Bone Marrow Transplantation Across Major Genetic Barriers

493 Pages·2009·3.34 MB·English

by  Yair Reisner

Yair Reisner * Massimo F Martelli
Editors
Bone Marrow
Transplantation Across
Major Genetic Barriers
World Scientific
Bone Marrow Transplantation
Across Major Genetic Barriers
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Bone Marrow
Transplantation
Across Major
Genetic Barriers
Editors
Yair Reisner
Weizmann Institute of Science, Israel
Massimo F Martelli
Perugia University, Italy
World Scientific
NEW JERSEY • LONDON • SINGAPORE • BEIJING • SHANGHAI • HONG KONG • TAIPEI • CHENNAI
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Published by
World Scientific Publishing Co. Pte. Ltd.
5 Toh Tuck Link, Singapore 596224
USA office: 27 Warren Street, Suite 401-402, Hackensack, NJ 07601
UK office: 57 Shelton Street, Covent Garden, London WC2H 9HE
Library of Congress Cataloging-in-Publication Data
Bone marrow transplantation across major genetic barriers / editors, Yair Reisner,
Massimo F. Martelli.
p. ; cm.
Includes bibliographical references and index.
ISBN-13: 978-9814271264 (hardcover : alk. paper)
ISBN-10: 9814271268 (hardcover : alk. paper)
1. Bone marrow--Transplantation. 2. Hematopoietic stem cells. 3. Graft versus host disease--
Prevention. 4. Graft rejection--Prevention. 5. Human immunogenetics. I. Reisner, Yair.
II. Martelli, M. F.
[DNLM: 1. Bone Marrow Transplantation--methods. 2. Genetic Variation. 3. HLA Antigens--
genetics. 4. Hematopoietic Stem Cell Transplantation--methods. 5. Hematopoietic Stem Cells--
immunology. 6. T-Lymphocytes--immunology. WH 380 B71193 2010]
RD123.5.B6475 2010
617.4'410592--dc22
2010025734
British Library Cataloguing-in-Publication Data
A catalogue record for this book is available from the British Library.
Copyright © 2010 by World Scientific Publishing Co. Pte. Ltd.
All rights reserved. This book, or parts thereof, may not be reproduced in any form or by any means,
electronic or mechanical, including photocopying, recording or any information storage and retrieval
system now known or to be invented, without written permission from the Publisher.
For photocopying of material in this volume, please pay a copying fee through the Copyright
Clearance Center, Inc., 222 Rosewood Drive, Danvers, MA 01923, USA. In this case permission to
photocopy is not required from the publisher.
Typeset by Stallion Press
Email: [email protected]
Printed in Singapore.
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This book is dedicated to Robert A. Good, father of modern
clinical immunology and cellular engineering whose vision paved
the way to haploidentical bone marrow transplantation.
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Preface
The importance of bone marrow transplantation for patients who do not
have a matched sibling donor cannot be overestimated. The availability
of matched volunteer donors in the public at large is limited by the
remarkable genetic diversity of humans. Thus, although registries of such
volunteers now include more than eight million individuals, we still face
the problem of finding a matched donor for about 30% of patients in
need. To address this burning issue, extensive clinical and investigational
use of haploidentical hematopoietic stem cell transplantation is increas-
ing rapidly in leading institutes around the world. This book summarizes
the state of the art of these transplants in children and in adults, empha-
sizing future directions. Prevention of GVHD and graft rejection are
clearly satisfactory and disease-free survival rates in acute leukemia
patients in remission are similar to rates in transplants from unrelated
donors or with cord blood. Since enhancing immune post-transplant
reconstitution will improve survival even further, a major part of this
book is dedicated to pre-clinical studies investigating how to boost thy-
mus output or use adoptive transfer of immunity against infectious agents
or malignant cells. We also present the exciting possibility of durable
immune tolerance to donor tissues and organs by means of bone marrow
transplantation.
We wish to thank our esteemed colleagues for presenting here their
most up to date experience in various aspects of haploidentical stem cell
transplantation. We also extend our thanks to Doreen Rosenberg and
Geraldine Anne Boyd for their invaluable assistance in bringing this book
to fruition.
Yair Reisner Massimo F. Martelli
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Contents
Preface vii
1. Crossing HLABarriers by “Megadose” Stem Cell Transplants 1
Yair Reisner, Massimo F. Martelli and Esther Bachar-Lustig
2. The Haploidentical Option for High-Risk Hematological 29
Malignancies
Franco Aversa, Yair Reisner and Massimo F. Martelli
3. Haploidentical Allogeneic Hematopoietic Cell Transplantation 53
inAdults Using CD3/CD19 Depletion and Reduced Intensity
Conditioning
Wolfgang A. Bethge
4. Unmanipulated HLA-Mismatched/Haploidentical Blood 67
and Marrow Hematopoietic Stem Cell Transplantation
Xiao-Jun Huang
5. Alloanergization in Haploidentical Hematopoietic Stem Cell 97
Transplantation
Jeff K. Davies, Lee M. Nadler and Eva C. Guinan
6. Hematopoietic Stem Cell Transplantation Across Genetic 119
Barriers Using a Nonmyeloablative Conditioning Regimen
Liang-Piu Koh, David A. Rizzieri and Nelson J. Chao
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