Table Of Content/VOLUME 11 1993 INDEX
TABLE OF CONTENTS
Page numbers beginning with “S” Dixon (Article) Bureaucracy, Brussels- Smeekens (Review)
refer to the 10th anniversary special Fetal Bovine Serum Style, Bernard Dixon A Thioredoxin Gene
supplement in the March issue Revisited, John Hodgson (Opinion) Fusion Expression System
(Article) FDA Approves Cytogen’s That Circumvents
Jan uary 1993 Miami Bio/ Monoclonal Imaging Inclusion Body Formation
Technology Winter Agent, (News Briefs) in the E. coli Cytoplasm,
Preserving Biotechnology, Symposium Listing of PTOReexamines Roche’s Edward R. LaVallie,
Douglas K. McCormick
Papers and Posters -interferon Patent, Elizabeth A. DiBlasio,
(Opinion) Application of Magnetic Jeffrey L. Fox (News) Sharlotte Kovacic,
Sour Milk and All-Natural
Beads in Bioassays, Bjorn- Immunex/Cyanimid Kathleen L. Grant, Paul F.
Science, Bernard Dixon Ivar Haukanes, Catrine Merger Focuses on Cancer, Schendel, John M. McCoy
(Opinion)
Kvam (Review) B.J. Spalding (News) (Research)
Sandoz and Scripps Join in
Production of Recombinant Stock-Exchange Proposals Field Performance of Elite
$300-Million Pact, (News
Salmon Calcitonin by /n Disappoint U.K. Firms, “sansgenic Maize Plants
Briefs) Vitro Amidation of an E. Mike Ward (News) Expressinagn Insecticidal
HIV is No Longer Latent, coli Produced Precursor Biotech Stocks Won’t Heat Protein Derived from
Says NIAID’s Fauci,
Peptide, Martha V.L. Ray, Up This Year, Jeffrey Bacillus thuringiensis,
Stephen M. Edgington Paul Van Duyne, Arthur H. Cassdin (News) Michael G. Koziel, Gary L.
(News) Bertelsen, Dianne E. 1992 Financing Nets $2 Beland, Cindy Bowman,
Biotech Sector Rides on Jackson-Matthews, Amy Billion, B.J. Spalding Nadine B. Carozzi,
Synergen’s Shoulders, B.J.
M. Sturmer, David J. (News) Rebecca Crenshaw, Lyle
Spalding (News) Merkler, Angelo P. R&D Alliances Give Crossland, John Dawson,
Diagnostic Firms Discover Consalvo (Research) Biggest Bang for Buck, Nalini Desai, Martha Hill,
Key to Profitability, Efficient Production ofa Joseph Alper (News) Sue Kadwell, Karen
Joseph Alper (News) Functional Single-Chain Shelved by Campbell, Launis, Kelly Lewis, Daryl
TSI Uses Services to Fund Antidigoxin Antibody via Calgene Retreats at FDA, Maddox, Kathryn
Transgenic Research, Ray an Engineered Bacillus Russ Hoyle (News) McPherson, Moez R.
Potter (News) subtilis Expression Thrombolytic Survival Meghii, Ellis Merlin,
Rival Biotech Stock Secretion System, Xu-Chu Test, Jeffrey L. Fox (News) Richard Rhodes, Gregory
Indexes Start Slowly, B.J. Wu, Shi-Chung Ng, Thioredoxin Fusions W. Warren, Martha Wright,
Spalding (News) Richard I. Near, Sui-Lam Eliminate E. coli Inclu- Stephen V. Evola
There’s Hope for Biotech Wong (Research) sions, Harvey Bialy (News) (Research)
Stocks in °93, David The Effect of Folding IOM endorses FDA A Streptavidin Mutant
Webber (News) Catalysts on the Jn Vivo Advisory-Committee Containing a Cysteine
CF Researchers Fight Folding Process of System, Jeffrey L. Fox Stretch That Facilitates
License, lan Mundell Different Antibody (News) Production of a Variety of
(News) Fragments Expressed in E. Biology and Chemical Specific Streptavidin
Will Clinton/Gore Rollback
coli, Achim Knappik, Engineering Bond, Douglas Conjugates, Takeshi Sano,
Recombinants?, Russ
Claus Krebber, Andreas Lauffenburger (News) Cassandra L. Smith,
Hoyle (News) Pliickthun (Research) Have Monoclonals Charles R. Cantor
Hauser Chemical Research Stable Transformation of FulfThieilr Plroemisde? , (Research)
Wins Award, Douglas K. Picea glauca by Particle Paul Abrams (News) A Novel Process for the
McCormick (News) Acceleration, D.D. Ellis, Prestidigitation in the Large-Scale Purification of
NIHRAC and FDA Ponder D.E. McCabe, S. McInnis, Clinic, John Hodgson Recombinant Tick
Gene-Therapy Risks, R. Ramachandran, D.R. (Article) Anticoagulant Peptide
Jeffrey L. Fox (News) Russell, K.M. Wallace, B.J. Empiricism Strikes Back: Using Perfusion Chroma-
NIHRAC Okays Gene Martinell, D.R. Roberts, Neural Networks in tography, E. Dale Lehman,
Therapy for Cystic K.F. Raffa, B.H. McCown Biotechnology, Mark Joseph G. Joyce, Daniel K.
Fibrosis, Jeffrey L. Fox (Research) Collins (Article) Freymeyer, II, James
(News) Plant Regeneration from Biopharmaceuticals Goto Bailey, Wayne K. Herber,
Asseas Fsirsit-tno-gFil e Mesophyll Protoplasts of Market: Patterns of William J. Miller
Patent System, Daniel P. Rice (Oriza sativa L.), Hari Worldwide Development, (Research)
Burke, Kevin J. McGough S. Gupta, Arunava Brigitta Bienz-Tadmor Selective Release of
(News) Pattanayak (Research) (Article) Recombinant Protein
CBER Narrows the Stable Plasmid Transfor- Virus Harvesting and Particles (VLPs) from
Product-Review Pipeline, mation in PEG-treated Affinity-Based Liquid Yeast by Enzymatic Lysis,
Josef von Rickenbach Protoplasts of Nicotiana Chromatography, P.F. J.A. Asenjo, A.M. Ventom,
(News) tabacum, Timothy Golds, O’Neil, E.S. Balkovic R.B.Huang, B.A. Andrews
Integrating NMR and X- Pal Maliga, Hans-Ulrich (Article) (Research)
Ray CrystallographJyoh,n Koop (Research) Biotechnology and the Selectable Marker Genes
Hodgson (Article) 116 1992 Volume 10 Index Public Interest, Rollin B. Engineered for Specific
Breaking Open the Johnson (Book Review) Expression in Target Cells
Bottlenecks in Genomic February Processing of Protein for Plant Transformation,
DNA Sequencing, Stephen Precursors by a Novel Sebahattin Ozcan, Simon
M. Edgington (Article) 131 Please, Mr. Clinton, Family of Subtilisin- Firek, John Draper
Who’s Who in European Douglas K. Related Mammalian (Research)
Antibiotech?, Bernard McCormick (Opinion) Endoproteases, Steven P. Correspondence
BIO/TECHNOLOGY VOL. 12 JANUARY 1994 95
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181 Books Received Hood (Special Section) Construction of Metabolic 450 Analyzing Biotech’s Past,
222 Diagnostic Kits Biotechnology, Ethics, and Operons Catalyzing the De Present, and Future, Paul
223 New Products Society, Daniel J. Kevles Novo Biosynthesiosf Abrams (News)
223 Display Advertisers’ Index (Special Section) Indigo in E. coli, Douglas Forestry in the 21st
226 Free Literature Agbio and Third World Murdock, Burt D. Ensley, Century, Pramod K. Gupta,
235 Announcements Development, Hope Shand Cuneyt Serdar, Marcel Gerald Pullman, Roger
236 IsItReally Environmental (Special Section) Thalen (Research) Timmis, Mary Kreitinger,
ism Versus Biotechnology?, 100 Years of Biotechnology, Effect of Culture William C. Carlson, Jim
Walter Truett Robert Bud (Special Conditions onIgM Grob, Elaine Welty
Anderson (Opinion) Section) Antibody Structure, (Article)
Biotechnology and the Pharmacokinetics, and Off to a Fast Start—and a
Pharmaceutical Industry, Activity, B.L. Maiorella, J. Promising, if Uncertain,
March
Jiirgen Drews (Special Winkelhake, J. Young, B. Future, Russ Hoyle
243 So, We Have Survived Section) Moyer, R. Bauer, M. Hora, (Article)
Again, Douglas K. Ti to Tomato, Tomato to J. Andya, J. Thomson, R. Molecular Crosstalk,
McCormick (Opinion) Market, Jan Leemans Parekh (Research) Stephen M. Edgington
What They Were Saying in (Special Section) Correspondence (Article)
*83, Bernard Dixon Knocking On Opportuni- Announcements Desktop Molecular
(Opinion) ty’s Window, George B. Spinout Success Stories, Modeling: Another Look,
Centocor in Mortal Danger Rathmann (Special Samuel D. Colella Stephen Edgington,
After Halting Centoxin Section) (Opinion) (BioTools)
Trials, (News Briefs) Biotech’s Product Sales New Programs for Protein
2 Compassionate Use of 1983-1993, Arthur April Tertiary Structure
Gene Therapy Stirs Storm, Klausner (Special Section) Prediction, Jaquelin S.
Jeffrey L. Fox (News) The Biotech Class of *82- Solitaire, Douglas K. Fetrow, Stephen H. Bryant
Three Neuropharmaceutical 83, Al Middleton (Special McCormick (Opinion) (Review)
Firms Target ALS, Joseph Section) 425 Oil Eaters in Nature, Immune Enhancers
Alper (News) The European Perspective, Bernard Dixon (Opinion) Composed of Polyvalent
Biotech Boosts 1992 David P. Collingham 426 87 Biopharmacuetical Binding Sites of Anti-CD3
Venture-Backed IPO (Special Section) Firms Lose $662 Million, Antibodies, Andrzej
Market, B.J. Spalding Process Economics of B.J. Spalding (News) Wedrychowski, Young-
(News) Animal Cell and Bacterial In Blocking Synergen, Woo Kim, Tse Wen Chang
Health/Biotech Funds Fall Fermentations: A Case Sepsis Tallies Third (Research)
8 Percent in 1992, B.J. Study Analysis of Tissue Victim, B.J. Spalding Specific Adhesion and
Spalding (News) Plasminogen Activator, (News) Hydrolysis of Cellulose by
Biotech Stocks Won’t Rally Rajiv V. Datar, Terence U.S. Biotech Firms Tackle Intact E. coli Expressing
Until Early Next Year, Cartwright, Carl-Gustaf Overseas Markets First, Surface Anchored
Denise Gilbert (News) Rosen (Review) Joseph Alper (News) Cellulase or Cellulose
Why Do Agbiotech Firms Expansion of Primitive Enzon Lines Up 11 New Binding Domains, Joseph
Neglect Turf Grasses?, Human Hematopoietic Alliances in a Busy Year, A. Francisco, Christos
George Kidd (News) Progenitors in a Perfusion Ray Potter (News) Stathopoulos, R. Anthony
IBA/ABC Merger Boosts Bioreactor System with IL- How Biotech Will Cope J. Warren, Douglas G.
Clout, Jeffrey L. Fox 3, IL-6, and Stem Cell With HillBilly Health Care, Kilburn, George Georgiou
(News) Factor, Manfred R. Koller, Gregory Brown, Peter (Research)
PTO Opens Floodgates on James G. Bender, William Drake (News) Particle Bombardment-
Animal Patents, Daniel P. M. Miller, Eleftherios T. Bracing for Shorter Mediated Gene Transfer
Burke, KevinJ. McGough Papoutsakis (Research) Reviews in FDA’s User- and Expression in Rat
(News) Expansion of Human Bone Fee Era, Josef von Brain Tissues, Shoushu
Will Fallout from the Marrow Progenitor Cells in Rickenbach (News) Jiao, Liang Cheng, Jon A.
Delaney Flap Help a High Cell Density Scios Nova May Purge Wolff, Ning-Sun Yang
Agbiotech?, Russ Hoyle Continuous Perfusion Pergamid After FDA (Research)
(News) System, Bernhard O. Setback, Jeffrey L. Fox Chaperonin-Assisted Phage
User Fees Pose Formidable Palsson, Se-Hwan Paek, (News) Display of Antibody
Challenge for FDA, Jeffrey Richard M. Schwartz, NIHRA Approves Six Fragments on Filamentous
L. Fox (News) Mahshid Palsson, Gyun- Gene-Transfer Bacteriophages, Eskil
Protein Engineering Min Lee, Samuel Silver, Protocols, Jeffrey L. Fox Séderlind, Ann Catrin
Succeeds, Harvey Bialy Stephen G. Emerson (News) Simonsson Lagerkvist,
(News) (Research) High-Tech Policy May Marta Duefias, Ann-
Shape Space, Stephen M. Manipulation of the Force EPA to Innovate, Christin Malmborg, Marta
Edgington (Article) Repertoire of Digestive Russ Hoyle (News) Ayala, Lena Danielsson,
Immunosorbent Cytometry, Enzymes Secreted into the Ampligen Forces Focus on Carl A.K. Borrabaeck
Tse-Wen Chang (Article) Gastrointestinal Tract of CFS, Jeffrey L. Fox (News) (Research)
Transgenic Mice, Judith IBA Fears Clinton’s Agrobacterium-Mediated
10th Anniversary Hall, Simi Ali, M. Azim Promised Health-Care Tranosf Afntieserns e
Surani, Geoffry P. Reform, B.J. Spalding Chalcone Synthase cDNA
Supplement Hazelwood, A. John Clark, (News) to Gerbera hybrida Inhibits
J. Paul Simons, Barry H. Is Pursuing Improved Flower Pigmentation, Paula
S9 Meethte Initerndiscgipl i- Hirst, Harry J. Gilbert Canola an Unctuous Aim?, Elomaa, Jarmo Honkanen,
nary Challenge, Leroy (Research) George Kidd (News) Reetta Puska, Pauli
96 _BIO/TECHNOLOGY VOL. 12 JANUARY 1994
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Seppinen, Yrjé Helariutta, BST, Jeffrey L. Fox (News) Efficient Bacterial Export From Off-the-Wall to Off-
Merja Mehto, Mika CLIA °88 Lab Regulations ofa Eukaryotic Cytoplas the-Shelf, John Hodgson
Kotilainen, Leena Are Watered Down, Joseph mic Cytochrome, Amna (Article)
Nevalainen, Teemu H. Alper(News) Karim, Naheed Kaderbhai, Biocatalysts and Immobi-
Teeri (Research) Vague Shape of Clinton’s Alun Evans, Victoria lized Enzyme/Cell
Comparative Biochemical Biotech Policy Emerges, Harding, Mustak A. Bioreactors, M. Abdul
Characterization ofa Russ Hoyle (News) Kaderbhai (Research) Mazid (Article)
Human IgM Produced in Mulituse Correspondence Patents and the Human
both Ascites and /n Vitro Biopharmaceutical BioQ&A Genome Project, Michael
Cell Culture, Thomas J. Manufacturing, Mic. N. Fermentors H. Davis (BioTools)
Monica, Charles F. Hamers (Article) New Products Patent Law in Principle and
Goochee, Brian L. Flow Cytometry in Animal A Word or Two from the in Practice, S. Leslie
Maiorella (Research) Cell Culture, Mohamed Al- Wise, John Hodgson Misrock, Adriane M.
Correspondence Rubeai, A. Nicholas Emery (Opinion) Antler (Book Review)
BioQ&A (Article) Is a Positive Western Blot
New Products Nuclease Therapeutics in June Prooof HfIV Infection?,
Announcements the Clinic, Stephen M. Eleni Papadopulos-
Pesticide Problems, Susan Edgington (Article) 643 CRADA in Un Deo Cruele, Eleopulos, Valendar F.
E. Dudley (Opinion) The Driving Forces of Douglas K. McCormick Turner, John M.
Biotechnology, Jan A. (Opinion) Papadimitriou (Review)
May Witkowski (Book Review) Mendel’s Heirs and the Optimization ofa
BioBOSS: A Bioprocessing Summer of °39, Bernard Recombinant of von
531 Blues, Douglas K. Software Tool, Terhi Dixon (Opinion) Willebrand Factor
McCormick (Opinion) Siimes, Marjut Pokkinen, QLT Wins Approval of Fragmentas an Antagonist
535 The Strange Case of the Andrea Holmberg, Pekka Photodynamic Therapy, of the Platelet Glycoprotein
Pitter, 3ernard Dixon Linko, (BioTools) B.J. Spalding (News) Ib Receptor, Christopher P.
(Opinion) Molecular Analysis of Will Bone Morphogenic Prior, Valeria Chu, Bernard
Clinton Seeks $4.3 Billion Small Grain Cereal Proteins Pay Off?, Joseph Cambou, Judith A. Dent,
for Biotech R&D, Jeffrey Genomes: Current Status Alper(News) Beth Ebert, Richard Gore,
L. Fox (News) and Prospects, Graham Genentech’s t-PA Finally John Holt, Thomas Irish
FDA Advisory Panel Okays Moore, Michael D. Gale, Wins, Ray Potter (News) Ted Lee, Jon Mitschelen,
B-Interferon for MS, Jeffrey Nori Kurata, Richard B. The Future Remains Bright Richard A. McClintock,
L. Fox (News) Flavell (Review) for Biotech Stocks, Denise George Searfoss, George A.
Centocor’s CentoRx Efficient Production of Gilbert (News) Ricca, Criss Tarr, David
Benefits Angioplasty Antibody Fragments by the FDA Ponders Label for Weber, Jerry L. Ware,
Patients, B.J. Spalding Filamentous Fungus BST-Derived Foods, Zaverio M. Ruggeri,
(News) Trichoderma reesei, P Eini Jeffrey L. Fox (News) Michael Hrinda (Research)
Does Gensia’s Arasine Nyyss6nen, Merja Penttila, FDA Reexamines Biotech Bacterial
Help Heart Patients?, B.J. Anu Saloheimo, Jonathan Food Policy, Jeffrey L. Fox Dihydrodipicolinate
Spalding (News) K.C. Knowles, Sirkka (News) Synthase and Desensitized
Firms Should Pursue Keriinen (Research) Smart Multiple Niching is Aspartate Kinase: Two
Narrow Indications, Paul Transformation of Elite the Way to Go, George Novel Selectable Markers
Abrams (News) Cotton Cultivars via Kidd (News) for Plant Transformation,
Drug Price Controls Will Particle Bombardment of Transgenic Mice Fall Far Avihai Perl, Shmuel Galili,
Stunt Biotech’s Growth, Meristems, Dennis E. Short, Jeffrey L. Fox Orit Shaul, Inbal Ben-Tzvi,
Jeffrey Casdin (News) McCabe, Brian Martinell (News) Gad Galili (Research)
Public-Firm Execs’ Get (Research) Biotech Securities Culture pH Affects
$116,000, B.J. Spalding Recombinant Colorimetric Litigation is Running Expression Rates and
(News) Antibodies: Construction Rampant, Bruce Vanyo, Glycosylations of
First Quarter Sees 27 Firms and Characterization of a Boris Feldman (News) Recombinant Mouse
Raise $649.7 Million, B.J. Bifunctional F (ab)2/ Clinton Likes Biodiversity Placental Lactogen Proteins
Spalding (News) Alkaline Phosphotase Treaty, Jeffrey L. Fox by Chinese Hamster Ovary
Shaman’s $45 Million IPO Conjugate Produced in (News) (CHO) Cells, Michael C.
is Quarter’s Biggest, Mark E. coli, Frédéric Ducancel, Amicus Offers Up Borys, Daniel I.H. Linzer.
Goodstein (News) Daniel Gillet, Alice Carrier, Disinformation and Eleftherios T. Papoutsakis
Latvian Biotech Firm Evelyne Lajeunesse, André Distortion, Russ (Research)
Busted for Selling Speed, Ménez, Jean-Claude Hoyle (News) Fiber-Optic Sensor for
GerardO’ Dwyer (News) Boulain (Research) Does U.K. Biotech Offer Continuous Monitoring of
European Trade Associa- Conversion of Starch to Better Opportunities?, Paul Fermentation pH, Venetka
tions Move to Consolidate, Ethanol ina Recombinant Haycock (News) I. Agayn, David R. Walt
Mike Ward (News) Saccharomyces serevisiae Product Update, Claire (Research)
Improved Animal Feed Strain Expressing Rice a- Corcoran (News) Improved Growth and
May Be Just “Chicken Amylase from a Novel Alliance Update, Mark Taxol Yield in Developing
Feed”, George Kidd (News) Pichia pastoris Alcohol Goodstein (News) Calli of Taxus cuspidata by
15 Agbiotech Firms Lost Oxidase Promoter, Monto Chemokines and Medium Composition
$126.4 Million Last Year, H. Kumagai, Genadie G. Cardiovascular Drug Modification, ArthurG.
B.J. Spalding (News) Sverlow, Guy della-Cioppa, Development, Stephen M. Fett-Neto, Stewart J.
FDA Advisory Panel Laurence K. Grill Edgington (Article) Melanson, Ko Sakata,
Mooooves Monsanto’s (Research) Pharmaceutical Screening: Frank DiCosmo (Research)
BIO/TECHNOLOGY VOL. 12 JANUARY 1994 9O7
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644 Correspondence 837 Mapping the Human General Method Applied to Product Update, Claire
740 BioQ&A Genome, Mark C. Gordon Lignin Peroxidase Genes of Corcoran (News)
744 New Products (Book Review) Phanerochaete Alliance Update, Mark
747 Pharmaceutical Screening 839 Old Drug, New Use: chrysosporium, Paul Goodstein (News)
748 Announcements Article of Manufacture Brooks, Paul Sims, Paul Expression Systems: A
749 Free Literature Claims, Patrick D. Kelly Broda (Research) User’s Guide, John
756 The Message Behind the (BioTools) Bialaphos Treatment of Hodgson (Article)
Movie, William Bains Scientific Information Transgenic Rice Plants Biotechnology inthe Food
(Opinion) Retrieval, Roslyn C. Potter, Expressing a bar Gene Industry, Charles I Beck,
Carol P. Bertram Prevents Infection by the Thomas H. Ulrich (Article)
July (BioTools) Sheath Blight Pathogen An Ecological Look at
§-(L-a-Aminoadipyl)-L- (Rhizoctonia solani), GMOs, David Marsh
763 Upbeat in a Bad Mood, Cysteinyl-D-Valine Hirofumi Uchimiya, (Book Review)
Douglas K. McCormick Synthetase, the Multien- Michiaki Iwata, Chuhei PCR: Applications and
(Opinion) zyme Integrating the Four Nojiri, Pallepitiya K. Alternative Technologies,
767 Gene Flow and Bacterial Primary Reactions in B- Samarajeewa, Susumu Lawrence Haff (BioTools)
Transformation, Bernard Lactam Biosynthesis, as a Takamatsu, Shinya Ooba, Recent Advances in the
Dixon (Opinion) Model Peptide Synthetase, Hiroyuki Anzai, Alan H. Expression of Foreign
Biopharmaceutical Firms Yair Aharonowitz, Jiirgen Christensen, Peter H. Genes in Pichia pastoris,
Up R&D Spending 71 Bergmeyer, Jesus M. Quail, Seiichi Toki James M. Cregg, Thomas
Percent, B.J. Spalding Cantoral, Gerald Cohen, (Research) S. Vedvick, William C.
(News) Amold L. Demain, Uwe Correspondence Raschke (Review)
MedImmune’s Respivir Fink, Jim Kinghorn, Horst Filtration Creation of Mice
Benefits RSV Patients, B.J. Kleinkauf, Andrew Release and Regulations, Expressing Human
Spalding (News) MacCabe, Harriet Palissa, John Hodgson (Opinion) Antibody Light Chains by
Companies Settle Brave Eva Pfeifer, Torsten Introduction of a Yeast
New Frontier of Schwecke, Henk van August Artificial Chromosome
Xenografting, Joseph Alper Liempt, Hans von Dohren, Containing the Core
(News) Saul Wolfe, Jinyou Zhang 859 Right of Reply, Douglas K. Region of the Human
Even Promising (Review) McCormick (Opinion) Immunogloblin k Locus,
Alzheimer’s Research Has Phytase-Containing 863 Giving Public Awareness Nicholas P. Davies, Ian R.
Gaps, David Webber Transgenic Seeds as a Its Due, Bernard Dixon Rosewell, Jenny C.
(News) Novel Feed Additive for (Opinion) Richardson, Graham P.
“Virtual’’ Biotech Improved Phosphorus Rh6ne-Poulenc Buys 37% Cook, Michael S.
Companies May Win Out, Utilization, Jan Pen, Theo of Applied Immune, B.J. Neuberger, Bernard H.
Paul Abrams (News) C. Verwoerd, Peter A. van Spalding (News) Brownstein, Mike L.
Legislation Closes Gap in Paridon, Rob F. Beudeker, National Body Will Spur Norris, Marianne
Patent Protection, Kevin J. Peter J.M. van den Elzen, Vaccine Development, Briiggermann (Research)
McGough, Daniel Burke Kees Geerse, Jan van der Jeffrey L. Fox (News) Semliki Forest Virus
(News) Klis, Hans A.J. Versteegh, Second Quarter Sees 3 Expression System:
Healy’s Strategic Plan for Albert J.J. van Ooyen, Firms Raise $56.3 Million, Production of Conditional
NIH Faces Uncertainty, André Hoekema (Research) B.J. Spalding (News) ly Infectious Recombinant
Jeffrey L. Fox (News) AGlucose-Derepressed FDA Advisory Panel Nixes Particles, Peter Berglund,
NIHRAC Approves 11 Promoter for Expression of Vestar’s DaunoXome, Mathilda Sjéberg, Henrik
Gene-Therapy Protocols, Heterologous Products in Jeffrey L. Fox (News) Garoff, Gregory J. Atkins,
Jeffrey L. Fox (News) the Filamentous Fungus European Commission Brian J. Sheahan, Peter
NAFTA Could Open Big Aspergillus nidulans, Proposes Ban on bST, Liljestrém (Research)
Markets in Mexico, George William E. Hintz, Peter Mike Ward (News) Hyperproduction of
Kidd (News) Lagosky (Research) Searching for Miracle Tryptophan in Corynebac-
Can Microbes Economical Different Mechanisms Biopharmaceuticals, R. terium glutamicum by
ly Remove Sulfur?, Jeffrey Protect Transgenic Brandon Fradd (News) Pathway Engineering,
L. Fox (News) Tobacco Against Tomato DNAP Takes the Lead in Ryoichi Katsumata,
Herbicide-Resistant Crops Spotted Wilt and Impatiens Genetic Subtraction, Masato Ikeda (Research)
Are No Conspiracy, Russ Necrotic Spot George Kidd (News) The Production of
Hoyle (News) Tospoviruses, Sheng-Zhi Agbiotech Firms Increase Cephalosporin C by
Product Update, Claire Pang, Jerry L Slightom, R&D Spending 39.6%, B.J. Acremonium chrysogenum
Corcoran (News) Dennis Gonsalves Spalding (News) is Improved by the
Alliance Update, Mark (Research) Biotech Needs Positive Intracellular Expression of
Goodstein (News) Surface-Density and Legislation and Regulation, a Bacterial Hemoglobin,
Looking Death in the Eye: Orientation Effects on Tom Wiggans (News) J.A. DeModena, S.
Apoptosis and Cancer Immobilized Antibodies Biotech Helps Salvage Gutiérrez,,J .V elasco, F.J.
Research, Stephen M. and Antibody Fragments, Biodiversity Treaty, Russ Fernandez, R.A. Fachini,
Edgington (Article) Thomas A. Spitznagel, Hoyle (News) J.L. Galazzo, D.E. Hughes
Robotics-Based Laboratory Douglas S. Clark Fermenta’s El-Sayed (Research)
Automation, Alain Donzel, (Research) Returns, GeraO’r Dwdye r A New Tobacco Mosaic
Steve Hamilton (Article) Isozyme-Specific (News) Virus Vector and its Use
Rhéne-Poulenc: From Polymerase Chain Reaction FDA Finally Begins forthe Systemic Produc
Bioscience to Markets, Analysis ofD ifferential Collecting User Fees, tion of Angiotensin-I-
Mike Ward (Article) Gene Expression: A Jeffrey L. Fox (News) Converting Enzyme
98 BIO/TECHNOLOGY VOL. 12 JANUARY 1994
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Inhibitoirn Transgenic Compensation Survey, Herpes Virus VP16 GerO’ Dawyerr (dNew s)
Tobacco and Tomato, Douglas K. McCormick, Transactivator, Paul 1108 Using Scientific Evidence
Hiroshi Hamamoto, Mark Goodstein (Article) Hippenmeyer, Maureen After Daubert, Kevin J.
Yoshinori Sugiyama, Biotherapies and B-Cell Highkin (Research) McGough (News)
Noriaki Nakagawa, Eiji Differentiation, Stephen M. 1042 A Reverse Transcriptase- 1109 Cultural Differences Let
Hashida, Yuji Matsunaga, Edgington (Article) Polymerase Chain Reaction U.S. Dominate U.K., B.J.
Shizume Takemoto, 1003 Does Biotechnology Assay for the Detection and Spalding (News)
Yuichiro Watanabe, Measure Up?, John Quantitation of Murine 1110 How to Secure a Corporate
Yoshimi Okada (Research) Hodgson, Kirsty Barlow Retroviruses, John M. Partner in Japan, James
Recombinant Baculovirus (Article) Irving, Lucille W.S. Chang, Reid (News)
Vectors Expressing 1053 Highly Readable, Seriously FranciscJo. Castillo 1112 Product Update, Mark
Glutathione-S-Transferase Flawed, Bernard Dixon (Research) Goodstein (News)
Fusion Proteins, Anthony (Book Review) 1048 Transgenic Potato Plants 1114 Alliance Update, Mark
H. Davies, Jeremy B.M. 1056 Biotechnology Patent Expressing Mammalian 2'- Goodstein (News)
Jowett, lan M. Jones Protection in Japan, 5' Oligoadenylate 1117 Turning On Tumor-
(Research) Elizabeth F. Enayati Synthetase Are Protected Fighting T-Cells , Stephen
Correspondence (BioTools) from Potato Virus X M. Edgington (Article)
BioQ&A 1059 Expanded Bed Adsorption, Infection Under Field 1120 Blood Brothers, Mark D.
PCR Tools Douglas K. McCormick Conditions, Erkki Truve, Dibner (Article)
New Products (BioTools) Anu Aaspéllu, Jarmo 1125 Viral Genes and
Announcements 1061 Chromatography: Honkanen, Reeta Puska, Transgenic Plants, Mark
The HIV Gap in National Separation and Purifica- Merja Mehto, Anja Hassi, Tepfer (Article)
Aids Statistics, Peter H. tion, John Hodgson Teemu H. Teeri, Merike 1173 A Win-Win Scenario for
Duesberg (Opinion) (BioQ&A) Kelve, Pauli Seppanen, Natural Resource Access,
1007 Jn Situ Product Removal as Mart Saarma (Research) David Marsh (Book
September aTool for Bioprocessing, 964 Correspondence review)
Amihay Freeman, John M. 1064 New Products 1174 Product, Product-by-
963 Bovine Growth Hormone Woodley, Malcolm D. Lilly 1065 Chromatography Tools Process, Process and Use,
and Pork-Barrel Politics, (Review) 1067 Free Literature Volker Vossius, Stefan
Douglas K. McCormick 1014 Recombinant Human 1075 Perception of Biotechnolo- Féaux de Lacroix, Ulrich
(Opinion) Thyroid Stimulating gy Risks: The Emotional D6rries (BioTools)
Unsolved Mysteries, Hormone: Developmenotf Dimension, Henry I. Miller 1177 Carbohydrate Flourescence
Bernard Dixon (Opinion) a Biotechnology Product (Opinion) Electrophoresis, Margaret
U.S. Lags in for Detection of Metastatic M. Wacker (BioTools)
Nutriceutical Lesions of Thyroid October 1179 Biomateriaalnsd
Development, Lantz Miller Carcinoma, Edward S. Biotechnology, KikiB.
(News) Cole, Karen Lee, Kevin 1083 Envoi, or A Night at the Hellman, Grace Lee
FDA Advisory Panel Okays Lauziere, Christine Kelton, Oscars, Douglas K. Picciolo, Edward P.
Genentech’s DNase, Ray Scott Chappel, Bruce McCormick (Opinion) Mueller(BioTools)
Potter (News) Weintraub, Dawn Ferrara, 1090 Is Public Opposition to 1181 The Ins and Outs of
Biotreatment Firms Rush to Pamela Peterson, Rick Biotechnology Real?, Electrophoresis, John
Marketplace, Joseph Alper BernasconiTi,m Edmunds, Bernard Dixon (Opinion) Hodgson, Kirsty Barlow
(News) Susan Richards, Lydia 1093 Carbohydrates Surge (BioQ&A)
Going Gets Weird with Dickrell, James M. Through Clinical Trials, 1133 Conversion to Mucoidy in
BST and Wildlands Kleeman, John M. Joseph Alper (News) Pseudomonas aeruginosa,
Project, Russ Hoyle (News) McPherson, Bruce M. Pratt 1096 Institutions Shun U.S. V. Deretic, D.W. Martin,
Impacting Biological (Case Study) Biopharmaceutical Firms, M.J. Schurr, M.H. Mudd,
Weapons, Jeffrey L. Fox 1026 Kinetic PCR Analysis: B.J. Spalding (News) N.S. Hibler, R. Curcic, J.C.
(News) Real-Time Monitoring of 1100 U.S. Federal Biotech- Boucher (Review)
Analyzing the U.S. Corn- DNA Amplification Budget Initiative Ends, 1138 Use of Peptide Libraries to
Genetics Business, George Reactions, Russell Higuchi, Jeffrey L. Fox (News) Map the Substrate
Kidd (News) Carita Fockler, Gavin 1100 Estonia Will Sell Four of Specificity of a Peptide-
Telor Opthalmic is Second Dollinger, Robert Watson Its Biggest Biotech Firms, Modifying Enzyme: A 13
Quarter’s Sole IPO, Claire (Research) Gerard O’ Dwyer (News) Residue Consensus Peptide
Corcoran (News) Soluble Forms of the 1101 Second Quarter Sees Specifies Biotinylation in
Human Gene Sequencing Human T Cell Receptor Stocks Trade on Own E. coli, Peter J. Schatz
Makes Advances, Joseph CD4 Are Efficiently Merits, R. Brandon Fradd (Research)
Alper (News) Expressed by Streptomyces (News) 1145 Human Antibody
Analysts Assess lividans, James A. 1102 Battle Brewing Between Fragments Specific for
Biopharmaceutical Firms, Fornwald, Mary Jo PVP and Patents, George Human Blood Group
B.J. Spalding (News) Donovan, Robert Gerber, Kidd (News) Antigens from a Phage
Corporate Communications John Keller, Dean P. 1105 Pesticide Policy is Display Library, James D.
Are Worth a Million, Taylor, Edward J. Arcuri, Clinton’s Acid Test, Russ Marks, Willem H.
David Stone (News) Mary E. Brawner Hoyle (News) Ouwehand, Jacqueline M.
Product Update, Mark (Research) 1106 Designing and Managing Bye, RicardaFinnem,
Goodstein (News) 1037 High-Level, Stable Strategic Alliances, B.J. Barbara D. Gorick,
Alliance Update, Mark Production of Recombinant Spalding (News) Douglas Voak, Susan J.
Goodstein (News) Proteins in Mammalian 1107 Denmark and Sweden Plan Thorpe Nevin C. Hughes-
1993 Bio/Technology Cell Culture Using the Joint Biotech Center, Jones, Greg Winter
BIO/TECHNOLOGY VOL. 12 JANUARY 1994 99
/VOL.UME I11 1993 INDEX
Special International
(Research) Spalding (News) Antitrypsin by a Flock of
1151 Insect-Resistant Rice 1216 U.S. Biotech Firms Sheep, Andrew S. Carver, Buyers Guide Issue
Generated by Introduction Embrace “Virtual Michael A. Dalrymple,
of a Modified 6-Endotoxin Integration”, B.J. Spalding Gordon Wright, Denise S. for 1994
Gene of Bacillus (News) Cotton, Dawn B. Reeves,
thuringiensis, Hideya 1218 Stocks Look Better Now Yvonne H. Gibson, Jayne 1331 Alphabetical Product
Fujimoto, Kimiko Itoh, Than Earlier This Year, L. Keenan, J. David Listing
Mikihiro Yamamoto, Junko David Webber (News) Barrass, Ann R. Scott, Alan 1336 Display Advertiser’ Index
Kyozuka, Ko Shimamoto 1220 Third Quarter Sees 10 Coleman, lan Garner and Buyers’ Guide Fax
(Research) Firms Raise $152.4 (Research) Form
Thermal Stabilization of Million, B.J. Spalding Improved Bivalent 1341 Antibody Products Table
Xylose Isomerase from (News) Miniantibodies, with 1346 Monoclonal Antibody
Thermoanaerobacterium 1220 Kemira Sheds European Identical Avidity as Whole Products Table
thermosulfurigene, Micropropagation Units, Antibodies, Produced by 1350 Chromatography Products
Menghsiao Meng, Michael GerO’aD wyrer d(Ne ws) High Cell Density Table
Bagdasarian, Gregory 1221 Institutions Lukewarm on Fermentation of 1362 Antibodies and Antigens
Zeikus (Research) U.S. Agbiotech Firms, B.J. E. coli, Peter Pack, Marian 1363 Bacterial and Cell Analysis
Electrospray Mass Spalding (News) Kujau, Volker Schroeckh, 1368 Balances and Scales
Spectrometry Characteriza- 1222 Will Agbiotech’s First Uwe Kniipfer, Rolf 1373 Chromatography
tion of Posttranslational Tomatoes Meet Expecta- Wenderoth, Dieter 1377 Clinical Diagnostics
Modifications of Barley a- tions?, George Kidd Riesenberg, Andreas 1385 Computer Hardware and
Amylase | Produced in (News) Pliickthun (Research) Software
Yeast, Morten Sogaard, 1225 Oligonucleotides Surge 1278 Separation and Isolation of 1388 Electrophoresis
Jens S. Andersen, Peter into Clinical Trials, Joseph Viable Bacteria by 1393 Fermentors, Bioreactors,
Roepstorff, Birte Svensson Alper (News) Capillary Zone Electro- and Cell Culture
(Research) 1226 Clinton’s Doomed phoresis, Richard C. 1399 General Molecular Biology
1166 High-Level Production of Technology-Development Ebersole, Randy M. 1412 Laboratory Animals and
Hybrid Potyvirus-Like Policy, Russ Hoyle (News) McCormick (Research) Animal Care
Particles Carrying 1227 NIHRAC Okays Gene 1286 Transposition Mediated 1413 Laboratory and Scientific
Repetitive Copies of Therapy, Jeffrey L. Fox Repositioning and Apparatus
Foreign Antigens in (News) Subsequent Elimination of 1423 Labware
E. coli, Mittur N. Jagadish, 1229 Finland Pushes Develop Marker Genes from 1425 Liquid Handling
Ross C. Hamilton, Caroline ment ofB ioenergy, Gerard Transgenic Tomato, 1431 Microscopy and Optical
S. Fernandez, Peter O’Dwyer(News) Andrew P. Goldsbrough, Equipment
Schoofs, Kathy M. Davern, 1230 Alliance Update, Mike Cleofe N. Lastrella, John I. 1434 Nuclear Instrumentation
Harry Kalnins, Colin W. Ginsberg (News) Yoder (Research) 1437 Recording Equipment,
Ward, Ian T. Nisbet 1231 Product Update, Mike 1293 Assessing Genetic Electrical, and Electronic
(Research) Ginsberg (News) Heterogeneity in Equipment
1084 Correspondence 1237 Neuronal Signal Transduc- Production Cell Lines: 1438 Spectroscopy
1184 New Products tion: Will Controlling Detection by Peptide 1441 Technical, Analytical, and
1186 Electrophoresis Phosphorylation Cure Mapping ofa Low Level Research Services
1191 Free Literature Disease?, Stephen M. Tyr to Gln Sequence 1444 Pharmaceutical Intermedi-
1196 Peace and Biotechnology Edgington (Article) Variant in a Recombinant ates and Bulk Raw
in the Middle East, John 1243 Biotechnology For Pleasure Antibody, Reed J. Harris, Materials
Hodgson (Opinion) and Profit, William Bains Amy A. Murane, Shannon 1446 U.S. Biotech Firms
(Article) L. Utter, Karen L. Wagner, Embrace “Virtual
November 1250 Mining by Microbe, Alan Edward T. Cox, Gian D. Integration”, B.J. Spalding,
H. Goldstein, Robert D. Polastri, Judith C. Helder, (News)
1203 Taking the Initiative in Rogers, Gerald Mead Mary B. Silwkowski 1449 Suppliers
Health-Care Reform, Susan (Article) (Research)
Hassler (Opinion) 1302 Determining Amino Acid 1299 Enzyme Catalysts in December
1208 Public Awareness, Not Composition, Robert F. Multiphase Systems: Direct
Public Relations, Bernard Burgoyne (BioTools) Determination of Water 1495 Waiter, There’s a Protein in
Dixon (Opinion) 1306 Recombinant Conception: Distribution, Robert A. My Soup, Susan Hassler
1212 Bio Rages Against Does It Require the DNA?, Stenning, Eric C. Needs, (Opinion)
Pharmaceutical Price Richard J. Warburg Brian E. Brooker, Evgeny 1499 The Carbon Cycle: A Well-
Control, Jeffrey L. Fox (BioTools) N. Vulfson (Research) Known Tale is Full of
(News) 1309 Putting the “Pep” in 1204 Correspondence Holes, Bernard Dixon
1212 Health-Care Reform Will Peptides, John Hodgson 1311 Peptides (Opinion)
Speed Alliances, B.J. (BioQ&A) 1312 New Products 1502 FDA Finally Approves
Spalding (News) 1256 Nuclear Hormone 1314 Announcements BST for Milk Production,
1213 DoU.K. Regulationosf Receptors as Targets for 1315 Free Literature Jeffrey L. Fox (News)
GMOs Hamper Industry?, New Drug Discovery, 1323 Risk Assessment 1502 DoFlagship-Product
Mike Ward (News) Donald P. McDonnell, Experiments for“Geneti- Failures Cheat Investors?,
1214 Univax Files PLA for Elisabetta Vegeto, Martin cally Modified” Plants, B.J. Spalding (News)
WinRho for ITP, B.J. A.G. Gleeson (Review) Henry I. Miller, Susanne L. 1504 Comments from the White
Spalding (News) 1263 Transgenic Livestock as Huttner, Roger Beachy House’s Greg Simon, Russ
1214 Using Vacction Deeveslo p Bioreactors: Stable (Opinion) Hoyle (News)
Specific Polyclonals, B.J. Expression of Human a-1- 1506 FDA Advisory Panel Okays
100 = BIO/TECHNOLOGY VOL. 12 JANUARY 1994
/VOLUME 11 1993 INDEX
Genentech’s Nutropin, Phosphotransferase II 1574 Large-Scale Productioonf Paradigm for Food, the
Jeffrey L. Fox (News) (NPTII) Protein and its Vibrio cholerae Toxin B Farm, and the
1506 Biotech Executives Loathe Equivalence to the Plant Subunit for Use in Oral Public, Proceedings of an
Price Controls, B.J. Expressed Protein, Roy L. Vaccines, M. Lebens, S. Institute for Science in
Spalding (News) Fuchs, Robert A. Heeren, Johansson, J. Osek, M. Society conference
1508 The Hot New Field of Mark E. Gustafson, Glen J. Lindblad,J .H olmgren (Supplement)
Molecular Diversity, David Rogan, David E. Bartnicki, (Research) 1600 Clinical Trials Liability:
Stone (News) Richard M. Leimgruber, 1496 Correspondence The Hidden Risks, Wayne
1509 Funding Through Rory F. Finn, Arnold 1590 Cryogenics Clifton (Opinion)
Alliances, B.J. Spalding Hershman, Sharon A. 1584 Food Technology: A New
(News) Berberich (Case Study)
1510 Analyzing the U.S. Safety Assessmeofnt th e
Horticultural Industry, Neomycin
George Kidd, Melanie Phosphotransferase II
Davis (News) (NPTID) Protein, Roy L.
1512 Will Genetic Tests and Fuchs, Joel E. Ream, Bruce AUTHOR INDEX
Computers Invade G. Hammond, Mark W.
Privacy?, Jeffrey L. Fox Naylor, Richard M. Page numbers beginning with “S” Bienz-Tadmor, Brigitta, 168
(News) Leimgruber, Sharon A. refer to the 10th anniversary special Bono, Angiola, 1515
1513 The Inventorship Lessons Berberich (Case Study) supplement in the March issue Borrabaeck, Carl A.K., 503
of Burroughs Wellcome, 1548 Searching Sequence Space A Borys, Michael C., 720
KevinJ . McGough (News) to Engineer Proteins: Boucher, J.C., 1133
1514 FDA Rules for Somatic- Exponential Ensemble Aaspollu, Anu, 1048 Boulain, Jean-Claude, 601
Cell and Gene Therapy, Mutagenesis, Simon Abrams, Paul, 156, 450, 542, Bowman, Cindy, 194
Jeffrey L. Fox (News) Delagrave, Douglas C. 775 Bradbury, Andrew, 1565
1514 Dutch Okay Streamlined Youvan (Research) Agayn, Venetka I., 726 Brawner, Mary E., 1031
Rules for GMOs, Mike 1553 Rapid Production of Aharonowitz, Yair, 807 Broda, Paul, 830
Ward (News) Transgenic Wheat Plants Al-Rubeai, Mohamed, 572 Brooker, Brian E., 1299
1515 France Considers Law by Direct Bombardment of Ali, Simi, 376 Brooks, Paul, 830
Regulatintgh e Human Cultured Immature Alper, Joseph, 19, 150, 254, 429, Brown, Gregory, 434
Body, Angiola Bono Embryos, Vimla Vasil, 556, 649, 772, 973, 982,1093, Brownstein, Bernard H., 911
(News) Vibha Srivastava, Ana M. 1225 Brunke, Karen J., 1559
1515 Finland Considering Far- Castillo, Michael E. Andersen, Jens S., 1162 Bryant, Stephen H., 479
Reaching Biotech Rules, Fromm, Indra K. Vasil Anderson, Walter Truett, 236 Briiggermann, Marianne, 911
Gerard O’Dwyer(News) (Research) Andrews, B.A., 214 Bud, Robert, S14
1516 Quietly Rationalizing Drug 1559 Transgenic Corn Plants Andya, J., 387 Burgoyne, Robert F., 1302
Discovery, Harvey Bialy Expressing MDMV Strain Anthony, R., 1570 Burke, Daniel P., 30,
(News) B Coat Protein are Antler, Adriane M., 742 270, 778
1518 Back to the Future with Resistantt o Mixed Anzai, Hiroyuki, 835 Bye, Jacqueline M., 1145
Polyclonal AntibodiesW,. Infections of Maize Dwarf Arcuri, Edward J., 1031
Scott Harkonen, Keith A. Mosaic Virus and Maize Asenjo, J.A.,214 C
Gregg (News) Chlorotic Mottle Virus, Atkins, Gregory J.,916
1520 Alliance Update, Mike Lynn E. Murry, Laurie G. Ayala, Marta, 503 Cambou, Bernard, 709
Ginsberg (News) Elliot, Sherry A. Capitant, Cantor, Charles R., 201
1522 Product Update, Mike Joanne A. West, Kimberly B Cantoral, Jesus M., 807
Ginsberg (News) K. Hanson, Liliana Capitant, Sherry A..,
1524 Environmental Release Scarafia, Scott Johnston, Bagdasarian, Michael, 1157 1559
Permits, Charles I Beck, Camille DeLuca-Flaherty, Bailey, James, 207 Carlson, William C., 454
Thomas H. Ulrich (Article) Scott Nichols, Dolores Bains, William, 756, 1243 Carozzi, Nadine B., 194
1529 Consolidated Alliances, Cunanan, Paul Dietrich, Balkovic, E.S., 173 Carrier, Alice, 601
Peter D. Lyons, Julius Irvin J. Mettler, Steve Barlow, Kirsty, 1003 Cartwright, Terence, 349
Lang, Michael A. Guzzo Dewald, Debra A. Barrass, J. David, 1263 Carver, Andrew S., 1263
Article) Warnick, Carol Rhodes, Bartnicki, David E., Casdin, Jeffrey, 544
1534 Self-Assembling Ralph M. Sinibaldi, Karen 1537 Castillo, Ana M., 1553
Nanostructures, Nir J. Brunke (Research) Bauer, R., 387 Cassdin, Jeffrey, 148
Kossovsky, David Millett, 565 Use of Living Columns to Beachy, Roger, 1323 Castillo, Francisco J.,
Andrew Gelman, Ed Select Specific Phage Beck, Charles I, 895, 1524 1042
Sponsler, H. James Antibodies, Andrew Beland, Gary L., 194 Cattaneo, Antonio, 1565
Hnatyszyn (Article) Bradbury, Lidija Persic, Ben-Tzvi, Inbal, 715 Chang, Lucille W.S.,
1579 Sequence into Structure, Thomas Werge, Antonio Bender, James G., 358 1042
Subhashini Srinivasan, Cattaneo (Research) Berberich, Sharon A., 1537, Chang, Tse-Wen, 291,
Carl J. March, Sucha 1570 A Bifunctional Affinity 1543 486
Sudarsanam (BioTools) Linker to Couple Berglund, Peter, 916 Chappel, Scott, 1014
1582 The Invention Equation, Antibtood Ceilluelosse , Bergmeyer, Jiirgen, 807 Cheng, Liang, 497
Eugene C. Rzucidlo Celia Ramirez, Julian Bernasconi, Rick, 1014 Christensen, Alan H.,
(BioTools) Fung, Robert C. Miller Jr., Bertelsen, Arthur H., 64 835
1537 Purification and Character- R. Anthony, J. Warren, Bertram, Carol P., 843 Chu, Valeria, 709
ization of Microbially Douglas G. Kilburn Beudeker, Rob F., 811 Clark, A. John, 376
Expressed Neomycin (Research) Bialy, Harvey, 154, 278, 1516 Clark, Douglas S., 825
BIO/TECHNOLOGY VOL. 12 JANUARY 1994 101
/VOLUME 11 1993 INDEX
Clifton, Wayne, 1600 Ebert, Beth, 709 Gelman, Andrew, 1534 Higuchi, Russell, 1026 Keriinen, Sirkka, 591
Colella, Samuel D., 412 Edgington, Stephen M., Georgiou, George, 491 Hill, Martha, 194 Kevles, Daniel J.,S11
Cohen, Gerald, 807 16, 39, 285, 465, 580, Gerber, Robert, 1031 Hintz, William E., 815 Kidd, George,
Cole, Edward S., 1014 676, 787, 998, 1117, Gibson, Yvonne H., Hippenmeyer, Paul, 1037 268, 448, 552, 662,
Coleman, Alan, 1263 1237 1263 Hirst, Barry H., 376 781, 874, 980, 1102,
Collingham, David P., Edmunds, Tim, 1014 Gilbert, Denise, 264, 654 Hnatyszyn, H. James, 1222, 1510
$44 Elliot, Laurie G., 1559 Gilbert, Harry J., 376 1534 Kilburn, Douglas G.,
Collins, Mark, 163 Ellis, D.D., 84 Gillet, Daniel, 601 Hodgson, John, 491, 1570
Consalvo, Angelo P., 64 Elomaa, Paula, 508 Ginsberg, Mike, 36, 49, 159, 636, 683, Kim, Young-Woo, 486
Cook, Graham P., 911 Emerson, StephenG., 1230, 1231, 1520, 852, 887, 1003, 1061, Kinghorn, Jim, 807
Corcoran, Claire, 670, 368 1522 1181, 1196, 1309 Klausner, Arthur, S35
785, 881, 982 Emery, A. Nicholas, 572 Gleeson, MartinA.G., Hoekema, André, 811 Kleeman, James M..,
Cotton, Denise S., 1263 Enayati, Elizabeth F., 1256 Holmberg, Andrea, 622 1014
Cox, Edward T., 1293 1056 Golds, Timothy, 95 HolmgrenJ,. , 1574 Kleinkauf, Horst, 807
Cregg, James M., 905 Ensley, Burt D., 381 Goldsbrough, Andrew P., Holt, John, 709 Knappik, Achim, 77
Crenshaw, Rebecca, 194 Evans, Alun, 612 1286 Honkanen, Jarmo, 508, Knowles, Jonathan K.C.,
Crossland, Lyle, 194 Evola, Stephen V., 194 Goldstein, Alan H., 1250 1048 591
Cunanan, Dolores, 1559 Gonsalves, Dennis, 819 Hood, Leroy, S9 Kniipfer, Uwe, 1271
Curcic, R., 1133 F Goochee, Charles F.,512 Hora, M., 387 Koller, Manfred R., 358
Goodstein, Mark, Hoyle, Russ, Koop, Hans-Ulrich, 95
D Fachini, R.A., 926 549, 672, 786, 884, 24, 152, 274, 442, Kossovsky, Nir, 1534
Feldman, Boris, 664 989, 992, 994, 1112, 460, 558, 666, 783, Kotilainen, Mika, 508
Dalrymple, Michael A., Fernandez, Caroline S., 1114 878, 978, 1105, 1226, Kovacic, Sharlotte, 187
1263 1166 Gordon, Mark C., 837 1504 Koziel, Michael G., 194
Danielsson, Lena, 503 Fernandez, F.J.,926 Gore, Richard, 709 Hrinda, Michael, 709 Krebber, Claus, 77
Datar, Rajiv V., 349 Ferrara, Dawn, 1014 Gorick, Barbara D., 1145 Huang, R.B., 214 Kreitinger, Mary, 454
Davern, Kathy M., 1166 Fetrow, Jaquelin S.,479 Grant, Kathleen L., 187 Hughes, D.E., 926 Kujau, Marian, 1271
Davies, Anthony H., 933 Fett-Neto, Arthur G., 731 Gregg, Keith A., 1518 Hughes-Jones, NevinC., Kumagai, Monto H., 606
Davies, Nicholas P.,911 Fink, Uwe, 807 Grill, Laurence K., 606 1145 Kurata, Nori, 584
Davis, Melanie, 1510 Finn, Rory F., 1537 Grob, Jim, 454 Huttner, Susanne L., Kvam, Catrine, 60
Davis, Michael H., 736 Finnern, Ricarda, 1145 Gupta, Hari S., 90 1323 Kyozuka, Junko, 1151
Dawson, John, 194 Firek, Simon, 218 Gupta, Pramod K., 454
Della-Cioppa, Guy, 606 Flavell, Richard B., 584 Gustafson, Mark E., I L
DeLuca-Flaherty, Fockler, Carita, 1026 1537
Camille, 1559 Fornwald, James A.., Gutiérrez, S.,926 Ikeda, Masato, 921 LaVallie, Edward R., 187
DeModena, J.A.,926 1031 Guzzo, Michael A., 1529 Irish, Thomas, 709 Lagosky, Peter, 815
Delagrave, Simon, 1548 Fox, Jeffrey L., Irving, John M., 1042 Lajeunesse, Evelyne, 601
Demain, Arnold L., 807 28, 143, 153, 154, H Itoh, Kimiko, 1151 Lang, Julius, 1529
Dent, Judith A., 709 252, 269, 276, 439, Iwata, Michiaki, 835 Lastrella, CleofeN..,
Deretic, V., 1133 443, 536, 538, 554, Haff, Lawrence, 938 1286
Desai, Nalini, 194 656, 663, 665, 779, Hall, Judith, 376 J Lauffenburger, Douglas,
Dewald, Steve, 1559 780, 782, 867, 868, Hamamoto, Hiroshi, 930 155
DiBlasio, Elizabeth A.., 880, 1100, 1212, Hamers, Mic. N., 561 Jackson-Maithews, Launis, Karen, 194
187 1227, 1502, 1506, Hamilton, Ross C., 1166 Dianne E., 64 Lauziere, Kevin, 1014
DiCosmo, Frank, 731 1512, 1514 Hamilton, Steve, 793 Jagadish, Mitiur N., Lebens, M., 1574
Dibner, Mark D., 1120 Fradd, R. Brandon, 8/0, Hammond, BruceG., 1166 Lee, Gyun, Min, 368
Dickrell, Lydia, 1014 1101 1543 Jiao, Shoushu, 497 Lee, Karen, 1014
Dietrich, Paul, 1559 Francisco, Joseph A., Hanson, Kimberly K., JohanssonS,. , 1574 Lee, Ted, 709
Dixon, Bernard, 9, 44, 491 1559 John M., McCoy, 187 Leemans, Jan, S22
135, 249, 425, 535, Freeman, Amihay, 1007 Harding, Victoria, 612 Johnson, Rollin B., 180 Lehman, E. Dale, 207
646, 767, 863, 968, Freymeyer, II, Daniel K.., Harkonen, W. Scott, Johnston, Scott, 1559 Leimgruber, Richard M.,
1053, 1090, 1208, 207 1518 Jones, Ian M., 933 1537, 1543
1499 Fromm, Michael E., Harris, Reed J., 1293 Jowett, Jeremy B.M.,933 Lewis, Kelly, 194
Dollinger, Gavin, 1026 1553 Hashida, Eiji, 930 Joyce, Joseph G., 207 Liljestrém, Peter, 916
Donovan, Mary Jo, 1031 Fuchs, Roy L., 1537, Hassi, Anja, 1048 Lilly, Malcolm D., 1007
Donzel, Alain, 793 1543 Hassler, Susan, 1203, K Lindblad, M., 1574
D6orries, Ulrich, 1174 Fujimoto, Hideya, 1151 1495 Linko, Pekka, 622
Drake, Peter, 434 Fung, Julian, 1570 Haukanes, Bjorn-Ivar, 60 Kaderbhai, Mustak A., Linzer, Daniel 1.H., 720
Draper, John, 218 Féaux de Lacroix, Stefan, Haycock, Paul, 668 612 Lyons, Peter D., 1529
Drews, Jiirgen, S16 1174 Hazelwood, Geoffry P., Kaderbhai, Naheed, 612
Ducancel, Frédéric, 601 376 Kadwell, Sue, 194 M
Dudley, Susan E., 524 G Heeren, Robert A., 1537 Kalnins, Harry, 166
Duesberg, Peter H., 955 Helariutta, Yrj6, 508 Karim, Amna, 612 MacCabe, Andrew, 807
Duejias, Marta, 503 Galazzo, J.L.,926 Helder, Judith C., 1293 Katsumata, Ryoichi, 921 Maddox, Daryl, 194
Gale, Michael D., 584 Hellman, Kiki B., 1179 Keenan, Jayne L., 1263 Maiorella, Brian.L., 387,
E Galili, Gad, 715 Herber, Wayne K., 207 Keller, John, 1031 512
Garner, Ian, 1263 Hershman, Arnold, 1537 Kelly, Patrick D., 839 Maliga, Pal, 95
Ebersole, RichardC., Garoff, Henrik, 916 Hibler, N.S., 1133 Kelton, Christine, 1014 Malmborg, Ann-Christin,
1278 Geerse, Kees, 811 Highkin, Maureen, 1037 Kelve, Merike, 1048 503
1402 BIO/TECHNOLOGY VOL. 12 JANUARY 1994
/VOLUME 11 1993 INDEX
March, Carl J., 1579 Nevalainen, Leena, 508 Rathmann, George B., 1096, 17, 21, 144, Velasco, J.,926
Marks, James D., 1145 Ng, Shi-Chung, 71 $27 149, 256, 260, 426, Ventom, A.M.,214
Marsh, David, 937, 1173 Nichols, Scott, 1559 Ray, Martha V.L., 64 428, 444, 539, 541, Versteegh, Hans A.J.,
Martin, D.W., 1133 Nisbet, Ian T., 1166 Ream, Joel E., 1543 545, 548, 554, 648, 811
Martinell, Brian, 84, 596 Nojiri, Chuhei, 835 Reeves, Dawn B., 1263 768, 770, 866, 868, Verwoerd, Theo C., 811
Matsunaga, Yuji, 930 Norris, Mike L., 911 Reid, James, 1110 875, 986,1106, 1109, Voak, Douglas, 1145
Mazid, M. Abdul, 690 Nyyss6nen, P Eini, 591 Rhodes, Carol, 1559 1212, 1214, 1216, Von Déhren, Hans, 807
McCabe, Dennis E., 84, Rhodes, Richard, 194 1220, 1221, 1502, Vossius, Volker, 1174
596 0 Ricca, George A., 709 1506, 1509 Vulfson, Evgeny N.,1299
McClintock, Richard A., Richards, Susan, 1014 Spitznagel, Thomas A.,
709 O’ Dwyer, Gerard, Richardson, Jenny C., 825 W
McCormick, Douglas K., 549, 879, 1100, 1107, 911 Sponsler, Ed, 1534
7, 26, 131, 243, 1220, 1229, 1515 Rickenbach, Josef von, Srinivasan, Subhashini, Wacker, Margaret M.,
419, 531, 643, 763, O'Neil, P.F., 173 30 1579 1177
859, 963, 994, 1059, Okada, Yoshimi, 930 Riesenberg, Dieter, 1271 Srivastava, Vibha, 1553 Wagner, Karen L., 1293
1083 Ooba, Shinya, 835 Roberts, D.R., 84 Stathopoulos, Christos, Wallace, K.M., 84
McCormick, Randy M., Osek, J., 1574 Roepstorff, Peter, 1162 491 Walt, David R., 726
1278 Ouwehand, Willem H., Rogan, Glen J., 1537 Stenning, Robert A., Warburg, Richard J.,
McCown, B.H., 84 1145 Rogers, Robert D., 1250 1299 1306
McCoy, John M., 187 Ozcan, Sebahattin, 218 Rosen, Carl-Gustaf, 349 Stone, David, 988, 1508 Ward, Colin W., 1166
McDonnell, Donald P., Rosewell, Ian R., 911 Sturmer, Amy M., 64 Ward, Mike,
1256 P Ruggeri, Zaverio M., 709 Sudarsanam, Sucha, 146, 551, 798, 869,
McGough, Kevin J., 30, Russell, D.R., 84 1579 1213, 1514
270, 778, 1108 Pack, Peter, 1271 Rzucidlo, Eugene C., Sugiyama, Yoshinori, Ware, Jerry L., 709
McInnis, S., 84 Paek, Se-Hwan, 368 1582 936 Warnick, Debra A., 1559
McPherson, John M., Palissa, Harriet, 807 Surani, M. Azim, 376 Warren, Gregory W., 194
1014 Palsson, Bernhard O., 5 Svensson, Birte, 1162 Warren, J., 1570
McPherson, Kathryn, 368 Sverlow, Genadie G., Warten, R. Anthony J.,
194 Pang, Sheng-Zhi, 819 Saarma, Mart, 1048 606 491
Mead, Gerald, 1250 Papadimitriou, John M., Sakata, Ko, 731 Watanabe, Yuichiro, 930
Meghji, Moez R., 194 696 Saloheimo, Anu, 591 T Watson, Robert, 1026
Mehto, Merja, 508, 1048 Papadopulos-Eleopulos, Samarajeewa, Pallepitiya Webber, David, 22, 774,
Melanson, Stewart J., Eleni, 696 K., 835 Takamatsu, Susumu, 835 1218
731 Papoutsakis, Eleftherios Sano, Takeshi, 201 Takemoto, Shizume, 930 Weber, David, 709
Meng, Menghsiao, 1157 T., 358, 720 Scarafia, Liliana, 1559 Tarr, Criss, 709 Wedrychowski, Andrzej,
Merkler, David J., 64 Parekh, R., 387 Schatz, Peter J., 1138 Taylor, Dean P., 1031 486
Merlin, Ellis, 194 Pattanayak, Arunava, 90 Schendel, Paul F., 187 Teeri, Teemu H., 508, Weintraub, Bruce, 1014
Mettler, Irvin J., 1559 Pen, Jan, 811 Schoofs, Peter, 1 166 1048 Welty, Elaine, 454
Middleton, Al, S40 Penttila, Merja, 591 Schroeckh, Volker, 1271 Tepfer, Mark, 1125 Wenderoth, Rolf, 1271
Miller, Henry I.,1075, Perl, Avihai, 715 Schurr, M.J., 1133 Thalen, Marcel, 381 Werge, Thomas, 1565
1323 Persic, Lidija, 1565 Schwartz, Richard M., Thomson, J., 387 West, Joanne A., 1559
Miller, Lantz, 969 Peterson, Pamela, 1014 368 Thorpe, Susan J., 1145 Wiggans, Tom, 876
Miller Jr., Robert C., Pfeifer, Eva, 807 Schwecke, Torsten, 807 Timmis, Roger, 454 Winkelhake, J., 387
1570 Picciolo, Grace Lee, Scott, Ann R., 1263 Toki, Seiichi, 835 Winter, Greg, 1145
Miller, William J., 207 1179 Searfoss, George, 709 Truve, Erkki, 1048 Witkowski, Jan A., 620
Miller, William M., 358 Pliickthun, Andreas, 77, Seppanen, Pauli, 508, Tumer, Valendar F., 696 Wolfe, Saul, 807
Millett, David, 1534 1271 1048 Wolff, Jon A., 497
Misrock, S. Leslie, 742 Pokkinen, Marjut, 622 Serdar, Cuneyt, 381 U Wong, Sui-Lam, 71
MitscheJloen,n 7,0 9 Polastri, Gian D., 1293 Shand, Hope, S13 Woodley, John M., 1007
Monica, Thomas J., 512 Potter, Ray, 20, 432, Shaul, Orit, 715 Uchimiya, Hirofumi, 835 Wright, Gordon, 1263
Moore, Graham, 584 651, 972 Sheahan, Brian J.,916 Ulrich, Thomas H., 895, Wright, Martha, 194
Moyer, B., 387 Potter, Roslyn C., 843 Shimamoto, Ko, 1151 1524 Wu, Xu-Chu, 71
Mudd, M.H., 1133 Pratt, Bruce M., 1014 Siimes, Terhi, 622 Utter, Shannon L., 1293
Mueller, Edward P., Prior, Christopher P., Silver, Samuel, 368 Y
1179 709 Silwkowski, Mary B., V
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Murane, Amy A., 1293 Puska, Reeta, 508, 1048 Simons, J. Paul, 376 Van Duyne, Paul, 64 1151
Murdock, Douglas, 381 Simonsson Lagerkvist, Van Liempt, Henk, 807 Yang, Ning-Sun, 497
Murry, Lynn E., 1559 Ann Catrin, 503 Van Ooyen, Albert J.J., Yoder, John I., 1286
Ménez, André, 601 Sims, Paul, 830 811 Young, J., 387
Quail, Peter H., 835 Sinibaldi, Ralph M., Van Paridon, Peter A., Youvan, Douglas C.,
N 1559 811 1548
R Sjéberg, Mathilda, 916 Van den Elzen, Peter
Nakagawa, Noriaki, 930 Slightom, Jerry L, 819 J.M., 811 Z
Naylor, Mark W., 1543 Raffa, K.F., 84 Smeekens, Steven P., 182 Van der Klis, Jan, 811
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Needs, Eric C., 1299 Ramirez, Celia, 1570 Séderlind, Eskil, 503 Vasil, Indra K., 1553 Zhang, Jinyou, 807
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BIO/TECHNOLOGY VOL. 12 JANUARY 1994 103
