Table Of ContentManuel L. Penichet, Erika Jensen-Jarolim
Editors
Cancer and IgE
Introducing the Concept
of AllergoOncology
Cancer and IgE
·
Manuel L. Penichet Erika Jensen-Jarolim
Editors
Cancer and IgE
Introducing the Concept of AllergoOncology
Editors
ManuelL.Penichet ErikaJensen-Jarolim
AssociateProfessor ProfessorandChair
DivisionofSurgicalOncology, DepartmentofPathophysiology
DepartmentofSurgery, CenterofPathophysiology,Infectiology
andDepartmentofMicrobiology, andImmunologyMedicalUniversity
ofViennaWaehringerG.18-20,
Immunology,andMolecularGenetics
1090Vienna,Austria
DavidGeffenSchoolofMedicine
[email protected]
UniversityofCalifornia
atLosAngeles(UCLA)
10833LeConteAvenue
LosAngeles,CA90095
USA
[email protected]
ISBN978-1-60761-450-0 e-ISBN978-1-60761-451-7
DOI10.1007/978-1-60761-451-7
SpringerNewYorkDordrechtHeidelbergLondon
LibraryofCongressControlNumber:2009939537
©SpringerScience+BusinessMedia,LLC2010
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Coverillustration:ThelogoofAllergoOncologycreatedbyDr.ErikaJensen-JarolimandMr.Walter
Jarolimtopromotethefirst“1stInternationalAllergoOncologySymposium,”whichtookplaceinVienna,
Austria,onApril16,2007.
Printedonacid-freepaper
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Contents
1 Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1
ErikaJensen-JarolimandManuelL.Penichet
2 TheBiologyofIgE:MolecularMechanismRestraining
PotentiallyDangerousHighSerumIgETitresInVivo . . . . . . . 13
GernotAchatz,GertrudeAchatz-Straussberger,
StefanFeichtner,SebastianKoenigsberger,
StefanLenz,DorisPeckl-Schmid,NadjaZaborsky,
andMarinusLamers
3 TheBiologyofIgE:TheGenerationofHigh-AffinityIgE
Antibodies . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 37
MariaA.CurottodeLafailleandJuanJ.Lafaille
4 EpidemiologicalEvidence:IgE,Atopy,andSolidTumors . . . . . 47
MichelleC.Turner
5 Epidemiological Evidence: IgE, Allergies, and
HematopoieticMalignancies . . . . . . . . . . . . . . . . . . . . . 79
OtonielMartínez-Maza,AlanDuaneMoreno,and
WendyCozen
6 MastCellsinAllergyandTumorDisease . . . . . . . . . . . . . . 137
AnnaWasiuk,VictorC.deVries,ElizabethC.Nowak,
andRandolphJ.Noelle
7 TheIgEAntibodyandItsUseinCancerImmunotherapy . . . . . 159
TracyR.Daniels,JoséA.Rodríguez,Elizabeth
Ortiz-Sánchez,GustavoHelguera,andManuelL.Penichet
8 IgEInteractswithPotentEffectorCellsAgainstTumors:
ADCCandADCP . . . . . . . . . . . . . . . . . . . . . . . . . . . 185
SophiaN.Karagiannis,FrankO.Nestle,andHannahJ.Gould
9 IgEasAdjuvantinTumorVaccination . . . . . . . . . . . . . . . 215
ElisaA.Nigro,AntonioG.Siccardi,andLucaVangelista
v
vi Contents
10 TheTargetsofIgE:Allergen-Associatedand
Tumor-AssociatedMolecularPatterns. . . . . . . . . . . . . . . . 231
ErikaJensen-Jarolim,DianaMechtcheriakova,andIsabella
Pali-Schoell
11 The Role of Th2-Mediated Anti-Tumor Immunity
inTumorSurveillanceandClearance . . . . . . . . . . . . . . . . 255
LjubovSimson,JuliaI.Ellyard,andChristopherR.Parish
SubjectIndex . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 277
Contributors
GernotAchatz DepartmentofMolecularBiology,UniversityofSalzburg,
Salzburg,Austria
GertrudeAchatz-Straussberger DepartmentofMolecularBiology,University
ofSalzburg,Salzburg,Austria
WendyCozen DepartmentsofPreventiveMedicineandPathology,KeckSchool
ofMedicine,UniversityofSouthernCalifornia,LosAngeles,CA,USA
MariaA.CurottodeLafaille MolecularPathogenesisProgram,TheKimmel
CenterforBiologyandMedicineoftheSkirballInstituteandDepartmentof
Pathology,NewYorkUniversitySchoolofMedicine,NewYork,NY,USA
TracyR.Daniels DivisionofSurgicalOncology,DepartmentofSurgery,
UniversityofCalifornia,LosAngeles(UCLA),LosAngeles,CA,USA
VictorC.deVries DepartmentofMicrobiologyandImmunology,Dartmouth
MedicalSchool,Lebanon,NH,USA
JuliaI.Ellyard DivisionofImmunologyandGenetics,JohnCurtinSchoolof
MedicalResearch,AustralianNationalUniversity,Canberra,ACT,Australia
StefanFeichtner DepartmentofMolecularBiology,UniversityofSalzburg,
Salzburg,Austria
HannahJ.Gould RandallDivisionofCellandMolecularBiophysics,King’s
CollegeLondon,Guy’sCampus,London,UK
GustavoHelguera DivisionofSurgicalOncology,DepartmentofSurgery,
UniversityofCalifornia,LosAngeles(UCLA),LosAngeles,CA,USA
ErikaJensen-Jarolim IPP–DepartmentofPathophysiology,Centerof
Pathophysiology,InfectiologyandImmunology,MedicalUniversityofVienna,
Vienna,Austria
SophiaN.Karagiannis NIHRBiomedicalResearchCentreatGuy’sandSt.
Thomas’sHospitalsandKing’sCollegeLondon,CutaneousMedicineand
Immunotherapy,St.John’sInstituteofDermatology,DivisionofGeneticsand
vii
viii Contributors
MolecularMedicine,King’sCollegeLondonSchoolofMedicine,Guy’sHospital,
London,UK
SebastianKoenigsberger DepartmentofMolecularBiology,Universityof
Salzburg,Salzburg,Austria
JuanJ.Lafaille MolecularPathogenesisProgram,TheKimmelCenterfor
BiologyandMedicineoftheSkirballInstituteandDepartmentofPathology,New
YorkUniversitySchoolofMedicine,NewYork,NY,USA
MarinusLamers MaxPlanckInstituteforImmunobiology,Freiburg,Germany
StefanLenz DepartmentofMolecularBiology,UniversityofSalzburg,Salzburg,
Austria
OtonielMartínez-Maza DepartmentsofObstetricsandGynecologyand
DepartmentofMicrobiology,Immunology,andMolecularGenetics,Jonsson
ComprehensiveCancerCenter,AIDSInstitute,DavidGeffenSchoolofMedicine,
UniversityofCalifornia,LosAngeles(UCLA),LosAngeles,CA,USA
DianaMechtcheriakova IPP–DepartmentofPathophysiology,Centerof
Pathophysiology,InfectiologyandImmunology,MedicalUniversityofVienna,
Vienna,Austria
AlanDuaneMoreno DepartmentofPreventiveMedicine,KeckSchoolof
Medicine,UniversityofSouthernCalifornia,LosAngeles,CA,USA
FrankO.Nestle NIHRBiomedicalResearchCentreatGuy’sandSt.Thomas’s
HospitalsandKing’sCollegeLondon,CutaneousMedicineandImmunotherapy,
St.John’sInstituteofDermatology,DivisionofGeneticsandMolecularMedicine,
King’sCollegeLondonSchoolofMedicine,Guy’sHospital,London,UK
ElisaA.Nigro DepartmentofBiologyandGenetics,UniversityofMilanandSan
RaffaeleScientificInstitute,Milan,Italy
RandolphJ.Noelle DepartmentofMicrobiologyandImmunology,Dartmouth
MedicalSchool,Lebanon,NH,USA
ElizabethC.Nowak DepartmentofMicrobiologyandImmunology,Dartmouth
MedicalSchool,Lebanon,NH,USA
ElizabethOrtiz-Sánchez DivisionofSurgicalOncology,DepartmentofSurgery,
UniversityofCalifornia,LosAngeles(UCLA),LosAngeles,CA,USA
IsabellaPali-Schoell IPP–DepartmentofPathophysiology,Centerof
Pathophysiology,InfectiologyandImmunology,MedicalUniversityofVienna,
Vienna,Austria
ChristopherR.Parish DivisionofImmunologyandGenetics,JohnCurtin
SchoolofMedicalResearch,AustralianNationalUniversity,Canberra,ACT,
Australia
Contributors ix
DorisPeckl-Schmid DepartmentofMolecularBiology,UniversityofSalzburg,
Salzburg,Austria
ManuelL.Penichet DivisionofSurgicalOncology,DepartmentofSurgeryand
DepartmentofMicrobiology,Immunology,andMolecularGenetics,Molecular
BiologyInstitute,JonssonComprehensiveCancerCenter,DavidGeffenSchoolof
Medicine,UniversityofCalifornia,LosAngeles(UCLA),LosAngeles,CA,USA
JoséA.Rodríguez DivisionofSurgicalOncology,DepartmentofSurgeryand
MolecularBiologyInstitute,UniversityofCalifornia,LosAngeles(UCLA),Los
Angeles,CA,USA
AntonioG.Siccardi DepartmentofBiologyandGenetics,UniversityofMilan
andSanRaffaeleScientificInstitute,Milan,Italy
LjubovSimson CentreforBiomedical,MolecularandChemicalResearch,
UniversityofCanberra,ACT,Australia
MichelleC.Turner McLaughlinCentreforPopulationHealthRiskAssessment,
InstituteofPopulationHealth,FacultyofGraduateandPost-GraduateStudies,
UniversityofOttawa,Ottawa,ONT,Canada
LucaVangelista DepartmentofBiologyandGenetics,UniversityofMilanand
SanRaffaeleScientificInstitute,Milan,Italy
AnnaWasiuk DepartmentofMicrobiologyandImmunology,DartmouthMedical
School,Lebanon,NH,USA
NadjaZaborsky DepartmentofMolecularBiology,UniversityofSalzburg,
Salzburg,Austria
Chapter 1
Introduction
ErikaJensen-JarolimandManuelL.Penichet
1.1 Background
Infectious diseases, being the major burden in the history of mankind worldwide
untilthebeginningofthe20thcentury,wereimportanttriggersintheunderstanding
of immunological mechanisms. In contrast to infectious diseases, reports of aller-
gies and cancers were less common, but increased tremendously within the last
century.BasedontheUSmortalitydataoftheNationalCenterforHealthStatistics,
CentersforDiseaseControlandPrevention2009,arecentreportfromtheAmerican
CancerSocietyindicatedthatthenumberofcancerdeathsincreasedapproximately
from100,000to550,000peryearbetween1930and2006,parallelingtheincrease
of the total population during this period. Leading causes of death from cancer
are lung and bronchus cancer, in men prostate cancer, and in women breast can-
cer [1, 2]. Normalization to population size shows that the cancer death rate for
mostmalignancieshasbeengenerallystable,althoughthemortalityrateofcertain
malignancies,suchaslungandbronchuscancer,hasincreasedoverthelast50years
[1-3].
Inallergy,thesituationislessclear,becauseforthetimeperiodaroundtheturnof
the19thcentury,onlyimpreciseinformationisavailable.However,withinthelast30
yearstheincidencesofallergieshasdoublednotonlyinindustrialcountries,butin
developingcountriesaswell[4].Fromthediagnosedatopicstateitisconcludedthat
insomeareas,suchasinNewZealand,theincidenceofskinandrespiratoryaller-
gies increased as much as40% inthepopulation [5].Thus,thecancer andallergy
incidenceparalleleachother,whereasinfectiousdiseaseshavedecreasedinindustri-
alizedcountries.Fromanepidemiologicalpointofview,thedecreasedparasiteand
bacterialburden mayindirectlycorrelatewiththeincreasingcurves ofallergyand
cancer,beingthusinaccordancewiththeso-calledhygienehypothesis.Thistheory
linkstherecentlowerparasiteandmicrobeburdentoaberrantimmuneresponsesor
failureofimmunemechanisms[6,7].However,ifallergiesandmalignanciesboth
B
E.Jensen-Jarolim( )
IPP-DepartmentofPathophysiology,CenterofPathophysiology,InfectiologyandImmunology,
MedicalUniversityofVienna,Vienna,Austria
e-mail:[email protected]
M.L.Penichet,E.Jensen-Jarolim(eds.),CancerandIgE, 1
DOI10.1007/978-1-60761-451-7_1,(cid:2)C SpringerScience+BusinessMedia,LLC2010
