Table Of Content�M�e�d�i�c�a�l� �P�h�y�s�i�c�s
�H�e�r�o�l�d
SERIES IN SENSORS SERIES IN SENSORS
�R�a�s�o�o�l�y
SERIES EDITORS: BARRY JONES WILLIAM B. SPILLMAN
�B�I�O�S�E�N�S�O�R�S
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�A�B
�T�E�C�H�N�O�L�O�G�I�E�S� �F�O�R� �C�A�N�C�E�R�
�N
�D�I�A�G�N�O�S�T�I�C�S
�F�D
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�O � �A�N�D� �M�O�L�E�C�U�L�A�R� �T�E�C�H�N�O�L�O�G�I�E�S
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Bridging the gap between research and clinical application, Biosensors �M�O
�R
and Molecular Technologies for Cancer Diagnostics explores �F�O�R� �C�A�N�C�E�R� �D�I�A�G�N�O�S�T�I�C�S
� �O
the use of biosensors as effective alternatives to the current standard �C
methods in cancer diagnosis and detection. It describes the major �A�L
�E�S �E�d�i�t�e�d� �b�y� �K�e�i�t�h� �E�.� �H�e�r�o�l�d • �A�v�r�a�h�a�m� �R�a�s�o�o�l�y
aspects involved in detecting and diagnosing cancer as well as the �N
�C
basic elements of biosensors and their applications in detection and
�C
�U
diagnostics. �E
�E
�L
�R
�A
The book addresses cancer molecular diagnostics, including genomic � �N
�D�R
and proteomic approaches, from the perspective of biosensors and
�
biodetection. It explains how to measure and understand molecular �I�T
�A
markers using biosensors and discusses the medical advantages of �E
�G �S
rapid and accurate cancer diagnostics. It also describes optical, �C
electrochemical, and optomechanical biosensor technologies, with �N�H
�O
a focus on cancer analysis and the clinical utility of these technologies �O�N
for cancer detection, diagnostics, prognostics, and treatment.
�S�O
�T
�L
Making biosensor technology more accessible to molecular biologists, �I �R
�C�O
oncologists, pathologists, and engineers, this volume advances the
integration of this technology into mainstream clinical practice. Through �S�G
its in-depth coverage of a range of biosensors, the book shows how they �I�S
�E
can play instrumental roles in the early molecular diagnosis of cancer.
�S
K11937
ISBN: 978-1-4398-4165-5
90000
9 781439 841655
�B�I�O�S�E�N�S�O�R�S
� �A�N�D� �M�O�L�E�C�U�L�A�R� �T�E�C�H�N�O�L�O�G�I�E�S
�F�O�R� �C�A�N�C�E�R� �D�I�A�G�N�O�S�T�I�C�S
Series in Sensors
Series Editors: Barry Jones and Haiying Huang
Other recent books in the series:
Biosensors and Molecular Technologies for Cancer Diagnostics
Keith E. Herold and Avraham Rasooly
Compound Semiconductor Radiation Detectors
Alan Owens
Metal Oxide Nanostructures as Gas Sensing Devices
G. Eranna
Nanosensors: Physical, Chemical, and Biological
Vinod Kumar Khanna
Handbook of Magnetic Measurements
S. Tumanski
Structural Sensing, Health Monitoring, and Performance Evaluation
D. Huston
Chromatic Monitoring of Complex Conditions
Edited by G. R. Jones, A. G. Deakin, and J. W. Spencer
Principles of Electrical Measurement
S. Tumanski
Novel Sensors and Sensing
Roger G. Jackson
Hall Effect Devices, Second Edition
R. S. Popovic
Sensors and Their Applications XII
Edited by S. J. Prosser and E. Lewis
Sensors and Their Applications XI
Edited by K. T. V. Grattan and S. H. Khan
Thin Film Resistive Sensors
Edited by P. Ciureanu and S. Middelhoek
Electronic Noses and Olfaction 2000
Edited by J. W. Gardner and K. C. Persaud
Sensors and Their Applications X
Edited by N. M. White and A. T. Augousti
Sensor Materials
P. T. Moseley and J. Crocker
SERIES IN SENSORS
�B�I�O�S�E�N�S�O�R�S
� �A�N�D� �M�O�L�E�C�U�L�A�R� �T�E�C�H�N�O�L�O�G�I�E�S
�F�O�R� �C�A�N�C�E�R� �D�I�A�G�N�O�S�T�I�C�S
�E�d�i�t�e�d� �b�y �K�e�i�t�h� �E�.� �H�e�r�o�l�d • �A�v�r�a�h�a�m� �R�a�s�o�o�l�y
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Contents
Preface.......................................................................................................................................................xi
Contributors..............................................................................................................................................xv
Part I Introduction
1. Cancer and the Use of Biosensors for Cancer Clinical Testing....................................................3
R.F. Chuaqui, Keith E. Herold, and Avraham Rasooly
Part II Optical Technologies for Cancer Detection and Diagnostics:
Surface Plasmon Resonance
2. Surface Plasmon Resonance Biosensor Based on Competitive Protein Adsorption for
the Prognosis of Thyroid Cancer...................................................................................................43
Seokheun Choi and Junseok Chae
3. Surface Plasmon Resonance Analysis of Nanoparticles for Targeted Drug Delivery..............55
Emilie Roger, Alex E. Grill, and Jayanth Panyam
4. Dual-Functional Zwitterionic Carboxybetaine for Highly Sensitive and Specific
Cancer Biomarker Detection in Complex Media Using SPR Biosensors..................................69
Norman D. Brault, Shaoyi Jiang, and Qiuming Yu
5. Surface Plasmon Resonance (SPR) and ELISA Methods for Antibody
Determinations as Tools for Therapeutic Monitoring of Patients with Acute
Lymphoblastic Leukemia (ALL) after Native or Pegylated Escherichia coli
and Erwinia chrysanthemi Asparaginases...................................................................................89
Vassilios I. Avramis
Part III Optical Technologies for Cancer Detection and
Diagnostics: Evanescent Wave and Waveguide Biosensors
6. Photonic Biochip Sensor System for Early Detection of Ovarian Cancer................................111
Debra Wawro, Peter Koulen, Shelby Zimmerman, Yiwu Ding, Charles Kearney,
and Robert Magnusson
7. Label-Free Optofluidic Ring Resonator Biosensors for Sensitive Detection of Cancer
Biomarkers.....................................................................................................................................125
Hongying Zhu and Xudong Fan
v
vi Contents
8. Resonant Waveguide Grating Biosensor for Cancer Signaling.................................................141
Ye Fang and Ann M. Ferrie
9. Optical Waveguide-Based Biosensors for the Detection of Breast Cancer Biomarkers.........155
Harshini Mukundan, John E. Shively, Aaron S. Anderson, Nile Hartman, W. Kevin Grace,
and Basil I. Swanson
10. Label-Free Resonant Waveguide Grating (RWG) Biosensor Technology for
Noninvasive Detection of Oncogenic Signaling Pathways in Cancer Cells..............................171
Yuhong Du, Min Qui, and Haian Fu
Part IV Optical Technologies for Cancer Detection and
Diagnostics: Spectrometry for Cancer Analysis
11. Noninvasive and Quantitative Sensing of Tumor Physiology and Function via
Steady-State Diffuse Optical Spectroscopy.................................................................................187
Karthik Vishwanath, Gregory Palmer, Quincy Brown, and Nimmi Ramanujam
12. Noble Metal Nanoparticles as Probes for Cancer Biomarker Detection and Dynamic
Distance Measurements in Plasmon Coupling Microscopy......................................................209
Hongyun Wang, Guoxin Rong, Jing Wang, Bo Yan, Lynell R. Skewis, and Björn M. Reinhard
13. Cost-Effective Evaluation of Cervical Cancer Using Reflectance
and Fluorescence Spectroscopy...................................................................................................229
Shabbir B. Bambot
Part V Optical Technologies for Cancer Detection and Diagnostics:
Optical Imaging for Cancer Analysis
14. Location and Biomarker Characterization of Circulating Tumor Cells.................................257
H. Ben Hsieh, George Somlo, Xiaohe Liu, and Richard H. Bruce
15. High-Resolution Microendoscopy for Cancer Imaging............................................................275
Mark C. Pierce, Veronica Leautaud, Ann Gillenwater, Sharmila Anandasabapathy,
and Rebecca Richards-Kortum
16. Lensless Fluorescent Imaging on a Chip: New Method toward High-Throughput
Screening of Rare Cells................................................................................................................293
Ahmet F. Coskun, Ting-Wei Su, Ikbal Sencan, and Aydogan Ozcan
17. Multiphoton Luminescence from Gold Nanoparticles as a Potential Diagnostic
Tool for Early Cancer Detection..................................................................................................307
Nicholas J. Durr, Marica B. Ericson, and Adela Ben-Yakar
18. Early Detection of Oral Cancer Using Biooptical Imaging Technologies...............................323
Malini Olivo, Ramaswamy Bhuvaneswari, Kho Kiang Wei, Ivan Keogh, and Soo Khee Chee
19. Tactile Sensing and Tactile Imaging in Detection of Cancer...................................................337
A. Sarvazyan, V. Egorov, and N. Sarvazyan
Contents vii
Part VI Optical Technologies for Cancer Detection and
Diagnostics: Fluorescence, Luminescence, Refractive Index
Detection Technologies
20. Biomechanics-Based Microfluidic Biochip for the Effective Label-Free Isolation and
Retrieval of Circulating Tumor Cells...........................................................................................355
Swee Jin Tan, Wan Teck Lim, Min-Han Tan, and Chwee Teck Lim
21. Sensitive Mesofluidic Immunosensor for Detection of Circulating Breast Cancer Cells
onto Antibody-Coated Long Alkylsilane Self-Assembled Monolayers.....................................375
François Breton and Phuong-Lan Tran
22. Micropatterned Biosensing Surfaces for Detection of Cell-Secreted
Inflammatory Signals...................................................................................................................389
Jun Yan and Alexander Revzin
23. Quantum Dots Nanosensor Analysis of Tumor Cells................................................................405
Lee-Jene Lai, Yi-Heui Hsieh, and Shih-Jen Liu
24. Compact Discs Technology for Clinical Analysis of Drugs.......................................................417
Ángel Maquieira
25. Colorimetric Multiplexed Immunoassay for Sequential Detection of Tumor Markers.........441
Jing Wang and Genxi Li
26. Molecular Pincers for Detecting Cancer Markers......................................................................455
Ewa Heyduk and Tomasz Heyduk
27. Fluorescent Nanoparticles for Ovarian Cancer Imaging.........................................................465
Xu Hun, Liang Tiao, and Zhujun Zhang
28. Detection of Cancer-Associated Autoantibodies as Biosensors of Disease by Tumor
Antigen Microarrays.....................................................................................................................483
Steven P. Dudas, Madhumita Chatterjee, Wei Chen, and Michael A. Tainsky
Part VII Optical Technologies for Cancer Detection and
Diagnostics: Photoacoustic for Cancer Analysis
29. Detecting Circulating Melanoma Cells in Blood Using Photoacoustic Flowmetry................505
John A. Viator, Benjamin S. Goldschmidt, and Kyle D. Rood
Part VIII Electrochemical Biosensors
30. Self-Contained Enzymatic Microassay Biochip for Cancer Detection.....................................517
Jianwei Mo, JrHung Tsai, and Brian J. Sullivan
31. Electrochemical Protein Chip for Tumor Marker Analysis......................................................541
Michael S. Wilson
32. Characterization of Cancer Cells Using Electrical Impedance Spectroscopy.........................559
Dorielle Price, Abdur Rub Abdur Rahman, and Shekhar Bhansali
viii Contents
33. Electrochemical Immunosensor for Detection of Proteic Cancer Markers............................573
Alex Fragoso and Ciara K. O’Sullivan
34. Electrochemical Biosensors for Measurement of Genetic Biomarkers of Cancer..................591
Robert Henkens and Celia Bonaventura
35. Microimpedance Measurements for Cellular Transformation and Cancer Treatments......609
Chang Kyoung Choi, Giljun Park, and Tim E. Sparer
36. Multiplexible Electrochemical Sensor for Salivary Cancer Biomarker Detection.................629
Fang Wei, Wei Liao, and David T.W. Wong
37. Microelectrode Array Analysis of Prostate Cancer..................................................................643
Frank Davis, Andrew C. Barton, and Séamus P.J. Higson
38. Graphene-Based Electrochemical Immunosensor for the
Detection of Cancer Biomarker.................................................................................................657
Minghui Yang, Alireza Javadi, and Shaoqin Gong
39. Label-Free Electrochemical Sensing of DNA Hybridization for Cancer Analysis..................671
Venkataraman Dharuman and Jong Hoon Hahn
40. Electrochemical Biosensor for Detection of Chronic Myelogenous Leukemia
and Acute Promyelocytic Leukemia............................................................................................693
Yuanzhong Chen, Xinhua Lin, Ailin Liu, and Kun Wang
Part IX Electronic and Magnetic Technologies for Cancer Analysis
41. Nanowire Transistor–Based DNA Methylation Detection.........................................................713
Wusi C. Maki, Gary K. Maki, and Niranka Mishra
42. Cancer Cell Detection and Molecular Profiling Using Diagnostic Magnetic Resonance.......731
Cesar M. Castro, Hakho Lee, and Ralph Weissleder
43. Field Effect Transistor Nanosensor for Breast Cancer Diagnostics.........................................747
Pritiraj Mohanty, Yu Chen, Xihua Wang, Mi K. Hong, Carol L. Rosenberg,
David T. Weaver, and Shyamsunder Erramilli
44. Measuring the Electric Field in Skin to Detect Malignant Lesions.........................................765
Richard Nuccitelli, KaYing Lui, Kevin Tran, Brian Athos, Mark Kreis,
and Pamela Nuccitelli
Part X Thermometric Sensing
45. Next Generation Calorimetry Based on Nanohole Array Sensing...........................................777
Gregory J. Kowalski, Mehmet Sen, and Dale Larson
