Cell Biology and Translational Medicine, Volume 5: Stem Cells: Translational Science to Therapy

179 Pages·2019·5.677 MB·English

by  Kursad Turksen

Advances in Experimental Medicine and Biology 1144
Cell Biology and Translational Medicine
Kursad Turksen Editor
Cell Biology and
Translational
Medicine, Volume 5
Stem Cells: Translational Science to
Therapy
Advances in Experimental Medicine
and Biology
Cell Biology and Translational Medicine
Volume 1144
SubseriesEditor
KursadTurksen
Moreinformationaboutthissubseriesathttp://www.springer.com/series/15838
Kursad Turksen
Editor
Cell Biology and
Translational Medicine,
Volume 5
Stem Cells: Translational Science
to Therapy
Editor
KursadTurksen(Retired)
OttawaHospitalResearchInstitute
Ottawa,ON,Canada
ISSN0065-2598 ISSN2214-8019 (electronic)
AdvancesinExperimentalMedicineandBiology
ISSN2522-090X ISSN2522-0918 (electronic)
CellBiologyandTranslationalMedicine
ISBN978-3-030-17588-7 ISBN978-3-030-17589-4 (eBook)
https://doi.org/10.1007/978-3-030-17589-4
#SpringerNatureSwitzerlandAG2019
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Preface
InthisnextvolumeintheCellBiologyandTranslationalMedicineseries,we
continuetoexplorethepotentialutilityofstemcellsinregenerativemedicine.
Thechaptersinthisvolumecoverarangeoftopicsinthearea,frombiological
functionofstemcellsintranslationalstudiestotissueandorganregeneration
andrestorationoffunctioninclinicalsettings.Whatallofthechaptershavein
common is a focus on both the advances and the challenges in this rapidly
evolvingfield.
IremainverygratefultoPeterButler,EditorialDirector,andMeranLloyd-
Owen, Senior Editor, for their ongoing support of this series that we have
embarkedupon.
I would also like to acknowledge and thank Sara Germans-Huisman,
Assistant Editor, for her outstanding efforts in getting the volume to the
productionstages.
A special thank you also goes to the production crew for their work in
generatingthevolume.
Finally,Ithankthecontributorsnotonlyfortheirsupportoftheseriesbut
alsofortheireffortstocaptureboththeadvancesandremainingobstaclesin
theirareasofresearch.Iamgratefulfortheirefforts,andtrustreaderswillfind
theircontributionsinterestingandhelpful.
Ottawa,CA,Canada KursadTurksen
v
Contents
TherapeuticCardiacPatchesforRepairingtheMyocardium. . . . 1
BenjaminW.StreeterandMichaelE.Davis
HumanInducedPluripotentStemCellsintheCurative
TreatmentofDiabetesandPotentialImpedimentsAhead. . . . . . . 25
NidheeshDadheechandA.M.JamesShapiro
CRISPR/Cas9forSickleCellDisease:Applications,Future
Possibilities,andChallenges. . . . . . . . . . . . . . . . . . . . . . . . . . . . . 37
SelamiDemirci,AlexisLeonard,JuanJ.Haro-Mora,NaoyaUchida,
andJohnF.Tisdale
PhotoresponsiveHydrogelswithPhotoswitchableStiffness:
EmergingPlatformstoStudyTemporalAspects
ofMesenchymalStemCellResponsestoExtracellular
StiffnessRegulation. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 53
DavidRichards,JoeSwift,LuShinWong,
andStephenM.Richardson
CellularComplexityattheInterface:ChallengesinEnthesis
TissueEngineering. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 71
IsabelCalejo,RaquelCosta-Almeida,andManuelaE.Gomes
InducedPluripotentStemCellsinDiseaseModelling
andRegeneration. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 91
BurcuTalugandZeynepTokcaer-Keskin
StemCellsfortheOromaxillofacialArea:Couldtheybea
promisingsourceforregenerationindentistry?. . . . . . . . . . . . . . 101
AyşegülMendi,HacerUlutürk,MustafaSancarAtaç,
andDervişYılmaz
StemCellsDerivedfromDentalTissues. . . . . . . . . . . . . . . . . . . . 123
SafaAydinandFikrettinŞahin
vii
viii Contents
ANovelVirtueinStemCellResearch:ExosomesandTheir
RoleinDifferentiation. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 133
HüseyinAbdik,EzgiAvsarAbdik,AyşenAslıHızlıDeniz,
PakizeNeslihanTaşlı,andFikrettinŞahin
MesenchymalStemCellsasRegulatorsofCarcinogenesis. . . . . . . 147
TahaBartuHayal,BinnurKıratlı,HaticeBurcuŞişli,FikrettinŞahin,
andAyşegülDoğan
Index. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 167
Contributors
Ezgi Avsar Abdik Department of Genetics and Bioengineering, Faculty of
EngineeringandArchitecture,YeditepeUniversity,Istanbul,Turkey
Hüseyin Abdik Department of Genetics and Bioengineering, Faculty of
EngineeringandArchitecture,YeditepeUniversity,Istanbul,Turkey
Mustafa Sancar Ataç Faculty of Dentistry, Department of Oral and
MaxillofacialSurgery,GaziUniversity,Ankara,Turkey
Safa Aydin Department of Genetics and Bioengineering, Faculty of
Engineering,YeditepeUniversity,İstanbul,Turkey
Isabel Calejo 3B’s Research Group, I3Bs – Research Institute on
Biomaterials, Biodegradables and Biomimetics, University of Minho, Head-
quarters of the European Institute of Excellence on Tissue Engineering and
RegenerativeMedicine,Guimarães,Portugal
ICVS/3B’s – PT Government Associate Laboratory, Braga/Guimarães,
Portugal
RaquelCosta-Almeida 3B’sResearchGroup,I3Bs–ResearchInstituteon
Biomaterials, Biodegradables and Biomimetics, University of Minho, Head-
quarters of the European Institute of Excellence on Tissue Engineering and
RegenerativeMedicine,Guimarães,Portugal
ICVS/3B’s – PT Government Associate Laboratory, Braga/Guimarães,
Portugal
Nidheesh Dadheech Alberta Diabetes Institute, University of Alberta,
Edmonton,Alberta,Canada
MichaelE.Davis WallaceH.CoulterDepartmentofBiomedicalEngineer-
ing, Emory University and Georgia Institute of Technology, Atlanta, GA,
USA
Selami Demirci Cellular and Molecular Therapeutics Branch, NHLBI/
NIDDK,NationalInstitutesofHealth,Bethesda,MD,USA
CellularandMolecularTherapeuticsBranch,NationalHeart,LungandBlood
Institute,Bethesda,MD,USA
ix
x Contributors
AyşenAslıHızlıDeniz HealthInstitutesofTurkey,TurkishCancerInstitute,
Istanbul,Turkey
Ayşegül Doğan Department of Genetics and Bioengineering, Faculty of
Engineering,YeditepeUniversity,İstanbul,Turkey
Manuela E. Gomes 3B’s Research Group, I3Bs – Research Institute on
Biomaterials, Biodegradables and Biomimetics, University of Minho, Head-
quarters of the European Institute of Excellence on Tissue Engineering and
RegenerativeMedicine,Guimarães,Portugal
ICVS/3B’s – PT Government Associate Laboratory, Braga/Guimarães,
Portugal
TheDiscoveriesCentreforRegenerativeandPrecisionMedicine,Headquar-
tersatUniversityofMinho,Avepark,Guimarães,Portugal
Juan J. Haro-Mora Cellular and Molecular Therapeutics Branch, NHLBI/
NIDDK,NationalInstitutesofHealth,Bethesda,MD,USA
TahaBartuHayal DepartmentofGeneticsandBioengineering,Facultyof
Engineering,YeditepeUniversity,Istanbul,Turkey
Zeynep Tokcaer-Keskin Faculty of Arts and Sciences, Department of
MolecularBiologyandGenetics,AcibademMehmetAliAydinlarUniversity,
Istanbul,Turkey
Binnur Kıratlı Department of Genetics and Bioengineering, Faculty of
Engineering,YeditepeUniversity,İstanbul,Turkey
Alexis Leonard Cellular and Molecular Therapeutics Branch, NHLBI/
NIDDK,NationalInstitutesofHealth,Bethesda,MD,USA
Ayşegül Mendi Faculty of Dentistry, Department of Basic Sciences, Gazi
University,Ankara,Turkey
David Richards Division of Cell Matrix Biology and Regenerative Medi-
cine,SchoolofBiologicalSciences,FacultyofBiology,MedicineandHealth,
University of Manchester, Manchester Academic Health Science Centre,
Manchester,UK
StephenM.Richardson DivisionofCellMatrixBiologyandRegenerative
Medicine, School of Biological Sciences, Faculty of Biology, Medicine and
Health, University of Manchester, Manchester Academic Health Science
Centre,Manchester,UK
Fikrettin Şahin Department of Genetics and Bioengineering, Faculty of
EngineeringandArchitecture,YeditepeUniversity,Istanbul,Turkey
A. M. James Shapiro Clinical Islet Transplant Program, Alberta Diabetes
Institute,UniversityofAlberta,Edmonton,AB,Canada
DepartmentofSurgery,UniversityofAlberta,Edmonton,AB,Canada
CanadianNationalTransplantResearchProgram,Edmonton,AB,Canada