Cell Adhesion

249 Pages·1996·11.95 MB·English

by  E. Edward Bittar and David R. Colman (Eds.)

ADVANCES IN
MOLECULAR AND
CELL BIOLOGY
Volume 76 7 996
CELL ADHESION
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ADVANCES IN
MOLECULAR AND
CELL BIOLOGY
CELL ADHESION
Series Editor: E. EDWARD BlITAR
Department of Physiology
University of Wisconsin
Guest Editor: DAVID R. COLMAN
Brookdale Center for Molecular Biology
The Mount Sinai Medical Center
VOLUME 16 1996
@
JAl PRESS INC.
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ISBN: 0-7623-0143-0
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CONTENTS
LIST OF CONTRIBUTORS vii
PREFACE
David R. Colman ix
THE STRUCTURE AND FUNCTION OF INTEGRINS
Eugene E. Marcantonio 1
FUNCTION AND REGULATION OF SELECTINS:
A NEW FAMILY OF LEUKOCYTE AND
ENDOTHELIAL CELL ADHESION PROTEINS
Mark A. lutila 31
DISCOVERY AND ANALYSIS OF
THE CLASSICAL CADHERINS
Gerald B. Crunwald 63
DESMOSOMAL CADHERINS AND THEIR
INTERACTIONS WITH PLAKOGLOBIN
Pamela Cowin and Sailaja Puttagunta 113
NEURAL CELL ADHESION MOLECULES OF
THE IMMUNOGLOBULIN SUPERFAMILY
lohn 1. Hemperly 137
PROTEIN ZERO OF PERIPHERAL NERVE MYELIN:
ADHESION PROPERTIES AND FUNCTIONAL MODELS
Marie T. Filbin, Donatella D’Urso, Keija Zhang,
Manhar Wong, loseph P. Doyle, and David R. Colman 159
GPI-ANCHORED PROTEINS IN NEURAL CELL ADHESION
lames 1. Salzer, Charles 1. Rosen, and Arie F. Struyk 193
V
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LIST OF CONTRIBUTORS
David R. Colman Brookdale Center for Molecular Biology
The Mount Sinai Medical Center
Pamela Cowin Department of Cell Biology
New York University Medical Center
loseph P. Doyle Brookdale Center for Molecular Biology
The Mount Sinai Medical Center
Donatella D’Urso Institute Superiori di Sanita
Rome
Marie T. Filbin Department of Biological Sciences
Hunter College
City University of New York
Gerald B. Grunwald Department of Pathology, Anatomy,
and Cell Biology
Thomas Jefferson University
john 1. Hempedy Becton Dickinson Research Center
Research Triangle Park, North Carolina
Mark A. lutila Veterinary Molecular Biology
Montana State University
Eugene E. Marcantonio College of Physicians and Surgeons
Columbia University
Sailaja Puttagunta Department of Cell Biology
New York University Medical Center
vi i
...
Vlll LIST OF CONTRIBUTORS
Charles L. Rosen Department of Cell Biology
New York University Medical Center
lames L. Salzer Departments of Cell Biology
and Neurology
New York University Medical Center
Arie F. Struyk Department of Cell Biology
New York University Medical Center
Manhar Wong Department of Biological Sciences
Hunter College
City University of New York
Keija Zhang Department of Biological Sciences
Hunter College
City University of New York
PREFACE
One prerequisite for the evolution of multicellular organisms was the
invention of mechanisms by which cells could adhere to one another.
At some point in our history, dividing cells no longer went their separate
protozoic ways in the primordial oceans, but instead found that by
maintaining an association, by sticking together but not fusing,
numerous evolutionary advantages became possible. The subsequent
development of specialized tissues and organs depended on the
elaboration of incredibly sophisticated, regulatable cell-to-cell adhesion
mechanisms which are known to operate in biological processes as
diverse as the growth of the embryo, the immune response, the
establishment of connections between nerve cells, and arteriosclerosis,
to name just a few. Although we can only guess at the ancestral mech-
anisms that fostered the first primitive intercellular unions, some one
billion years ago, we now recognize contemporary molecular “themes”
with presumably ancient origins that mediate cellcell interactions.
The chapters in this book serve as useful, thought-provoking, but
not exhaustive, commentaries on contemporary topics within the broad
field of cell adhesion. If the reader detects a slight tilt toward those
adhesion molecules that function in the nervous system, this is merely
a reflection of this editor’s interests, biases, and of course, limitations.
David R. Colman
Guest Editor
ix