Biologicals 2017

44 Pages·2017·6.07 MB·English

AAggrrooww
Agribusiness intelligence
Biologicals 2017
An analysis of corporate, product and
regulatory news in 2016/2017

AAggrrooww
Agribusiness intelligence
Contents
2 A grow biologicals review 2017
11 B iologicals-related mergers, acquisitions
and deals in 2016
13 Mergers, acquisitions and deals in 2017
15 N ew active ingredients registered or launched in 2016
17 N ew active ingredients registered or launched in 2017
19 E U to set new approval criteria for low-risk pesticides
21 Four biopesticides cleared for EU approval
22 M oving towards a simpler EU biostimulant
registration regime
24 DuPont ag sales up 4% in Q1
25 Dow AgroSciences sales down 5% in Q1
27 B ayer agchem sales up 3% in first quarter
32 S yngenta agchem sales down 2% in first quarter
35 A rysta’s sales up 3% in Q1
36 BASF agchem sales up 4% in first quarter
37 F MC’s agchem sales down 3% in Q1
38 T he Chemspec Agrochemical Outlook Conference:
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www.agribusinessintelligence.com Agrow | Biopesticide (SE Asia) / 1
Agrow biologicals
review 2017
By Sanjiv Rana
Welcome to the fifth instalment in Agrow’s medium- and long-term with potential for
series of annual biologicals reviews. further incremental innovation to address
Biologicals, especially biopesticides, came key challenges in the agricultural area in a
into prominence in the first half of the new way, it adds.
current decade when a mix of political and
regulatory pressures led to the big players Do the companies not involved in the mega
looking at biologicals as possible deals perceive them as a threat?
components of crop protection solutions.
That was followed by a flurry of BASF, the only one
acquisitions and deals during the period among the Big Six that
2012-2014 by the big agrochemical was not involved in a big-
players seeking to give a jump start to ticket deal, feels “very
their biopesticide programmes. comfortable” about
its position. “Our crop
But during the last couple of years, the Alyson Emanuel, protection business –
BASF
limelight has moved to mega deals and with approximately €5.6
acquisitions involving the Big Six billion ($6.1 billion at the
themselves: DuPont and Dow Chemical current rate) in sales, industry leading
agreeing to merge their businesses; margins (FY 2016: 29.9%) and supported
Syngenta’s board accepting ChemChina’s by about one quarter of BASF’s entire R&D
acquisition offer; and Monsanto accepting budget – has the critical mass to remain
Bayer’s acquisition offer. What could be competitive in a changing industry
the potential impact of these on the environment,” says BASF Crop Protection’s
biologicals sector? vice-president of global strategic
marketing for Functional Crop Care,
Bayer points out that its combined R&D Alyson Emanuel. She points to its “well
portfolio with Monsanto would have filled” innovation pipeline, with peak
exceptional depth, reach and great sales potential of €3 billion ($3.3 billion)
commercial potential. Both companies have from products launched between 2015
complementary pipelines over short-, and 2025.
2 / Biopesticide (SE Asia) | Agrow www.agribusinessintelligence.com
The company keeps a close watch on but this will give time for the SMEs to in May 2016 with a focus on plant growth
potential acquisition opportunities. “As a develop superior products and prove and yield effects. The bionematicide, BioAct
general practice, we constantly review efficacy and grower acceptance.” He sees Prime (Paecilomyces lilacinus 251), which
acquisitions and divestitures opportunities potentially more opportunity for smaller received Greek approval in April, will be
as part of our active portfolio players to have an impact in the biologicals launched there this year with many other
management.” The company has “clearly market with the upcoming consolidations. countries around the globe to follow.
defined” key criteria. “We focus on “There are still many well-established,
innovative business segments that offer independent, small and mid-sized In terms of forthcoming launches, Bayer’s
specific customer benefits, segments that companies working on biologicals that have bioinsecticide, Requiem Prime (extract of
can grow above market average and shown recent success in the market or that Chenopodium ambrosioides), will be
enable growth in attractive regions, have been building up their portfolios and launched in 2017/2018 in many European
especially in emerging markets, as well as pipelines for some time.” countries. The seed treatment, Votivo
segments that can make our portfolio even (Bacillus firmus + clothianidin), will be
more countercyclical.” Mr Meadows-Smith also points out that launched in Europe in 2018.
“most of the industry leaders have made
Arysta LifeScience (part of Platform research investments or acquisitions in the Bayer has production sites for biologicals
Specialty Products), which was an early biologics space at this time, and thus are at Tlaxcala, Mexico and Wismar, Germany.
entrant to the biologicals segment, says primed to support and advance acceptance Bacterial microbials are produced in
that most companies currently undergoing and usage of biologicals in standard Tlaxcala while Wismar produces fungal
an M&A process have a clear strategy on commercial agriculture”. Stockton CEO Guy microbials.
biologicals. “It will be interesting to see if Elitzur is in agreement. “Regardless the
synergies are found by the combined mega M&As, biopesticides will keep growing BASF launched the biofungicide, Serifel
companies,” says Paula Pinto, vice- and be integrated into the conventional (Bacillus amyloliquefaciens strain MBI600),
president, global portfolio management. programmes in the short and long run.” in South America and Central America. The
biofungicide, Integral (B subtilis strain MBI
Specialist biologicals companies such as Product launches 600), was launched in Asia. In the EU, an
Marrone Bio Innovations (MBI), Stockton and pipeline emergency measure based on the EU
and BioConsortia also do not seem to Regulation 1107/2009 was granted for use
Bayer CropScience’s
perceive the industry restructuring as a biofungicide, Contans WG of the bioinsecticide, Velifer (Beauveria
threat. “The bigger you get the slower you (Coniothyrium minitans), bassiana strain PPRI 5339), in Germany and
get,” says MBI chief executive officer received regulatory Austria on potatoes to protect against
Dr Pamela Marrone. “The combination of approval in South Africa wireworms in February 2017. Under the
research programmes within the soon to last year. The biofungicide, trade name Broadband, Velifer was initially
be ‘big four’ is expected to expand the Serenade ASO (Bacillus Benoit Hartmann, developed for and is on the market in South
spend on biological research but, subtilis strain QST 713), Bayer CropScience Africa, the company says.
historically, large organisations have a received use expansions in
harder time with rapid innovation,” concurs a number of markets. Bayer CropScience’s Velifer is currently under evaluation in
the chief executive officer of BioConsortia, head of biologics R&D, Benoit Hartmann, Australia and the company expects that
Marcus Meadows-Smith. says that apart from combating diseases to be completed by the end of 2017.
such as Botrytis spp, bacterial infections Velifer will be launched in Asia in 2017.
Dr Marrone also points out the and black sigatoka on bananas as well as The seed-applied biofungicide for
opportunities for small, nimble, fast soil-based syndromes, the product also oilseed rape, Integral Pro (Bacillus
companies to be innovators. Mr Meadows- shows strong effects on improved plant amyloliquefaciens MBI 600), is in the final
Smith has a similar view. “There will growth and stimulation of plant defence. stages of regulatory approval in France
probably be a lull in the M&A of the SMEs, Serenade Prime was launched in Australia and Germany.
Ashish Malik,
Bayer CropScience
www.agribusinessintelligence.com Agrow | Biopesticide (SE Asia) / 3

The company has also recently submitted range of inoculants. Expansion is underway Two of Arysta’s bioinsecticides based on
applications with the US EPA to register the at the site for Velifer production, which is B bassiana strain 147 and strain NPP111B005
biofungicidal seed treatments, Velondis Flex expected to come online this year. Other have recently been cleared for EU approval.
(Bacillus subtilis strain BU1814), Velondis facilities include: Littlehampton, UK for The company plans to launch them in 2018
Extra (B subtilis strain BU1814 + B beneficial nemotodes-based insect in France and southern Europe, contingent
amyloliquefaciens strain MBI 600) and management Nemasys products and the upon regulatory approvals.
Velondis Plus (B subtilis strain BU1814 + B inoculants, HiCoat and HiStick; Durban,
amyloliquefaciens strain MBI 600). South Africa for HiCoat, Broadband and A licensing agreement last year with the
Velifer; Saskatoon, Canada for Nodulator Chinese Academy of Agricultural Sciences’
Nodulator Duo is a combination of inoculants; Ames, Iowa, US for Serifel and Institute of Plant Protection for protein-
inoculant and biofungicide and will be Integral; and additional sites in the US and based plant disease control technology has
launched in Canada in 2018. It will have South America that produce a range of led to a biological product being under
the Nodulator rhizobia inoculant biologicals products including Gelfix, HiStick, evaluation. The next step will be the
(Bradyrhizobium japonicum) along with HiCoat, Rhizoflo, Nodulaid, Nodulator, Vault development and regulatory phases, with
the biofungicide, Velondis Flex (B subtilis and Integral. an expected launch around 2020-2021.
strain BU1814).
Dow AgroSciences points out that the An exclusive licensing agreement with US
In 2016, BASF agreed a deal with French majority of its activity in the biologicals biostimulant company Beem Biologics for
plant biotechnology company Plant space has involved natural products, such novel plant-derived biostimulant
Advanced Technologies for the discovery as the insecticide, spinosad. Microbial- technology has led to a product that is
and development of novel biopesticides. based biological products are a logical currently under field testing with aim of
Some promising starting points have been extension of its leadership in the natural having it registered with the US EPA as a
identified although BASF points out that products market space, it says. “We have plant growth regulator in 2019.
development time will take about ten years. expertise both inside the company and
with collaborators that can help us grow in Arysta has production sites at: St Malo, France
BASF has several production sites for this area.” The company has an “active for the production for seaweed extract-based
biologicals solutions, from foliar- and seed- testing programme” to work with multiple biostimulants and biofungicides; Pau, France
applied bioncontrols to seed-applied third parties in the biological technology mainly for the production of virus-based
biostimulants or inoculants. The facility at space, but does not currently offer any bioinsecticides, including carpovirusine and
Somersby, Australia produces the Nodulaid products in this area. B bassiana-based products; and Saltillo,
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Mexico for various biostimulants and that registrations in Spain, Portugal, Greece marked as F500 + Integral - Bacillus subtilis
nutrition products with a strong focus on and Italy will shortly follow. Bi-PA has other strain MBI 600).
natural plant extracts. uses in development for the product.
“Chemistry will always be more relied upon
Among recently launched products, MBI Earlier this year, Bi-PA acquired a 25% stake due to the typically wider spectrum of
highlights: the bionematicide, Majestene in Australian company Innovate Ag. Bi-PA control and efficacy under most
(Burkholderia rinojensis strain A396), in the will develop and register Innovate Ag’s environmental conditions, but we see
US; the bioinsecticide/acaricide, Grandevo bioinsecticide, Sero-X (Clitoria ternatea biologicals growing to be an important
(Chromobacterium subtsugae strain extract), outside Australia and New Zealand. factor in coming years,” says Ms Emanuel.
PRAA4-1T), in Mexico; the biofungicide, The product has received Australian approval. Biological products extend BASF’s portfolio
Regalia (Reynoutria sachalinensis extract), The generation of data for its development and are not substitutes for BASF chemical
in Chile; and the anti-transpirant product, outside Australia is ongoing and the dossier crop protection products, she says.
Haven, in the US. The company has also will be submitted as soon as possible, Bi-PA
launched an unnamed bioinsecticide/ says. The companies, Belchim, American Arysta LifeScience has more than 50 stand-
nematicide for seed treatment applications Vanguard and Unifert, hold stakes in Bi-PA, alone biosolutions products, covering
in collaboration with Albaugh, which is which gives it access to their marketing biocontrol, biostimulants and innovative
marketing the product. The deal between channels in Europe, Americas and North nutrition. The company has also developed
the two companies covers all crops in the Africa/Middle East, respectively. numerous ProNutiva crop production input
US and Canada. programmes, which are integrated solutions
BioConsortia is in its consisting of protection, stimulation and/or
Among new active ingredients in its research and development nutritional inputs, derived from natural
pipeline, MBI points to its biofungicide, phase. “Certain leads for biosolutions and conventional crop protection.
MBI 110, based on a new strain of are in second or third year It is also in the process of developing ProNutiva
B amyloliquefaciens, for which is being field trials with major pre-mixes, creating specific combinations of
considered for US approval. The company partners, as well as self- biological as well as conventional ais.
has also agreed a deal with Nufarm to funded trials, for drought Marcus
develop Grandevo for Australia and New tolerance, nutrient use Meadows-Smith, MBI is also looking for partners for pre-
BioConsotria
Zealand. MBI expects a launch in New efficiency and yield mixed combination products. Albaugh is
Zealand in 2018 and in Australia in 2019. improvement in stressed and standard already stacking MBI’s microbe with its
agronomic conditions,” says Mr Meadows- chemicals, points out Dr Marrone.
MBI produces Grandevo, Regalia and Smith. Some new
Zequanox at its facility in Michigan and has consortia for
contractor sites for its other products. biofungicide activity are
moving into their first
During 2016, Stockton’s year of field trials.
Melaleuca alternifolia
extract-based biofungicide, Combination
Timorex Gold, was approved products
in Brazil, South Africa, BASF’s view is that most
Serbia, New Zealand, China, often, biocontrols will be
Ecuador, Spain and several Guy Elitzur, used along with and to
Stockton
additional states in the US. complement chemistry-
In 2017, the company expects approvals based solutions in IPM
in Colombia, Argentina, Guatemala, Serbia, programmes, although
Peru, Nicaragua and Dominican Republic. it is possible
Stockton’s combined biological and chemical circumstances may
fungicide, Regev (M alternifolia extract + arise where a biocontrol
difenoconazole), was registered in Israel and can address a need for
is in the process of registration in Colombia. which there is no
chemistry-based Our expertise,
Belgian company Biological Products for solution available. The
your solution
Agriculture (Bi-PA) received EU approval in company’s research
2016 for its biofungicide based on directions include
Trichoderma atroviride strain SC1 for use on development of
grapevines. Vintec, the product based on combinations of
that ai, has been launched in five European biological and chemistry
countries (France, Belgium, Germany, Austria and it also has such
and Luxembourg). Registrations in other commercial offers on
European countries are ongoing. As France the market, such as the
was the zonal rapporteur member state for fungicide, Xanthion
www.saltigo.com
the southern zone, the company expects (pyraclostrobin - trade-
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