Table Of ContentBRAIN PLASTICITY,
LEARNING,
AND MEMORY
ADVANCES IN BEHAVIORAL BIOLOGY
Editorial Board:
Jan Bures Institute of Physiology, Prague, Czechoslovakia
Irwin Kopln National Institute of Mental Health, Bethesda, Maryland
Bruce McEwen Rockefeller University, New York, NfJw York
James McGaugh University of California, Irvine, California
Karl Prlbram Stanford University School of Medicine, Stanford, California
Jay Rosenblatt Rutgers University, Newark, New Jersey
Lawrence Welskrantz University of Oxford, Oxford, England
Recent Volumes in this Series
Volume 17 ENVIRONMENTS AS THERAPY FOR BRAIN DYSFUNCTION
Edited by Roger N. Walsh and William T. Greenough
Volume 18 NEURAL CONTROL OF LOCOMOTION
Edited by Richard M. Herman, Sten Grillner, Paul S. G. Stein,
and Douglas G. Stuart
Volume 19 THE BIOLOGY OF THE SCHIZOPHRENIC PROCESS
Edited by Stewart Wolf and Beatrice Bishop Berle
Volume 20 THE SEPTAL NUCLEI
Edited by Jon F. DeFrance
Volume 21 COCAINE AND OTHER STIMULANTS
Edited by Everett H. Ellinwood, Jr. and M. Marlyne Kilbey
Volume 22 DISCRIMINATIVE STIMULUS PROPERTIES OF DRUGS
Edited by Harbans Lal
Volume 23 THE AGING BRAIN AND SENILE DEMENTIA
Edited by Kalidas Nandy and Ira Sherwin
Volume 24 CHOLINERGIC MECHANISMS AND PSYCHOPHARMACOLOGY
Edited by Donald J. Jenden
Volume 25 CHOLINERGIC MECHANISMS: Phylogenic Aspects, Central and
Peripheral Synapses, and Clinical Significance
Edited by Giancarlo Pepeu and Herbert Ladinsky
Volume 26 CONDITIONING: Representation of Involved Neural Functions
Edited by Charles D. Woody
Volume 27 THE BASAL GANGLIA: Structure and Function
Edited by John S. McKenzie, Robert E. Kemm,
and Lynette N. Wilcock
Volume 28 BRAIN PLASTICITY, LEARNING, AND MEMORY
Edited by B. E. Will, P. Schmitt, and
J. C. Dalrymple-Alford
A Continuation Order Plan is available for this series. A continuation order will bring
delivery of each new volume immediately upon publication. Volumes are billed only upon
actual shipment. For further information please contact the publisher.
BRAIN PLASTICITY,
LEARNING,
AND MEMORY
Edited Dy
B. E. Will
Louis Pasteur University
Strasbourg, France
P. Schmitt
CNRS
Center for Neurochemistry
Strasbourg, France
and
J. C. Dalrymple-Alford
Louis Pasteur University
Strasbourg, France
PLENUM PRESS • NEW YORK AND LONDON
Library of Congress Cataloging in Publication Data
EBBS-SFECA Workshop on Brain Plasticity, Learning, and Memory (1984: Strasbourg, France)
Brain plasticity, learning, and memory.
(Advances in behavioral biology;v. 28)
Proceedings of an EBBS-SFECA Workshop on Brain Plasticity, Learning, and Memory, held
Aug. 30-Sept. 1, 1984, in Strasbourg, France.
Bibliography: p.
Includes indexes.
1. Learning-Physiological aspects-Congresses. 2. Memory-Congresses. 3. Neural cir
cuitry-Adaptation-Congresses. 3. Brain-Growth-Congresses. I. Will, Bruno. II. Schmitt,
Pierre. III. Dalrymple-Alford, J. C. (John C.) IV. European Brain and Behaviour Society. V. Socie'te'
frangaise pour I'etude du comportement animal. VI. Title. VII. Series.
QP408. E33 1984 153.1 85-12139
ISBN-13: 978-1-4684-5005-7 e-ISBN-13: 978-14684-5003-3
DOl: 10.1007.1978-1-4684-5003-3
Proceedings of an EBBS-SFECA workshop on Brain Plasticity, Learning,
and Memory, held August 30-September 1, 1984, in Strasbourg, France
(OJ 1985 Plenum Press, New York
A Division of Plenum Publishing Corporation
233 Spring Street, New York, N.Y. 10013
Softcover reprint of the hardcover 1s t edition 1985
All rights reserved
No part of this book may be reproduced, stored in a retrieval system, or transmitted,
in any form or by any means, electroniC, mechanical, photocopying, microfilming,
recording, or otherwise, without written permission from the Publisher
PREFACE
This book is the result of the contributions presented at a conference
held from August 30 to September 1, 1984 at the Universite Louis Pasteur,
Strasbourg, France. This meeting was organized under the joint auspices of
the European Brain and Behaviour Society (EBBS) and the Societe Fran~aise
pour 1 'Etude du Comportement Animal (SFECA).
The objective of this meeting was to bring together an international
group of participants to evaluate and to report on recent research in three
broad and overlapping fields within the general theme of the relationships
between brain plasticity and learning and memory. These three fields are
"developmental plasticity" "adaptive plasticity" and "restorative
plas tici ty." Al though the boundaries between these fie Ids are a rna t ter of
debate (see Introduction), they have been retained as the major sections of
this volume, the arrangement of which roughly parallels that of the meeting.
We believe and very much hope that the contents of this volume convey an
internal consistency despite the diversity of the material presented.
Developmental plasticity constitutes the first part of the book in which
are considered the repercussions of early external or intracerebral
stimulation and of early learning on brain development. These chapters are
based on studies on imprinting phenomena and visuocortical plasticity,
followed by work on the modulatory role of noradrenalin in plasticitv in
immature animals. The second part of this book, on adaptive plasticity in
adult animals, first presents chapters that describe some of the biochemical,
morphological and electrophysiological (long-term and short-term
potentiation) alterations that accompany or underlie learning and memory
processes. These chapters are complemented by work on the selective
activation of cerebral stuctures, together with sections on noradrenergic,
neuroendocrine and peptidergic factors that modulate learning and memory in
adult animals. The section on restorative plasticity presents chapters
looking at responses to different kinds of brain dysfunction in young, adult
and aged organisms, mostly in animals. This part of the book is completed by
several chapters that deal with the "recovery of function" in animals with
experimental brain lesions. These final chapters describe factors that play
a role in the expression of lesion-induced deficits and ways to reduce such
deficits. In addition, most of the poster abstracts, which summarise a
considerable amount of further information on brain plasticity, learning and
memory, are presented in an appendix.
We gratefully acknowledge the following organizations for financial
support: Dausse Labs., Merrell Dow Research Inst., Preclinical Research
Division of Sandoz Ltd., and the Conseil General du Bas-Rhin, Strasbourg.
Facilities and assistance were kindly provided by the Universite Louis
Pasteur and by the Mairie de Strasbourg. We are also indebted to our
colleagues F. Deluzarche, C. Kelche, C. Pacteau, V. Pallage and G. Toniolo of
the Laboratoire de Neurobiologie des Comportements, and M-J. Angst, A.
v
Boehrer, P. Carrive, B. Fritsch, B. Jardon, J-L. Moreau and G. Rudolf of the
Laboratoire de Neurophysiologie for their tremendotls work which contributed
to the success of this meeting. We thank Professor P. Karli, acting
president of the EBBS, for his assistance and for his welcoming address.
Special thanks are also due to Professor J. McGaugh and Dr. S. Sara for their
help in organizing the sessions on neuroendocrine and catecholaminergic
modulation of learning and memory.
Bruno E. Will
Pierre Schmitt
John C. Dalrymple-Alford
March 1985
vi
CONTENTS
INTRODUCTION
Brain plasticity, learning and memory: Historical background
and conceptual perspectives 1
B. Will, P. Schmitt and J. Dalrymple-Alford
DEVELOPMENTAL PLASTICITY: THE NEUROBIOLOGY OF LEARNING AND MEMORY
DURING ONTOGENY
Alterations induced by early learning and early stimulation
Imprinting and the neural basis of memory 13
G. Horn
Morphological correlates of imprinting 21
P.M. Bradley, G. Horn and B.J. McCabe
Noradrenaline and its possible role in imprinting 29
D.C. Davies, G. Horn and B.J. McCabe
The cell biological consequences of passive avoidance training
in the chick 39
S.P.R. Rose
Influence of developmental factors on imprinting 51
H.-J. Bischof
Extraretinal factors controlling the development of neuronal
selectivity 61
M. Imbert
Changes in the avian visual Wulst following early monocular
deprivation 71
P. Bagnoli, G. Casini and R. Alesci
Noradrenergic modulation of learning and brain plasticity
Are Beta adrenoreceptors involved in visuocortical plasticity? 79
T. Kasamatsu and T. Shirokawa
Role of the locus coeruleus system in behavioral plasticity 85
L. Velley, E. Kempf, J. Velly and B. Cardo
vii
ADAPTIVE PLASTICITY: TIlE NEUJtOBIOLOGY OF LEARNING AND HKKORY IN
ADULT ORGANISMS
Bioehe~cal and morphological alterations
Role of serotonin and cAMP on short-term plastic changes
underlying simple forms of learning process 97
M. Brunelli, G. Demontis and G. Traina
Protein kinase C and substrate protein Fl (47 kD, 4.5 pI):
Relation to synaptic plasticity and dendritic spine growth 107
A. Routtenberg
Turnover of cerebral DNA in learning and sleep 119
A. Giuditta, C.P. Capano and M.V. Ambrosini
Hippocampal mossy fiber distribution and two-way avoidance
learning in rats and mice 127
H. Schwegler, B. Heimrich, W.E. Crusio and H.P. Lipp
Short-term and long-term potentiation
What can the long-term potentiation procedure tell us about the
neural mechanisms of learning and memory? 139
S. Laroche
What does the "LTP model of memory" model? 157
G. Buzsaki
Selective activation of cerebral structures
The cholinergic septo-hippocampal pathway, learning and memory 167
R. Jaffard, D. Galey, J. Micheau and T. Durkin
Sequential intervention of different limbic structures in
memory processes 183
c. Destrade, M. Gauthier and J. Sif
Post-learning paradoxical sleep: A critical period when new
memory is reactivated? 193
E. Hennevin and B. Hars
Modulari ty of the prosencephalon: The vertical systemps 205
I. Divac and J. Mogensen
Catechola~nergic modulation of learning and memory
Selective attention, memory, and the locus coeruleus 211
S.J. Sara
Noradrenaline and selective attention 219
T.W. Robbins and B.J. Everitt
Modulation of spontaneous and sensory-evoked discharge of locus
coeruleus neurons by behavioral state: Functional implications 227
G. Aston-Jones
viii
/Mechanisms of action of norad["enali"le in the b["ain 235
M. Segal
.IModulation of selective processes in learning by neocortical
and limbic dopamine: Studies of behavioural strategies 241
R. Oades, M. Rea and K. Taghzouti
Neuroendocrine and peptidergic modulation of learning and memory
Hormonal influences on memory: InteractIon of central and
peripheral systems 253
J.L. McGaugh, K.C. Liang, M.C. Bennett and D.B. Sternberg
Effects of central administration of corticosterone or
adrenalectomy in mice on memory and evoked activity in the
hippocampus 261
E. Pomet, J. Micheau, E. Carlier and B. Soumireu-Mourat
Vasopressin, hippocampal excitability and paired-pulse
potentiation 275
J.E. Smithson and H.W. Brown
Effects of lysine-vasopressin on spontaneous behavior and
learning in appetitive tasks in the rat 285
T. Alexinsky and J. Alliot
Oxytocin and vasopressin. in memory and amnesia 297
G.L. Kovacs, G. Telegdy, F. Laczi and F.A. Laszlo
Cholecystokinin, learning and memory 303
G. Telegdy, T. Kadar and M. Fekete
Possible involvement of neuroexcitatory amino acids and related
pep tIdes in learning and memory processes 311
A. Ungerer, M. Bourgeois, J. Reinbolt and Y. Boulanger
RESTORATIVE PLASTICITY: BRAIN DAMAGE AND FUNCTIONAL RECOVERY
Early brain da.age
Functional deficits and anatomical sparing after prenatal brain
damage in the rat 321
S.C. Pereira, C.R. Legg, I. Steele Russell and M. Glickstein
Visual discrimination learning in rats following early life
undernutrition: Recent findings and review 331
J.L. Smart and J. Tonkiss
Ontogeny of acquisition and retention of two-way active
avoidance in the ["at: Effects of early septal damage 343
F. Eclanche ["
Dissociation of two behavioral fllnctions in the monkey 'lfter
early hippocampal ablations 353
H. Mahu t
ix
