BRS Biochemistry, Molecular Biology, and Genetics, Fifth Edition (Board Review Series)

398 Pages·2009·19.81 MB·English

by  Todd A. Swanson

Biochemistry, Molecular
Biology, and Genetics
Todd A. Swanson, M.D., Ph.D.
Resident in Radiation Oncology
William Beaumont Hospital
Royal Oak, Michigan
Sandra I. Kim, M.D., Ph.D.
Division of Nuclear Medicine and Molecular Imaging
Massachusetts General Hospital
Boston, Massachusetts
Marc J. Glucksman, Ph.D.
Professor, Department of Biochemistry and Molecular Biology
Director, Midwest Proteome Center
Rosalind Franklin University of Medicine and Science
The Chicago Medical School
North Chicago, Illinois
WITH EDITORIAL CONSULTATION BY
Michael A. Lieberman, Ph.D.
Dean, Instructional and Research Computing, UCit
Distinguished Teaching Professor
University of Cincinnati
Cincinnati, OH
Acquisitions Editor: Charles W. Mitchell
Product Manager: Stacey L. Sebring
Marketing Manager: Jennifer Kuklinski
Designer: Holly Reid McLaughlin
Compositor: Cadmus Communications
Printer: C & C Offset Printing
Copyright
C 2010 Lippincott Williams &Wilkins
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The publisher is not responsible (as a matter of product liability, negligence, or otherwise) for any injury resulting
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dosages, and precautions.
Printed in Hong Kong
First Edition, 1990
Second Edition, 1994
Third Edition, 1999
Fourth Edition, 2007
Library of Congress Cataloging-in-Publication Data
Swanson, Todd A.
Biochemistry, molecular biology, and genetics / Todd A. Swanson, Sandra I. Kim, Marc J. Glucksman ; with
editorial consultation by Michael A. Lieberman. — 5th ed.
p. ;cm. — (Board review series)
Rev. ed. of: Biochemistry and molecular biology / Todd A. Swanson, Sandra I. Kim, Marc J. Glucksman. 4th ed.
c2007.
Includes bibliographical references and index.
ISBN 978-0-7817-9875-4 (hardcopy : alk. paper) 1. Biochemistry—Examinations, questions, etc. 2. Molecular
biology—Examinations, questions, etc. I. Kim, Sandra I. II. Glucksman, Marc J. III. Lieberman, Michael, 1950- IV.
Swanson, Todd A. Biochemistry and molecular biology. V. Title. VI. Series: Board review series.
[DNLM: 1. Biochemical Phenomena—Examination Questions. 2. Biochemical Phenomena—Outlines.
3. Genetic Processes—Examination Questions. 4. Genetic Processes—Outlines. QU 18.2 S972b 2010]
QP518.3.S93 2010
572.8076—dc22
2009029693
The publishers have made every effort to trace the copyright holders for borrowed material. If they have
inadvertently overlooked any, they will be pleased to make the necessary arrangements at the first opportunity.
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For
Olga, Maxwell, Anneliese, and the eagerly awaited
new addition to the Swanson clan.
If not for you, all my efforts would be in vain.
Preface
This revision of BRS Biochemistry, Molecular Biology, and Genetics includes additional
high-yield material to help the reader master clinical principles of medical biochemistry as
they prepare for the revamped Step 1 USMLE. Our goal is to offer a review book that both
lays the foundations of biochemistry and introduces clinically relevant correlates. In doing
so, we have de-emphasized some of the rote memorization of structures and formulas that
often obscure the big picture of medical biochemistry. Clinical Correlates in each chapter
provide additional clinical insight, distilling numerous clinical correlations into a format
that offers the highest yield in review. We hope that these correlations will help answer a
commonly asked question: ‘‘Why do we have to know this for the boards?’’
This revised edition also includes a new chapter on genetics as related to medical bio-
chemistry. We hope this chapter will augment other review texts on genetics that students
may consult in preparation for Step 1.
Many of the questions at the end of each chapter have been revised to maximize their
value for the student preparing for the exam. A comprehensive exam at the end of this vol-
ume reinforces the concepts of the text. Our objective has been to provide the student with
clinically relevant questions in a format similar to that encountered on the USMLE Step 1
Boards. The breadth of questions is one of the many features of Lippincott’s Board Review
Series titles.
We hope that the new edition of BRS Biochemistry, Molecular Biology, and Genetics
becomes a valuable tool for students seeking high-yield resources as they prepare for the
USMLE Step 1. We recognize the changing nature of science and medicine, however, and
encourage readers to send suggestions for improvement for this text or for our companion
flash cards, to us via e-mail at LWW.com.
Todd Swanson
Sandra Kim
Marc Glucksman
v
Publisher’s Preface
The Publisher acknowledges the editorial consultation of Michael A. Lieberman, Ph.D.,
to this fifth edition. In addition to his role as editorial consultant on every chapter,
Dr. Lieberman reviewed the entire manuscript to help ensure the accuracy, consis-
tency, and timeliness of its content.
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