Table Of ContentBiological and Hormonal Therapies of Cancer
Cancer Treatment and Research
Steven T. Rosen, M.D., Series Editor
Surwit EA, Alberts DS (eds): Endometrial Cancer. 1989. ISBN 0-7923-0286-9.
Champlin R (ed): Bone Marrow Transplantation. 1990. ISBN 0-7923-0612-0.
Goldenberg D (ed): Cancer Imaging with Radiolabeled Antibodies. 1990. ISBN 0-7923-0631-7.
Jacobs C (ed): Carcinomas of the Head and Neck. 1990. ISBN 0-7923-0668-6.
Lippman ME. Dickson R (eds): Regulatory Mechanisms in Breast Cancer: Advances in Cellular and
Molecular Biology of Breast Cancer. 1990. ISBN 0-7923-0868-9.
Nathanson L (ed): Malignant Melanoma: Genetics, Growth Factors. Metastases, and Antigens. 1991.
ISBN 0-7923-0895-6.
Sugarbaker PH (ed): Management of Gastric Cancer. 1991. ISBN 0-7923-1102-7.
Pinedo HM, Verweij J, Suit HD (eds): Soft Tissue Sarcomas: New Developments in the MUltidisciplinary
Approach to Treatment. 1991. ISBN 0-7923-1139-6.
Ozols RF (ed): Molecular and Clinical Advances in Anticancer Drug Resistance. 1991. ISBN 0-7923-1212-0.
Muggia FM (ed): New Drugs. Concepts and Results in Cancer Chemotherapy. 1991. ISBN 0-7923-1253-8.
Dickson RB, Lippman ME (eds): Genes, Oncogenes and Hormones: Advances in Cellular and Molecular
Biology of Breast Cancer. 1992. ISBN 0-7923-1748-3.
Humphrey G, Bennett, Schraffordt Koops H, Molenaar WM, Postma A (eds): Osteosarcoma in Adolescents
and Young Adults: New Developments and Controversies. 1993. ISBN 0-7923-1905-2.
Benz CC, Liu ET (eds): Oncogenes and Tumor Suppressor Genes in Human Malignancies. 1993.
ISBN 0-7923-1960-5.
Freireich EJ, Kantarjian H (eds): Leukemia: Advances in Research and Treatment. 1993.
ISBN 0-7923-1967-2.
Dana BW (ed): Malignant Lymphomas, Including Hodgkin's Disease: Diagnosis, Management, and Special
Problems. 1993. ISBN 0-7923-2171-5.
Nathanson L (ed): Current Research and Clinical Management of Melanoma. 1993. ISBN 0-7923-2152-9.
Verweij J, Pinedo HM, Suit HD (eds): Multidisciplinary Treatment of Soft Tissue Sarcomas. 1993.
ISBN 0-7923-2183-9.
Rosen ST, Kuzel TM (eds): Immunoconjugate Therapy of Hematologic Malignancies. 1993.
ISBN 0-7923-2270-3.
Sugarbaker PH (ed): Hepatobiliary Cancer. 1994. ISBN 0-7923-2501-X.
Rothenberg ML (ed): Gynecologic Oncology: Controversies and New Developments. 1994.
ISBN 0-7923-2634-2.
Dickson RB. Lippman ME (eds): Mammary Tumorigenesis and Malignant Progression. 1994.
ISBN 0-7923-2647-4.
Hansen HH (ed): Lung Cancer. Advances in Basic and Clinical Research. 1994. ISBN 0-7923-2835-3.
Goldstein U, Ozols RF (eds): Anticancer Drug Resistance. Advances in Molecular and Clinical Research.
1994. ISBN 0-7923-2836-1.
Hong WK, Weber RS (eds): Head and Neck Cancer. Basic and Clinical Aspects. 1994. ISBN 0-7923-3015-3.
Thall PF (ed): Recent Advances in Clinical Trial Design and Analysis. 1995. ISBN 0-7923-3235-0.
Buckner CD (ed): Technical and Biological Components of Marrow Transplantation. 1995.
ISBN 0-7923-3394-2.
Winter IN (ed): Blood Stem Cell Transplantation. 1997. ISBN 0-7923-4260-7.
Muggia FM (ed): Concepts, Mechanisms, and New Targets for Chemotherapy. 1995. ISBN 0-7923-3525-2.
Klastersky J (ed): Infectious Complications of Cancer. 1995. ISBN 0-7923-3598-8.
Kurzrock R, Talpaz M (eds): Cytokines: Interleukins and Their Receptors. 1995. ISBN 0-7923-3636-4.
Sugarbaker P (ed): Peritoneal Carcinomatosis: Drugs and Diseases. 1995. ISBN 0-7923-3726-3.
Sugarbaker P (ed): Peritoneal Carcinomatosis: Principles of Management. 1995. ISBN 0-7923-3727-1.
Dickson RB, Lippman ME (eds): Mammary Tumor Cell Cycle, Differentiation and Metastasis. 1995.
ISBN 0-7923-3905-3.
Freireich EJ, Kantarjian H (eds): Molecular Genetics and Therapy of Leukemia. 1995. ISBN 0-7923-3912-6.
Cabanillas F, Rodriguez MA (eds): Advances in Lymphoma Research 1996. ISBN 0-7923-3929-0.
Miller AB (ed): Advances in Cancer Screening. 1996. ISBN 0-7923-4019-1.
Hait WN (ed): Drug Resistance. 1996. ISBN 0-7923-4022-1.
Pienta KJ (ed): Diagnosis and Treatment of Genitourinary Malignancies. 1996.0-7923-4164-3.
Arnold AJ (ed): Endocrine Neoplasms. 1997.0-7923-4354-9.
Pollock RE (ed): Surgical Oncology_ 1997.0-7923-9900-5.
Verweij J, Pinedo HM, Suit HD (eds): Soft Tissue Sarcomas: Present Achievements and Future Prospects.
1997. ISBN 0-7923-9913-7.
Biological and Hormonal
Therapies of Cancer
edited by
Kenneth A. Foon, M.D.
Lucille Parker Markey Cancer Center
University of Kentucky
Lexington, Kentucky
Hyman B. Muss, M.D.
University ofVermont, College of Medicine
Vermont Cancer Center
Burlington, Vermont
....
SPRINGER SCIENCE+BUSINESS ME"DIA, L LC
Library of Congress Cataloging-in-Publication Data
Biological and hormonal therapies of cancer/edited by
Kenneth A.
Foon, Hyman B. Muss.
p. cm. - (Cancer treatment and research; v. 94)
Includes bibliographical references and index.
ISBN 978-1-4613-7837-2 ISBN 978-1-4615-6189-7 (eBook)
DOI 10.1007/978-1-4615-6189-7
1. Cancer-Hormone therapy. 2. Cancer-Chemoprevention.
3. Biological response modifiers. 1. Foon, Kenneth A. II. Muss,
Hyman B. III. Series.
[DNLM: 1. Neoplasms-drug therapy. 2. Antineoplastic
Agents-therapeutic use. W1 CA693 v. 94 1998/QZ 267 B6149 1998]
RC271.H55B54 1998
616.99' 406 - dc21
DNLM/DLC
for Library of Congress 97-28807
CIP
Copyright © 1998 by Springer Science+Business Media New York
Originally published by Kluwer Academic Publishers in 1998
Softcover reprint of the hardcover 1s t edition 1998
AH rights reserved. No part of this publication may be reproduced, stored in a
retrieval system or transmitted in any form or by any means, mechanical,
photocopying, recording, or otherwise, without the prior written permis sion of
the publisher, Springer Science+Business Media. LLC.
Printed an acid-free paper.
Contents
Preface. . . . . .. . . . .. .. . .. .... . .. . . . . . ....... .. . ....... ..... . . . Xl
1. Interferon therapy of hematologic malignancies 1
KENNETH A. FOON
2. Interferon Use in Solid Tumors ............................ 23
WILLIAM J. JOHN and KENNETH A. FOON
3. Cellular vaccine therapies for cancer ....................... 35
MICHAEL J. MASTRANGELO, TAKAMI SATO,
EDMUND C. LATTIME, HENRY C. MAGUIRE JR. and
DAVIDBERD
4. Anti-idiotype antibody vaccine therapies of cancer ........... 51
MALA Y A BHATTACHARYA-CHATTERJEE and
KENNETH A. FOON
5. Endocrine therapy of prostate cancer ....................... 69
RICK L. BARE and FRANK M. TORTI
6. Endocrine therapy of endometrial cancer 89
SAMUEL S. LENTZ
7. Phytochemicals for the prevention of breast and
endometrial cancer. . . . . . . . . . . . . . . . . . . . . . . . . . . . ... . . . . . . . . 107
J. MARK CLINE and CLAUDE L. HUGHES, JR.
8. Hormonal strategies for the prevention of breast cancer . . . . . . . 135
MARK R. OLSEN and RICHARD R. LOVE
v
9. Ovarian ablation as adjuvant therapy for early-stage breast
cancer... . . . .... . .... . .. ...... . .. . . ... ...... . . . . .... . . . . 159
KATHLEEN I. PRITCHARD
10. The duration of adjuvant tamoxifen therapy ................. 181
MALCOLM M. BILIMORIA and V. CRAIG JORDAN
11. Tamoxifen and the endometrium 195
RICHARD R. BARAKAT
12. Hormone replacement therapy and nonhormonal control of
menopausal symptoms in breast cancer survivors ............ 209
MELODY A. COBLEIGH
13. Endocrine therapy in metastatic breast cancer ............... 231
GRETCHEN G. KIMMICK and HYMAN B. MUSS
14. The regulation of estrogen receptor expression and function
in human breast cancer ................................... 255
ANNE T. FERGUSON, RENA G. LAPIDUS, and
NANCY E. DAVIDSON
vi
List of contributors
Richard R. Barakat, M.D.
c/o Academic Office
Gynecology Service
Department of Surgery
Memorial Sloan-Kettering Cancer Center
1275 York Avenue
New York, NY 10021
Rick L. Bare, M.D.
Department of Urology and The Comprehensive Cancer Center
The Bowman Gray School of Medicine
Wake Forest University
Winston-Salem, NC 27157-1094
David Berd, M.D.
Division of Neoplastic Diseases
Jefferson Medical College
Suite 1024, Curtis Building
1015 Walnut Street
Philadelphia, PA 19107
Malaya Bhattacharya-Chatterjee, Ph.D.
Department of Internal Medicine
Markey Cancer Center
800 Rose Street, Room 207 Combs Bldg
Lexington, KY 40536-0093
Malcolm M. Bilimoria
Department of Surgery and Robert H. Lurie Comprehensive Cancer Center
Northwestern University Medical School
303 E. Chicago Avenue
8258 Olson Pavilion
Chicago, IL 60611
vii
J. Mark Cline, D.V.M., Ph.D.
Bowman Gray School of Medicine
Department of Comparative Medicine
Comprehensive Cancer Center of Wake Forest University
Medical Center Boulevard
Winston-Salem, NC 27157
Melody A. Cobleigh, M.D.
Rush Presbyterian - St. Luke's Medical Center
105 Michaux Road
Riverside, IL 60546-1827
Nancy E. Davidson
Johns-Hopkins Oncology Center
Johns-Hopkins Hospital
600 North Wolfe Street
Baltimore, MD 21287-0002
Anne T. Ferguson
Johns-Hopkins Oncology Center
Johns-Hopkins Hospital
600 North Wolfe Street
Baltimore, MD 21287-0002
Kenneth A. Foon, M.D.
Director, Lucille Parker Markey Cancer Center
Professor & Chief, Division of Hematology and Oncology
Department of Internal Medicine
University of Kentucky School of Medicine
800 Rose Street, Room CC140
Lexington, Kentucky 40536-0093
Claude L. Hughes, M.D., Ph.D.
Department of Obstetrics and Gynecology
Duke University Medical Center
Durham, NC 27710
William J. John, M.D.
Deputy Director,
Assistant Professor of Medicine
Lucille P. Markey Cancer Center
University of Kentucky
Lexington, Kentucky 40536
viii
v. Craig Jordan, Ph.D., D.Sc.
Robert H. Lurie Comprehensive Cancer Center
Northwestern University Medical School
303 E. Chicago Avenue
8258 Olson Pavilion
Chicago, IL 60611
Gretchen G. Kimmick, M.D.
Comprehensive Cancer Center of Wake Forest University
The Bowman Gray School of Medicine
Medical Center Boulevard
Winston-Salem, NC 27157
Rena G. Lapidus
Johns Hopkins Oncology Center
Johns Hopkins Hospital
600 North Wolfe Street
Baltimore MD 21287-0002
Edmund C. Lattime, Ph.D.
Division of Neoplastic Diseases
Jefferson Medical College
Suite 1014, College Building
1025 Walnut Street
Philadelphia, P A 19107
Samuel S. Lentz, M.D.
Section on Gynecologic Oncology
Comprehensive Cancer Center of Wake Forest University
Medical Center Boulevard
Winston-Salem, NC 27157-1065
Richard R. Love, M.D.
Cancer Prevention Program
University of Wisconsin
7C Medical Sciences Center
1300 University A venue
Madison, WI 53706
Henry C. Maguire, Jr., M.D.
Division of Neoplastic Diseases
Jefferson Medical College
Room 1008, College Building
1025 Walnut Street
Philadelphia, P A 19107
ix
Michael J. Mastrangelo, M.D.
Division of Neoplastic Diseases
Jefferson Medical College
Suite 1024, College Building
1025 Walnut Street
Philadelphia, P A 19107
Hyman B. Muss, M.D.
Professor of Medicine
Comprehensive Cancer Center of Wake Forest University
The Bowman Gray School of Medicine
Medical Center Boulevard
Winston-Salem, NC 27157
Mark R. Olsen, M.D., Ph.D.
••
••
••
Kathleen I. Pritchard, M.D., FRCPC
Division of Medical Oncology/Haematology
Toronto-Sunnybrook Regional Cancer Centre
University of Toronto
2075 Bayview Avenue
Toronto, Ontario
M4N 3M5 Canada
Takami Sato, M.D.
Division of Neoplastic Diseases
Jefferson Medical College
Room 1011, College Building
1025 Walnut Street
Philadelphia, P A 19107
Frank M. Torti, M.D.
Bowman Gray School of Medicine
Comprehensive Cancer Center
Medical Center Boulevard
Winston-Salem, NC 27157
x
