Table Of ContentBRAIN EDEMA
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BRAIN EDEMA
Proceedings of the Symposium
September 11-13, 1965, Vienna
Edited by
Igor Klatzo
National Institute of Neurological Diseases and Blindness
National Institutes of Health
Bethesda, Maryland, U.S.A.
and
Franz Seitelberger
Neurologisches Institut der UniversiHit Wien, Austria
SPRINGER-VERLAG • WIEN • NEW YORK • 1967
ISBN-13: 978-3-7091-7547-7 e-ISBN-13: 978-3-7091-7545-3
001: 10.1007/978-3-7091-7545-3
All rights, especially that of translation into foreign langnages, reserved.
It is also forbidden to reproduce this book, either whole or in part, by photomechanical
means (photostat, microfilm and/or microcard) or by other procedure without written
permission from Springer-Verlag New York Inc.
Library of Congress Catalog Card Number 67-26445
Title No. 9219
© 1967 by Springer-Verlag New York Inc.
Softeover reprint of the hardcover 1st edition 1967
Contributors
BITO, L., Department of Ophthalmology, College of Physicians and
Surgeons, Columbia University, New York, New York, U.S.A,
BLASBERG, R., New York State Research Institute for Neuro
chemistry and Drug Addiction, Ward's Island, New York, New
York, U.S.A.
BRADBURY, M., Cedars Sinai Hospitals, Los Angeles, California,
U.S.A.
BRZEZINSKI, J., Department of Neurosurgery, University of
Lund, Sweden
BUBIS, J.J., Department of Pathology, Tel-AvivUniversityMedical
School, Tel-Hashomer Government Hospital, Tel-Aviv, Israel
DUFTY, M. L., Department of Pathology, New York Hospital
Cornell Medical Center, New York, New York, U.S.A.
EBELS, E. J., Neurosurgical Clinic, Groningen, Netherlands
ESCOLA,*J., Max-Planck-Institut fUr Hirnforschung, Frankfurt/
M.-Niederrad, Germany
FRANKE, H. D., Department of Anatomy and Department of
Radiology, University of Hamburg, Germany
FRENCH, L. A., Division of Neurosurgery, University of Min
nesota Hospitals, Minneapolis, Minnesota, U.S.A.
GARRO, F., Division of Neuropathology, Armed Forces Institute
of Pathology, Washington, D.C., U.S.A.
GIORDANO, P. L., Clinica Psichiatrica Dell' Universita di Milano,
Italy
GORDON, J. S., Department of Pathology, New York Hospital
Cornell Medical Center, New York, New York, U.S.A.
HARTMANN, J. F., Department of Neurology, Presbyterian-St.
Luke's Hospital, Chicago, illinois, U.S.A.
HASS, G. M., Department of Biochemistry, Presbyterian-St.
Luke's Hospital, Chicago, illinois, U.S.A.
HAYMAKER, W., National Aeronautics and Space Administration,
Ames Research Center, Moffett Field, California, U.S.A.
HESS, 0., Institute of Pathochemistry and General Neurochemistry,
University of Heidelberg, Germany
INVERNIZ ZI, G., Clinica Psichiatrica Dell' Uni versita di Milano, Italy
*Deceased
v
vi Contributors
KALSBECK, J., Divisions of Neuropathology and Neurosurgery,
Indiana University Medical Center, Indianapolis, Indiana, U.S.A.
KARCHER, D., Institut Bunge, Berchem-Anvers, Belgium
KJALLQUIST, A., Department of Neurosurgery, University of
Lund, Sweden
KLEIHUES, P., Max-Planck-Institute fur Hirnforschung Abteilung
fUr Allgemeine Neurologie, Koln-Merheim, Germany
KONDO, Y., Department of Neurosurgery, University of Kyoto,
Japan
LAING, I., Department of Biochemistry, Presbyterian-St. Luke's
Hospital, Chicago, Illinois, U.S.A.
LEVI, G., Department of Neurology, University of Florence, Italy
LEVINE, S., Laboratory Division, Montefiore Hospital, New York
Medical College Center for Chronic Disease, New York,
New York, U.S.A.
OZAWA, K., Department of Neurosurgery, University of Kyoto,
Japan
PALMEIRO, J. F., Max-Planck-Institutftir Hirnforschung Abteilung
fUr Allgemeine Neurologie, Koln-Merheim, Germany
PANDOLFI,. S., Department of Biochemistry, Presbyterian-St.
Luke's Hospital, Chicago, Illinois, U.S.A.
PEARSON, D., Division of Neurological Surgery, University CliniCS,
University of Chicago, Illinois., U.S.A.
PONTEN, U., Department of Neurosurgery, University of Lund,
Sweden
RALL, D. P., Laboratory of Chemical Pharmacology, National
Cancer Institute, Bethesda, Maryland, U.S.A.
RIVERSON, E., Max-Planck-Institut fUr Hirnforschung Abteilung
fur Allgemeine Neurologie, KBln-Merheim, Germany
SCHRODER, J. M., Max-Planck-Institut fUr Hirnforschung Abteilung
fur Allgemeine Neurologie, Koln-Merheim, Germany
SIESJO, B. K., Department of Neurosurgery, University of Lund,
Sweden
SKY-PECK, H. H., Department of Biochemistry, Presbyterian-St.
Luke's Hospital, Chicago, Illinois, U.S.A.
STREICHER, E., National Institute of Neurological Diseases and
Blindness, National Institutes of Health, Bethesda, Maryland,
U.S.A.
TER WEEME, C. A., Neurosurgical Clinic, Groningen, Netherlands
TSUJI, H. Department of Neurosurgery, University of Kyoto, Japan
t
WISNIEWSKI, H., Neuropathologisches Institut, Warschau, Poland
Active Participants
ADAMS, R. D., Massachusetts General Hospital, Boston Massa
chusetts, U.S.A.
BAKAY, L., Edward J. Meyer Memorial Hospital, University of
Buffalo, New York, U.S.A.
BEKS, J. W. F., Neurosurgical Clinic, Groningen, Netherlands
BRIGHTMAN, M. W., National Institute of Neurological Diseases
and Blindness, National Institutes of Health, Bethesda, Mary
land, U.S.A.
BROMAN, T., Department of Neurology, University of GOteborg,
Sweden
CAVENESS, W. F., National Institute of Neurological Diseases and
Blindness, National Institutes of Health, Bethesda, Maryland,
U.S.A.
CAZZULLO, C. L., Clinica Psichiatrica Dell' Universita di Milano,
Italy
CERVOS-NA VA RRO, J., Institut fUr Neuropathologie der Universitat
Bonn, Germany
CLASEN, R. A., Department of Biochemistry, Presbyterian-st.
Luke's Hospital, Chicago, illinois, U oS.A.
COLMANT, Ho J., Neuropathologisches Institut der Universitlit
Hamburg, Germany
CUMINGS, J. N., Institute of Neurology, Department of Chemical
Pathology, The National Hospital, London, England
DA VSON, H., Department of Physiology, University College, London,
England
EVANS, J. P., Division of Neurological Surgery, University Clinics,
University of Chicago, illinois, U.S.A.
FEIGIN, I., New York University Medical Center, New York, New
York, U.S.A.
FLEISCHHAUER, K., Abteilung fUr Neuroanatomie, Anatomisches
Institut der Universitat Hamburg, Germany
FONCIN, J. F., Laboratoire de Physiologie et Psychologie Neuro
chirurgicales de l'Ecole Pratique des Hautes Etudes, Hopital
de la Salpetriere, Paris, France
GLOWACKI, J., Department of Neurosurgery, AcademyofMedicine~
Cracow, Poland
vii
viii Active Participants
GRUNER, J. E., 123, Boulevard de port royal, Paris XIV, France
HAGER, H., Abteilung fur Neurozytologie, Max-Planck-Institut fur
Psychiatrie, Munchen, Germany
HIRANO, A., Laboratory Division, Montefiore Hospital and Medical
Center, Bronx, New York, U.S.A.
HOFF, H., Psychiatrisch-Neurologische Universitatsklinik, Wien,
Austria
HOSSMANN, K. A., Max-Planck-Institute fiir Hirnforschung,
Abteilung fur Allgemeine Neurologie, Koln-Merheim, Germany
ISHII, S., Division of Neurological Surgery, University Clinics,
University of Chicago, Illinois, U.S.A.
JACOB, H., UniversiHits-Nervenklinik, Marburg/Lahn, Germany
JELLINGER, K., Neurologisches Institut d. Univ. Wien, Austria
KATZMAN, R., Department of Neurology, Albert Einstein College
of Medicine, Bronx, New York, U.S.A.
KIDD, M., Maida Vale Hospital, London, England
KLATZO, I., National Institute of Neurological Diseases and Blind
ness, National Institutes of Health, Bethesda, Maryland, U.S.A.
KOLKMANN, F. W., Neuropathologisches Institut Universit~t
Heidelberg, Germany
KRAUS, H., Neurochirurgische Universitats-Klinik, Wien, Austria
KRUCKE, W., Max-Planck-Institut fur Hirnforschung, Frankfurt/
M.-Niederrad, Germany
LAJTHA, A., New York State Research Institute for Neurochemistry
and Drug Addiction, Ward's Island, New York, New York, U.S.A.
LAMPERT, P., Division of Neuropathology, Armed Forces Institute
of Pathology, Washington, D.C., U.S.A.
LEE, J. C., Buffalo General Hospital, Buffalo, New York, U.S.A.
LIERSE, W., Anatomisches Institut der Universitat Hamburg,
Germany
LONG, D. M. Department of Surgery, University of Minnesota,
Hospitals, Minneapolis, Minnesota, U.S.A.
LOWENTHAL, A., Institut Bunge, Berchem-Anvers, Belgium
McMENEMEY, W. H., Maida Vale Hospital, London, England
MIQUEL, J., National Aeronautics and Space Administration,
Ames Research Center, Moffett Field, California, U.S.A.
OPPELT, W., Department of Pharmacology and Therapeutics,
University of Florida, Gainesville, Florida, U.S.A.
PAPPIUS, H. M., Donner Laboratory of Experimental Neurochem
istry, Montreal Neurological Institute; Department of Neurology
and Neurosurgery, McGill University, Montreal, Canada
PENTSCHEW, A., Division of Neuropathology, Armed Forces In
stitute of Pathology, Washington, D. C., U.S.A.
QUADBECK, G., Institute of Pathochemistry and General Neuro
chemistry, University of Heidelberg, Germany
Active Participants ix
SEITELBERGER, F., Neurologisches Institut der Universitat Wien,
Austria
SLUGA, E., Neurologisches Institut der Universitat Wien, Austria
STEINBEREITHNER, K., Institut fUr Anaesthesiologie, Wien,
Austria
STEINWALL, 0., Department of Neurology, University of GOteborg,
Sweden
TERRY, R., Albert Einstein College of Medicine, Bronx, New York,
U.S.A.
THOMAS, E., Max-Planck-Institut fur Hirnforschung, Frankfurt!
M.-Niederrad, Germany
TORACK, R. M., Department of Pathology, New York Hospital
Cornell Medical Center, New York, New York, U.S.A.
TOWER, D., National Institute of Neurological Diseases and Blind
ness, National Institutes of Health, Bethesda, Maryland, U ,S.A.
ULE, G., Neuropathologisches Institut der Universitat Heidelberg,
Germany
WALKER, A. E., Division of Neurological Surgery, The Johns
Hopkins Hospital, Baltimore, Maryland, U.S,A.
WECHSLER, W., Max-Planck-Institut fUr Hirnforschung Abteilung
fur Allgemeine Neurologie, Ktlln-Merheim, Germany
WOLMAN, M., Department of Pathology, Tel-Aviv UniversityMed
ical School, Tel-Hashomer Government Hospital, Tel-Aviv,
Israel
ZEMAN, W., Divisions of Neuropathology and Neurosurgery,
Indiana University Medical Center, Indianapolis, Indiana, U.S.A.
ZIMMERMAN, H. M., Laboratory Division, Montefiore Hospital,
The New York Medical College Center for Chronic Disease,
New York, New York, U.S.A.
ZULCH, K., Max-Planck-Institut fUr Hirnforschung Abteilung fur
Allgemeine Neurologie, KOln-Merheim, Germany
Introduction
The Symposium on Brain Edema has been organized by the
Osterreichische Arbeitsgemeinschaft fur Neuropathologie and by
the Problem Commission for Neuropathology of the World Federa
tion of Neurology.
We would like to express our thanks to Dr. L. van Bogaert,
president of the W.F.N., for his great interest in the design of
this conference and for his energetic support.
One of the aims ofthe Problem Commission for Neuropathology
has been to contribute to the advances in various problems which
are becoming ripe for elucidation by experts in different fields.
The idea of the Symposium on Brain Edema has as its background
a compelling necessity to elucidate this subject which is clinically
so important and neuropathologic ally so poorly understood. It was
hoped that this could be achieved by a multidisciplinary approach
involving a variety of aspects to be discussed and correlated.
Brain edema, being an abnormal cerebral condition, belongs
basically to the sphere of neuropathology, but to be successful in
our endeavors we had to apply neuropathology in its most modern
and widest terms. By this we understand that such neuropathology
includes the study of all abnormal phenomena in the nervous tissue
related to the structural alterations, and by "structural" we mean
not only tissual or cellular ones but also changes on ultrastructural
and molecular levels. Thus we needed close and integrated coopera
tion of experts in fields such as neurohistology, histochemistry,
electron microscopy, neurochemistry, and neurophysiology.
We fully realized that the sick man suffering from brain edema
is the ultimate motive of our undertaking. For this reason we de
pended greatly on the experience of clinicians who clearly define
the clinical problems involved and contribute to the correlation and
evaluation of the laboratory data. From morphologists we expected
mainly understanding and agreement on histological recognition
and definitions of brain edema, a controversial and confused subj ect
in the past. The experts in the neurobiological sciences tackled the
complex problems dealing with abnormal accumulation of fluid in
the nervous tissue, and by this endeavor they also contributed
substantially to the understanding of the basic mechanisms in the
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