Candida albicans: Cellular and Molecular Biology

552 Pages·2017·9.62 MB·English

by  Rajendra Prasad (eds.)

Rajendra Prasad Editor
Candida
albicans: Cellular
and Molecular
Biology
Second Edition
Candida albicans
: Cellular and Molecular Biology
Rajendra Prasad
Editor
Candida albicans
: Cellular
and Molecular Biology
Second Edition
123
Editor
Rajendra Prasad
Amity Institute of Integrative Sciences
andHealthandAmity Institute
ofBiotechnology
AmityUniversityHaryana,AmityEducation
Valley
Gurgaon,Haryana
India
ISBN978-3-319-50408-7 ISBN978-3-319-50409-4 (eBook)
DOI 10.1007/978-3-319-50409-4
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2ndedition:©SpringerInternationalPublishingAG2017
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Contents
1 Introduction... .... .... ..... .... .... .... .... .... ..... .... 1
Rajendra Prasad
2 Current Trends in Candidiasis. .... .... .... .... .... ..... .... 5
Priya Uppuluri, Afshin Khan and John E. Edwards
3 Invasive Candidiasis in the Southeast-Asian Region.... ..... .... 25
Rachna Singh and Arunaloke Chakrabarti
4 Morphogenesis in C. albicans.. .... .... .... .... .... ..... .... 41
David Kadosh
5 Candida albicans Biofilms..... .... .... .... .... .... ..... .... 63
Priya Uppuluri and Jose Luis Lopez Ribot
6 Candida Biofilm Tolerance: Comparison of Planktonic
and Biofilm Resistance Mechanisms. .... .... .... .... ..... .... 77
Eddie G. Dominguez and David R. Andes
7 In Vivo Candida Device Biofilm Models . .... .... .... ..... .... 93
David R. Andes
8 Fungal–Bacterial Interactions: In Health and Disease .. ..... .... 115
Patrick Van Dijck and Mary Ann Jabra-Rizk
9 Host Immune Responses During Infections
with Candida albicans... ..... .... .... .... .... .... ..... .... 145
Mark H.T. Stappers and Gordon D. Brown
10 AMPlified Defense: Antimicrobial Peptides During Candida
albicans Infection... .... ..... .... .... .... .... .... ..... .... 185
Joachim F. Ernst and Marc Swidergall
v
vi Contents
11 Genome Diversity and Dynamics in Candida albicans .. ..... .... 205
Christophe d’Enfert, Marie-Elisabeth Bougnoux, Adeline Feri,
Mélanie Legrand, Raphaël Loll-Krippleber, Timea Marton,
Corinne Maufrais, Jeanne Ropars, Natacha Sertour
and Emilie Sitterlé
12 Chromosome Components Important for Genome Stability
in Candida albicans and Related Species. .... .... .... ..... .... 233
Lakshmi Sreekumar, Neha Varshney and Kaustuv Sanyal
13 Infection-Associated Gene Expression—The Pathogen
Perspective.... .... .... ..... .... .... .... .... .... ..... .... 253
Saranna Fanning and Aaron P. Mitchell
14 Signaling Mechanisms in Pathogenesis and Virulence
of Candida albicans. .... ..... .... .... .... .... .... ..... .... 271
Neeraj Chauhan
15 Mechanisms of Drug Resistance in Candida albicans ... ..... .... 287
Dominique Sanglard
16 Unlocking the Therapeutic Potential of the Fungal Cell Wall:
Clinical Implications and Drug Resistance ... .... .... ..... .... 313
Chibuike Ibe, Louise A. Walker, Neil A.R. Gow
and Carol A. Munro
17 Iron Acquisition in the Pathobiology of Candida albicans .... .... 347
Manjit Kumar Srivastav, Remya Nair
and Krishnamurthy Natarajan
18 Structure–Function Analyses of Multidrug Transporters..... .... 379
Erwin Lamping, Golnoush Madani, Hee Ji Lee, Masakazu Niimi
and Richard D. Cannon
19 MDR1 and Its Regulation..... .... .... .... .... .... ..... .... 407
Joachim Morschhäuser
20 Insights into Candida Lipids... .... .... .... .... .... ..... .... 417
Rajendra Prasad, Sudhanshu Shukla and Ashutosh Singh
21 Molecular Targets for Anticandidal Chemotherapy.... ..... .... 429
Sławomir Milewski
22 Antifungals.... .... .... ..... .... .... .... .... .... ..... .... 471
David S. Perlin
Contents vii
23 Using Yeast to Discover Inhibitors of Multidrug Efflux
in Candida albicans. .... ..... .... .... .... .... .... ..... .... 491
Brian C. Monk and Mikhail V. Keniya
24 Inhibitors of Cancer Cell Multidrug ABC Transporters:
Extrapolation to Combat Candida albicans Resistance
to Antifungals . .... .... ..... .... .... .... .... .... ..... .... 545
Attilio Di Pietro
Contributors
David R. Andes Departments of Medicine and Medical Microbiology and
Immunology, University of Wisconsin, Madison, WI, USA
Marie-Elisabeth Bougnoux Unité Biologie et Pathogénicité Fongiques, Institut
Pasteur, INRA, Paris, France; Unité de Parasitologie-Mycologie, Service de
MicrobiologieClinique,HôpitalNecker-Enfants-Malades,AssistancePubliqueDes
Hôpitaux de Paris (APHP), Paris, France
GordonD.Brown AberdeenFungalGroup,MRCCentreforMedicalMycology,
Institute of Medical Sciences, University of Aberdeen, Aberdeen, UK
Richard D. Cannon Sir John Walsh Research Institute, Faculty of Dentistry,
University of Otago, Dunedin, New Zealand
Neeraj Chauhan Public Health Research Institute, New Jersey Medical School,
Rutgers, The State University of New Jersey, Newark, NJ, USA; Department of
Microbiology,BiochemistryandMolecular Genetics, NewJerseyMedical School,
Rutgers, The State University of New Jersey, Newark, NJ, USA
Arunaloke Chakrabarti Department of Medical Microbiology, Postgraduate
Institute of Medical Education and Research, Centre of Advance Research in
Medical Mycology & WHO Collaborating Centre, Chandigarh, India
Christophe d’Enfert Unité Biologie et Pathogénicité Fongiques, Institut Pasteur,
INRA, Paris, France
Patrick Van Dijck VIB Department of Molecular Microbiology, KU Leuven,
Louvain, Belgium
Eddie G. Dominguez Departments of Medicine and Medical Microbiology and
Immunology, University of Wisconsin, Madison, WI, USA
John E. Edwards Los Angeles Biomedical Research Institute, Harbor-UCLA,
Torrance, CA, USA
ix
x Contributors
Joachim F. Ernst Department Biologie, Molekulare Mykologie,
Heinrich-Heine-Universität Düsseldorf, Düsseldorf, Germany
SarannaFanning WhiteheadInstituteforBiomedicalResearch,Cambridge,MA,
USA
Adeline Feri Unité Biologie et Pathogénicité Fongiques, Institut Pasteur, INRA,
Paris, France; Cellule Pasteur, Univ. Paris Diderot, Sorbonne Paris Cité, Paris,
France
NeilA.R.Gow AberdeenFungalGroup,InstituteofMedicalSciences,University
of Aberdeen, Aberdeen, UK
Chibuike Ibe Aberdeen Fungal Group, Institute of Medical Sciences, University
of Aberdeen, Aberdeen, UK
Mary Ann Jabra-Rizk University of Maryland School of Dentistry, Baltimore,
MD, USA
David Kadosh Department of Microbiology and Immunology, University of
Texas Health Science Center at San Antonio, San Antonio, TX, USA
Mikhail V. Keniya Department of Oral Sciences, University of Otago, Dunedin,
New Zealand
Afshin Khan Tulane University School of Medicine, New Orleans, LA, USA
Erwin Lamping Sir John Walsh Research Institute, Faculty of Dentistry,
University of Otago, Dunedin, New Zealand
Hee Ji Lee Sir JohnWalsh Research Institute, Faculty ofDentistry, University of
Otago, Dunedin, New Zealand
Mélanie Legrand Unité Biologie et Pathogénicité Fongiques, Institut Pasteur,
INRA, Paris, France
Raphaël Loll-Krippleber Unité Biologie et Pathogénicité Fongiques, Institut
Pasteur,INRA, Paris,France; Cellule Pasteur,Univ.Paris Diderot,SorbonneParis
Cité, Paris, France
JoseLuisLopezRibot DepartmentofBiology,UniversityofTexasSanAntonio,
San Antonio, TX, USA
Golnoush Madani Sir John Walsh Research Institute, Faculty of Dentistry,
University of Otago, Dunedin, New Zealand
TimeaMarton UnitéBiologieetPathogénicitéFongiques,InstitutPasteur,INRA,
Paris, France
CorinneMaufrais InstitutPasteur,Centred’InformatiquepourlaBiologie,Paris,
France
Contributors xi
Sławomir Milewski Department of Pharmaceutical Technology and
Biochemistry, Gdańsk University of Technology, Gdańsk, Poland
Aaron P. Mitchell Department of Biological Sciences, Carnegie Mellon
University, Pittsburgh, PA, USA
BrianC.Monk DepartmentofOralSciences,UniversityofOtago,Dunedin,New
Zealand
Joachim Morschhäuser Institut für Molekulare Infektionsbiologie, Universität
Würzburg, Würzburg, Germany
Carol A. Munro Aberdeen Fungal Group, Institute of Medical Sciences,
University of Aberdeen, Aberdeen, UK
Remya Nair Membrane Biology Laboratory, School of Life Sciences, Jawaharlal
Nehru University, New Delhi, India
KrishnamurthyNatarajan LaboratoryofEucaryoticGeneRegulation,Schoolof
Life Sciences, Jawaharlal Nehru University, New Delhi, India
Masakazu Niimi Sir John Walsh Research Institute, Faculty of Dentistry,
University of Otago, Dunedin, New Zealand; Mycology Unit, Department of
Microbiology,FacultyofMedicine,ChulalongkornUniversity,Bangkok,Thailand
David S. Perlin Public Health Research Institute, New Jersey Medical School –
Rutgers Biomedical and Health Sciences, Newark, NJ, USA
AttilioDiPietro InstituteofProteinBiologyandChemistry,MMSB, UMR5086
CNRS-University of Lyon, Lyon, France
RajendraPrasad AmityInstituteofIntegrativeSciencesandHealthandInstitute
of Biotechnology, Amity University Haryana, Gurgaon, Haryana, India
Jeanne Ropars Unité Biologie et Pathogénicité Fongiques, Institut Pasteur,
INRA, Paris, France
Dominique Sanglard Institute of Microbiology, University of Lausanne and
University Hospital Center, CH-1011 Lausanne, Switzerland
Kaustuv Sanyal Molecular Mycology Laboratory, Molecular Biology and
Genetics Unit, Jawaharlal Nehru Centre for Advanced Scientific Research, Jakkur,
Bangalore, India
Natacha Sertour Unité Biologie et Pathogénicité Fongiques, Institut Pasteur,
INRA, Paris, France
SudhanshuShukla AmityInstituteofBiotechnology,AmityUniversity,Haryana,
India
Ashutosh Singh Department of Biochemistry, Lucknow University, Lucknow,
India