Table Of ContentCALCIUM AND PHOSPHATE TRANSPORT
ACROSS BIOMEMBRANES
edited by
FELIX BRONNER
Department of Oral Biology
School of Dental Medicine
The University of Connecticut
Farmington, Connecticut
MEINRAD PETERLIK
Department of General
and Experimental Pathology
University of Vienna
Vienna, Austria
ACADEMIC PRESS 1981
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Library of Congress Cataloging in Publication Data
Main entry under title:
Calcium and phosphate transport across biornembranes.
Includes index.
1. Calcium—Metabolism. 2. Biological transport,
Active. 3. Phosphorus — Metabolism. 4. Membranes
(Biology) I. Bronner, Felix. II. Peterlik, Meinrad.
[DNLM: 1. Calcium and phosphate transport across
biomembranes. QU 130 CI44 1981]
QP535.C2C262 612'.3924 81-17617
ISBN 0-12-135280-3 AACR2
PRINTED IN THE UNITED STATES OF AMERICA
81 82 83 84 9 8 7 6 5 4 3 2 1
CONTRIBUTORS
Numbers in parentheses indicate the pages on which the authors* contributions begin.
ο
K. Akerman (83), Neurochemistry Laboratory, Department of Psychiatry,
Dundee University, Dundee, Scotland
C. Amiel (251), Department of Physiology, Faculty of Medicine Xavier
Bichat, Université Paris 7, Paris, France
T. J. Andreasen (45), Department of Pharmacology, University of Wash
ington, Seattle, Washington
S. Angielski* (231), Department of Clinical Biochemistry, Medical Aca
demy, Gdansk, Poland
G. D. Aurbach* (239), Metabolic Diseases Branch, NIAMDD, National
Institutes of Health, Bethesda, Maryland
P. F. Baker (3), Department of Physiology, King's College, London,
United Kingdom
G. L. Becker* (79), Department of Biochemistry, University of Alabama
in Birmingham, Birmingham, Alabama
C. Bellaton (147), Ecole Pratique des Hautes Etudes, Unite INSERM
U45, Hôpital Ε. Herriot, Lyon, France
D. M. Biddulph* (243), Department of Anatomy, Bowman Gray School of
Medicine, Winston-Salem, North Carolina
S. J. Birge* (181), Department of Medicine, Washington University,
School of Medicine, St. Louis, Missouri
M. P. Blaustein* (53), Department of Physiology, University of Maryland,
School of Medicine, Baltimore, Maryland
J. H. Bloor (269), Division of Gastroenterology and Nutrition, Department
of Medicine, State University of New York at Buffalo, Buffalo,
New York
J. P. Bonjour* (185, 215), Department of Pathophysiology, University of
Bern, Bern, Switzerland
A. B. Borle* (193), Department of Physiology, School of Medicine, Univer
sity of Pittsburgh, Pittsburgh, Pennsylvania
J. E. Bourdeau* (199), Department of Medicine, Northwestern University
Medical School, and V. A. Lakeside Medical Center, Chicago, Illinois
* Workshop participant.
xi
xii Contributors
J. M. Brenza (95), Department of Biological Chemistry, School of Med
icine, University of Maryland, Baltimore, Maryland
L. M. Brewer (275), Department of Physiology, New York State of
Veterinary Medicine, Cornell University, Ithaca, New York
M. Brigida (99), Department of Cell Physiology, Boston Biomedical
Research Institute and Department of Biological Chemistry, Harvard
Medical School, Boston, Massachusetts
M. E. Brindak (279), Department of Physiology, New York State College
of Veterinary Medicine, Cornell University, Ithaca, New York
F. Bronner* (135, 147), Department of Oral Biology, School of Dental
Medicine, University of Connecticut, Farmington, Connecticut
M. Buckley (135), Department of Oral Biology, School of Dental Medicine,
University of Connecticut, Farmington, Connecticut
W. H. Burgess (37), Department of Biology, University of Virginia,
Charlottesville, Virginia
E. Carafoli* (9), Laboratory of Biochemistry, Swiss Federal Institute of
Technology (ΕΤΗ), Zurich, Switzerland
P. Caroni* (19), Laboratory of Biochemistry, Swiss Federal Institute of
Technology (ΕΤΗ), Zurich, Switzerland
J. Caverzasio (215), Department of Pathophysiology, University of Bern,
Bern, Switzerland
L. Cheng (117), Gerontology Research Center, National Institute of Health,
Baltimore, Maryland
R. A. Corradino* (275), Department of Physiology, New York State
College of Veterinary Medicine, Cornell University, Ithaca, New York
D. Costello (99), Department of Cell Physiology, Boston Biomedical
Research Institute and Department of Biological Chemistry, Harvard
Medical School, Boston, Massachusetts
L. E. Costello (259), Department of Biochemistry, Merck Sharp & Dohme
Research Laboratories, Rahway, New Jersey
H. S. Cross (173, 293), Department of General and Experimental
Pathology, University of Vienna, Vienna, Austria
M. G. Currie (243), Department of Anatomy, Bowman Gray School of
Medicine, Winston-Salem, North Carolina
S. Czekalski (247), Department of Physiology and Biophysics and Medicine,
Mayo Clinic and Foundation, Rochester, Minnesota
G. Danisi* (185), Department of Pharmacology, University of Geneva,
Switzerland
A. Dasmahapatra (269), Division of Gastroenterology and Nutrition,
Department of Medicine, School of Medicine, State University of New
York at Buffalo, Buffalo, New York
H. De Jonge (159), Department of Biochemistry I, Erasmus University,
Rotterdam
T. P. Dousa (247), Department of Physiology and Biophysics and
Contributors xiii
Medicine, Mayo Clinic and Foundation, Rochester, Minnesota
K. Drewnowska (231), Department of Clinical Biochemistry, Medical
Academy, Gdansk, Poland
M. Endo (87), Department of Pharmacology, Tohoku University, Sendai,
Japan
M. P. Esnouf (25), Inorganic Chemistry Laboratory, University of Oxford,
Oxford, England
J. N. Fain* (255), Section of Physiological Chemistry, Division of Biology
and Medicine, Brown University, Providence, Rhode Island
D. D. Fanestil* (123), Department of Medicine, University of California,
San Diego, La Jolla, California
D. K. Fast (221), MRC Genetics Group, De Belle Laboratory for
Biochemical Genetics, McGill University—Montreal Children's
Hospital Research Institute, Montreal, Quebec, Canada
G. Fiskum (73), Department of Physiological Chemistry, Johns Hopkins
University, Baltimore, Maryland
H. Fleisch (215), Department of Pathophysiology, University of Bern, Bern,
Switzerland
N. Flowers (99), Department of Cell Physiology, Boston Biomedical
Research Institute and Department of Biological Chemistry, Harvard
Medical School, Boston, Massachusetts
R. A. Freedman (269), Division of Gastroenterology and Nutrition,
Department of Medicine, School of Medicine, State University of New
York at Buffalo, Buffalo, New York
J. Froehlich (15), National Institute on Aging, Gerontology Research
Center, Baltimore, Maryland
R. Fuchs* (173), Department of General and Experimental Pathology,
University of Vienna, Vienna, Austria
C. S. Fullmer (279), Department of Physiology, New York State College of
Veterinary Medicine, Cornell University, Ithaca, New York
W. Ghijsen* (159), Department of Physiology, University of Nijmegen,
Nijmegen, The Netherlands
G. Giebisch* (225), Department of Physiology, Yale University School of
Medicine, New Haven, Connecticut
P. Giraud (25), Inorganic Chemistry Laboratory, University of Oxford,
Oxford, England
P. Gmaj (231), Department of Clinical Biochemistry, Medical Academy,
Gdansk, Poland
T. K. Gray (167), Department of Medicine and Pharmacology, University
of North Carolina, Chapel Hill, North Carolina
G. Hellmann (67), Institute of Pharmacology, University of Vienna,
Vienna, Austria
B. Hildmann* (111), Max Plank Institut fur Biophysik, Frankfurt,
Germany
xiv Contributors
T. R. Hinds (45), Department of Pharmacology, University of Washington,
Seattle, Washington
G. Inesi (87), Department of Physiology, University of Maryland,
Baltimore, Maryland
M. Iskandarani (151), Gastroenterology Research Laboratories, College of
Medicine, University of Iowa, Iowa City, Iowa
K. J. Isselbacher* (129), Department of Medicine, University of California,
San Diego, La Jolla, California
P. Jaeger* (225), Department of Physiology, Yale University School of
Medicine, New Haven, Connecticut
P. Jirounek (185), Department of Pharmacology, University of Geneva,
Switzerland
J. Joost (209), Department of Physiology, University of Innsbruck,
Innsbruck, Austria
G. J. Kaczorowski* (259), Department of Biochemistry, Merck Sharp &
Dohme Research Laboratories, Rahway, New Jersey
M. Kadoma (15), National Institute on Aging, Gerontology Research
Center, Baltimore, Maryland
B. Karlmark (225), Department of Physiology, Yale University School of
Medicine, New Haven, Connecticut
A. M. Katz* (59), Division of Cardiology, Department of Medicine,
University of Connecticut Health Center, Farmington, Connecticut
R. J. Kessler (123), Department of Medicine, University of California, San
Diego, La Jolla, California
R. Kinne* (105), Department of Cell Physiology, Albert Einstein College of
Medicine, Bronx, New York
R. E. Klevit (25), Inorganic Chemistry Laboratory, University of Oxford,
Oxford, England
F. G. Knox* (247), Department of Physiology and Biophysics and
Medicine, Mayo Clinic and Foundation, Rochester, Minnesota
N. Kolassa (67), Institute of Pharmacology, University of Vienna, Vienna,
Austria
S. Kowarski (155), Department of Physiology, College of Physicians and
Surgeons, Columbia University, New York, New York
R. H. Kretsinger* (31, 37), Department of Biology, University of Virginia,
Charlottesville, Virginia
H. E. Kuntziger* (251), Department of Nephrology, Centre Hospitalier de
Luxembourg, Luxembourg
F. Lang* (209), Department of Physiology, University of Innsbruck,
Innsbruck, Austria
C. O. Lee (203), Department of Physiology, Cornell University Medical
College, New York, New York
A. L. Lehninger* (73), Department of Physiological Chemistry, Johns
Hopkins University, Baltimore, Maryland
Contributors XV
J. H. Lipton (135), Department of Oral Biology, School of Dental
Medicine, University of Connecticut, Farmington, Connecticut
I. Litosch (255), Section of Physiological Chemistry, Division of Biology
and Medicine, Brown University, Providence, Rhode Island
R. S. Lorenc* (167), Department of Biochemistry and Experimental
Medicine, Hospital-Monument Child's Health Center, Warsaw,
Poland
M. Lorenzen (203), Department of Physiology, Cornell University Medical
College, New York, New York
J. E. Mcintosh (289), Department of Microscopic Anatomy, Baylor College
of Dentistry, Dallas, Texas
J. A. Maclaughlin (269), Division of Gastroenterology and Nutrition,
Department of Medicine, School of Medicine, State University of New
York at Buffalo, Buffalo, New York
E. Marcinowska-Suchowierska (167), Department of Biochemistry and
Experimental Medicine, Hospital-Monument Child's Health Center,
Warsaw, Poland
A. Miller III (135), Department of Oral Biology, School of Dental Medicine,
University of Connecticut, Farmington, Connecticut
D. L. Miller (151), Gastroenterology Research Laboratories, University of
Iowa, College of Medicine, Iowa City, Iowa
R. Miihlbauer (215), Department of Pathophysiology, University of Bern,
Bern, Switzerland
H. Murer* (111), Physiologisches Institut, Universitat, Zurich, Switzerland
H. N. Nellans* (163), Department of Physiology and Medicine, College of
Physicians and Surgeons, Columbia University, New York, New York
I. Nemere (262), Department of Biochemistry, University of California,
Riverside, California
D. Nicholls* (83), Neurochemistry Laboratory, Department of Psychiatry,
Dundee University, Dundee, Scotland
A. W. Norman* (263), Department of Biochemistry, University of
California, Riverside, California
H. Oberleithner* (209), Department of Physiology, University of
Innsbruck, Innsbruck, Austria
D. Pansu* (135, 147), Laboratoire de Pathologie, et Thérapeutique des
Echanges Minéraux, Pavillion Hbis, Hôpital E. Herrot, Lyon, France
D. Pastner (209), Department of Physiology, University of Innsbruck,
Innsbruck, Austria
M. Peterlik* (173, 293), Department of General and Experimental
Pathology, University of Vienna, Vienna, Austria
B. Plank (67), Institute of Pharmacology, University of Vienna, Vienna,
Austria
J. R. Popovitch (163), Department of Physiology and Medicine, College of
Physicians and Surgeons, Columbia University, New York, New York
xvi Contributors
P. Preis (67), Institute of Pharmacology, University of Vienna, Vienna,
Austria
J. A. Putkey (263), Department of Biochemistry, University of California,
Riverside, California
T. Hong Que (231), Department of Clinical Biochemistry, Medical
Academy, Gdansk, Poland
H. Rasgado-Flores (53), Department of Physiology, School of Medicine,
University of Maryland, Baltimore, Maryland
J. Reeves* (15), Department of Physiology, Internal Medicine and
Pharmacology, University of Texas Health Sciences Center at Dallas,
Dallas, Texas
M. Rouiller (185), Department of Pharmacology, University of Geneva,
Switzerland
S. E. Rudnick (31), Department of Biology, University of Virginia,
Charlottesville, Virginia
B. Sacktor* (117), Gerontology Research Center, National Institutes of
Health, Baltimore, Maryland
A. Scarpa (87), Department of Physiology, University of Pennsylvania,
Philadelphia, Pennsylvania
D. Schachter* (155), Department of Physiology, College of Physicians and
Surgeons, Columbia University, New York, New York
H. P. Schedl* (151), Gastroenterology Research Laboratories, College of
Medicine, University of Iowa, Iowa, City, Iowa
S. Schwarz (209), Department of Physiology, University of Innsbruck,
Innsbruck, Austria
C. R. Scriver* (221), MRC Genetics Group, De Belle Laboratory for
Biochemical Genetics, McGill University—Montreal Children's
Hospital Research Institute, Montreal, Quebec, Canada
A. E. Shamoo* (95), Department of Biological Chemistry, School of
Medicine, University of Maryland, Baltimore, Maryland
H. Shuman (87), Department of Physiology, University of Pennsylvania,
Philadelphia, Pennsylvania
R. P. Singh (3, 135), Department of Oral Biology, University of
Connecticut, School of Dental Medicine, Farmington, Connecticut
W. P. Smales, (243), Department of Anatomy, Bowman Gray School of
Medicine, Winston-Salem, North Carolina
P. M. Sokolove (95), Department of Biological Chemistry, School of
Medicine, University of Maryland, Baltimore, Maryland
A. P. Somlyo (87), Department of Physiology, University of Pennsylvania,
Philadelphia, Pennsylvania
Α. V. Somlyo* (87), Department of Physiology, University of
Pennsylvania, Philadelphia, Pennsylvania
R. W. Straub (185), Department of Pharmacology, University of Geneva,
Geneva, Switzerland
Contributors xvii
J. Suko* (67), Institute of Pharmacology, University of Vienna, Vienna,
Austria
J. Sutko (15), Department of Physiology, Internal Medicine, and
Pharmacology, University of Texas Health Sciences Center at Dallas,
Dallas, Texas
M. Szczepanska-Konkel (231), Department of Clinical Biochemistry,
Medical Academy, Gdansk, Poland
H. Takenaka (59), Division of Cardiology, Department of Medicine,
University of Connecticut Health Center, Farmington, Connecticut
A. Taylor (203), Department of Physiology, Cornell University Medical
College, New York, New York
A. N. Taylor* (289), Department of Microscopic Anatomy, Baylor College
of Dentistry, Dallas, Texas
C. A. Telakowski-Hopkins (259), Department of Biochemistry, Merck
Sharp & Dohme Research Laboratories, Rahway, New Jersey
H. S. Tenenhouse (221), MRC Genetics Group, De Belle Laboratory for
Biochemical Genetics, McGill University—Montreal Children's
Hospital Research Institute, Montreal, Quebec, Canada
W. Tew (73), Department of Physiological Chemistry, Johns Hopkins
University, Baltimore, Maryland
W. Trumble (15), Department of Physiology, Internal Medicine, and
Pharmacology, University of Texas Health Sciences Center at Dallas,
Dallas, Texas
C. Van Os (159), Department of Physiology, College of Physicians and
Surgeons, Columbia University, New York, New York
R. L. Vandlen (259), Department of Biochemistry, Merck Sharp & Dohme
Research Laboratories, Rahway, New Jersey
A. Vercesi (73), Department of Physiological Chemistry, Johns Hopkins
University, Baltimore, Maryland
F. F. Vincenzi* (45), Department of Pharmacology, University of
Washington, Seattle, Washington
J. Vitus (185), Department of Pharmacology, University of Geneva,
Switzerland
R. H. Wasserman* (279), Department of Physiology, New York State
College of Veterinary Medicine, Cornell University, Ithaca, New York
M. W. Weiser* (269), Division of Gastroenterology and Nutrition,
Department of Medicine, School of Medicine, State University of New
York at Buffalo, Buffalo, New York
R. J. P. Williams* (25), Inorganic Chemistry Laboratory, University of
Oxford, Oxford, England
Ε. E. Windhager* (203), Department of Physiology, Cornell University
Medical College, New York, New York
H. Wohlrab* (99), Department of Cell Physiology, Boston Biomedical
Research Institute and Department of Biological Chemistry, Harvard
Medical School, Boston, Massachusetts
xviii Contributors
R. W. Wrenn (243), Department of Anatomy, Bowman Gray School of
Medicine, Winston-Salem, North Carolina
J. Wrobel* (143), Department of Biochemistry, Medical School, Gdansk,
Poland
