Table Of ContentAdvances in Experimental Medicine and Biology 1092
Cheng Dong · Nastaran Zahir
Konstantinos Konstantopoulos Editors
Biomechanics
in Oncology
Advances in Experimental Medicine
and Biology
Volume 1092
EditorialBoard
IRUNR.COHEN,TheWeizmannInstituteofScience,Rehovot,Israel
ABELLAJTHA,N.S.KlineInstituteforPsychiatricResearch,Orangeburg,
NY,USA
JOHND.LAMBRIS,UniversityofPennsylvania,Philadelphia,PA,USA
RODOLFOPAOLETTI,UniversityofMilan,Milan,Italy
NIMAREZAEI,TehranUniversityofMedicalSciencesChildren’sMedical
Center,Children’sMedicalCenterHospital,Tehran,Iran
Moreinformationaboutthisseriesathttp://www.springer.com/series/5584
Cheng Dong · Nastaran Zahir
Konstantinos Konstantopoulos
Editors
Biomechanics in
Oncology
123
Editors
ChengDong NastaranZahir
DepartmentofBiomedicalEngineering DivisionofCancerBiology
PennsylvaniaStateUniversity NationalCancerInstitute,
UniversityPark,PA,USA NationalInstitutesofHealth
Rockville,MD,USA
KonstantinosKonstantopoulos
DepartmentofChemicalandBiomolecular
Engineering
InstituteforNanoBioTechnology
JohnsHopkinsUniversity
Baltimore,MD,USA
ISSN0065-2598 ISSN2214-8019 (electronic)
AdvancesinExperimentalMedicineandBiology
ISBN978-3-319-95293-2 ISBN978-3-319-95294-9 (eBook)
https://doi.org/10.1007/978-3-319-95294-9
LibraryofCongressControlNumber:2018955701
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Preface
Adecadeago,theNationalCancerInstitute(NCI)launchedanewprogram
called the Physical Science-Oncology Network (PS-ON; https://physics.
cancer.gov) in order to broadly support the integration of physical sciences
perspectivesandtheoriesincancerresearchusingnewandperhapsnontradi-
tionalapproaches.
The overarching theme of the PS-ON program, which is to explore and
uncover the physics and physical sciences principles underlying cancer-
relevantperturbations,remainsvirtuallyunexploredandnotunderstood.The
physicalprinciplesandlawsthatdefinethebehaviorofmatterareprofoundly
important in developing an understanding of the initiation and evolution of
cancer at all length scales (i.e., submolecular, molecular, cellular, tissues,
organisms, and populations). The goal is to unravel the complicated and
multifaceted cancer disease process through the application of approaches
fromthephysicalsciencesthataretraditionallyusedtocomprehendcomplex
problems.Thereremainedanopportunitytobringprinciplesandapproaches
to bear from physics and engineering to cancer research. Embracing novel
tool and technology development from the physical sciences into biology
hasthereforebecomeanewchallengetomanyphysicalscientistsandanew
adaptationbymanybiologists.
Biomechanics represents an extremely important branch of the physical
sciences.Inthemid-1960s,ProfessorY.C.Fungpioneeredhisvisionforap-
plications oftraditionalengineeringmechanicsandtechniquesto medicine,
physiology,and biology,which was a beginningera of biomechanics. Over
the past several decades, biomechanics has already grown into a mature
discipline in engineering and physical sciences. Investigatorsin the field of
biomechanics have recently had a vested interest in conducting transdisci-
plinary research in physical sciences-oncology. In 2012, the United States
National Committee on Biomechanics (USNCB) sponsored its national
Frontiers Symposium and, for the first time, focused on “Mechanics in
Oncology,”chairedbyChengDongfromPennState, FanYuanfromDuke,
andLanceMunnfromMGH/Harvard(http://usncb.org/frontiers).Thisseries
of symposia and workshops of Bioengineering in Oncology has become
a sustained event at the Biomedical Engineering Society (BMES) annual
conferences.
This is certainly an exciting time to be studying Biomechanics in On-
cology. To maintain a vision on the horizon of where the biomechanics
in oncology field will need to go, we brought several leading scientists
v
vi Preface
to contribute to this book that is centered on discussing our emerging
challenges and identifying context for the current state of biomechanics in
oncology.Mostimportantly,thisbookhighlightstheaspectsofbiomechanics
at different biological length scales, from inside and outside the cancer
cell as well as in the circulation, all in the context of tumor initiation,
progressionandmetastasis, andtreatment.Manyofthechallengesinstudy-
ing biomechanics in oncology have been tempered by the development of
novel technologies for imaging and precisely measuring and quantifying
cellular and extracellular mechanical forces. The book also discusses those
technological approaches for studying biomechanics in oncology. In every
aspect of biomechanics, it critically evaluates where we are and where we
need to be to understand the significance and impact of mechanics in the
contextofcancer.
Thisbookismostappropriateforanyonewhowantstokeepabreastofthis
new,convergingfieldandtheever-changingapplicationssinceProfessorY.C.
Fung started in the mid-1960s. We hope you enjoy this book highlighting
the latest and greatest in biomechanics, and we look forward to your
contributionstothefutureofBiomechanicsinOncology.
UniversityPark,PA,USA ChengDong
Rockville,MD,USA NastaranZahir
Baltimore,MD,USA KonstantinosKonstantopoulos
Contents
1 TheNationalCancerInstituteInvestmentinBiomechanics
inOncologyResearch .................................... 1
AnthonyDickherber,ShannonK.Hughes,andNastaranZahir
2 DNAMechanicsandTopology ............................ 11
SumitabhaBrahmachariandJohnF.Marko
3 MechanicsoftheCellNucleus............................. 41
Dong-HweeKim,JungwonHah,andDenisWirtz
4 ExtracellularMatrixStiffnessExistsinaFeedbackLoopthat
DrivesTumorProgression ................................ 57
AllisonK.Simi,Mei-FongPang,andCelesteM.Nelson
5 Microenvironment Influences Cancer Cell Mechanics
fromTumorGrowthtoMetastasis......................... 69
DeeprajGhoshandMichelleR.Dawson
6 MechanicalForcesinTumorAngiogenesis.................. 91
MatthewR.ZanotelliandCynthiaA.Reinhart-King
7 FromCancerImmunoediting toNewStrategiesinCancer
Immunotherapy:TheRolesofImmuneCellsandMechanics
inOncology ............................................. 113
VirginiaAragon-Sanabria,GloriaB.Kim,andChengDong
8 Exposing Cell-Itary Confinement: Understanding
theMechanismsofConfinedSingleCellMigration .......... 139
BinShengWong,PanagiotisMistriotis,
andKonstantinosKonstantopoulos
9 ModelingCellMigrationMechanics ....................... 159
LouisS.PrahlandDavidJ.Odde
10 EngineeredModelsofMetastasiswithApplicationtoStudy
CancerBiomechanics .................................... 189
MichelleB.Chen,RogerD.Kamm,andEmadMoeendarbary
11 BiomechanicsoftheCirculatingTumor
CellMicroenvironment................................... 209
BenjaminL.KrogandMichaelD.Henry
vii
viii Contents
12 Platelet-BasedDrugDeliveryforCancerApplications....... 235
NerymarOrtiz-Otero,ZeinabMohamed,andMichaelR.King
13 BiomaterialsinMechano-oncology:MeanstoTuneMaterials
toStudyCancer......................................... 253
Shelly R. Peyton, Maria F. Gencoglu, Sualyneth Galarza,
andAlyssaD.Schwartz
14 DesignofFiberNetworksforStudyingMetastatic
Invasion................................................ 289
ApratimMukherjee,AniketJana,BrianKoons,
andAmrinderNain
15 TractionForceMicroscopyforNoninvasiveImagingofCell
Forces ................................................. 319
JeffreyA.Mulligan,FrançoisBordeleau,
CynthiaA.Reinhart-King,andStevenG.Adie
16 NoninvasiveImaging:BrillouinConfocalMicroscopy ....... 351
MilošNikolic´,ChristinaConrad,JitaoZhang,
andGiulianoScarcelli
Index ...................................................... 365
Contributors
Steven G.Adie Meinig School of Biomedical Engineering, Cornell Uni-
versity,Ithaca,NY,USA
VirginiaAragon-Sanabria DepartmentofBiomedicalEngineering,Penn-
sylvaniaStateUniversity,UniversityPark,StateCollege,PA,USA
FrançoisBordeleau Centre de Recherche du CHU de Québec, Université
Laval,Québec,Qc,Canada
Département de Biologie Moléculaire, Biochimie, Médicale et Pathologie,
Université,Laval,Québec,Qc,Canada
SumitabhaBrahmachari NorthwesternUniversity,Evanston,IL,USA
Michelle B.Chen Department of Mechanical Engineering, Massachusetts
InstituteofTechnology,Cambridge,MA,USA
ChristinaConrad Fischell Department of Bioengineering, University of
Maryland,CollegePark,MD,USA
Michelle R.Dawson DepartmentofMolecularPharmacology,Physiology,
andBiotechnology,BrownUniversity,Providence,RI,USA
CenterforBiomedicalEngineering,BrownUniversity,Providence,RI,USA
SchoolofEngineering,BrownUniversity,Providence,RI,USA
AnthonyDickherber Center for Strategic Scientific Initiatives, National
CancerInstitute,NationalInstitutesofHealth,Bethesda,MD,USA
ChengDong Department of Biomedical Engineering, Pennsylvania State
University,UniversityPark,StateCollege,PA,USA
SualynethGalarza Department of Chemical Engineering, University of
MassachusettsAmherst,Amherst,MA,USA
Maria F.Gencoglu Department of Chemical Engineering, University of
MassachusettsAmherst,Amherst,MA,USA
DeeprajGhosh Department of Molecular Pharmacology, Physiology, and
Biotechnology,BrownUniversity,Providence,RI,USA
JungwonHah KoreaUniversity,Seoul,S.Korea
ix
x Contributors
Michael D.Henry Department of Molecular Physiology and Biophysics,
CarverCollegeofMedicine,UniversityofIowa,IowaCity,IA,USA
DepartmentofPathologyandUrology,CarverCollegeofMedicine,Univer-
sityofIowa,IowaCity,IA,USA
HoldenComprehensiveCancerCenter,CarverCollegeofMedicine,Univer-
sityofIowa,IowaCity,IA,USA
Shannon K.Hughes Division of Cancer Biology, National Cancer Insti-
tute,NationalInstitutesofHealth,Rockville,MD,USA
AniketJana STEP Lab, Department of Mechanical Engineering, Virginia
Tech,Blacksburg,VA,USA
Roger D.Kamm Department of Mechanical Engineering, Massachusetts
InstituteofTechnology,Cambridge,MA,USA
Department of Biological Engineering, Massachusetts Institute of Technol-
ogy,Cambridge,MA,USA
Dong-HweeKim KoreaUniversity,Seoul,S.Korea
Gloria B.Kim DepartmentofBiomedicalEngineering,PennsylvaniaState
University,UniversityPark,StateCollege,PA,USA
Michael R.King DepartmentofBiomedicalEngineering,VanderbiltUni-
versity,Nashville,TN,USA
KonstantinosKonstantopoulos Department of Chemical and Biomolecu-
larEngineering,InstituteforNanoBioTechnology,JohnsHopkinsUniversity,
Baltimore,MD,USA
BrianKoons STEP Lab, Department of Mechanical Engineering,Virginia
Tech,Blacksburg,VA,USA
Benjamin L.Krog Department of Molecular Physiology and Biophysics,
CarverCollegeofMedicine,UniversityofIowa,IowaCity,IA,USA
John F.Marko NorthwesternUniversity,Evanston,IL,USA
PanagiotisMistriotis DepartmentofChemicalandBiomolecularEngineer-
ing,InstituteforNanoBioTechnology,JohnsHopkinsUniversity,Baltimore,
MD,USA
EmadMoeendarbary Department of Biological Engineering, Massa-
chusettsInstituteofTechnology,Cambridge,MA,USA
Department of Mechanical Engineering, University College London,
London,UK
ZeinabMohamed DepartmentofBiomedicalEngineering,CornellUniver-
sity,Ithaca,NY,USA
ApratimMukherjee STEP Lab, Department of Mechanical Engineering,
VirginiaTech,Blacksburg,VA,USA
