York Inc.
Softcover reprint of the hardcover 1st edition 1988
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ISBN-Il 978-1-4612-8401-7/1988 $0.00 + 0.20.
Camera-ready text prepared by the editors.
9 8 7 6 5 4 3 2 1
Series Preface
The eye has fascinated scientists from the earliest days of biological in
vestigation. The diversity of its parts and the precision of their interaction
make it a favorite model system for a variety of developmental studies.
The eye is a particularly valuable experimental system not only because
its tissues provide examples of fundamental processes, but also because
it is a prominent and easily accessible structure at very early embryonic
ages.
In order to provide an open forum for investigators working on all aspects
of ocular development, a series of symposia on ocular and visual devel
opment was initiated in 1973. A major objective of the symposia has been
to foster communication between the basic research worker and the clinical
community. It is our feeling that much can be learned on both sides from
this interaction. The idea for an informal meeting allowing maximum ex
change of ideas originated with Dr. Leon Candeub, who supplied the nec
essary driving force that made the series a reality. Each symposium has
concentrated on a different aspect of ocular development. Speakers have
been selected to approach related topics from different perspectives.
This book series, "Cell and Developmental Biology of the Eye," is derived
from the Philadelphia symposia on ocular and visual development. Pre
vious volumes are listed on the series page. We hope that the introduction
of this proceedings series will make the results of research on ocular cell
and developmental biology more widely known and more easily accessible.
Preface
The 11th Symposium on Ocular and Visual Development was held in
October, 1987 to review the current understanding of cellular interactions
in the development of the visual system. This volume is derived from the
presentations at that symposium. Over the past few years, advances in
monoclonal antibody technology and cell surface biochemistry have re
vealed a complex set of cell surface molecules that appear to convey in
formation between different cells of the embryonic retina and control the
ultimate organization of the tissue. Many of the chapters in this volume
are concerned with these molecules and how they interact with other fac
tors to create the ordered structure of the mature system. These studies
have been aided by the development of sensitive techniques for marking
cells so that their fates can be traced. Other chapters discuss the role of
the Muller cells in retinal organization. Increasing evidence suggests that
interactions between Muller cells and neuronal cells direct the develop
ment and maturation of the tissue. This has become particularly significant
in view of recent studies which indicate that proliferative vitreoretino
pathy, a major cause of blindness after retinal reattachment surgery, may
arise through inappropriate stimulation of division in Muller cells.
We are grateful to Dr. E. Gruberg of the Biology Department at Temple
for his expertise and assistance in the organization of the meeting, to the
speakers for their presentations and contributions to this volume, and to
the reviewers of the manuscripts for their helpful comments.
This symposium could not have been held without the generous support
of the Provost and the College of Arts and Sciences of Temple University.
We also thank the Albert B. Millett foundation for additional funding.
This volume was prepared with the skillful assistance of George Basila,
to whom we are indebted.
S. Robert Hilfer
Philadelphia, Pennsylvania Joel B. Sheffield
Contents
Series Preface v
Preface
S. Robert Hilfer and Joel B. Sheffield vii
Contributors ............................................................... xi
Photoreceptor-Muller Cell Interactions: Effects of Photoreceptor
Degeneration on GF AP Expression in Muller Cells
P. Vijay Sarthy ..................................................... . . .. .. . 1
Muller Cells Guide Migrating Neuroblasts in the Developing
Teleost Retina
Pamela A. Raymond ..................................................... 11
Plasticity of Retinal Glioblast Cells: Neuronal Contact Regulates
Phenotypic Maturation of Embryonic Muller Cells
Paul f. Linser .............................................................. 29
Positional Cues in the Developing Eyebud of Xenopus
Nancy A. O'Rourke and Scott E. Fraser................................ 47
Factors Underlying Loss of Retinal Ganglion Cells
Leo M. Chalupa ........................................................... 69
Activity, Chemoaffinity, and Competition: Factors in the
Formation of the Retinotectal Map
Ronald L. Meyer.......................................................... 87
Neuronal Surface Receptors in Axon Fasciculation and
Regeneration
Vance Lemmon, Kathryn Farr, and Carl Lagenaur ............ ........ 113
x Contents
Cognin and Retinal Cell Differentiaion
Robert E. Hausman ....................................................... 133
Embryonic Chick Neural Retinal Cell Interactions with Extracellu
lar Matrix Proteins: Characterization of Neuronal ECM Receptors
and Changes in Receptor Activity During Development
Deborah E. Hall, Karla M. Neugebauer, and Louis F. Reichardt .... 151
Index ....................................................................... 171
Contributors
Leo M. Chalupa, Department of Psychology and the Physiology Graduate
Group, University of California, Davis, California 95616, U.S.A.
Kathryn Farr, Department of Neurobiology, Anatomy, and Cell Science
and The Center for Neuroscience, University of Pittsburgh, Pittsburgh,
Pennsylvania 15261, U.S.A.
Scott E. Fraser, Department of Physiology and Biophysiology, University
of California, Irvine, California 92717, U.S.A.
Deborah E. Hall, Howard Hughes Medical Institute, University of Cali
fornia, San Francisco, California 94143-0724, U.S.A.
Robert E. Hausman, Department of Biology, Boston University, Boston,
Massachusetts 02215, U.S.A.
Carl Lagenaur, Department of Neurobiology, Anatomy, and Cell Science
and The Center for Neuroscience, University of Pittsburgh, Pittsburgh,
Pennsylvania 15261, U.S.A.
Vance Lemmon, Department of Neurobiology, Anatomy, and Cell Science
and The Center for Neuroscience, University of Pittsburgh, Pittsburgh,
Pennsylvania 15261, U.S.A.
Paul J. Linser, The C.V. Whitney Laboratory and the Department of Anat
omy and Cell Biology, University of Florida, St. Augustine, Florida 32086,
U.S.A.
Ronald L. Meyer, Department of Developmental and Cell Biology, Uni
versity of California, Irvine, California 92717, U.S.A.
Karla M. Neugebauer, Howard Hughes Medical Institute, University of
California, San Francisco, California 94143-0724, U.S.A.
xii Contributors
Nancy A. O'Rourke, Department of Physiology and Biophysiology, Uni
versity of California, Irvine, California 92717, U.S.A.
Pamela A. Raymond, Department of Anatomy and Cell Biology and The
Neuroscience Program, University of Michigan, Ann Arbor, Michigan
48109-0616, U.S.A
Louis F. Reichardt, Howard Hughes Medical Institute, University of Cali
fornia, San Francisco, California 94143-0724, U.S.A.
P. Vijay Sarthy, Departments of Ophthalmology, Physiology, and Bio
physics, University of Washington, Seattle, Washington 98195, U.S.A.
