Table Of ContentBiotechnology and Safety Assessment
Second Edition
Biotechnology and Safety Assessment
Second Edition
Editor
John A. Thomas
University of Texas Health Science Center
San Antonio, Texas
Boca Raton London New York
CRC Press is an imprint of the
Taylor & Francis Group, an informa business
A TAYLOR & FRANCIS BOOK
BIOTECHNOLOGY AND SAFETY ASSF.SSMENT, 2/E
First published 1999 by Taylor & Francis
Published 2019 by CRC Press
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© 1999 by Taylor & Francis Group, LLC
CRC Press is an imprint of Taylor & Francis Group, an Informa business
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ISBN 13: 978-1-56032-721-9 (hbk)
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A CIP catalog record for this book is available from the British Library.
Library of Congress Cataloging-in-Publication Data
Biotechnology and safety assessment/ editor, John A. Thomas.-2nd ed.
p. cm.
Includes bibliographical references and index.
ISBN 1-56032-721-9 (cloth: alk. paper)
I. Biotechnology-Safety measures. I. Thomas J. A. (John A.),
1933- ,
TP248.2.B55126 1999
660.6'0289-dc2l 98-21963
CIP
Acknowledgment
The editor wishes to express his sincere appreciation to Nancy Ibach for her diligence
in processing and collating Biotechnology and Safety Assessment. Her dedication to
administrative detail and her professional manner greatly expedited the assembling
of this monograph.
v
Contents
Acknowledgment ..................................................................................... v
Contributing Authors................................................................................. ix
Preface ........................................................................................................ xi
1. Genomic Information: Frontiers of Toxicology ......................... 1
James R. Beall and Marvin Stodolsky
2. Antisense Therapeutics ................................................................... 23
Stanley T. Crooke
3. Safety Evaluation for New Varieties of Food Crops Developed
Through Biotechnology.................................... 61
Bruce G. Hammond and Roy L. Fuchs
4. Therapeutic Manipulation of Cytokines....................................... 81
Robert V, House
5. Triplex and Ribozyme Technology in Gene Repression............ 109
Yan Lavrovsky, Shuo Chen, and Arun K. Roy
6. Food Allergens: Implications for Biotechnology ....................... 127
Samuel B. Lehrer and Gerald Reese
7. The Pharmacokinetics and Toxicity of Phosphorothioate
Oligonucleotides.............................................................................. 151
Arthur A. Levin, RichardS. Geary, Janet M. Leeds, David
K. Monteith, Rosie Yu, Mike V. Templin, and Scott P. Henry
8. Biotechnology in Agriculture and the Environment: Benefits
and Risks............................................................................................ 177
Christine McCullum, David Pimentel, and Maurizio G. Paoletti
9. Biotechnology and Risk................................................................... 219
Henry I. Miller
10. Safety Assessment of Insect-Protected Com................................. 241
Patricia R. Sanders, Thomas C. Lee, Mark E. Groth,
Jim D. Astwood, and Roy L. Fuchs
vii
viii CONTENTS
11. Pharmacology of Recombinant Proteins........................................ 257
James E. Talmadge
12. Biotechnology: Therapeutic and Nutritional Products .............. 283
John A. Thomas
13. Clinical Toxicity of Interferons ..................................................... 301
Thierry Vial and Jacques Descotes
Index ............................................................................................................. 331
Contributing Authors
Jim D. Astwood, Monsanto Company; 800 North Lindbergh Blvd., Saint Louis,
MO 63167
James R. Beall, U.S. Department of Energy, 1000 Independence Ave., S.W.,
Washington, DC 20585
Shuo Chen, University of Texas Health Science Center, 7703 Floyd Curl Drive,
San Antonio, TX 78284
Stanley T. Crooke, Isis Pharmaceuticals, Inc., 2280-B Faraday Avenue Carlsbad,
CA 92008
Jacques Descotes, INSERM U98-X, Claude Bernard University, Lyon France
F-69008
Roy L. Fuchs, Monsanto Company, 800 North Lindbergh Blvd., St. Louis,
MO 63167
Richard S. Geary, Isis Pharmaceuticals, Inc., 2280-B Faraday Avenue, Carlsbad,
CA 92008
Mark E. Groth, Monsanto Company, 800 North Lindbergh Blvd., Saint Louis, MO
63167
Bruce G. Hammond, Monsanto Company, 800 North Lindbergh Blvd., St. Louis,
MO 63167
Scott R Henry, Isis Pharmaceuticals, Inc., 2280-B Faraday Avenue, Carlsbad,
CA 92008
Robert V. House, ITT Research Institute, 10 West 35th Street, Chicago, FL 60616
Yan Lavrovsky, University of Texas Health Science Center, 7703 Floyd Curl
Drive, San Antonio, TX 78284
Thomas C. Lee Monsanto Company, 800 North Lindbergh Blvd., Saint Louis, MO
63167
Janet M. Leeds, Isis Pharmaceuticals, Inc., 2208-B Faraday Avenue, Carlsbad,
CA 92008
Samuel B. Lehrer, Tulane University Medical Center, 1700 Perdido Street, New
Orleans, LA 70112
ix
