Table Of ContentBone Metastasis and Molecular Mechanisms
Cancer Metastasis - Biology and Treatment
VOLUME 6
Series Editors
Richard J. Ablin, Ph.D., Tnnapharma, Inc., Park Ridge, NJ, U.S.A.
Wen G. Jiang, M.D., University ofW ales College of Medicine, Cardiff, u.K.
Advisory Editorial Board
Harold F. Dvorak, M.D.
Phil Gold, M.D., Ph.D.
Ian R. Hart, Ph.D.
Hiroshi Kobayashi, M.D.
Robert E. Mansel, M.S., FRCS.
Marc Mareel, M.D., Ph.D.
Titles published in this Series are:
Volume I: Cancer Metastasis, Molecular and Cellular Mechanisms and Clinical Intervention.
Editors: Wen G. Jiang and Robert E. Mansel.
ISBN 0-7923-6395-7
Volume 2: Growth Factors and Receptors in Cancer Metastasis.
Editors: Wen G. Jiang, Kunio Matsumoto and Toshikazu Nakamura.
ISBN 0-7923-7141-0
Volume 3: Cancer Metastasis-Related Genes
Editor: Danny R. Welch
ISBN 1-4020-0522-9
Volume 4: Proteases and Thcir Inhibitors in Cancer Metastasis
Editor: Jean-Michel Foidart and Ruth J. Muschel
ISBN 1-4020-0923-2
Volume 5: Micrometastasis
Editor: Klaus Pantel
ISBN 1-4020-1155-5
Bone Metastasis and
Molecular Mechanisms
Pathophysiology
Edited by
Gurmit Singh
Director ofR esearch, Juravinski Cancer Centre/
Professor of Pathology & Molecular Medicine,
McMaster University, Hamilton, Ontario, Canada
and
William Orr
Chair, Department ofP athology, University ofM anitoba,
Winnipeg, Manitoba, Canada
Springer Science+Business Media, B.V.
A C.I.P. Catalogue record for this book is available from the Library of Congress.
ISBN 978-90-481-6563-6 ISBN 978-1-4020-2036-0 (eBook)
DOI 10.1007/978-1-4020-2036-0
Printed on acid-free paper
All Rights Reserved
© 2004 Springer Science+ Business Media Dordrecht
Originally published by Kluwer Academic Publishers in 2004
Softcover reprint of the hardcover 1s t edition 2004
No part of this work may be reproduced, stored in a retrievaI system, or transmitted
in any form or by any means, electronic, mechanical, photocopying, microfilrning, recording
or otherwise, without written permission from the Publisher, with the exception
of any material supplied specifically for the purpose ofbeing entered
and executed on a computer system, for exclusive use by the purchaser of the work.
Dedicated to:
Bone Metastasis Researchers and Cancer Patients.
CONTENTS
List of Contributors ............................................................. .ix
Preface ............................................................................ xv
Gurmit Singh
Chapter 1 ............................................................................ 1
Models of Breast Cancer Metastasis to Bone:
Characterization of a Clinically Relevant Model
Belinda S. Parker, Bederich L. Eckhardt and Robin L. Anderson
Chapter 2 .......................................................................... 19
Quantitation of Bone Metastasis in Experimental Systems
Julie A. Sharp and Erik W. Thompson
Chapter 3 .......................................................................... 31
Comparative Morphometric Study on Bone Remodeling in
Human Specimens and in Experimental Models of
Metastatic Bone Disease
Snezana Vukmirovic-Popovic, Eric Seidlitz, F. William Orr and
Gurmit Singh
Chapter 4 ..........................................................................4 9
Clinical Modalities for the Diagnosis, Characterization and
Detection of Bone Metastases
Michael H. Weber, Jonathan C. Sharp, Thomas H. Hassard,
Martin Reed, James A. Thliveris and F. William Orr
Chapter 5 .......................................................................... 71
Metastasis in the Bone Marrow Microenviroment
Paolo Bianco, Mara Riminucci and Pamela Gehron Robey
vii
Chapter 6 .......................................................................... 87
The Role of Tumor-Associated Macrophages in Metastasis
Associated Osteolysis
Nicholas. A. Athanasou
Chapter 7 ........................................................................ 10 9
The Malignant Hierarchy in Multiple Myeloma:
Relationships between Malignant Cells and Bone Disease
Linda M. Pilarski, Tony Reiman, Patrick M. Pilarski, F. William
Orr and Andrew R. Belch
Chapter 8 ......................................................................... 139
Angiogenesis and Lymphangiogenesis in Metastatic Bone
Disease: A Matter of Networking
Gabri Van Der Pluijm, and Jereon Buijs
Chapter 9 ........................................................................ 163
Prostate Cancer: Models for Developing Novel Therapeutic
Approaches
Shafaat A. Rabbani, Nicholas Shukeir and Andrew P. Mazar
Chapter 10 ....................................................................... 187
Potential Therapeutic Targets for Bone Metastasis
Sadmeet Singh and Gurmit Singh
Chapter 11 .......................................................................2 11
OPG, RANK and RANKL in Bone Metastasis and Cancer
Associated Osteolysis
Paul J. Kostnuik
Chapter 12 ....................................................................... 241
Role of Matrix Metalloproteinases in Bone Metastasis from
Human Breast and Prostate Cancer
Wilhelmina C.M Duivendoorden and Gurmit Singh
Chapter 13 ....................................................................... 277
The Role of Bisphosphonates in Bone Metastasis
Mary Mackenzie and Pierre Major
INDEX ........................................................................... 303
VlIl
CONTRIBUTORS
EDITORS
Gurmit Singh
Director of Research
Juravinski Cancer Centre
Professor of Pathology and Molecular Medicine
McMaster University
Hamilton, Ontario, Canada
William F. Orr
Chair of Pathology
Health Sciences Center
University of Manitoba
Winnipeg, Manitoba, Canada
CONTRIBUTORS
Robin L. Anderson
Head, Cancer Biology Laboratory
Peter MacCallum Cancer Institute
East Melbourne, Victoria, Australia
Nicholas A. Athanasou
Departments of Surgery and Pathology
Nuffield Department of Orthopaedic Surgery
University of Oxford
Oxford, UK
ix
Andrew Belch
University of Alberta and Cross Cancer Institute
Alberta, Canada
Paolo Bianco
Dipartmeento di Medicina Sperimentale e Patologia
Universita "La Sapeinza"
Parco Scientifico Biomedico San Raffaele
Rome, Italy
J eroen Buij s
Department of Endocrinology
Leiden University Medical Center
Leiden, Netherlands
Wilhelmina C.M Duivenvoorden
Northwestern Ontario Regional Cancer Centre
Thunder Bay, Ontario, Canada
Bedrick L. Eckhardt
Peter MacCallum Cancer Centre
East Melbourne, Victoria, Australia
Thomas H. Hassard
Department of Community Health Science
University of Manitoba
Winnipeg, Manitoba, Canada
Paul J. Kostenuik
Research Scientist
Amgen Inc.
Thousand Oaks, California, USA
Mary Mackenzie
Medical Oncology
Juravinski Cancer Centre
Hamilton, Ontario, Canada
Pierre P. Major
Medical Oncology
Juravinski Cancer Centre
Hamilton, Ontario, Canada
x
Andrew P. Mazar
Attenuon, LLC
San Diego, California, USA
Belinda S. Parker
Peter MacCallum Cancer Center
East Melbourne, Victoria, Australia
Linda M. Pilarski
University of Alberta and Cross Cancer Institute
Alberta, Canada
Patrick M. Pilarski
University of Alberta and Cross Cancer Institute
Alberta, Canada
Shafaat A. Rabbani
Departments of Physiology and Medicine
Royal Victoria Hospital
McGill University Health Centre
Montreal, Quebec, Canada
Martin Reed
Department of Radiology
Health Sciences Center
Winnipeg, Manitoba, Canada
Tony Reiman
University of Alberta and Cross Cancer Institute
Alberta, Canada
Mara Riminucci
Parco Scientifico Biomedico San Raffaele
Rome Italy
Departmento di Medicina Sperimentale
Universita dell' Aquila
L' Aquila, Italy
xi
