Table Of ContentCANCER FACTS
CANCER FACTS
A Concise Oncology Text
Edited by
James F.Bishop
Professor of Cancer Medicine
University of Sydney
and
Director
Sydney Cancer Centre
Australia
harwood academic publishers
Australia • Canada (cid:127) China (cid:127) France (cid:127) Germany (cid:127) India (cid:127) Japan
Luxembourg (cid:127) Malaysia (cid:127) The Netherlands (cid:127) Russia (cid:127) Singapore (cid:127)
Switzerland
This edition published in the Taylor & Francis e-Library, 2004.
Copyright © 1999 OPA (Overseas Publishers Association) N.V. Published by license under the
Harwood Academic Publishers imprint, part of The Gordon and Breach Publishing Group.
All rights reserved.
No part of this book may be reproduced or utilized in any form or by any means, electronic or
mechanical, including photocopying and recording, or by any information storage or retrieval system,
without permission in writing from the publisher. Printed in Singapore.
Amsteldijk 166
1st Floor
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The Netherlands
British Library Cataloguing in Publication Data
A catalogue record for this book is available from the British Library.
ISBN 0-203-30487-X Master e-book ISBN
ISBN 0-203-34325-5 (Adobe eReader Format)
ISBN 90-5702-470-5 (Print Edition)
Cover design by Kerry Klinner.
CONTENTS
List of Plates xi
Foreword xiii
Preface xv
Contributors xvii
PART I THE INCIDENCE AND AETIOLOGY OF CANCER
Chapter 1 Cancer Incidence, Mortality and Trends 3
Bruce K.Armstrong
Chapter 2 Tumour Pathology 10
Jeremy R.Jass
Chapter 3 Molecular Basis of Carcinogenesis 13
Robert L.Sutherland
Chapter 4 Genetic Changes in Cancer 17
Ronald J.Trent
Chapter 5 Genetic Counselling for Cancer Risk 22
Kelly-Anne Phillips
Chapter 6 Cancer Prevention, Screening and Early Detection 28
Robert C.Burton and Graham G.Giles
PART II THE PRINCIPLES OF CANCER TREATMENT
Chapter 7 Radiobiology: Its Relevance to Treatment 35
Andrew A.Miller and John H.Kearsley
Chapter 8 Principles of Radiotherapy 42
Michael Barton
Chapter 9 Principles of Chemotherapy 46
James F.Bishop
Chapter 10 Actions of Anti-cancer Drugs 52
Stephen J.Clarke and Laurent P.Rivory
Chapter 11 New Anti-cancer Agents 59
Michael Millward
v
vi CONTENTS
Chapter 12 Hormonal Therapy of Cancer 63
Robin Murray
Chapter 13 Drug Resistance 67
Stephen J.Clarke
Chapter 14 Principles of Surgical Oncology 72
John F.Thompson
Chapter 15 Principles of Palliative Care 76
J.Norelle Lickiss
PART III SYMPTOM CONTROL AND QUALITY OF LIFE
Chapter 16 Anti-emetics and Symptom Control 85
Ian N.Olver
Chapter 17 Pain Management 91
Paul Glare
Chapter 18 Measurement of Quality of Life in Cancer 97
Martin Stockler
PART IV LUNG CANCER
Fast Fact Sheet 1 Lung Cancer 103
R.Supramanian and Bruce K.Armstrong
Chapter 19 Non-Small Cell Lung Cancer: Surgical Management 108
Brian C.McCaughan
Chapter 20 Non-Small Cell Lung Cancer: Radiation Therapy 113
Graham Stevens
Chapter 21 Non-Small Cell Lung Cancer: Chemotherapy 118
Michael Boyer
Chapter 22 Small Cell Lung Cancer 121
James F.Bishop
PART V BREAST CANCER
Fast Fact Sheet 2 Breast Cancer 127
Bruce K.Armstrong and H.L.Nguyen
Chapter 23 Early Breast Cancer: Surgical Management 133
David Gillett
Chapter 24 Early Breast Cancer: Adjuvant Therapy 142
Alan Coates
Chapter 25 Radiotherapy in the Management of Breast Cancer 146
Susan C.Pendlehury
Chapter 26 Locally Advanced and Metastatic Breast Cancer 151
Stephen P.Ackland and John F.Stewart
CONTENTS vii
PART VI GASTROINTESTINAL CANCERS
Chapter 27 Upper Gastrointestinal Malignancy: Surgical Management 161
David W.Storey
Chapter 28 Upper Gastrointestinal Malignancy: Systemic Therapy 171
Michael P.N.Findlay
Fast Fact Sheet 3 Colorectal Cancer 176
H.L.Nguyen and Bruce K.Armstrong
Chapter 29 Colorectal Cancer: Surgical Management 182
E.L.Bokey and Brian D.Draganic
Chapter 30 Colorectal Cancer: Systemic Therapy 187
Stephen J.Clarke
Chapter 31 Hepatocellular Carcinoma 191
John E.L.Wong
PART VII UROGENTIAL CANCERS
Fast Fact Sheet 4 Prostate Cancer
D.P.Smith And Bruce K.Armstrong 197
Chapter 32 Cancers of the Urogenital Tract: Surgical Management
Mohamed H.Khadra 202
Chapter 33 Cancers of the Urogenital Tract: Systemic and Radiation
Treatment
Michael Boyer and Michael Jackson 209
Chapter 34 Germ Cell Tumours
Guy C.Toner 214
PART VIII GYNAECOLOGICAL CANCERS
Chapter 35 Gynaecological Cancers: Surgical Management
Jonathan Carter 221
Chapter 36 Gynaecological Cancers: Systemic Treatment
Alison Davis and Michael Friedlander 226
PART IX HEAD AND NECK CANCER
Chapter 37 Head and Neck Cancers: Surgical Management
Christopher J.O’Brien 233
Chapter 38 Head and Neck Cancers: Radiation Therapy
Michael Jackson 239
Chapter 39 Head and Neck Cancers: Systemic Therapy
Danny Rischin 245
Chapter 40 Nasopharyngeal Cancers
John E.L.Wong 249
viii CONTENTS
PART X MELANOMA
Fast Fact Sheet 5 Melanoma
H.L.Nguyen And Bruce K.Armstrong 255
Chapter 41 Melanoma and Other Skin Cancers
William H.McCarthy 260
Chapter 42 Melanoma: Systemic Therapy
Richard F.Kefford 266
PART XI HAEMATOLOGICAL MALIGNANCIES
Chapter 43 Molecular Genetics of Haematological Diseases
Harry J.Iland 273
Chapter 44 Haematopoietic Growth Factors in Oncology
Guy C.Toner 279
Chapter 45 The Acute Leukaemias
James F.Bishop 283
Chapter 46 Chronic Leukaemias and Myelodysplastic Disease
Peter Mollee and Kerry Taylor 288
Chapter 47 Lymphoma
Graham A.R.Young 295
Chapter 48 Multiple Myeloma
Douglas E.Joshua 301
Chapter 49 Bone Marrow and Stem Cell Transplantation
Ken F.Bradstock 306
PART XII MISCELLANEOUS CANCERS
Chapter 50 Sarcomas: Diagnosis and Surgery
Paul D.Stalley 315
Chapter 51 Sarcoma: Systemic Treatment
Martin H.N.Tattersall 320
Chapter 52 Tumours of the Central Nervous System
Jane Beith 323
Fast Fact Sheet 6 Tumours Of The Endocrine System
Elizabeth Chua And John R.Turtle 328
Chapter 53 Tumours of the Endocrine System
Elizabeth Chua and John R.Turtle 330
Chapter 54 Paediatric Cancer
Keith Waters 336
Chapter 55 Cancers in AIDS Patients
Sam Milliken and Ronald Penny 342
Chapter 56 Carcinoma of Unknown Primary Origin
John A.Levi 349
CONTENTS ix
PART XIII COMPLICATIONS IN CANCER PATIENTS
Chapter 57 Oncological Emergencies
Paul R.Harrnett 357
Chapter 58 Infections in Cancer Patients
David Mitchell 361
PART XIV PSYCHO-SOCIAL ISSUES IN CANCER
Chapter 59 Breaking Bad News
Rhonda F.Brown, Afaf Girgis and Robert W.Sanson-Fisher 367
Chapter 60 Patient’s Expectations of Cancer
Rob Sanson-Fisher 372
Chapter 61 Working with Cancer Patients
Andrea Szendroe 377
Chapter 62 Medical Statistics and Clinical Trials
Jane P.Matthews 381
Appendix I ECOG Performance Status 387
Appendix II Commonly Used Chemotherapy Protocols 388
Colour Plates 397
Index 399
