CDC Anthrax Vaccine Safety & Efficacy Research Program: Interim Report

58 Pages·2001·0.96 MB·English

by  Medicine, I.

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Paall The members of the committee responsible for the report were chosen for their special competences and with regard for appropriate balance.
s. ent Support for this project was provided by the Centers for Disease Control and Prevention, Department of Health and Human Services
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al typhave The National Academy of Sciences is a private, nonprofit, self-perpetuating society of distinguished
ginay scholars engaged in scientific and engineering research, dedicated to the furtherance of science and
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ooyp of Sciences, as a parallel organization of outstanding engineers. It is autonomous in its administration and in
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m tret The Institute of Medicine was established in 1970 by the National Academy of Sciences to secure the
oe services of eminent members of appropriate professions in the examination of policy matters pertaining to
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ge bry ins COMMITTEE TO REVIEW THE CDC ANTHRAX VACCINE SAFETY AND
Paall EFFICACY RESEARCH PROGRAM
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original typmay have TRUPEDrpeYivd eeBnmtUiivoSelHo Mg,*ye daPitc rtoihnfeee s Uaston trihv eae nrUsdin tyiDv oierfre sNcittoyor rto hfo fCM atahrroeyl liGannard aSd Scuhcaohteoo lo Plo rofo fMg Mreademdic iicinnine etih.ne C Dhaeppealr tHmielln.t of Epidemiology and
he ors THEODORE C.EICHOFF, Professor of Medicine, Division of Infectious Disease, University of Colorado
m terr Health Sciences Center.
k, not froographic PEAMTICRLl IiCnCi.cIGAalO MFTEiScRCroRHbIiLEoIlRoCgIH,y P,L†r aoVbfeoicsresao tPor rroyesf a idLt etahnbeto fUroanrto iMvryee rMdsiitceyad loi cfSi Mcnieei nnancneedss oPatata t ThMoheleod Rgicyoa,c lak Snecdfhe loPloeerld. iUatnriivcse,r saintyd, DR.iGrewctionr Foof lltihse-
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original ed, and DENPNroIfSe sKsoArS oPfE MRi,c†r oEbxieocluotgiyv ea Dnde aMn fooler cAuclaard eGmenice tPicros garta mHsa,r vWarildl iaMme dEilclaelr yS Cchhoaorml, iDngir Pecrotofre sosfo rt hoef MCheadrimciinneg,
he ain Laboratory, and a senior physician at Brigham and Women's Hospital.
m tret REGINA RABINOVICH, Director, Malaria Vaccine Initiative, Program for Appropriate Technology in Health
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ed frat bnnot BRIA(PNA TLH.S)T. ROM,† Chair and Professor of Biostatistics & Epidemiology, Professor of Medicine, Professor of
ea Pharmacology, Director of the Center for Clinical Epidemiology & Biostatistics, and Chair of the Graduate
es crer, c Group in Epidemiology & Biostatistics, University of Pennsylvania School of Medicine.
L filwev HUGH H.TILSON,† Clinical Professor of Epidemiology and Health Policy and Senior Advisor to the Dean at
XMho the University of North Carolina School of Public Health.
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s. ent JOHN C.BAILAR III, Professor Emeritus, Health Studies, University of Chicago.
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al typhave GERNMatAioInNaEl I nBstUituCteK o, f CChhiieldf, HEeaplitdhe m&i Holuomgya nB Dreavneclho, pmDeivnits, iNona tioofn alE Ipnisdteitmutieoslo ogfy H, eSalttahti.stics & Prevention,
ginay DANIEL H.FREEMAN, Jr., Professor and Director, Office of Biostatistics, University of Texas Medical
m the orierrors m IRVBINraGn chI..GOTTESMAN, Sherrell J.Aston Professor of Psychology, Professor of Clinical Pediatrics,
k, not froographic NTHANOUCMnYiAv eMSr sAUit.yEL LoOfL UVEIiRSrg,, iSPneirano.ifoers sSotra,t Disteipcaarl tSmceiennt toisf tE, Tpihdee RmAioNloDg yC, oHraprovraartdio Snchool of Public Health.
ooyp PHILIP K.RUSSELL, Professor Emeritus, Department of International Health, Johns Hopkins School of
er bme t Hygiene and Public Health.
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m terr ACKNOWLEDGMENTS xi
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m tret ACRONYMS 39
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he ors as a weapon of biological warfare, and examples of weapons development efforts using anthrax are well known.
m terr It is important to protect the men and women in our armed services to the greatest extent possible. The
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he ain application to change the labeling of the licensed anthrax vaccine, specifically to change the route of
m tret administration from subcutaneous to intramuscular injection and to reduce the total number of doses. Based upon
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ea inoculation. In addition, the CDC is also researching the acceptability of the anthrax vaccine, and so part of the
es crer, c research program involves assessing the knowledge, attitudes, and beliefs of vaccine recipients concerning the
L filwev anthrax vaccine.
XMho While restricted by the statement of task to an evaluation of the CDC's anthrax vaccine safety and efficacy
m g, research program using the licensed vaccine, the committee cannot help but observe the substantial opportunity
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